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Poisoning Patterns Before, During, and after the COVID-19 Pandemic in the Poisoning Centers in Urmia: A Six-Year Retrospective Study
Full text linkBackground: Poisoning is one of the main causes of emergency admissions and deaths worldwide, which could be affected by the COVID-19 pandemic. This study aimed to assess poisoning patterns before, during, and after the COVID-19 pandemic at poisoning centers in Urmia.
Methods: In this retrospective, descriptive-analytical study, all poisoned patients hospitalized in Urmia poisoning centers from 2018 to 2023 were studied. Patients were categorized into groups before, during, and after the COVID-19 pandemic. Then, statistical analyses were performed using SPSS version 21.
Results: This investigation evaluated 13197 patients (51.7% males, 48.3% females). The mortality rate was 323 (2.45% total; 75.9% males; 24.1% females). The patients' Mean± standard deviation age was (28 ± 14.05) years (min=14, max=96). Most patients were aged 21-30 years, and approximately half were male. The number of hospitalizations during the COVID-19 pandemic (2,665) decreased significantly compared with before (5,697) and after (4,835). Pesticide (41.1%), Pharmaceuticals (20.6%), Substance abuse (17.8%), Mixed poisonings (12.2%), and Alcohol (6.5%) were the most common causes of death during the COVID-19 pandemic, respectively. Mortality among males was higher than among females at all times. But the mortality rate during the COVID-19 pandemic (4%) increased significantly compared to before (1.7%) and after (2.5%). Significant relationships were detected between the patients' outcomes and age>60 years, Male, Widowed status, Higher (Academic) education, and Alcohol poisoning, Gases, Pesticides, Bites, and Foods/Mushrooms.
Conclusion: Despite a decline in hospitalizations due to fears of COVID-19, it was able to change patterns of poisoning and mortality. Therefore, education to prevent pesticides, Alcohol, and drugs during public health crises can reduce morbidity and mortality
The Right to Mental Health of Children in Cyberspace in the Light of the International Human Rights System: Background and Aims: The right to mental health is one of the main components of the right to health and one of the most important examples of children's rights. Various factors are effective in threatening or realizing this right of children, and cyberspace is one of them. Virtual space is important because nowadays children spend a lot of time in that environment, and this happens while a significant part of this space is not only not suitable for the specific age and mental state of children, but also the effects of It also leaves a damage on their soul and spirit. This research, with descriptive analytical method, seeks to answer the question: How can the right to mental health of children be realized in cyberspace according to international human rights documents? To answer this question, various children's rights in cyberspace such as the right to education, the right to privacy, the right to security, and the right to play and have fun and their relationship with the right to children's mental health have been investigated.The results of this research indicate that in the international human rights system, especially in the field of protecting children's rights, comprehensive measures have been put before the States. Materials and Methods: The current research is applied in terms of purpose and descriptive-analytical in terms of the type of research, which has been collected and analyzed by using library resources and examining a wide range of documents and procedures and other research works. Ethical Considerations: Honesty and ethics have been observed in searching and referencing. Finding and Conclusion: It is necessary to pay attention to the duties of States in protecting and protecting the rights of children in the digital environment at the international and domestic levels. General comment No. 25 published on March 21, 2021, by the United Nations Committee on the Rights of the Child, on how to apply the Convention on the Rights of the Child Children paid by states in the digital sphere. The committee's purpose of this General comment was to provide a strategy for legislation and policy making in the field of fulfilling the obligations of states in the framework of the Convention on the Rights of the Child and its optional protocols in the light of the opportunities, risks and challenges of the digital environment. To put it better, today with the general interpretation of this committee, the rights of the child are guaranteed not only in the offline environment but also in the digital and online environment.
No full textThe right to mental health is a fundamental component of the right to health and a core aspect of children’s rights. Among the factors influencing the realization or violation of this right, cyberspace plays a significant role, as children increasingly spend substantial time in digital environments that are often inappropriate for their age and mental development and may negatively affect their psychological well-being. Using a descriptive-analytical method, this study examines how children’s right to mental health can be realized in cyberspace in light of international human rights instruments. It analyzes key related rights in the digital context, including the rights to education, privacy, security, and play, and their connection to children’s mental health. The findings indicate that international human rights law, particularly in the field of children’s rights, provides comprehensive measures and obligations for States to protect children in the digital environment. Special attention is given to General Comment No. 25 (2021) of the UN Committee on the Rights of the Child, which clarifies States’ duties under the Convention on the Rights of the Child and its Optional Protocols in addressing the opportunities, risks, and challenges of the digital sphere, thereby affirming that children’s rights must be protected both offline and online
حمایت از حقوق کودکان در برابر تغییرات اقلیمی در پرتو نظریه عدالت بیننسلی
No full textBackground and Aim: Climate change directly or indirectly places the fundamental rights of children - protected under the Convention on the Rights of the Child- at risk, depriving both the present generation and future generations of their rights to survival, development, protection, and participation in society. Throughout history, justice has been regarded as the ultimate goal of legal science and, from an axiological perspective, has been presented as encompassing all values. Nevertheless, the scope and subject of justice have been discussed less frequently. In other words, justice is generally conceived as governing matters and persons who exist in the present world; yet do future generations - particularly children- have no share in justice? This is the question that the theory of intergenerational justice seeks to uncover and address.
Methods: This research adopts a qualitative approach with the aim of describing and analyzing theoretical foundations and international documents, employing a documentary-library method. Data collection was conducted through a review of written documents in the two key domains of children's rights and intergenerational justice in climate change.
Ethical Considerations: In compiling this article, ethical aspects including preserving the originality of texts, honesty, and trustworthiness have been observed.
Findings: In General Comment No. 26, the Committee on the Rights of the Child has adopted a child-rights-based approach and has paid due regard to human rights and environmental principles, the recognition of the human right to a clean, healthy and sustainable environment, as well as the existing and evolving principles and obligations of international environmental law.
Conclusion: The Committee on the Rights of the Child seeks, by emphasizing the theory of intergenerational justice, to obligate the present generation to recognize the rights of future generations particularly children, over natural resources and the environment, and to find solutions for a world currently facing environmental degradation. In this regard, States, on the basis of the principle of common but differentiated responsibilities, are committed to undertaking individual and collective actions, through international cooperation, to respect, promote and fulfil children’s rights in the face of climate change, as Article 4 of the Convention underscores the implementation of the Convention as a joint endeavour by States for the full realization of children’s rights.زمینه و هدف: تغییرات اقلیمی، حقوقِ اساسی کودکان را که در کنوانسیون حقوق ِکودک از آنها حمایت به عمل آمده به طور مستقیم یا غیرمستقیم در معرضِ تهدید قرار میدهد و نسلِ حاضر و نسلهای آتی را از حقوق خود جهتِ بقا، توسعه، حفاظت و مشارکت در جامعه محروم میسازد. در طول تاریخ، «عدالت» را غایت علم حقوق دانستهاند و از لحاظ ارزششناسی، آن را جامع ارزشها معرفی نمودهاند. با این همه، حیطه و موضوعِ عدالت، کمتر به بحث گذاشته شده است. به تعبیر دیگر، عموماً عدالت را حاکم بر موضوعات و اشخاصی قرار میدهند که در اکنونِ جهان حضور دارند، اما آیا آیندگان بهخصوص کودکان از عدالت بهرهای ندارند؟ این پرسشی است که «نظریه عدالتِ بیننسلی» از آن پرده برمیدارد.
روش: این پژوهش با رویکرد کیفی و با هدف توصیف و تحلیل مبانی نظری و اسناد بینالمللی، به روش کتابخانهای-اسنادی انجام شده است. گردآوری دادهها از طریق مرور اسناد مکتوب در دو حوزهی کلیدی «حقوق کودک» و «عدالت بیننسلی در تغییرات اقلیمی» صورت پذیرفته است.
ملاحظات اخلاقی: در تدوین این مقاله جنبههای اخلاقی شامل حفظ اصالت متون، صداقت و امانتداری رعایت شده است.
یافتهها: کمیته حقوق کودک ملل متحد در نظر تفسیری شماره ۲۶ رویکردی مبتنی بر حقوق کودک اتخاذ کرده و به اصول حقوق بشر و محیط زیست، به رسمیت شناختن حق بشر برای داشتن محیط زیستی پاک، سالم و پایدار و اصول و تعهدات موجود و در حال تحول حقوق بینالملل محیط زیست توجه داشته است.
نتیجهگیری: کمیته حقوق کودک در تلاش است تا با تأکید بر «نظریه عدالت بیننسلی» نسل کنونی را مکلّف بدارد تا حق نسلهای آینده بهخصوص کودکان را در منابع طبیعی و محیط زیست به رسمیت بشناسد و برای جهانِ در حالِ نابودیِ فعلی، راه چارهای بیابد. در همین راستا دولتها براساس اصل مسئولیت مشترک اما متمایز متعهد هستند اقداماتی را جهت احترام، ارتقا و تحقق حقوق کودکان در برابر تغییرات اقلیمی به صورت جداگانه و مشترک از طریق همکاریهای بینالمللی انجام دهند، همانطورکه ماده ۴ کنوانسیون بر اجرای کنوانسیون بهعنوان یک اقدام مشترک برای دولتها جهت تحقق کامل حقوق کودکان تأکید میکند
Simultaneous Inhibition of Histone Deacetylases and EZH2 Reduces SASP in Non-Small Cell Lung Cancer
No full textBackground: Cellular senescence, a common outcome of treatments like chemotherapy and radiotherapy, often acts as a therapeutic hurdle. Our prior investigations revealed that this senescent state is accompanied by the secretion of the senescence-associated secretory phenotype (SASP), a potent driver of chronic inflammation and a factor that can paradoxically facilitate tumor progression.
Methods: We investigated the effects of SAHA, alone or combined with the EZH2 inhibitor EPZ-6438, on NSCLC cell lines. Senescence induction was confirmed via SA-β-galactosidase staining, while cell growth was evaluated using MTT and colony formation assays. Mechanistic studies, including Western blotting, qPCR for SASP factors, and immunofluorescence for Cytoplasmic Chromatin Fragments (CCF), were performed to assess the underlying pathway.
Results: SAHA effectively induced senescence-mediated growth inhibition in A549 and H1299 cells but simultaneously triggered the SASP. This SAHA-induced SASP was linked to the generation of CCFs, thereby activating the cGAS–STING pathway. Importantly, the combined administration of SAHA and EPZ-6438 significantly reduced the expression of inflammatory mediators, such as IL6 and IL8. This co-treatment not only provided superior anti-proliferative activity compared to SAHA alone but also enhanced the suppression by attenuating the SASP.
Conclusion: Collectively, our data demonstrate that SAHA-induced senescence in NSCLC cells is critically linked to detrimental SASP production mediated by CCF formation. Crucially, combining SAHA with EZH2 inhibition successfully suppressed the SASP, leading to enhanced growth inhibition, thereby providing a robust rationale for this combination therapy in NSCLC treatment
تأثیر هشت هفته تمرینات سیکلیک یوگا بر سندرم متقاطع فوقانی، لوردوز افزایش یافته و سلامت روانی زنان سالمند
No full textBackground and Aim: Postural abnormalities and Upper Crossed Syndrome are common problems among elderly women that can lead to physical and psychological disorders. The aim of the present study was to investigate the effect of eight weeks of cyclic yoga exercises on Upper Crossed Syndrome and mental health in elderly women.
Methods: 30 elderly women over 60 years old with postural abnormalities including thoracic kyphosis, forward head, and lumbar lordosis were purposefully selected and randomly divided into two experimental and control groups (15 people in each group). This research was conducted with ethical approval code IR.SHAHROODUT.REC.1403.008 from the Ethics Committee of Shahrood University of Technology, and ethical considerations such as informed consent, voluntary participation, and confidentiality of information were observed. The experimental group participated in selected cyclic yoga exercises for eight weeks, three sessions per week, each session lasting 45 to 90 minutes. A flexible ruler was used to measure thoracic kyphosis and lumbar lordosis, a goniometer for forward head angle, and the General Health Questionnaire (GHQ) to assess mental health status. Data were analyzed using paired t-test and analysis of covariance in SPSS software version 22.
Results: The results showed that cyclic yoga exercises led to a significant reduction in thoracic kyphosis angle, forward head angle, lumbar lordosis angle, and a significant improvement in mental health in the exercise group compared to the control group.
Conclusion: Cyclic yoga exercises can be used as an effective intervention to improve skeletal-muscular abnormalities and promote mental health in elderly women.
Please cite this article as:
Soltanian T. Rezvani MH, Naderi A, ChoromZadeh H. Effect of Eight Weeks of Cyclic Yoga Practice on Upper Crossed Syndrome, Increased lordosis and Mental Health in Elderly Women. Irtiqa Imini Pishgiri Masdumiyat .2024;12(4):248-259. https://doi.org/10.22037/iipm.v11i3.49200سابقه و هدف: ناهنجاریهای وضعیتی و سندرم متقاطع فوقانی از مشکلات شایع در میان زنان سالمند هستند که میتوانند منجر به اختلالات جسمانی و روانی شوند. هدف پژوهش حاضر بررسی تأثیر هشت هفته تمرینات سیکلیک یوگا بر سندرم متقاطع فوقانی و سلامت روانی در زنان سالمند بود.
روش کار: ۳۰ زن سالمند بالای ۶۰ سال با ناهنجاریهای وضعیتی شامل کیفوز پشتی، سر به جلو و لوردوز کمری بهصورت هدفمند انتخاب و بهطور تصادفی در دو گروه آزمایش و کنترل (هر گروه ۱۵ نفر) تقسیم شدند. این پژوهش با اخذ تأییدیه اخلاقی با کد IR.SHAHROODUT.REC.1403.008 از کمیته اخلاق دانشگاه صنعتی شاهرود انجام شد و ملاحظات اخلاقی نظیر رضایت آگاهانه، مشارکت داوطلبانه و محرمانگی اطلاعات رعایت گردید. گروه آزمایش به مدت هشت هفته، سه جلسه در هفته و هر جلسه به مدت ۴۵ تا ۹۰ دقیقه در تمرینات منتخب سیکلیک یوگا شرکت کردند. برای سنجش کیفوز پشتی و لوردوز کمری از خطکش منعطف، برای زاویه سر به جلو از گونیامتر و برای بررسی وضعیت سلامت روانی از پرسشنامه سلامت عمومی GHQ استفاده شد. دادهها با استفاده از آزمون تی زوجی و تحلیل کوواریانس در نرمافزار SPSS نسخه ۲۲ تحلیل شدند.
یافته ها: نتایج نشان داد که تمرینات سیکلیک یوگا منجر به کاهش معنادار زاویه کیفوز پشتی، زاویه سر به جلو، زاویه لوردوز کمری و بهبود معنادار سلامت روانی در گروه تمرین نسبت به گروه کنترل شد.
نتیجه گیری: تمرینات سیکلیک یوگا میتواند بهعنوان یک مداخله مؤثر برای بهبود ناهنجاریهای اسکلتیـعضلانی و ارتقاء سلامت روانی در زنان سالمند مورد استفاده قرار گیرد.
به این مقاله، به صورت زیر استناد کنید:
Soltanian T. Rezvani MH, Naderi A, ChoromZadeh H. Effect of Eight Weeks of Cyclic Yoga Practice on Upper Crossed Syndrome, Increased lordosis and Mental Health in Elderly Women. Irtiqa Imini Pishgiri Masdumiyat .2024;12(4):248-259. https://doi.org/10.22037/iipm.v11i3.4920
Author Package-2025: Author Package-2025
No full textThe Trends in Peptide and Protein Sciences is a peer-reviewed, online-only (previously print-online), scientific journal owned by Protein Technology Research Center, Shahid Beheshti University of Medical Sciences and documents in all important aspects of the research in peptides and proteins focusing on analytics and impurities, bioinformatics, biopharmaceuticals and vaccines, biotechnology, chemical synthesis, conformational analysis, design and development of protein therapeutics, determination of structure, enzymology, folding and sequencing, formulation and stability, function, genetics, immunology, kinetics, modeling, molecular biology, pharmacokinetics and pharmacodynamics of therapeutic proteins and antibodies, pharmacology, protein engineering and development, protein-protein interaction, proteomics, purification/expression/production, simulation, thermodynamics and hydrodynamics and protein biomarkers. The aim of this Journal is to publish high quality original research articles, reviews, short communications and letters and to provide a medium for scientists and researchers to share their findings from the area of peptides and proteins. The Trends in Peptide and Protein Sciences is published in collaboration with Iranian Association of Pharmaceutical Scientists. From volume 3 (2018) of TPPS, articles are continuously published online only, as soon as the review process is completed
Multicystic Dysplastic Kidney Disease: A Review: Multicystic Dysplastic Kidney
No full textThe cystic kidney is one of the most common abnormalities detectable by ultrasound beforeand after birth and is also a cause of hydronephrosis; therefore, ultrasound is necessary foraccurate diagnosis. Multicystic dysplastic kidney (MCDK) is a congenital disease in whichthe kidney is filled with multiple cysts and does not function properly. This article describesan article review of MCDK and new attention. This study aimed to increase awareness ofthe importance of diseases that cause kidney cysts, especially dysplastic multicystic kidneydisease, to promote understanding of diagnostic methods before and after birth, and toinvestigate its cause
Gelatin sponge scaffolds loaded with adipose-derived mesenchymal stem cell secretome enhance full-thickness skin wound healing in rats
Full text linkBackground: Skin wounds that are full-thickness present a major clinical problem. Although cell-based treatments have limitations, the secretome of adipose-derived mesenchymal stem cells (ADMSCs) stimulates recovery through paracrine signaling. This study utilized a gelatin sponge scaffold as a biocompatible delivery platform for the ADMSC secretome, creating a cell-free therapeutic system.
Methods: Human ADMSCs were characterized. Their conditioned medium (secretome) was collected and analyzed for key growth factors. Gelatin sponge scaffolds were fabricated by freeze-drying and crosslinking, then loaded with the secretome. Scaffolds were characterized physico-chemically (SEM, FTIR, porosity, degradation). In vitro biocompatibility was tested on dermal fibroblasts. Gelatin/secretome scaffolds, gelatin-only scaffolds, or gauze were used to treat full-thickness excisional wounds in rats (n = 6 per group). Wound closure, histology, collagen, and angiogenesis were evaluated on days 10 and 20.
Results: ADMSCs expressed characteristic markers. The secretome contained hepatocyte growth factor (124.45 pg/mL), basic fibroblast growth factor-2 (42.18 pg/mL), and vascular endothelial growth factor (7.54 pg/mL). Scaffolds showed high porosity (85-90%) and supported high fibroblast viability/proliferation. In vivo, gelatin/secretome scaffolds achieved significantly faster wound closure (87.4 ± 4.3% on day 10; 98.7 ± 1.2% on day 20) versus controls (gelatin: 68.2 ± 5.7% and 92.1%; gauze: 62.5 ± 6.1%). They also promoted superior re-epithelialization, collagen deposition (62.4 ± 5.8%), and neovascularization (32.8 ± 4.6 vessels/field).
Conclusion: Gelatin scaffolds loaded with ADMSC secretome significantly enhance full-thickness wound healing by accelerating closure, improving tissue regeneration, and stimulating angiogenesis. This cell-free platform represents a promising strategy for clinical wound care
جایگاه حسن نیت در قراردادهای مشارکت در تولید
No full textBackground and Aim: Good faith as an ethical principle, along with the developments of human society and the development of complex social and commercial relationships of the people of the society, has been established in line with human standards, social justice and fairness. This study was conducted with the aim of examining the importance and status of good faith in Production Sharing Contracts.
Methods: This research is theoretical in nature and adopts a descriptive–analytical method, with data collection carried out through library research and consultation of legal texts.
Ethical Considerations: In the present study, the ethical aspects of library study, including the originality of the texts, honesty, and trustworthiness, have been observed.
Findings: The principle of good faith and the obligation to observe it hold a special significance in contract law and govern all stages of a contract, to the extent that the existence of mutual good faith may be regarded as the very framework of any contractual relationship. This principle likewise applies to production sharing agreements. One of the manifestations of compliance with the principle of good faith in production sharing contracts is the transfer of technology. In this context, technology refers to a set of knowledge, products, processes, tools, methods, and systems that are employed in the creation of goods or the provision of services. Contract law is one of the fields in which the principle of good faith, as a standard of customary and fair conduct, plays an active and effective role, and its observance is emphasized throughout all the different stages of the contractual process.
Conclusion: Although the observance of the principle of good faith constitutes a reciprocal obligation incumbent upon both parties to the contract, in this category of contracts, due to the lack of adequate legal safeguards and the insufficient protection and effective observance of intellectual property rights by the other party, the contractor, in practice, lacks the necessary willingness to transfer and make available technology to the host country.زمینه و هدف: حسن نیت بهعنوان یک اصل اخلاقی، همگام با تحولات جامعه بشری و گسترش ارتباطات پیچیده اجتماعی و تجاری افراد جامعه، در راستای موازین انسانی و عدالت اجتماعی و انصاف بنا نهاده شده است. این مطالعه با هدف بررسی اهمیت و جایگاه حسن نیت در قراردادهای مشارکت در تولید به انجام رسید.
روش: این تحقیق از نوع نظری بوده و از روش توصیفی ـ تحلیلی بهره برده و جمعآوری دادهها در آن با استفاده از ابزار کتابخانه و مراجعه به متون حقوقی انجام پذیرفته است.
ملاحظات اخلاقی: در پژوهش حاضر جنبههای اخلاقی مطالعه کتابخانهای شامل اصالت متون، صداقت و امانتداری رعایت شده است.
یافتهها: اصل حسن نیت و لزوم رعایت آن از اهمیت ویژهای در حقوق قراردادها برخوردار است و در تمامی مراحل قرارداد حاکم میباشد؛ بهگونهای که میتوان وجود حسن نیت متقابل را شاکله هر قرارداد دانست. این اصل در قراردادهای مشارکت در تولید نیز حاکم است. یکی از جلوههای رعایت اصل حسن نیت در قراردادهای مشارکت در تولید، انتقال فناوری است. در این معنا، فناوری به مجموعهای از دانشها، محصولات، فرایندها، ابزارها، روشها و نظامهایی اطلاق میشود که در خلق کالا یا ارائه خدمات مورد استفاده قرار میگیرند. حقوق قراردادها یکی از عرصههایی است که اصل حسن نیت بهعنوان رفتار متعارف و منصفانه، حضوری فعال و مؤثر دارد و رعایت آن در تمامی مراحل مختلف قرارداد مورد تأکید قرار میگیرد.
نتیجهگیری: هرچند رعایت اصل حسن نیت بهعنوان تکلیفی متقابل بر عهده طرفین قرارداد است، اما در این دسته از قراردادها، به دلیل فقدان تضمینهای حقوقی کافی و نیز عدم رعایت مؤثر حقوق مالکیت فکری از سوی طرف مقابل، پیمانکار عملاً تمایل لازم برای انتقال و در اختیار گذاشتن فناوری به کشور میزبان را ندارد
The Role of Omega-3 in Improving Clinical Symptoms of Children With Urinary Tract Infections: A Randomized Clinical Trial: Omega-3 in Children With Urinary Tract Infections
No full textBackground and Aim: Inflammatory urinary tract infection (UTI) is a common infectiousdisease in childhood, causing significant discomfort. Omega-3 fatty acids are well-known fortheir anti-inflammatory properties, which may aid in decreasing UTI symptoms. This studyaimed to investigate the effects of omega-3 therapy in children with UTI.Methods: This randomized clinical trial enrolled 100 children with UTIs, randomized intoplacebo and intervention groups. In addition to standard treatment, the intervention groupreceived one omega-3 capsule daily. Symptoms were assessed at the baseline and again afterthe treatment period.Results: At baseline, no significant differences were observed between the two groupsin age, gender, or symptom prevalence. However, after the treatment period, omega-3supplementation resulted in a significant decrease in dysuria and urinary frequency symptomscompared to the placebo group.Conclusion: Omega-3 supplementation as adjunct therapy can significantly improve theseverity of symptoms in children with UTIs