150 research outputs found
Author response image 1. Author response
No full textAnimals can learn causal relationships between pairs of stimuli separated in time and this ability depends on the hippocampus. Such learning is believed to emerge from alterations in network connectivity, but large-scale connectivity is difficult to measure directly, especially during learning. Here, we show that area CA1 cells converge to time-locked firing sequences that bridge the two stimuli paired during training, and this phenomenon is coupled to a reorganization of network correlations. Using two-photon calcium imaging of mouse hippocampal neurons we find that co-time-tuned neurons exhibit enhanced spontaneous activity correlations that increase just prior to learning. While time-tuned cells are not spatially organized, spontaneously correlated cells do fall into distinct spatial clusters that change as a result of learning. We propose that the spatial re-organization of correlation clusters reflects global network connectivity changes that are responsible for the emergence of the sequentially-timed activity of cell-groups underlying the learned behavior. DOI: http://dx.doi.org/10.7554/eLife.01982.001
Correction to: Safety of laparoscopic compared to open right hepatectomy after portal vein occlusion: results from a multicenter study (Surgical Endoscopy, (2025), 39, 3, (1839-1847), 10.1007/s00464-025-11532-8)
No full textThe original online version of this article was revised to correct the presentation of the name of coauthor Nadia Russolillo, and to correct the affiliation information for corresponding author Serena Langella. The original article has been corrected
Psychological treatments in schizophrenia: II. Meta-analyses of randomized controlled trials of social skills training and cognitive remediation
No full textBackground. Social skills training and cognitive remediation are psychological techniques with considerable face validity for the treatment of negative symptoms of schizophrenia and their consequences. This paper provides a meta-analytical review of these treatments. It includes an appreciable number of randomized controlled trials, using comparisons against both standard care and other active interventions. However, the assessment of particular outcomes sometimes had to be based on single studies.Method. A detailed search strategy was used to identify randomized controlled trials of social skills training and cognitive remediation, primarily employing electronic databases. Randomized controlled trials (RCTs) that met predefined criteria were then subjected to meta-analysis on a variety of outcome measures.Results. There was no clear evidence for any benefits of social skills training on relapse rate, global adjustment, social functioning, quality of life or treatment compliance. Cognitive remediation had no benefit on attention, verbal memory, visual memory, planning, cognitive flexibility or mental state.Conclusions. Social skills training and cognitive remediation do not appear to confer reliable benefits for patients with schizophrenia and cannot be recommended for clinical practice
Adjustment of India’s Foreign Policy for Southeast Asia in the Time of Prime Minister Narendra Modi and its Impacts on India - Vietnam Relationships
No full textObjective: The purpose of the article will present and analyze the adjustment of India’s foreign policy towards Southeast Asia under Prime Minister N. Modi and its impacts on Vietnam - India relations.
Theoretical framework: In this study, International Relations theories such as those of Realism, Liberalism and Constructivism have been used to clear the goals, approaches and content of India’s policies for Southeast Asia, the adjustment of Prime Minister N. Modi towards ASEAN and Southeast Asian countries.
Method: The author uses historical methods, interdisciplinary research methods and comparative methods to present and evaluate India’s foreign policy with ASEAN and Southeast Asian countries under Prime Minister Modi compared to before and evaluate the impacts of this adjustment on Vietnam - India relations in the future.
Results and conclusions: Historically, India has reached Southeast Asia by way of peace, trade and religion. Entering the 21st century, Southeast Asia is one of the focal points in India’s strategic adjustment to the Asia-Pacific region because of its extremely important geo-political and geo-economical position. However, India’s foreign policy before 2014 (Look East Policy) was primarily “observation” rather than “action”. Since Prime Minister Narendra Modi came to power in May 2014, the Look East Policy has been adjusted into the Act East Policy to expand the goals, scope and areas of cooperation, and enhance the actions and strategic priorities in relations with its extended neighbor Southeast Asia.
Implication of the research: This adjustment has greatly impacted on India, Southeast Asian countries and the Vietnam - India Comprehensive Strategic Partnership. The article provides some policy implications for Vietnam to promote the Vietnam - India Comprehensive Strategic Partnership in the coming time.
Originality/ Value: This study is an elaborate, comprehensive and systematic work of the authors through an international approach.
 
Heterosynaptic Plasticity Underlies Aversive Olfactory Learning in Drosophila
No full textSummary Although associative learning has been localized to specific brain areas in many animals, identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the first demonstration of long-term synaptic plasticity at the output site of the Drosophila mushroom body. Pairing an odor with activation of specific dopamine neurons induces both learning and odor-specific synaptic depression. The plasticity induction strictly depends on the temporal order of the two stimuli, replicating the logical requirement for associative learning. Furthermore, we reveal that dopamine action is confined to and distinct across different anatomical compartments of the mushroom body lobes. Finally, we find that overlap between sparse representations of different odors defines both stimulus specificity of the plasticity and generalizability of associative memories across odors. Thus, the plasticity we find here not only manifests important features of associative learning but also provides general insights into how a sparse sensory code is read out
Building resilient societies after COVID-19: the case for investing in maternal, neonatal, and child health
No full textResilient societies respond rapidly and effectively to health challenges and the associated economic consequences, and adapt to be more responsive to future challenges. Although it is only possible to recognise resilience retrospectively, the COVID-19 pandemic has occurred at a point in human history when, uniquely, sufficient knowledge is available on the early-life determinants of health to indicate clearly that a focus on maternal, neonatal, and child health (MNCH) will promote later resilience. This knowledge offers an unprecedented opportunity to disrupt entrenched strategies and to reinvest in MNCH in the post-COVID-19 so-called new normal. Furthermore, analysis of the short-term, medium-term, and longer-term consequences of previous socioeconomic shocks provides important insights into those domains of MNCH, such as neurocognitive development and nutrition, for which investment will generate the greatest benefit. Such considerations apply to high-income countries (HICs) and low-income and middle-income countries (LMICs). However, implementing appropriate policies in the post-COVID-19 recovery period will be challenging and requires political commitment and public engagement. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licens
Flexible specificity of memory in Drosophila depends on a comparison between choices
No full textInternational audienceMemory guides behavior across widely varying environments and must therefore be both sufficiently specific and general. A memory too specific will be useless in even a slightly different environment, while an overly general memory may lead to suboptimal choices. Animals successfully learn to both distinguish between very similar stimuli and generalize across cues. Rather than forming memories that strike a balance between specificity and generality, Drosophila can flexibly categorize a given stimulus into different groups depending on the options available. We asked how this flexibility manifests itself in the well-characterized learning and memory pathways of the fruit fly. We show that flexible categorization in neuronal activity as well as behavior depends on the order and identity of the perceived stimuli. Our results identify the neural correlates of flexible stimulus-categorization in the fruit fly
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