155 research outputs found
Análisis de la fotografía documental de Cristina García Rodero: Estudio de la colección ‘Historia de una pasión’
No full textEl presente trabajo surge bajo el propósito de realizar un análisis de la obra fotográfica de Cristina García Rodero a través de un acercamiento teórico a los postulados posestructuralistas sobre la imagen fotográfica y el género fotográfico documental.
La idea de imagen fotográfica resultante del análisis teórico de las propuestas antropológicas y filosóficas posmaterialistas seleccionadas, nos permite entender el empleo del género fotográfico documental como método de expresión artística por parte de la fotógrafa Cristina García Rodero durante toda su trayectoria profesional.
Además, el análisis de la obra de García Rodero desde la corriente del documentalismo fotográfico contemporáneo nos conduce a concebir las realidades sociales que la autora documenta como un preámbulo para la expresión de sus emociones, para lo que empleará dos elementos narrativos claves en sus fotografías: 1) las representaciones visuales de la religiosidad popular y 2) la gestualidad de los sujetos fotografiados.
Esta forma de entender el modo de operar de Cristina García Rodero nos permite entender cómo ha logrado aunar a través de la fotografía situaciones culturales tan diferentes como son las representaciones religioso-populares de la España rural de los setenta y ochenta y la cotidianidad en la Georgia posbélica en la década de los noventa, entre otras.The purpose of this paper is to analyse the photographic work of Cristina García Rodero by means of a theoretical approach to the post-structuralist postulates on the photographic image and the documentary photographic genre. The idea of the photographic image resulting from the theoretical analysis of the selected postmaterialist anthropological and philosophical proposals allows us to understand the use of the documentary photographic genre as a method of artistic expression by the photographer Cristina García Rodero throughout her professional career. Furthermore, the analysis of García Rodero's work from the contemporary current of photographic documentary leads us to conceive of the social realities that the author documents as a preamble to the expression of her emotions, for which she employs two key narrative elements in her photographs: 1) the visual representations of popular religiosity and 2) the gestures of the photographed people. This way of understanding Cristina García Rodero's way of operating allows us to understand how she has managed to bring together through photography such different cultural situations as the popular-religious representations of rural Spain in the seventies and eighties and everyday life in post-war Georgia in the nineties, among others.Universidad de Sevilla. Grado en Periodism
Reduced Il17a expression distinguishes a Ly6c lo MHCIIhi macrophage population promoting wound healing
No full textMacrophages are the main components of inflammation during skin wound healing. They are critical in wound closure and in excessive inflammation, resulting in defective healing observed in chronic wounds. Given the heterogeneity of macrophage phenotypes and functions, we here hypothesized that different subpopulations of macrophages would have different and sometimes opposing effects on wound healing. Using multimarker flow cytometry and RNA expression array analyses on macrophage subpopulations from wound granulation tissue, we identified a Ly6c lo MHCIIhi "noninflammatory" subset that increased both in absolute number and proportion during normal wound healing and was missing in Ob/Ob and MYD88-/-models of delayed healing. We also identified IL17 as the main cytokine distinguishing this population from proinflammatory macrophages and demonstrated that inhibition of IL17 by blocking Ab or in IL17A-/-mice accelerated normal and delayed healing. These findings dissect the complexity of the role and activity of the macrophages during wound inflammation and may contribute to the development of therapeutic approaches to restore healing in chronic wounds
Interleukin-23 regulates interleukin-17 expression in wounds, and its inhibition accelerates diabetic wound healing through the alteration of macrophage polarization
No full textInflammation is a critical phase in the healing of skin wounds. Excessive inflammation and inflammatory macrophages are known to cause impaired wound closure and outcome. This prompted us to test the role of IL-23 in IL-17 expression and in modulating wound inflammation and macrophage polarization. Full-thickness wounds (4 × 6 mm) were created on the dorsal surface of multiple genetically modified mouse models. Obese diabetic mouse wounds were treated with anti-IL-17A, anti-IL-23, or isotype-matched antibodies. We found IL-23- but not IL-12-deficient mice displayed significantly reduced IL-17 expression in wounds. This was rescued by delivery of recombinant IL-23. IL-23- and IL-17-deficient mice showed a significant increase in noninflammatory macrophages. Obese diabetic mice treated with anti-IL-17A and anti-IL-23p19 blocking antibodies had significantly improved wound reepithelialization. Similarly, IL-17-/- obese mice had accelerated wound closure, resulting in reduced iNOS expression and inflammatory macrophages while maintaining prohealing CD206 and lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1)-expressing macrophages. This study highlights the importance of the IL-17 pathway in wound closure offering new possibilities of therapeutic intervention in chronic wounds.-Lee, J., Rodero, M. P., Patel, J., Moi, D., Mazzieri, R., Khosrotehrani, K. Interleukin-23 regulates interleukin-17 expression in wounds, and its inhibition accelerates diabetic wound healing through the alteration of macrophage polarization
Chemokine receptor CCR1 disruption limits renal damage in a murine model of hemolytic uremic syndrome
No full textShiga toxin (Stx)producing Escherichia coli is the main etiological agent that causes hemolytic uremic syndrome (HUS), a microangiopathic disease characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Although direct cytotoxic effects on endothelial cells by Stx are the primary pathogenic event, there is evidence that indicates the inflammatory response mediated by polymorphonuclear neutrophils and monocytes as the key event during HUS development. Because the chemokine receptor CCR1 participates in the pathogenesis of several renal diseases by orchestrating myeloid cell kidney infiltration, we specifically addressed the contribution of CCR1 in a murine model of HUS. We showed that Stx type 2treated CCR1 -/- mice have an increased survival rate associated with less functional and histological renal damage compared with control mice. Stx type 2triggered neutrophilia and monocytosis and polymorphonuclear neutrophil and monocyte renal infiltration were significantly reduced and delayed in CCR1 -/- mice compared with control mice. In addition, the increase of the inflammatory cytokines (tumor necrosis factor-α and IL-6) in plasma was delayed in CCR1 -/- mice compared with control mice. These data demonstrate that CCR1 participates in cell recruitment to the kidney and amplification of the inflammatory response that contributes to HUS development. Blockade of CCR1 could be important to the design of future therapies to restrain the inflammatory response involved in the development of HUS.Fil: Ramos, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Auvynet, Constance. Universite Pierre et Marie Curie; Francia. Inserm; FranciaFil: Poupel, Lucie. Inserm; Francia. Universite Pierre et Marie Curie; FranciaFil: Rodero, Mathieu. Universite Pierre et Marie Curie; Francia. Inserm; FranciaFil: Mejias, María Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Panek, Cecilia Analía. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Combadiere, Christophe. Universite Pierre et Marie Curie; Francia. Inserm; FranciaFil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentin
Chimiokines cellules myéloïdes et cancer
No full textLE KREMLIN-B.- PARIS 11-BU Méd (940432101) / SudocSudocFranceF
Type I interferonâ-mediated monogenic autoinflammation:The type i interferonopathies, a conceptual overview
No full textType I interferon is a potent substance. As such, the induction, transmission, and resolution of the type I interferonâ-mediated immune response are tightly regulated. As defined, the type I interferonopathies represent discrete examples of a disturbance of the homeostatic control of this system caused by Mendelian mutations. Considering the complexity of the interferon response, the identification of further monogenic diseases belonging to this disease grouping seems likely, with the recognition of type I interferonopathies becoming of increasing clinical importance as treatment options are developed based on an understanding of disease pathology and innate immune signaling. Definition of the type I interferonopathies indicates that autoinflammation can be both interferon and noninterferon related, and that a primary disturbance of the innate immune system can spill over into autoimmunity in some cases. Indeed, that several non-Mendelian disorders, most particularly systemic lupus erythematosus and dermatomyositis, are also characterized by an up-regulation of type I interferon signaling suggests the possibility that insights derived from this work will have relevance to a broader field of clinical medicine.</p
See it on a radio story: sound effects and shots to evoked imagery and attention on audio fiction
No full textRadio’s capacity to stimulate the creation of mental images in the mind of its listeners has long been acknowledged. Nevertheless, research into mental imagery has focused principally on the study of visual stimuli, although studies into radio itself have mostly concerned the field of advertising. In this study, we examine the influence of two stimuli associated with auditory processing on radio: sound effects and sound shots. The chosen context for the study is that of a fictional story, or audio drama, through which to measure the role of these stimuli both in creating mental images in the listener’s mind and in maintaining his or her attention. Our findings demonstrate that the inclusion of descriptive sound effects and especially of sound shots in a fictional radio drama increases mental imagery and that a relationship exists between this increase and the degree of listener attention.The author received no financial support for the research and/or authorship of this article
On the use of Biplot analysis for multivariate bibliometric and scientific indicators
No full textBibliometric mapping and visualization techniques represent one of the main pillars in the field of scientometrics. Traditionally, the main methodologies employed for representing data are Multi-Dimensional Scaling, Principal Component Analysis or Correspondence Analysis. In this paper we aim at presenting a visualization methodology known as Biplot analysis for representing bibliometric and science and technology indicators. A Biplot is a graphical representation of multivariate data, where the elements of a data matrix are represented according to dots and vectors associated with the rows and columns of the matrix. In this paper we explore the possibilities of applying the Biplot analysis in the research policy area. More specifically we will first describe and introduce the reader to this methodology and secondly, we will analyze its strengths and weaknesses through three different study cases: countries, universities and scientific fields. For this, we use a Biplot analysis known as JK-Biplot. Finally we compare the Biplot representation with other multivariate analysis techniques. We conclude that Biplot analysis could be a useful technique in scientometrics when studying multivariate data and an easy-to-read tool for research decision makers
Biallelic mutations in MTPAP associated with a lethal encephalopathy
No full textBackground A homozygous founder mutation in MTPAP/TENT6, encoding mitochondrial
poly(A) polymerase (MTPAP), was first reported in six individuals of Old Order
Amish descent demonstrating an early-onset, progressive spastic ataxia with optic
atrophy and learning difficulties. MTPAP contributes to the regulation ofmitochondrial
gene expression through the polyadenylation of mitochondrially encoded mRNAs.
Mitochondrial mRNAs with severely truncated poly(A) tails were observed in affected
individuals, and mitochondrial protein expression was altered.
Objective To determine the genetic basis of a perinatal encephalopathy associated with
stereotyped neuroimagingandinfantile death in three patients fromtwounrelated families.
Methods Whole-exome sequencing was performed in two unrelated patients and the
unaffected parents of one of these individuals. Variants and familial segregation were
confirmed by Sanger sequencing. Polyadenylation of mitochondrial transcripts and de
novo synthesis of mitochondrial proteins were assessed in patient’s fibroblasts
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