3,456 research outputs found
Cardiolipin acyl chain composition tailors the conformation of mammalian ATP synthase dimers
No full textAuthor contributions:
M.M. and I.L.M.: conceptualization; M.M. simulation and analysis; M.M., V.G.A.V., and I.L.M.: writing and editingThe interplay between ATP synthase dimers and the four-tailed lipid cardiolipin (CL) shapes mitochondrial cristae structure and function. In the mitochondrial disorder Barth syndrome (BTHS), cristae membranes accumulate a less unsaturated, three-tailed form of cardiolipin (MLCL). These cristae become structurally and functionally compromised through mechanisms poorly understood. We have studied through molecular dynamics simulations how BTHS lipid composition affects the conformation of the ATP synthase dimer. The wedge-shaped transmembrane region of the ATP synthase dimer attracts cardiolipins through shape complementarity. MLCL showed decreased affinity for the dimer interface than CLs of the healthy model. A more heterogeneous lipid environment with a higher elastic strain promoted a dimer conformation that would stabilize wider intracrista spaces, and hence, less efficient OXPHOS reactions in BTHS. Our results provide clues on the role played by the CL acyl chain composition in the architecture and function of mitochondria in health and BTHS.Ministerio de Ciencia, Innovación y Universidades ( España)Comunidad de MadridFundación ComplutenseDepto. de Farmacia Galénica y Tecnología AlimentariaDepto. de Química FísicaFac. de VeterinariaFac. de Ciencias QuímicasTRUEpu
Authority and Personality in M.M. Bakhtin\u27s Author and Hero in Aesthetic Activity
No full textM.M. Bakhtin\u27s fundamental claim in his seminal essay Author and Hero in Aesthetic Activity situates verbal action as the most essential constituent of human personality. A careful reading of this text reveals important truths about the relationship between free individual personhood and the nature of the speech utterance. Bakhtin connects the human experience of speech to the life and person of Jesus Christ emphasizing the incarnation and the Trinitarian view of God as essential principles for understanding the creative power of the word and consequent liabilities. Bakhtin develops these theological and philosophical coordinates around a discussion of the author-hero relationship in the novel asserting that the verbal utterance is creatively involved in building and sustaining the inner personhood of those it addresses. Bakhtin\u27s critical conclusion substantiates that from whom a word is received, and to whom the spoken word appeals has weighty influence on the type and character of human personality, and that personality\u27s relationship to authority
Documento Bancario, M.M. Mayence & Cie., Paris, 1908 Junio 14
No full textabstract: Handwritten letter from Rubén Darío to M.M. Mayence & Cie, informing about one meeting with the Spain's King and the location of Nicaraguan legation in Madrid.The original Rubén Darío Papers 1882-1945 (MSS-339) are located at ASU Libraries Archives & Special Collections. For more information about visiting the collection see http://hdl.handle.net/2286/L.A.0.The top margin has the hand written word "Particular" ("Private, Personal").In the left top margin apparently are written the words "Documento 267" ("Documento 267").Heading the letter there is a reference to a person called Santiago, whose last name hasn't been identified
M.M. Arkas: through the correlation between professional and patriotic
No full textУ статті розглянуто проблему співвідношення у творчому спадку М.М. Аркаса,
композитора, історика, громадського діяча, професійних і патріотичних засад. Проаналізовано
життєдіяльність М.М. Аркаса та виявлені основні чинники, що вплинули на формування його
світоглядних уявлень і врешті сприяли становленню у представника грецького роду українського
менталітету.В статье рассматривается проблема соотношения в творческом наследии Н.Н. Аркаса, композитора,
историка и общественного деятеля, профессионализма и патриотизма. Анализируется жизнедеятельность
Н.Н. Аркаса и выявляются основные компоненты, что способствовали формированию его духовного космоса
и становлению у представителя греческого рода украинского менталитета.The article examines the issues of rating the professional and patriotic constituents in the creative legacy of
M.M. Arkas, - the composer, historian and social activist. By researching into the life of M.M. Arkas, the author uncovers
the key factors and events that influenced the formation of his spiritual cosmos and thus eventually conduced
to moulding the Ukrainian mentality in a member of the Greek kinship
M.M. Arkas: through the correlation between professional and patriotic
No full textУ статті розглянуто проблему співвідношення у творчому спадку М.М. Аркаса,
композитора, історика, громадського діяча, професійних і патріотичних засад. Проаналізовано
життєдіяльність М.М. Аркаса та виявлені основні чинники, що вплинули на формування його
світоглядних уявлень і врешті сприяли становленню у представника грецького роду українського
менталітету.В статье рассматривается проблема соотношения в творческом наследии Н.Н. Аркаса, композитора,
историка и общественного деятеля, профессионализма и патриотизма. Анализируется жизнедеятельность
Н.Н. Аркаса и выявляются основные компоненты, что способствовали формированию его духовного космоса
и становлению у представителя греческого рода украинского менталитета.The article examines the issues of rating the professional and patriotic constituents in the creative legacy of
M.M. Arkas, - the composer, historian and social activist. By researching into the life of M.M. Arkas, the author uncovers
the key factors and events that influenced the formation of his spiritual cosmos and thus eventually conduced
to moulding the Ukrainian mentality in a member of the Greek kinship
M.M. Arkas: through the correlation between professional and patriotic
No full textУ статті розглянуто проблему співвідношення у творчому спадку М.М. Аркаса,
композитора, історика, громадського діяча, професійних і патріотичних засад. Проаналізовано
життєдіяльність М.М. Аркаса та виявлені основні чинники, що вплинули на формування його
світоглядних уявлень і врешті сприяли становленню у представника грецького роду українського
менталітету.В статье рассматривается проблема соотношения в творческом наследии Н.Н. Аркаса, композитора,
историка и общественного деятеля, профессионализма и патриотизма. Анализируется жизнедеятельность
Н.Н. Аркаса и выявляются основные компоненты, что способствовали формированию его духовного космоса
и становлению у представителя греческого рода украинского менталитета.The article examines the issues of rating the professional and patriotic constituents in the creative legacy of
M.M. Arkas, - the composer, historian and social activist. By researching into the life of M.M. Arkas, the author uncovers
the key factors and events that influenced the formation of his spiritual cosmos and thus eventually conduced
to moulding the Ukrainian mentality in a member of the Greek kinship
Plant introduction, conservation and enrichment of biodiversity in M.M. Gryshko National Botanical Garden of the NAS of Ukraine
No full textThe paper deals with the main achievements of scientists of M.M. Gryshko National Botanical Garden of the NAS of Ukraine (NBG) in scientific, conservation, cultural and educational activities. The results of researches on biodiversity, conservation, plants protection, introduction, acclimatization and selection, allelopathy, medical botany, landscape design, bioindication and hemosystematycs are given. It is noted that over 14 thousands species, forms and varieties of plants, are collected in NBG, and the most unique collections attributed to the objects of national heritage. Breeders have obtained more than 300 certificates or author ship on plant varieties. NBG carries out extensive international cooperation, several new exposition of plant collection appeared in Botanical Garden. In recent years the achievements of NBG scientists were awarded by two State Awards in the field of science and technology of Ukraine
Perception of M.M. Bakhtin in the West: some general remarks
No full textIn the present work is a translation of the short introductory work of Turin’s Professor Roberto Salizzoni dedicated to the analysis of art of M.M. Bakhtin and some reflections of the author of the translation, which led him to assess creativity Russian thinker, present in this book of the Italian scientist. First of all, the author of the translation does not agree with the disparaging assessment of creativity of Bakhtin how unoriginal and more abounding plagiarism. The author of the translation argues injustice exaggerated influence on the concept of Bakhtin from literary trends and ideas, including by the media those of the so-called “circle of Bakhtin”. The necessity of considering of creativity of Russian thinker as philosophical, creativity independent and original. Such a conclusion can fail and approval of Neokantian origin of “philosophical roots” of Bakhtin’s concept of philosophy of culture
The relationship of maternal and fetal glucose concentrations in the human from midgestation until term
No full textThe relationship between maternal and fetal glucose concentrations was investigated in pregnant women at different gestational ages. Maternal and fetal blood samples were obtained during 14 fetoscopies (17 to 21 weeks), four umbilical cord samples (32 to 36 weeks), nine elective cesarean sections with appropriate for gestational age (AGA) fetuses (35 to 39 weeks) and nine elective cesarean sections with small for gestational age (SGA) fetuses (34 to 37 weeks). A significant linear relationship between maternal and fetal glucose concentrations was demonstrated at midgestation (P less than .001) and at late gestation (P less than .001). At equal maternal concentrations there were no significant differences in fetal glucose concentration between the cord samples obtained in late gestation and those obtained at cesarean section. At midgestation fetal glucose concentration is independent of and may exceed maternal concentration at maternal glucose levels less than 4.44 mmol/L. Furthermore, the relationship between maternal and fetal concentrations at maternal glucose concentrations greater than 4.44 mmol/L is significantly different at midgestation from that at late gestation (P less than .01); at equal maternal concentrations there were higher glucose concentrations in the mid trimester fetus. In late gestation as the maternal glucose concentration increases there is an increase in the maternal arterial-umbilical arterial glucose concentration difference and the umbilical glucose/oxygen quotient (P less than .003) reflecting increased glucose utilization by the fetus. There were no significant differences between AGA and SGA babies with respect to these relationships
Author Correction: the Influence of Nano Filter Elements on Pressure Drop and Pollutant Elimination Efficiency in Town Border Stations
No full textThe original version of this Article contained an error in the order of the author names, which was incorrectly given as Hamed Ebadiyan, Saeed Zeinali Heris, Seyed Borhan Mousavi, Shamin Hosseini Nami ; Mousa Mohammadpourfard. Consequently, in the Author Contributions section, “H.E. Investigation. S.Z.H. Supervision, Conceptualization, Methodology, Validation. S.B.M. Formal analysis, Writing original draft. S.H.N. Formal analysis, Writing original draft. M.M. Validation.” now reads: “S.Z.H. Supervision, Conceptualization, Methodology, Validation. H.E. Investigation. S.B.M. Formal analysis, Writing original draft. S.H.N. Formal analysis, Writing original draft. M.M. Validation.” The original Article has been corrected. © 2023, The Author(s)
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