171,826 research outputs found
Search for four-top-quark production in the single-lepton and opposite-sign dilepton final states in proton-proton collisions at √s = 13 TeV with the ATLAS detector
No full textRecent published results on a search for four-top-quark production, tttt, are presented, based on a dataset collected at √s = 13 TeV with the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of 36.1 fb−1. The single-lepton and opposite-sign dilepton final states are analysed. The search exploits the high multiplicity of jets/b-tagged jets and the large total sum of jet transverse momenta, which characterise signal events and provide a good discrimination against the tt+jets dominant background, which is estimated through a data-driven method. No significant excess above the Standard Model expectation is observed
Has something changed in the smoking attitudes of parents in the household in the last 15 years? Epidemiological survey among the students of the city of Agrigento [È cambiato qualcosa nelle abitudini dei genitori fumatori in ambito domestico negli ultimi 15 anni? Indagine epidemiologica tra gli alunni della città di Agrigento]
No full textBACKGROUND:
Exposure of children to passive tobacco smoking in the household setting has been demonstrated to cause respiratory diseases. Early atherosclerosis has also been demonstrated in young people previously exposed to passive tobacco smoking. Functional damage can initiate at the fetal age due to maternal smoking, with a tendency towards over-time progress. To date only scant data are available about indoor parental smoking attitudes and their changes after campaigns against smoke and risk factors in exposed youths. Questionnaires are useful tools in order to search for information on cigarette smoking and parental household lifestyle. In this study, we asked pupils of primary schools for providing information on their relatives' every 5 years throughout the period 1994-2009.
METHODS:
A multiple-choice answer questionnaire about sharing household parental smoking was administered to all primary school children (mean age 10.5 ± 0.5 years) of the city of Agrigento (Sicily, Italy).
RESULTS:
A total of 2221 questionnaires were collected from 637 children in 1994, 687 in 1999, 516 in 2004, and 381 in 2009. Important findings show a significant reduction in both smoking parents and exposure to passive tobacco smoking (from 64% in 1994 to 45% in 2009, p<0.00001). In 2009, 22% of mothers and 39% of fathers resulted to be smokers in the household setting yet.
CONCLUSIONS:
In agreement with the 2011 Italian DOXA survey on the general population, the present study demonstrates a negative trend in the prevalence of household smoker parents (predominantly mothers) and exposure of children to passive tobacco smoking. These results likely reflect such a greater awareness about smoke-related risks in children, and the effectiveness of medical campaigns against cardiovascular risk factors as well
Ángel Bahamonde Magro y Juan Carlos Sánchez Illán, Una república de papel: «L’Espagne Républicaine» (1945-1949)
No full textL’étude consacrée par Ángel Bahamonde Magro et Juan Carlos Sánchez Illán à la revue L’Espagne républicaine vient enrichir notre connaissance des milieux de l’exil républicain en France. Spécialistes de l’histoire contemporaine de l’Espagne (Á. Bahamonde Magro) et de l’histoire des médias (J. C. Sánchez Illán), les auteurs explorent le projet politique défendu par cet hebdomadaire. Publié en français et en espagnol, à Toulouse, puis à Paris, il a été créé principalement par Ricardo Gasset Alzu..
Targeting and understanding hiv latency: The crispr system against the provirus
No full textThe presence of latently infected cells and reservoirs in HIV-1 infected patients constitutes a significant obstacle to achieve a definitive cure. Despite the efforts dedicated to solve these issues, the mechanisms underlying viral latency are still under study. Thus, on the one hand, new strategies are needed to elucidate which factors are involved in latency establishment and maintenance. On the other hand, innovative therapeutic approaches aimed at eradicating HIV infection are explored. In this context, advances of the versatile CRISPR-Cas gene editing technology are extremely promising, by providing, among other advantages, the possibility to target the HIV-1 genome once integrated into cellular DNA (provirus) and/or host-specific genes involved in virus infection/latency. This system, up to now, has been employed with success in numerous in vitro and in vivo studies, highlighting its increasing significance in the field. In this review, we focus on the progresses made in the use of different CRISPR-Cas strategies to target the HIV-1 provirus, and we then discuss recent advancements in the use of CRISPR screens to elucidate the role of host-specific factors in viral latency
Ángel Bahamonde Magro y Juan Carlos Sánchez Illán, Una república de papel: «L’Espagne Républicaine» (1945-1949)
No full textL’étude consacrée par Ángel Bahamonde Magro et Juan Carlos Sánchez Illán à la revue L’Espagne républicaine vient enrichir notre connaissance des milieux de l’exil républicain en France. Spécialistes de l’histoire contemporaine de l’Espagne (Á. Bahamonde Magro) et de l’histoire des médias (J. C. Sánchez Illán), les auteurs explorent le projet politique défendu par cet hebdomadaire. Publié en français et en espagnol, à Toulouse, puis à Paris, il a été créé principalement par Ricardo Gasset Alzu..
Second and third line treatment in non-small cell lung cancer
No full textNon-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide, and the advances in second and third line treatment have led to prognostic improvements in the latest years. Besides the two cytotoxic agents, docetaxel and pemetrexed, approved in NSCLC second line treatment, a new class of drugs against specific molecular targets seems to be an alternative to conventional treatment. Many trials are ongoing to assess the activity of new drugs, alone or in association, and new combinations of third-generation chemotherapeutic agents. © 2009 Elsevier Ireland Ltd. All rights reserved
Pitfalling in nanomedical targeting of melanoma: a 'clinical' case of misdelivered RNAi
No full textNon disponibil
Inovação no setor público: um estudo sobre o software de gestão administrativa da Universidade Federal de Santa Catarina
No full textDissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico, Programa de Pós-Graduação em Administração Universitária, Florianópolis, 2015.Esta dissertação tem por objetivo avaliar o processo de aquisição e adoção do software de gestão administrativa pela Universidade Federal de Santa Catarina (UFSC), no período compreendido entre o quarto trimestre do ano de 2009 ao segundo trimestre de 2015, sob a suposição de que ele ainda não se concretizou como um padrão eficiente de comunicação entre os setores, observando também o seu enquadramento sob a ótica da teoria da inovação. Para tanto, foi elaborada uma pesquisa bibliográfica sobre administração pública, administração universitária, inovação, inovação no setor público, governo eletrônico, sistemas de informação e avaliação de sistemas de informação. Posteriormente foi desenvolvida uma pesquisa documental que elencou os processos administrativos relacionados com o software adquirido, as instruções normativas comuns ao setor público federal no que diz respeito à contratação de soluções de tecnologia da informação (TI) e demais documentos pertinentes ao caso. Também foi realizada uma pesquisa que reuniu respostas de dois grupos de interesse: 12 dos 21 servidores da área de sistemas de TI e 8 representantes de 6 dos 13 setores que compõe a administração central da instituição. Os principais resultados da dissertação foram a concretização da relação da introdução do software com o conceito de inovação e inovação no setor público, a identificação da falta de um planejamento inicial para a aquisição do software, problemas na campanha de conscientização dos usuários sobre o novo sistema e na geração de lideranças e multiplicadores, além de inadequações às normatizações comuns ao setor público federal.Abstract : This dissertation aims to assess the acquisition and adoption of administrative management software from the Universidade Federal de Santa Catarina (UFSC), in the period between the fourth quarter of 2009 to the second quarter of 2015, under the assumption that it has yet to materialize as an efficient standard of communication between sectors, also noting its classification from the perspective of innovation theory. To this end, a bibliographical research on public administration, university administration, innovation, innovation in the public sector, e-government, information systems and evaluation of information systems, was prepared. Later, a documentary research was developed, listing the administrative processes related to acquired software, the common normative instructions to the federal public sector with regard to the hiring of information technology (IT) solutions, and other documents relevant to the case. It was also realized a survey with two groups of interest: 12 of the 21 IT servers and 8 representatives of the sectors that are part of institution central administration. The main results of the dissertation were the achievement of the introduction of the software related to the concept of innovation and innovation in the public sector, identifying the lack of initial planning for the software acquisition, problems in the progress of the awareness campaign on the new system and the generation of leaders and multipliers, as well as inadequacies to common norms to the federal public sector
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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