3,314 research outputs found
A imagem de Alessandro Baricco no Brasil
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis, 2013.Com a intenção de delinear o modo pelo qual o escritor italiano Alessandro Baricco se inseriu no sistema literário brasileiro e os caminhos percorridos pelos seus livros traduzidos, esta dissertação dá voz às experiências tradutórias de seus tradutores. A inserção de Bariccono Brasil tem seu início em 1997, através de uma proposição da Profa. Dra. Roberta Barni à editora Iluminuras da tradução de Oceano Mare. A partir daí, outras sete obras foram publicadas no Brasil, sendo três delas traduzidas por Roberta Barni e as outras quatro por quatro tradutores diferentes. De um lado, considera-se o tradutor como figura principal namediação entre culturas, e, de outro, se analisa a realidade desta figuradentro do sistema literário, sua invisibilidade, seus limites e o exercíciode sua profissão. A pesquisa conta, ainda, com críticas e resenhas referentes ao autor italiano publicadas em jornais consagrados no Brasil, considerando estas como parte constituinte da imagem de Baricco refletida em território nacional. Abstract : Intending to delineate the way the Italian writer Alessandro Baricco has been inserted in the Brazilian literary system and the paths his translated books have followed, this thesis gives voice to the translating experiences of his translators. Baricco's insertion in Brazil began in 1997, through a personal project of Dr. Roberta Barni, with her translation of Oceano Mare. Since then, seven other of his works have been published in Brazil, three of which were translated by Roberta Barni and the other four by four different translators. On the one hand,the translator is considered as the main figure in mediation betweencultures and, on the other, this figure's reality is analyzed within theliterary system: its invisibility, its limits and its professional practice. Criticisms and reviews of this Italian author published in well established Brazilian newspapers are also considered, with the understanding that they are part of Baricco's image reflected here
La maturità di Alessandro Fei del Barbiere, in bilico tra Maniera e Riforma
No full textThis article studies the mature career of the Florentine painter Alessandro Fei del Barbiere (1537-1592), beginning with the rediscovery of the 'Ascension' altarpiece formerly in the Albizi Chapel in the destroyed church of San Pier Maggiore, Florence. Studying this painting and others recorded in 1584 by the biographer Raffaello Borghini, such as the two altarpieces for Santa Maria delle Grazie and the Madonna dell'Umiltà in Pistoia, the author reconstructs a body of works showing how in the 1580s Fei gradually went beyond the archaic style of his apprenticeship - he had been trained by Ridolfo del Ghirlandaio and Pierfrancesco Foschi, but was also marked by the Maniera of Vasari - evolving towards naturalism in both mimesis and pictorial handling. In Florence, his development partly parallels that of Santi di Tito and his circle, but Fei was also influenced by a probable sojourn during the early part of that decade in Rome, where he could have been inspired by Girolamo Muziano and the painters working for Pope Gregory XIII. Among other proposals, the author suggests that the artist was responsible for decorating the chancel of Fiesole Cathedral (c. 1584-1589), which consisted of an altarpiece, only rarely discussed by scholars, and a cycle of frescoes hitherto attributed to Nicodemo Ferrucci
Drug delivery strategies for mTOR inhibitors therapy in neurodegenerative and neuro-oncologic disease.
No full textRapamycin (Rp) is an mammalian target of rapamycin-inhibitor (mTOR-I) approved by the U.S. Food and Drug Administration for clinical use as an immunosuppressant. It is currently used to induce tolerance in organ-transplanted patients, but also in oncology for treatment of advanced renal cancer. Recent studies demonstrate that Rp leads to benefits also in neurological diseases. In fact, a prolonged Rp treatment gives rise to the rescue of the learning deficit and the reduction of the intraneural Aβ in an Alzheimer’s Disease mouse model [1]. In 2006, Franz DN et coworkers reported the regression of subependymal giant cell astrocytomas in the brain of patients affected by the Tuberous Sclerosis Complex (TSC) after a prolonged oral Rp administration [2]. Unfortunately systemic administration of Rp, and more generally of mTOR-Is, even are though it offers significant benefits, produces a number of side effects that may impair their therapeutic efficacy, especially upon chronic administration [2,3]. The administration of mTOR-Is directly to central nervous system (CNS) carry the advantage of limiting systemic exposure to the drug and, in addition, it allows to fully exploiting the local benefit [4]. In our work, we administered everolimus, an Rp analogs, directly to the CNS of symptomatic 3xTgAD mice via intracerebroventricular infusion. We showed that everolimus, administered for a short period, caused the improvement of behavioral, biochemical and pathological dysfunctions of 3xTg-AD mice, allowing their preservation for a relatively long time. Alternatively to the invasive CNS administration, we are developing site-specific nanocarriers for intravenous injection with the aim to pass the blood-brain barrier (BBB) and release therapeutic mTOR-Is doses directly to the CNS. In this regard, we prepared Rp-loaded solid lipid nanoparticles (SLNs) functionalized with polysorbate 80 (P80) on the surface and demonstrated their ability to be internalized into the cell and to release an efficacious dose of drug to inhibit mTOR activity [6, 7]. Moreover, Rp-SLNs increased stability/integrity of the drug thus prolonging its bioavailability in the cells. Thus, Rp-SLNs could represent a promising tool for the treatment of diseases with neurological involvement.
Acknowledgments
Work supported by Cassa di Risparmio di Perugia Foundation, Italy (Grant no.2016-0050.021 to Carla Emiliani)
References
[1] Caccamo et al. (2010) J Biol Chem 285, 13107-20
[2] Franz et al., (2006) Ann Neurol 59, 490-498
[3] Krueger et al. (2010) N Engl J Med 363,1801-11
[4] Patent EP2846770A15
[5] Giovagnoli et al. (2015) J Chromatogr B Analyt Technol Biomed Life Sci. 985, 155-63
[6] Mazurik J et al. (2016) Colloids Surf A Physicochem Eng Asp. 502, 54-65
[7] Polchi et al (2016) Nanomaterials (Basel) 6(5). pii: E8
Extending lifespan through autophagy stimulation: a future perspective
No full textAging is a natural process characterized by the gradual decline of physiological functions. In the last decades, human lifespan has considerably increased. Consequently, population aging and the resulting increase of people affected by age-related diseases, is emerging as a major social and economic challenge in developed countries. This scenario has led to an exponential growth of research projects in the field of aging, with the aim of identifying amenable drug targets and pharmacological interventions to extend human healthy lifespan. Extensive evidence in literature suggests that the dysfunction of autophagy, a highly conserved pathway involved in maintaining cellular homeostasis, is part of the aging process with roles in the pathobiology of age-related diseases. Moreover, accumulating experimental data from invertebrate and vertebrate animal models demonstrate that intervening to increase lifespan also induces autophagy, suggesting that stimulating such cellular process may represent an effective strategy to increase longevity. Here, we reviewed the literature on autophagy in aging and age-related diseases, also discussing the perspective of behavioral and pharmacological interventions that may increase healthy lifespan through autophagy stimulation
Mixture containing calixarenes, process for the production thereof and use thereof for preparing detergent compositions for lubricants
No full textThe present invention relates to mixtures containing calixarenes of
formula (I) with a reduced alkyl phenol and linear oligomer content and the preparation
process thereof, wherein: a. R is selected between a linear or branched alkyl
having a number of carbon atoms comprised between 4 and 40, more preferably
between 4 and 24, even more preferably comprised between 8 and 18; b. n is the
number of units of the calixarene cycle and is comprised in the range from 4 to 16,
preferably between 4 and 12. Furthermore, the present invention relates to detergent
compositions containing overbased metal salts of calixarenes, the preparation
process thereof and the use thereof in lubricant compositions
Intrathecal administration of mTOR inhibitors for the therapy of neurodegenerative, neuroinflammatory and neurooncologic diseases
No full textThe invention relates to the use of inhibitors of the enzyme mTOR kinase (mammalian target of rapamycin) in the treatment of neuro-oncol. diseases, in particular tuberous sclerosis, neurodegenerative diseases, in particular Alzheimer's disease, and neuroinflammatory diseases, in particular multiple sclerosis and primary progressive aphasia, via intrathecal, or preferably intraventricular, administration of said inhibitors. Thus, from the evidence presented in the disclosure, it was evident that it is possible to reaching locally, within the cranial theca, a concn. of inhibitor greater than that reached in the same region through systemic administration; from there it is concluded that the inhibitor present here is capable of inhibiting the mTOR signalling pathway; it is also seen that this concn. is capable of performing an immunosuppressive action locally, while remaining in the blood at unassayable levels and without affecting the normal activity of mTOR in peripheral organs
Tra socialdemocrazie e Perestrojka. Le relazioni internazionali del Pci attraverso le carte di Alessandro Natta
No full textThis essay reconstructs the foreign policy of the Italian Communist Party during the four
years of Alessandro Natta’s secretariat (1984-1988) through largely original archival documentation,
from the Alessandro Natta Fonds of the Historical Archive of the Chamber of
Deputies. Natta’s papers are also cross-referenced with those kept in the PCI Archive at the
Gramsci Foundation. The author analyses the relationship that the PCI establishes with
Gorbachev’s Perestroika, Deng’s China, and European social democracies during the last
years of the Cold War
Jurkat T-cell stimulation up-regulates the expression of lysosomal β-hexosaminidase and β-galactosidase and triggers their recruitment to lipid microdomains
No full textSignaling Pathways in Exosomes Biogenesis, Secretion and Fate
No full textExosomes are small extracellular vesicles (30–100 nm) derived from the endosomal system, which have raised considerable interest in the last decade. Several studies have shown that they mediate cell-to-cell communication in a variety of biological processes. Thus, in addition to cell-to-cell direct interaction or secretion of active molecules, they are now considered another class of signal mediators. Exosomes can be secreted by several cell types and retrieved in many body fluids, such as blood, urine, saliva and cerebrospinal fluid. In addition to proteins and lipids, they also contain nucleic acids, namely mRNA and miRNA. These features have prompted extensive research to exploit them as a source of biomarkers for several pathologies, such as cancer and neurodegenerative disorders. In this context, exosomes also appear attractive as gene delivery vehicles. Furthermore, exosome immunomodulatory and regenerative properties are also encouraging their application for further therapeutic purposes. Nevertheless, several issues remain to be addressed: exosome biogenesis and secretion mechanisms have not been clearly understood, and physiological functions, as well as pathological roles, are far from being satisfactorily elucidated
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