785 research outputs found
Teacher formative assessment: the missing link in response to intervention
No full textResponse to Intervention (RtI) focuses on the assessment, intervention, and progress monitoring of student academic performance and social behavior. Despite requiring highly-qualified personnel for successful implementation, the implementation of Rtl has not focused on applying its foundational principles towards promoting teacher effectiveness through assessment, intervention, and progress monitoring of teacher classroom practice. Compounding this problem is the lack of availability of reliable and valid teacher assessments to apply in an Rtl model for teacher professional development. This chapter provides a rationale for applying RtI principles to teacher professional development and how teacher formative assessment can improve educator effectiveness, student learning, and social behaviors. The Classroom Strategies Scale (CSS, Reddy & Dudek, 2014), a new multidimensional assessment of instructional and behavioral management practices is discussed as an example of one promising tool for promoting teachers professional development within an Rtl model. We offer a synthesis of the theory, research, and evidence of reliability and validity of the CSS. The application of teacher formative assessment in job-embedded professional development/coaching models for schools is discussed. Finally, implications for practice and research are outlined.Peer reviewe
The world's first malaria vaccine – promising clinical results
No full textDudek Iga, Czarnota Jakub, Hajduga Danuta, Dobrzyński Michał, Marzęda Magdalena. The world's first malaria vaccine – promising clinical results. Journal of Education, Health and Sport. 2019;9(8):912-919. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3408433
http://ojs.ukw.edu.pl/index.php/johs/article/view/7452
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2019;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 05.07.2019. Revised: 25.07.2019. Accepted: 14.09.2019.
The world's first malaria vaccine – promising clinical results
Iga Dudek, Jakub Czarnota, Danuta Hajduga, Michał Dobrzyński, Magdalena Marzęda
Student Research Circle at the Department of Epidemiology and Clinical Research
Methodology, Medical University of Lublin
Supervisor: dr n. med. Halina Piecewicz-Szczęsna
Corresponding author: Halina Piecewicz-Szczęsna, e-mail: [email protected]
ORCID ID:
Iga Dudek: orcid.org/0000-0002-8101-074X; [email protected]
Jakub Czarnota: orcid.org/0000-0003-2783-0349; [email protected]
Danuta Hajduga: orcid.org/0000-0002-7018-340X; [email protected]
Michał Dobrzyński: orcid.org/0000-0002-1416-6568; [email protected]
Magdalena Marzęda: orcid.org/0000-0003-4397-5214; [email protected]
Abstract
Work on the malaria vaccine has been going on since the early 20st century. The RTS,S/AS01 (Mosquirix) vaccine is the first and only in the world that has shown action against Plasmodium falciparum, a germ that contributes to the highest number of deaths from malaria. After passing the three phases of clinical tests positively, the fourth phase was launched in 2019 - the MVIP program (The Malaria Vaccine Implementation Program). It covers three African countries: Kenya, Ghana and Modawi. Around 360,000 children are expected to receive the vaccine from these countries annually. The third phase of Mosquirix vaccine testing lasted five years (2009-2014) and was based on the extraction of 15 459 children and infants from seven African countries, followed by the administration of four doses of each medicine. In four years, among children aged 5-17 months who received 4 doses of Mosquirix, 4 out of 10 (39%) managed to prevent the development of malaria. The number of hospitalizations for malaria and severe anemia, which is one of the consequences of this disease, has also decreased significantly. In the fourth phase of the study, the role of the vaccine in reducing the number of deaths in children and its safety will be assessed in the context of routine, global use. Data from the MVIP program will include WHO recommendations on the wider use of the vaccine.
Keywords: malaria, the MVIP programme, vaccin
Postpamięciowy dyskurs w literaturze dla dzieci i młodzieży. Małgorzata Wójcik-Dudek. “W(y)czytać Zagładę. Praktyki postpamięci w polskiej literaturze XXI wieku dla dzieci i młodzieży”. Wydawnictwo Uniwersytetu Śląskiego, Katowice 2016, ss. 332
No full textRecenzja książki Małgorzaty Wójcik-Dudek, “W(y)czytać Zagładę. Praktyki postpamięci w
polskiej literaturze XXI wieku dla dzieci i młodzieży”. Wydawnictwo
Uniwersytetu Śląskiego, Katowice 2016
Reading as an art of empathy
No full textArtykuł jest próbą krytycznej lektury książki Lucyny Sadzikowskiej Listy z lagrów i więzień 1939−1945. Wybrane zagadnienia opublikowanej w 2019 roku. Publikacja przedstawia metodologiczne konteksty studium korespondencji obozowej. Małgorzata Wójcik-Dudek poddaje krytycznej analizie zastosowaną przez autorkę teorię listu jako komunikatu oraz komentuje wyniki badań śląskiej literaturoznawczyni.The article is an attempt to critically read Lucyna Sadzikowska’s book Listy z lagrów i więzień 1939−1945. Wybrane zagadnienia (Letters from the labor camps and prisons 1939-1945. Selected issues) published in 2019. The publication presents the methodological contexts of the camp correspondence study. Małgorzata Wójcik-Dudek critically analyzes the theory of letter used by the author as a message and comments on the results of research by a Silesian literary researcher
Lektura jako sztuka empatii
No full textThe article is an attempt to critically read Lucyna Sadzikowska’s book Listy z lagrów i więzień 1939−1945. Wybrane zagadnienia (Letters from the labor camps and prisons 1939-1945. Selected issues) published in 2019. The publication presents the methodological contexts of the camp correspondence study. Małgorzata Wójcik-Dudek critically analyzes the theory of letter used by the author as a message and comments on the results of research by a Silesian literary researcher
Technical and economic analysis of a car park for electric cars with a charging station powered from solar panels
No full textpraca inżyniersk
Life and death in light of tombstone inscriptions in Orthodox necropolises in eastern Lublin region
No full textThe analyzed inscriptions in the eastern Lublin region enable reconstruction of selected essential aspects of the worldly life of the deceased. On the basis of gravestone inscriptions in the Orthodox cementeries in the Lublin region the author tries to reconstruct the ways of perceiving life and death, reflected in the inscriptions. Many inscriptions reflect Christian beliefs about eternal life and resurrection; they describe death as a stage of waiting for as sleeping, rest, and as [email protected] Marii Curie-Skłodowskiej w Lublinie. Wydział Humanistyczny. Instytut Filologii SłowiańskiejBorkowski I., 2000, Śmierci tajemnicze wrota. Językowy świat inskrypcji nagrobnych, „Język a kultura”, t. 13, Wrocław, s. 343–354.Czyżewski F., 2013, Antroponimia pogranicza polsko-wschodniosłowiańskiego w świetle inskrypcji nagrobnych, Lublin.Dąbrowska A., 1991, Kwalifikowanie eufemizmów przez niektóre współczesne słowniki języka polskiego, [w:] Język a kultura. Podstawowe pojęcia i problemy, red. J. Anusiewicz i J. Bartmiński, Wrocław, s. 131–136.Długosz 2010 – K. Długosz, Inskrypcje nagrobne w ujęciu językoznawczym, Gorzów Wielkopolski.Dudek-Szumigaj A., 2008, Eufemizmy śmierci w świetle inskrypcji nagrobnych wybranych nekropolii prawosławnych Wołynia, [w:] Tabu językowe i eufemizacja w dialektach słowiańskich, red. F. Czyżewski, A. Tyrpa, Lublin, s. 201–209.Dudek-Szumigaj A., 2011, Postrzeganie śmierci w świetle inskrypcji nagrobnych nekropolii prawosławnych pogranicza polsko-ukraińskiego, [w:] Nekropolie jako znak kultury pogranicza polsko-wschodniosłowiańskiego, red. F. Czyżewski, A. Dudek-Szumigaj, L. Frolak, Lublin, s. 67–74.Dudek-Szumigaj A., 2014, Funkcja ekspresywna inskrypcji nagrobnych (na przykładzie nekropolii prawosławnych pogranicza polsko-ukraińskiego), [w:] Cmentarze po obu stronach Bugu, red. H. Arkuszyn, F. Czyżewski, A. Dudek-Szumigaj, Włodawa–Lublin, s. 177–190.Engelking A., 1984, Istota i ewolucja eufemizmów (na przykładzie zastępczych określeń śmierci), „Przegląd Humanistyczny” t. 4, s. 115–129.Kolbuszewski J., 1996, Cmentarze, Wrocław.Kozłowska-Doda J., 2014, U dalokuju staronku odjeżdżasz, czyli odbicie tradycyjnej metaforyki śmierci w tekstach obrzędowych i opowieściach Polaków z Woronowszczyzny,
[w:] Cmentarze po obu stronach Bugu, red. H. Arkuszyn, F. Czyżewski, A. Dudek-Szumigaj, Włodawa–Lublin, s. 71–84.Kupiszewski W., 1986, Groby mówią, „Literatura Ludowa” 1986, nr 2, s. 27–47.Marciniak R., 2008, Określenia śmierci i umierania w inskrypcjach nagrobnych cmentarzy w Łowiczu i Złakowie Kościelnym, [w:] Tabu językowe i eufemizacja w dialektach słowiańskich, red. F. Czyżewski, A. Tyrpa, Lublin, s. 181–200.Steczko I., 2011, Portret funeralny mężczyzny w świetle XIX-wiecznych inskrypcji nagrobnych z cmentarza Rakowickiego w Krakowie, „Prace Komisji Językoznawczej BTN” Nr XXI–2011, s. 17–29.Седакова О.А, 1983, Метафорическая лексика погребального обряда. Материалы к словарю, „Славянское и балканское языкознание. Проблемы лексикологии”, вып. 8, под ред. Л.Н. Смирнова, Москва, с. 204–221.358-39
Fluorescence-Based Blood Coagulation Assay Device for Measuring Activated Partial Thromboplastin Time
No full textThe measurement of blood clotting time is important in a range of clinical applications such as assessing coagulation disorders and controlling the effect of various anticoagulant drug therapies. Clotting time tests essentially measure the onset of clot formation which results from the formation of fibrin fibers in the blood sample. However, such assays are inherently imprecise due to the highly variable nature of the clot formation process and the sample matrix. This work describes a clotting time measurement assay which uses a fluorescent probe to very precisely detect the onset of fibrin clot formation. It uses a microstructured surface which enhances the formation of multiple localized clot loci and which results in the abrupt redistribution of the fluorescent label at the onset of clot formation in both whole blood and plasma. This methodology was applied to the development of an activated partial thromboplastin time (aPTT) test in a lateral flow microfluidic platform and used to monitor the effect of heparin dosage where it showed linearity from 0 to 2 U/mL in spiked plasma samples (R-2=0.996, n = 3), correlation against gold standard coagulometry of 0.9986, and correlation against standard hospital aPTT in 32 patient samples of 0.78.Original Publication: Magdalena M Dudek, Nigel Kent, Kerstin Gustafsson, Tomas Lindahl and Anthony J Killard, Fluorescence-Based Blood Coagulation Assay Device for Measuring Activated Partial Thromboplastin Time, 2011, ANALYTICAL CHEMISTRY, (83), 1, 319-328. http://dx.doi.org/10.1021/ac102436v Copyright: ACS American Chemical Society http://pubs.acs.org
Zn(II) and Cu(II) binding sites of Calcitermin, an antimicrobial peptide found in human airways
No full textAntimicrobial peptides (AMPs) are evolutionarily conserved molecules with antimicrobial
and/or immunomodulatory properties. Almost all antimicrobial peptides are cationic and
amphipathic. AMPs are widely distributed in many tissues and cells and are potentially present
in any species of invertebrate, plant and animal. They act as mediators of innate host defense,
being able to target Gram-positive and Gram-negative bacteria as well as fungi and some
enveloped viruses. Therefore, they represent a fertile ground for the design of novel therapeutics
for the treatment of antibiotic-resistant infections and severe sepsis.[1] Mediators of innate host
defense are also found in mucosal secretions of the respiratory tract and include substances, like
antimicrobial proteins and (poly)peptides, that can sequester metal nutrients, such as Zn(II),
Cu(II), Ni(II), Ca(II), etc.[2-3]
Among several uncharacterized molecules that contribute to the overall antimicrobial
activity of human nasal fluid, a 15-residue antimicrobial peptide named Calcitermin has been
identified.[4] Its sequence (VAIALKAAHYHTHKE) exactly corresponds to the C-terminal
domain of Calgranulin C, a calcium-binding pro-inflammatory protein of the S100 family.
Several studies have reported that cleavage fragments of parent proteins have potent
antimicrobial activity (e.g. buforin I,[5] lactoferricin,[6] KDAMP,[7] vasostatin-1[8]).
While Calcitermin does not express, in vitro, any antimicrobial activity in phosphate
buffer at pH 7.4, under more acidic conditions (pH 5.4) – which are quite common in
inflammatory fluids – it was active against E. coli, P. aeruginosa and C. albicans. Furthermore,
it was demonstrated that the presence of micromolar concentrations of Zn(II) enhances its
antimicrobial activity against E. coli and L. monocytogenes.[4]
Calcitermin contains a putative metal-binding domain with three alternated histidine
residues (His9, His11 and His13) and the free terminal amino group. In addition, it has the
potential to adopt a helical conformation in membranes. The above results prompted us to
deeply investigate the complex-formation equilibria of Calcitermin with Zn(II) and Cu(II), two
endogenic and competing metal ions.
The unprotected peptide VAIALKAAHYHTHKE has been considered, along with its
three mutants, in which each His residue is replaced with one alanine (VAIALKAAAYHTHKE,
VAIALKAAHYATHKE, VAIALKAAHYHTAKE). The characterization of the complexes has
been achieved by means of mass spectrometry, potentiometry, UV-Vis spectrophotometry,
circular dichroism (CD) and nuclear magnetic resonance (NMR). Biological tests were also
performed.
The comparison among the behaviors of the different analogues helps to shed light on the
role played by each His residue in metal coordination geometry and complex stability also in
the view of its antimicrobial activity. The preliminary results show that all the investigated
peptides are efficient ligands for the considered metal ions and are able to form mono-nuclear
complexes where the histidine residues are by far the first metal anchor (Fig.1).
References:
[1] R. E. W. Hancock, H.-G. Sahl, Nat. Biotechnol. 2006, 24, 1551.
[2] K. A. Brogden, Nat. Rev. Microbiol. 2005, 3, 238.
[3] T. Ganz, Integr. Comp. Biol. 2003, 43, 300-304.
[4] A. M. Cole, Y.-H. Kim, S. Tahk, T. Hong, P. Weis, A. J. Waring, T. Ganz, FEBS Lett. 2001, 504, 5-10.
[5] I. Minn, H. S. Kim, S. C. Kim, Biochim. Biophys. Acta - Molecular Basis of Disease 1998, 1407, 31-39.
[6] K. Yamauchi, M. Tomita, T. J. Giehl, R. T. Ellison, 3rd, Infect. Immun. 1993, 61, 719-728.
[7] C. Tam, J. J. Mun, D. J. Evans, S. M. J. Fleiszig, J. Clin. Investig. 2012, 122, 3665-3677.
[8] K. Lugardon, R. Raffner, Y. Goumon, A. Corti, A. Delmas, P. Bulet, D. Aunis, M. H. Metz-Boutigue, J.
Biol. Chem. 2000, 275, 10745-10753
Case Study of Physiotherapeutic Treatment of a Patient Diagnosed with Nervus Peroneus Communis Paresis
No full textAuthor: Jan Dudek Title: Case study of Physiotherapeutic Treatment of a Patient Diagnosed with Nervus Peroneus Communis Paresis Aims: The aim of this bachelor thesis is to summarize the theoretical information about the diagnosis of peroneal paresis and to create a case study of physiotherapeutic care of a patient with peripheral paresis of the nervus peroneus communis followed up by an evaluation of the effect of therapy. Methods: In the general part of the thesis, the problems of peripheral paresis are summarized on the basis of the literature cited below, with a focus on rehabilitation procedures. The special part presents a case report of a patient with peripheral paresis nevus peroneus communis and the processing of the information obtained from it. Results: The therapeutic units described in the special part of the paper had a positive effect on the patient's condition. Keywords: physiotherapy, case report, peripheral paresis, nervus peroneu
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