1,727 research outputs found
O naturalismo de Maddy e a avaliação de candidatos a axioma em teoria dos conjuntos
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação em Filosofia, Florianópolis, 2012Em um certo sentido, a matemática usual pode ser reduzida à teoria dos conjuntos, isto é, os objetos matemáticos usuais podem ser definidos como conjuntos, e os teoremas que governam esses objetos podem ser provados em ZFC. Todavia, existem enunciados importantes - a hipótese do contínuo é o mais célebre deles - que são independentes de ZFC. A existência de enunciados independentes levanta a questão da necessidade e conveniência de estender ZFC pela adição de novos axiomas. Nesse contexto, é interessante dispor de critérios claros que permitam avaliar candidatos a axioma para uma extensão da teoria dos conjuntos que decidiria enunciados independentes. Maddy tem se dedicado intensamente à filosofia da teoria dos conjuntos, com destaque para a investigação de critérios para seleção de axiomas. Nesta dissertação, nosso objetivo é seguir o percurso de Maddy nessa investigação, atentando especialmente a sua defesa da autonomia da matemática com respeito à filosofia e às ciências naturais e ao correspondente papel preponderante da argumentação extrínseca nas discussões que estabeleceram os axiomas da atual teoria. Como pano de fundo filosófico, o naturalismo em matemática de Maddy é também objeto privilegiado da nossa atenção neste trabalho.Abstract : In a certain sense, ordinary mathematics can be reduced to set theory, i.e., general mathematical objects can be defined as sets and the theorems about them can be proved from ZFC. However, there are important statements - the continuum hypothesis is the most famous among them - which are independent of ZFC. The existence of these statements raises a question about the necessity and convenience of extending ZFC, adding to it new axioms. In this context, it is interesting to have clear criteria for evaluating axiom candidates for an extension of ZFC that would decide independent statements. Maddy has focused intensely on philosophy of set theory, emphasizing the investigation of criteria for selection of set-theoretic axioms. In this dissertation, our goal is to understand and explain Maddy's investigation, with special attention to her defense of the autonomy of mathematics with respect to philosophy and natural sciences and the corresponding leading role of extrinsic arguments in the debates that established the current axioms of set theory. As philosophical background, naturalism in mathematics is also a privileged object of our attention in this work
Imaging Cells Within 3D Cell-Derived Matrix
No full textMuch of what is known about the mechanisms regulating cell adhesion and migration come from in vitro studies of cells plated on 2-dimensional (2D) extracellular matrix (ECM) proteins. The importance of studying these processes in cells within 3-dimensional (3D) environments is becoming increasingly recognised, as a number of studies have now demonstrated that adhesion formation and migration are markedly different in cells within 3D environments (Cukierman et al. Science 1708-1712, 2001). It is also known that the composition and pliability or density of the ECM are important in regulating cell adhesion and migration (Cukierman et al. Science 1708-1712, 2001). Cell-derived matrices (CDM) are naturally deposited fibrillar ECM from fibroblasts that can be used to study the adhesions and migration of cells in a more physiologically relevant environment
Measuring FRET Using Time-Resolved FLIM
No full textCell migration is a process that is controlled by the formation and correct localization of protein complexes and by post-translational modification of individual proteins. Forster or fluorescent resonance energy transfer (FRET) detected using fluorescence lifetime imaging microscopy (FLIM) provides a method by which protein-protein interactions may be detected and spatially localized within a cell. This technique can be used to map protein activation states and the formation and dissolution of protein complexes that control movement of a cell. This chapter describes a protocol for detecting FRET between GFP- and mRFP1-tagged proteins in fixed adherent cells. A background to both FRET and FLIM is provided followed by an overview of the method and a full protocol for sample preparation, data acquisition, and analysis
CAR regulate epithelial cell junction stability through control of E-cadherin trafficking
No full textCAR (Coxsackie and Adenovirus Receptor) is the primary docking receptor for typeB coxsackie viruses and subgroup C adenoviruses. CAR is a member of the JAM family of adhesion receptors and is located to both tight and adherens junctions between epithelial cells where it can assemble adhesive contacts through homodimerisation in trans. However, the role of CAR in controlling epithelial junction dynamics remains poorly understood. Here we demonstrate that levels of CAR in human epithelial cells play a key role in determining epithelial cell adhesion through control of E-cadherin stability at cell-cell junctions. Mechanistically, we show that CAR is phosphorylated within the C-terminus by PKCδ and that this in turn controls Src-dependent endocytosis of E-cadherin at cell junctions. This data demonstrates a novel role for CAR in regulating epithelial homeostasis
Mitchell Point feasibility & cost study
No full textprepared for: Oregon Department of Transportation ; prepared by: Parsons Brinckerhoff ; report prepared by Evan Garich, PE ; report reviewed by: John Horne, PE, PhD.Title from PDF cover (viewed on April 26, 2021).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 38-39).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Readers are requested: Ancient Libraries and their problems
No full textA lecture given in honour of Miss Ana Healey on the occasion of her retirement as Librarian of the Institute of Classical Studies / Joint Library of the Hellenic and Roman Societies in 1989. The original lecture contained slides and the author has revised the text and added in further images in April 2015. This lecture is referred to in the obituary of Ana Healey written by Sue Willetts from the Institute of Classical Studies Library which will appear in the online CUCD Bulletin for 201
Alan Parsons' art & science of sound recording: the book
No full textTHE ART AND SCIENCE OF SOUND RECORDING THE BOOK More than simply the book of the award-winning DVD set, Art & Science of Sound Recording takes legendary engineer, producer, and artist Alan Parsons' approaches to sound recording to the next level. In book form, Parsons has the space to include more technical background information, more detailed diagrams, plus a complete set of course notes on each of the 24 topics, from "The Brief History of Recording" to the now-classic "Dealing with Disasters." Written with the DVD's co producer, musician, and author Julian Colbeck, ASSR offers readers a classic "big picture" view of modern recording technology in conjunction with an almost encyclopedic list of specific techniques, processes, and equipment. For all its heft and authority - authored by a man trained at London's famed Abbey Road studios in the 1970s - ASSR is also written in plain English and is packed with priceless anecdotes from Alan Parsons' own career working with the Beatles, Pink Floyd, and countless others. Not just informative, but also highly entertaining and inspirational, ASSR, the Book is the perfect platform on which to build expertise in the art and science of sound recording
Geo Parsons Letters, MSS.2556
No full textAbstract: Geo Parsons writes to his brother, Alvin Parsons, about his whereabouts and attempts to succeed in one form of business or another in order to pay back debts owed in Louisville, Kentucky. One letter of Alvin's, returned to sender from attempted delivery to China, expresses Alvin's concern for Geo.Scope and Content Note: Contains correspondence between two brothers, Geo Parsons, the author of three letters, and his brother, Alvin Parsons, the author of one returned letter that was kept with the collection of letters from Geo. The subject of the letters concerns Geo's whereabouts and attempts to succeed in one form of business or another in order to pay back debts in Louisville, Kentucky.Biographical/Historical Note: Geo Parsons, the primary author of the collection, writes from Wrangell, Alaska, and Seattle, Washington, to his brother, Alvin Parsons of Louisville, Kentucky
Parsons on Partnership
No full textParsons, Theophilus. A Treatise on the Law of Partnership. 3rd ed., revised and enlarged. Boston: Little, Brown, and Company, 1878.
Theophilus Parsons (1797-1882) was a prolific author and legal scholar. From 1848 to 1870, he served as the Dane Professor of Law at Harvard. In each section of his Treatise on the Law of Partnership (1867), Parsons gives a statement of the law before providing illustrations and explanations through updated caselaw.
You can also view the book\u27s record in the library catalog.https://scholarship.law.wm.edu/harriscollection/1056/thumbnail.jp
Parsons on Partnership
No full textParsons, Theophilus. A Treatise on the Law of Partnership. 3rd ed., revised and enlarged. Boston: Little, Brown, and Company, 1878.
Theophilus Parsons (1797-1882) was a prolific author and legal scholar. From 1848 to 1870, he served as the Dane Professor of Law at Harvard. In each section of his Treatise on the Law of Partnership (1867), Parsons gives a statement of the law before providing illustrations and explanations through updated caselaw.
You can also view the book\u27s record in the library catalog.https://scholarship.law.wm.edu/harriscollection/1056/thumbnail.jp
- …
