277 research outputs found
Lilith: a tool for constraining new physics from Higgs measurements
No full textThe properties of the observed Higgs boson with mass around 125 GeV can be affected in a variety of ways by new physics beyond the Standard Model (SM). The wealth of experimental results, targeting the different combinations for the production and decay of a Higgs boson, makes it a non-trivial task to assess the patibility of a non-SM-like Higgs boson with all available results. In this paper we present Lilith, a new public tool for constraining new physics from signal strength measurements performed at the LHC and the Tevatron. Lilith is a Python library that can also be used in C and C++/ROOT programs. The Higgs likelihood is based on experimental results stored in an easily extensible XML database, and is evaluated from the user input, given in XML format in terms of reduced couplings or signal strengths.The results of Lilith can be used to constrain a wide class of new physics scenarios. © The Author(s) 2015.171511Nsciescopu
Sénat. Question de M. Jean Beranger sur les crédits pour les grands travaux [Généralités]
No full textRéférence Question écrite n°11464 Intitulé Sénat Question écrite n°11464 et réponse Dates extrêmes 05/05/1983 – 09/02/1984 Niveau de description pièce Historique de la conservation Le fonds est conservé au Sénat Présentation du contenu Question de M. Jean BERANGER sur les crédits pour les grands travaux Instruments de recherche Le texte des questions et réponses n’est pas disponible en format numérique [voir les autres fonds sur les Grands travaux (généralités)] [sommaire
Probabilistic Assessment of Rockfall Impact on Subsea Pipelines
No full textSubsea pipelines are exposed to the risk of rockfall impacts near landfalls and outcrops of the seabed which exhibit steep and rocky features. Methodologies and tools are needed to model and assess the probability of occurrence of rockfall events, the consequences of the impact and possible protective measures.
The kinematics of falling rocks has been the object of several theoretical and experimental studies. Theoretical models developed to match the results of real scale testing in air are based on the principle of conservation of energy. The dissipation due to inelastic bounces and friction are modeled by means of coefficients treated as stochastic variables to represent the randomness of rock trajectories. Added mass and drag forces are included in the subsea model; the latter require integration of equation of motion due to their dependence to velocity. The methodology has been implemented in a code proposed for risk assessment of subsea installations.
The present paper briefly illustrates the basic methodological approach and presents a comprehensive case study to show the capabilities of the method, in terms of expected trajectories, histograms of run-out distances and velocities, and estimates of the probability of run-out distances exceeding the position of the pipeline. This information is used by the designers to select optimum positions of subsea pipelines and /or adopt protective measures
Likelihood-based inference for modelling packet transit from thinned flow summaries
No full textNetwork traffic speeds and volumes present practical challenges to analysis. Packet thinning and flow aggregation protocols provide smaller structured data summaries, but conversely impede statistical inference. Methodswhich model traffic propagation typically do not account for the packet thinning and aggregation in their analysis and are of limited practical use. We introduce a likelihood-based analysis which fully incorporates packet thinning and flow aggregation. Inferences can hence be made for models on the level of individual packets while only observing thinned flow summaries. We establish consistency of the resulting maximum likelihood estimator, derive bounds on the volume of traffic which should be observed to achieve a desired degree of efficiency, and identify an ideal family of models. The robust performance of the estimator is examined through simulated analyses and an application on a publicly accessible trace which captured in excess of 36 m packets over a 1 minute period.Prosha Rahman, Boris Beranger, Scott Sisson, and Matthew Rougha
Ancient earthen constructions and antiseismic dwellings: Boni's project after the earthquake of 13th January 1915 (Avezzano, Italy)
No full textAfter the earthquake of 13th January 1915, the archaeologist Giacomo Boni (1859-1925), inspired by ancient
building techniques. proposed the reconstruction of Marsica and the Middle Liri Valley with earthen dwellings.
With the cooperation of the Italian Ministry of Agriculture, he organized an exhibition where he collected
samples of vegetal trellises which were an essential support to implement these techniques. Furthermore, he
rebuilt two huts on the Palatine (Orti Farnesiani): one rectangular, the other circular, inspired by terracotta urns
which he himself had discovered a few years earlier exploring the famous ancient tombs in the Forum Romanum,
near the temple of Antonino and Faustina, by the Via Sacra. Boni's unusual proposal was intended as
an alternative to the plans put forward by seismic engineering which was developing in Italy at that time. This
is a prime example of a clash between two different outlooks and cultures (humanism versus science) each of
which claimed to offer solutions to attenuate the effect of earthquakes. We have so far been unable to establish
whether any earthen dwellings were actually constructed in Marsica or the surroundings of Sora for the survivors
of the earthquake of 13th January 1915. Unfortunately, only one of the many houses built with this
technique. still existing in the Soran countryside can be dated (1924).JCR Journalope
Agenda dell'Archeologia Italiana
No full textREPERTORIO delle sopraintendenze, istituti universitari, CNR,accademie,centri, fondazioni, riviste, ecc. concernenti il campo archeologic
Ancient earthen constructions and antiseismic dwellings: Boni's project after the earthquake of 13th January 1915 (Avezzano, Italy)
No full textAfter the earthquake of 13th January 1915, the archaeologist Giacomo Boni (1859-1925), inspired by ancient building techniques. proposed the reconstruction of Marsica and the Middle Liri Valley with earthen dwellings. With the cooperation of the Italian Ministry of Agriculture, he organized an exhibition where he collected samples of vegetal trellises which were an essential support to implement these techniques. Furthermore, he rebuilt two huts on the Palatine (Orti Farnesiani): one rectangular, the other circular, inspired by terracotta urns which he himself had discovered a few years earlier exploring the famous ancient tombs in the Forum Romanum, near the temple of Antonino and Faustina, by the Via Sacra. Boni's unusual proposal was intended as an alternative to the plans put forward by seismic engineering which was developing in Italy at that time. This is a prime example of a clash between two different outlooks and cultures (humanism versus science) each of which claimed to offer solutions to attenuate the effect of earthquakes. We have so far been unable to establish whether any earthen dwellings were actually constructed in Marsica or the surroundings of Sora for the survivors of the earthquake of 13th January 1915. Unfortunately, only one of the many houses built with this technique. still existing in the Soran countryside can be dated (1924)
Monitoring open-ocean deep convection from space
No full text0094-8276WOS:000263174700002Deep convection (DC) is a key-process of the oceanic circulation, costly to monitor in situ and under the influence of climate change. Our study is a first step toward monitoring DC from space: we investigate the feasibility of observing its variability using improved satellite altimetry. An oceanic simulation of the Mediterranean circulation was performed for the 1999-2007 period. DC interannual variability is realistically modelled, and the sea surface elevation (SSE) is in agreement with altimetry data. Numerical results show a strong correlation between the annual DC characteristics and the winter SSE. From that, we propose a method to monitor DC interannual variability and long term evolution using altimetry data. Our method, applied to the longest available altimetry series, represents correctly the interannual variability of DC in the Northwestern Mediterranean between 1994 and 2007. Citation: Herrmann, M., J. Bouffard, and K. Beranger ( 2009), Monitoring open-ocean deep convection from space, Geophys. Res. Lett., 36, L03606, doi:10.1029/2008GL036422
ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity
No full textErratum inCorrection to: ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity.Cheli Y, Tulic MK, El Hachem N, Nottet N, Jacquel A, Gesson M, Strub T, Bille K, Picard-Gauci A, Montaudié H, Beranger GE, Passeron T, Close P, Bertolotto C, Ballotti R.Mol Cancer. 2021 Jan 27;20(1):21. doi: 10.1186/s12943-021-01319-5.PMID: 33504341 Free PMC article. No abstract available.International audienceResistances to immunotherapies remains a major hurdle towards a cure for melanoma in numerous patients. An increase in the mesenchymal phenotype and a loss of differentiation have been clearly associated with resistance to targeted therapies. Similar phenotypes have been more recently also linked to resistance to immune checkpoint therapies. We demonstrated here that the loss of MIcrophthalmia associated Transcription Factor (MITF), a pivotal player in melanocyte differentiation, favors the escape of melanoma cells from the immune system. We identified Integrin beta-like protein 1 (ITGBL1), a secreted protein, upregulated in anti-PD1 resistant patients and in MITFlow melanoma cells, as the key immunomodulator. ITGBL1 inhibited immune cell cytotoxicity against melanoma cells by inhibiting NK cells cytotoxicity and counteracting beneficial effects of anti-PD1 treatment, both in vitro and in vivo. Mechanistically, MITF inhibited RUNX2, an activator of ITGBL1 transcription. Interestingly, VitaminD3, an inhibitor of RUNX2, improved melanoma cells to death by immune cells. In conclusion, our data suggest that inhibition of ITGBL1 might improve melanoma response to immunotherapies
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