93,220 research outputs found
Evolution of the G+C content frontier in the rat cytomegalovirus genome
No full textWithin the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%. A region of extremely low G+C content (33.8%) is found in the 5 kb immediately to the right of the frontier, in which there are no predicted coding sequences. To the right of position 147501, the G+C content rises and predicted coding sequences reappear. However, these genes are much shorter (average 848bp, 50% G+C) than those in the left two-thirds of the genome (average 1462bp, 70% G+C). Whole genome alignment of several viruses indicates that the initial ultra-low G+C region appeared in the common ancestor of the genera Cytomegalovirus and Muromegalovirus, and that the lowering of G+C in the right third has been a subsequent process in the lineage leading to RCMV. The left two-thirds of RCMV has stop codon occurrences at 67.5% of their expected level, based on a modified Markov chain model of stop codon distribution, and the corresponding figure for the right third is 78%. Therefore, despite heavy mutation pressure, selective constraint has operated in the right third of the RCMV genome to maintain a degree of gene length unusual for such low G+C sequences
J.M. Blázquez, G. Lopez Monteagudo, T. Mañanes, C. Fernandez Ochoa, Mosaicos romanos de Leon y Asturias
No full textBalty Janine. J.M. Blázquez, G. Lopez Monteagudo, T. Mañanes, C. Fernandez Ochoa, Mosaicos romanos de Leon y Asturias. In: L'antiquité classique, Tome 66, 1997. pp. 695-696
Canariomys tamarani Lopez-Martinez and Lopez-Jurado 1987
No full textCanariomys tamarani Lopez-Martinez and Lopez-Jurado, 1987. Donana, Pubi, ocas., 2: 10. TYPE LOCALITY: Canary Islands, Gran Canaria Isl, "La Aldea de San Nicolas de Tolentino" (Lopez-Martinez and Lopez-Jurado (1987:12). DISTRIBUTION: Canary Islands, Gran Canaria Isl. COMMENTS: An endemic of Gran Canaria Isl known only by specimens from the Holocene to pre-hispanic epoch (about 2000 year before present). Its congener, C. bravoi is documented by Pliocene-Pleistocene fossils from Tenerife Isl in the Canary group (Crusafont-Pairo and Petter, 1964). A cladistic analysis by Lopez-Martinez and Lopez-Jurado (1987) suggested that C. bravoi and C. tamarani were in the same monophyletic group, one related to the African Pelomys-Arvicanthis assemblage. However, a cladistic analysis by Hutterer et al. (1988) indicated that each species of Canariomys was in a different monophyletic cluster. Careful re-examination of the material will be necessary to resolve these contrasting views.Published as part of Guy G. Musser & Michael D. Carleton, 1993, Order Rodentia - Family Muridae, pp. 501-755 in Mammal Species of the World (2 nd Edition), Washington and London :Smithsonian Institution Press on page 582, DOI: 10.5281/zenodo.735309
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Phoenix dactylifera L. seeds: A by-product as a source of bioactive compounds with antioxidant and enzyme inhibitory properties
No full textDate (Phoenix dactylifera L.) seeds are a valuable and abundant by-product with various potential food applications and a source of functional and bioactive ingredients. In this study, date seeds from eight cultivars (Ourous "OUR", Tazizaout "TAZ", Tazarzeit "TAR", Tazoughart "TAG", Ouaouchet "OUC", Oukasaba "OUK", Delat "DEL" and Tamezwertn'telet "TWT") cultivated in the M'zab oasis (south of Algeria) were analyzed for their chemical and phytochemical compositions, antioxidant capacities and in vitro inhibition of some enzymes. Variations in chemical compositions were observed in the studied date seeds. The greatest contents of total phenolic compounds (476 mg GAE per g dw), total flavonoids (6.52 mg QE per g dw), anthocyanins (1.26 mg Q3GE per g dw), flavonols (3.36 mg Q3GE per g dw), proanthocyanidins (85.13 mg CE per g dw), and ascorbic acid were detected in the seeds of the TAG cultivar. All extracts manifested good antioxidant activities tested by ORAC and FRAP assays. The OUC and OUR extracts displayed the most potent antioxidant capacity against DPPH free radicals (IC50 = 37.30 μg ml-1) and ABTS+ cation radicals (IC50 = 13.89 μg ml-1), respectively. The antioxidant activity evaluated through a xanthine/xanthine oxidase system demonstrated that the TAZ extract was more efficient as a superoxide radical scavenger (IC50 = 9.08 μg ml-1). Date seed extracts (DSE) exhibited inhibitory activities on enzymes, showing substantial potential as skin-whitening, neuroprotective, anti-hyperglycemic or anti-hyperlipidemic agents; the inhibitory potential was tested using tyrosinase (TYR), acetylcholinesterase (AChE), α-glucosidase (α-GLU) and lipase. All date seed cultivars were able to inhibit tyrosinase and α-glucosidase in a dose-dependent manner reaching the maximum inhibition
Cryptochromes and the circadian clock: The story of a very complex relationship in a spinningworld
No full textCryptochromes are flavin-containing blue light photoreceptors, present in most kingdoms, including archaea, bacteria, plants, animals and fungi. They are structurally similar to photolyases, a class of flavoproteins involved in light-dependent repair of UV-damaged DNA. Cryptochromes were first discovered in Arabidopsis thaliana in which they control many light-regulated physiological processes like seed germination, de-etiolation, photoperiodic control of the flowering time, cotyledon opening and expansion, anthocyanin accumulation, chloroplast development and root growth. They also regulate the entrainment of plant circadian clock to the phase of light-dark daily cycles. Here, we review the molecular mechanisms by which plant cryptochromes control the synchronisation of the clock with the environmental light. Furthermore, we summarise the circadian clock-mediated changes in cell cycle regulation and chromatin organisation and, finally, we discuss a putative role for plant cryptochromes in the epigenetic regulation of genes
Pyrosequencing unveils cystic fibrosis lung microbiome differences associated with a severe lung function decline
No full textChronic airway infection is a hallmark feature of cystic fibrosis (CF) disease. In the present study, sputum samples from CF patients were collected and characterized by 16S rRNA gene-targeted approach, to assess how lung microbiota composition changes following a severe decline in lung function. In particular, we compared the airway microbiota of two groups of patients with CF, i.e. patients with a substantial decline in their lung function (SD) and patients with a stable lung function (S). The two groups showed a different bacterial composition, with SD patients reporting a more heterogeneous community than the S ones. Pseudomonas was the dominant genus in both S and SD patients followed by Staphylococcus and Prevotella. Other than the classical CF pathogens and the most commonly identified non-classical genera in CF, we found the presence of the unusual anaerobic genus Sneathia. Moreover, the oligotyping analysis revealed the presence of other minor genera described in CF, highlighting the polymicrobial nature of CF infection. Finally, the analysis of correlation and anti-correlation networks showed the presence of antagonism and ecological independence between members of Pseudomonas genus and the rest of CF airways microbiota, with S patients showing a more interconnected community in S patients than in SD ones. This population structure suggests a higher resilience of S microbiota with respect to SD, which in turn may hinder the potential adverse impact of aggressive pathogens (e.g. Pseudomonas). In conclusion, our findings shed a new light on CF airway microbiota ecology, improving current knowledge about its composition and polymicrobial interactions in patients with CF. © 2016 Bacci et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
Étude historique de la pharmacie galénique dans la licence de pharmacie de Grenade
No full textLopez Andujar G., Arrebola Nacle P., Martin Martin C. Étude historique de la pharmacie galénique dans la licence de pharmacie de Grenade. In: Revue d'histoire de la pharmacie, 84ᵉ année, n°312, 1996. Actes du XXXIe Congrès International d'Histoire de la Pharmacie (Paris, 25-29 septembre 1995) pp. 258-263
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