61 research outputs found
COMUNICAÇÃO MATEMÁTICA NO PROCESSO ENSINO-APRENDIZAGEM DA MATEMÁTICA NA ESCOLA DE FORMAÇÃO DE PROFESSORES DO ENSINO PRIMÁRIO DO HUAMBO - ANGOLA
No full textThis article presents the results of the practical investigation of doctoral research with the participation of three teachers graduated in Educational Sciences in the area of Mathematics, the research had 110 students of the 10th grade of the Teacher Training School for primary education. The aim of this study is to improve Mathematical Communication (MC) in the Teaching Learning Process in the TLP. This study is qualitative, analytical-descriptive, which evidences a tool with an informative, relational and didactic dimension in order to offer quality learning in Mathematics, through the resolution of exercises and problems that leads to the understanding of the transfer of a natural communication (oral and written) to the symbolic, from there to the graphic and vice versa. It can be considered that the essence of the eductional, pedagogical and teaching-learning processes are communicative par excellence, which led the first author to investigate mathematical communication (MC), involving pedagogical communication and its antecedents and global perspectives. It is concluded that, in addition to the general conceptions that characterize education in the Republic of Angola, established from the normative documents, considerations about the (MC) are made in the TLP. The didactic strategy contributed to the improvement of the TLP in the school in question.Este artigo apresenta os resultados da investigação prática de uma pesquisa de doutoramento com a participação de três professores formados em Ciências da Educação na área de Matemática, a pesquisa contou com 110 alunos da 10ª classe da Escola de Formação de Professores para o ensino primário. O objetivo deste estudo é de melhorar Comunicação Matemática (CM) no Processo de Ensino-aprendizagem (PEA). Este estudo é qualitativo, analítico-descritivo, que evidência uma ferramenta com dimensão informativa, relacional e didática de forma a oferecer uma aprendizagem de qualidade em Matemática, através da resolução de exercícios e problemas que leva à compreensão da transferência de uma comunicação natural (oral e escrita) para a simbólica, daí para a gráfica e vice-versa. Pode-se considerar que a essência dos processos educativos, pedagógicos e de ensino-aprendizagem são comunicativas por excelência, o que levou a primeira autora a investigar sobre a comunicação matemática (CM), envolvendo a comunicação pedagógica e seus antecedentes e perspectivas globais. Conclui-se que, para além das concepções gerais que caracterizam a educação na República de Angola, estabelecidas a partir dos documentos normativos, são feitas considerações sobre a (CM) 24 no PEA. A estratégia didática contribuiu para o melhoramento do PEA na escola em referência.Este artigo apresenta os resultados da investigação prática de uma pesquisa de doutoramento com a participação de três professores formados em Ciências da Educação na área de Matemática, a pesquisa contou com 110 alunos da 10ª classe da Escola de Formação de Professores para o ensino primário. O objetivo deste estudo é de melhorar Comunicação Matemática (CM) no Processo de Ensino-aprendizagem (PEA). Este estudo é qualitativo, analítico-descritivo, que evidência uma ferramenta com dimensão informativa, relacional e didática de forma a oferecer uma aprendizagem de qualidade em Matemática, através da resolução de exercícios e problemas que leva à compreensão da transferência de uma comunicação natural (oral e escrita) para a simbólica, daí para a gráfica e vice-versa. Pode-se considerar que a essência dos processos educativos, pedagógicos e de ensino-aprendizagem são comunicativas por excelência, o que levou a primeira autora a investigar sobre a comunicação matemática (CM), envolvendo a comunicação pedagógica e seus antecedentes e perspectivas globais. Conclui-se que, para além das concepções gerais que caracterizam a educação na República de Angola, estabelecidas a partir dos documentos normativos, são feitas considerações sobre a (CM) 24 no PEA. A estratégia didática contribuiu para o melhoramento do PEA na escola em referência
Influence of Functional Variations in Genes of Neurotrophins and Neurotransmitter Systems on the Development of Retinopathy of Prematurity
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Influence of Functional Variations in Genes of Neurotrophins and Neurotransmitter Systems on the Development of Retinopathy of Prematurity
by Mariza Fevereiro-Martins 1,2,3,4,*,Ana Carolina Santos 1,2ORCID,Carlos Marques-Neves 1,2,5,Hercília Guimarães 6ORCID,Manuel Bicho 1,2,3ORCID andon behalf of the GenE-ROP Study Group †
1
Faculdade de Medicina, Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028 Lisboa, Portugal
2
Grupo Ecogenética e Saúde Humana, Instituto de Saúde Ambiental-ISAMB, Laboratório Associado Terra, Faculdade de Medicina, Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028 Lisboa, Portugal
3
Instituto de Investigação Científica Bento da Rocha Cabral, Calçada Bento da Rocha Cabral 14, 1250-012 Lisboa, Portugal
4
Departamento de Oftalmologia, Hospital Cuf Descobertas, Rua Mário Botas, 1998-018 Lisboa, Portugal
5
Centro de Estudos das Ciências da Visão, Faculdade de Medicina, Universidade de Lisboa, Av. Professor Egas Moniz, Piso 1C, 1649-028 Lisboa, Portugal
6
Departamento de Ginecologia-Obstetrícia e Pediatria, Faculdade de Medicina, Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
*
Author to whom correspondence should be addressed.
†
Collaborators of the study group are included in the Acknowledgments.
Int. J. Mol. Sci. 2025, 26(3), 898; https://doi.org/10.3390/ijms26030898
Submission received: 7 December 2024 / Revised: 20 January 2025 / Accepted: 20 January 2025 / Published: 22 January 2025
(This article belongs to the Special Issue Molecular Aspects of Retinopathy and Protection)
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Abstract
Retinal neurodevelopment, vascularization, homeostasis, and stress response are influenced by factors such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), and erythropoietin (EPO). As retinopathy of prematurity (ROP) is a neurovascular retinal disease, this study analyzed the contributions of NGF (rs6330), BDNF (rs7934165), TH (rs10770141), and EPO (rs507392) genetic functional polymorphisms to the modulation of hematological and biochemical parameters of the first week of life and their association with ROP development. A multicenter cohort of 396 preterm infants (gestational age < 32 weeks or birth weight < 1500 g) was genotyped using MicroChip DNA and iPlex MassARRAY® platform. Multivariate regression followed univariate assessment of ROP risk factors. NGF (GG) genotype was associated with a higher ROP risk (OR = 1.79), which increased further (OR = 2.38) when epistatic interactions with TH (allele C) and BDNF (allele G) were present. Significant circulating biomarker differences, including bilirubin, erythrocytes, monocytes, neutrophils, lymphocytes, and platelet markers, were found between ROP and non-ROP groups, with variations depending on the polymorphism. These findings suggest that NGF (rs6330) and its interactions with related genes contribute to ROP risk, providing valuable insights into the genetic and biological mechanisms underlying the disease and identifying potential predictive biomarkers.info:eu-repo/semantics/publishedVersio
Evaluation of internet websites about retinopathy of prematurity patient education
No full textBackground/aims: the success of the treatment in patients with retinopathy of prematurity (ROP) is mainly associated with timely diagnosis and appropriate management. Information dissemination is crucial for the outcome of ROP. This study aimed to evaluate the quality of the information about ROP available for patients on the internet.Methods: Cross sectional study. in March 2004 the ROP information available on the internet was evaluated using two search engines (MetaCrawler and MSN) and four key terms (retinopathy of prematurity, premature eye, premature retina, and ROP). the quality of each website was evaluated using a score system. the sites were classified as academic, organisational, or commercial. Readability, general quality of the website (based on ownership, purpose, authorship, author qualification, attribution, interactivity, and currency), and quality of the content specific to ROP (definition, causes, epidemiology, risk factors, diagnosis, classification, treatment, and prognosis) were analysed.Results: of 114 websites evaluated, 40 were included. 10 sites (25.0%) were academic, eight (20.0%) organisational, and 22 (55.0%) commercial. in the majority of the sites (62.5%) the ROP information was fair or poor.Conclusions: A large amount of information about ROP is available on the internet. However, most websites were considered incomplete.Univ Calif Davis, Dept Ophthalmol, Sacramento, CA 95817 USAUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilWeb of Scienc
A EDUCAÇÃO E A POLÍTICA
No full text“Education and politics” is the title of this work that aims to study the close connection between education and politics, or the art of organizing society. In fact, the more education there is, the better a society is structured. A reminder of the pretensions that many people have to think they understand politics, forgetting that it requires well-founded knowledge, in fact it is also a science. Education professionals are the builders of society and must accept the challenge of knowing the truth. Important concepts are presented that can help understand the reality addressed. Expert views can lead to this goal. The research is centered on four fundamental points: 1. Education and the role of the teacher. An attempt is made to show the great importance of education in any society and also the great role of the teacher; 2. What is politics? This approach shows the man who wants to know more about the reality in which he lives, realizing that he must organize such a world; 3. What means does politics have at its disposal? We want to make people understand the importance of the norms that any society approves as instruments for good social coexistence; and, 4. Power. Central theme when it comes to politics, as it also addresses government issues. The work ends with a short Conclusion, after having presented an Introduction at the beginning. The method in evidence is fundamentally bibliographic with reasoned incidences from the author.“A educação e a política” é o título deste trabalho que visa estudar a estreita ligação entre educação e a política, ou a arte de organizar a sociedade. De facto, quanto mais instrução houver melhor se estrutura uma sociedade. Uma chamada de atenção sobre as pretensões que muitos têm de achar que percebem a política, esquecendo que ela exige conhecimentos fundados, aliás ela é também uma ciência. Os profissionais da educação são os construtores da sociedade e devem acatar o repto do conhecimento da verdade. Apresentam-se conceitos importantes que podem ajudar a compreender a realidade abordada. Os pontos de vista de especialistas podem encaminhar para esse desiderato. A investigação está centrada em quatro pontos fundamentais: 1. A educação e o papel do professor. Procura-se mostrar a grande importância da educação em qualquer sociedade e também o grande papel do professor; 2. O que é a política? Nesta abordagem mostra-se o homem que quer conhecer mais a realidade em que vive, percebendo que deve organizar tal mundo; 3. Quais os meios que a política tem à sua disposição? Quer-se fazer perceber a importância das normas que qualquer sociedade aprova como instrumento para a boa convivência social; e, 4. O poder. Tema central quando se trata da política, pois aborda também questões de governo. O trabalho termina com uma pequena Conclusão, depois de se ter apresentado, no início uma Introdução. O método em evidência é fundamentalmente bibliográfico com incidências arrazoadas do autor
Point-of-care C-reactive protein test results in acute infections in children in primary care: an observational study
No full textAbstract
Background Acute infections are a common reason for children to consult primary care. Serious infections are rare but differentiating them from self-limiting illnesses remains challenging. This can lead to inappropriate antibiotic prescribing. Point-of-care C-reactive protein testing is used to guide antibiotic prescribing in adults. However, in children its use remains unclear. The purpose of this study was to assess point-of-care CRP test levels with respect to patients’ characteristics, care setting, preliminary diagnosis, and management.
Methods A prospective observational study was performed in children with an acute infection presenting to ambulatory care in Belgium.
Results In this study 8280 cases were analysed, of which 6552 had a point-of-care CRP value available. A total of 276 physicians participated. The median patient age was 1.98 years (IQR 0.97 to 4.17), 37% of children presented to a general practitioner, 33% to a paediatric out-patient clinic, and 30% to the emergency department. A total of 131 different preliminary diagnoses were found, with acute upper airway infection as the most frequent. In 6% (n = 513) patients were diagnosed with a serious infection. The most common serious infection was pneumonia. Antibiotics were prescribed in 28% (n = 2030) of all episodes. The median CRP over all infectious episodes was
10 mg/L (IQR < 5–29). Children below 5 years of age and those presenting to a paediatrician had a higher median CRP. Median CRP in patients with serious infections was 21 mg/L (IQR 6 to 63.5). Pneumonia had a median CRP of 48 mg/L (IQR 13–113). In the episodes with antibiotics prescription, median CRP level was 29 mg/L (IQR 10–58) compared to
7 mg/L (IQR < 5–19) when they were not prescribed.
Conclusion A low POC CRP as a standalone tool did not seem to be sufficient to rule out serious infections, but its potential in assessing serious infections could increase when integrated in a clinical decision rule.sponsorship: This study was funded by the National Institute for Health and Disability Insurance (RIZIV, Belgium) under reference CGV no 2012/235 and the Research Foundation Flanders (FWO Vlaanderen) under research project no G067509N. (National Institute for Health and Disability Insurance (RIZIV, Belgium)|2012/235, Research Foundation Flanders (FWO Vlaanderen)|G067509N)status: Published onlin
Frecuencia, perfil clínico y epidemiológico de retinopatía del prematuro en pacientes con peso menor a 1900 gramos hospitalizados en el área de Neonatología del Hospital Vicente Corral Moscoso. Enero a noviembre del 2020
No full textAntecedentes: La retinopatía del prematuro (ROP) es la causa más frecuente de ceguera prevenible en los niños.
Objetivo: Determinar la frecuencia, perfil clínico y epidemiológico de la retinopatía del prematuro en pacientes hospitalizados en el área de neonatología del Hospital Vicente Corral Moscoso de enero a noviembre del 2020.
Metodología: Se realizó un estudio descriptivo, cuantitativo, la población de estudio fueron todos los pacientes prematuros con peso menor a 1900 gramos, que ingresaron a neonatología del Hospital Vicente Corral Moscoso, que cumplieron los criterios de inclusión. La información de interés se recolectó de los expedientes médicos de los participantes y del sistema MEDISYS, en un formulario elaborado por la autora. Para el análisis estadístico se utilizó el programa SPSS versión 15.0, las variables cualitativas se presentan en forma de frecuencias y porcentajes.
Resultados: Se encontró predominio en el sexo masculino (59,6%), principalmente de edad gestacional muy pretérmino (57,4%), con peso menor de 1500 gramos en un 89,4%, las comorbilidades más frecuentes fueron la anemia en un 97,9% y la transfusión sanguínea en un 93,6%, los diagnósticos de ingreso más frecuentes fueron la sepsis de origen precoz 97,9%, membrana hialina 91,5%, ROP en estadío 1 se encontró en un 74,5% y la localización en zona III representó un 89,4%. En relación al tratamiento el 91,5% requirió sólo observación.
Conclusiones: La retinopatía de la prematuridad es frecuente en recién nacidos con edad gestacional menor de 32 semanas y con peso menor a 1500 gramos.Background: Retinopathy of prematurity (ROP) is a leading cause of preventable childhood blindness. It has a multifactorial origin such as prematurity, low birth weight and the administration of high supplemental oxygen.
Objective: To determine frequency, clinical and epidemiological profile of retinopathy of prematurity in hospitalized patients in neonatology area of Vicente Corral Moscoso Hospital, from January to November 2020.
Methods: A descriptive, quantitative study was carried out; the study population was all premature patients weighing less than 1900 grams, who were admitted to the neonatology department of the Vicente Corral Moscoso Hospital, who met the inclusion criteria. The information of interest was collected from the medical records of the participants and from the MEDISYS system, in a form prepared by the author. For the statistical analysis, the SPSS version 15.0 program was used, the qualitative variables are presented in the form of frequencies and percentages.
Results: Male sex predominated (59.6%), mainly very preterm (57.4%), weight less than 1500 grams (89.4%); the most frequent comorbidities were anemia (97.9%), blood transfusion (93.6%); the most common admission diagnoses were sepsis (97.9%), hyaline membrane (91.5%). The maximum ROP stage reached was stage 1 in 74.5 % and the location in zone III represented 89.4%. Regarding the treatment, 91.5% required only observation.
Conclusion: Retinopathy of prematurity is frequent in infants born before 32 week’s gestational age and low birth weight.Especialista en PediatríaCuenc
Manual de enfermería: Manejo de oxigenoterapia en neonatos para disminuir el riesgo de retinopatías
No full textIntroducción : Los neonatos que nacen antes de tiempo pasan su transición del interior del útero a su vida extrauterina, enfrentándose a los niveles de oxígeno elevados provocando una sensación en donde la retina aún en desarrollo recibe demasiado oxígeno, esta sensación impide el crecimiento normal de los vasos sanguíneos.
A lo largo de los años se han estudiado múltiples factores de riesgo que contribuyen a desarrollar la retinopatía, uno de ellos el uso de oxígeno, actualmente se desconoce cuál es valor de oxígeno ideal para que el neonato no desarrolle la enfermedad. El presente trabajo consiste en un manual dirigido al personal de enfermería que labora dentro de la UCIN en donde se describe el manejo de la oxigenoterapia para disminuir el riesgo de retinopatías.
Objetivo: Desarrollar un manual de enfermería para el manejo de oxigenoterapia en los neonatos con riesgo de ROP en la unidad de cuidados intensivos neonatales.
Metodología: Se realizó una investigación documental para la fundamentación de este trabajo, considerando las siguientes fases: búsqueda de información en las diferentes bases de datos como: ClínicalKey, Scielo, PubMed, Elsevier, MedicLatina y Google académico, recopilando la información mediante la elaboración de una matriz con la información relevante extraída de cada uno de los artículos en los siguientes apartados: autor, año, tipo de estudio, resultado de estudio, facilitando su lectura y en la última fase de construcción de resultados corresponde a la elaboración del manual.
Resultados: Los cuidados especializados en enfermería neonatal son fundamentales para garantizar que los neonatos, en especial los que enfrentan desafíos de salud, reciban el tratamiento necesario para superar su enfermedad y desarrollarse de manera saludable, evitando así posibles complicaciones a largo plazo.
Un manual para dirigir los cuidados basados en evidencia permite al personal que labora dentro de la UCIN tener intervenciones más completas para su práctica del día a día.Introduction: Neonates born prematurely spend their transition from the inside of the uterus to their extrauterine life, facing high oxygen levels causing a sensation where the still developing retina receives too much oxygen, this sensation prevents the normal growth of blood vessels. Over the years, multiple risk factors have been studied that contribute to the development of retinopathy, one of them being the use of oxygen, currently it is unknown what is the ideal oxygen value for the newborn not to develop the disease. This paper consists of a manual aimed at nursing staff working in the NICU that describes the management of oxygen therapy to reduce the risk of retinopathies. Objective: To develop a nursing manual for the management of oxygen therapy in neonates at risk of ROP in the neonatal intensive care unit.
Methodology: A documentary research was carried out to support this work, considering the following phases: search for information in the different databases such as: ClínicalKey, Scielo, PubMed, Elsevier, MedicLatina and Google Scholar, compiling the information through the elaboration of a matrix with the relevant information extracted from each of the articles in the following sections: author, year, type of study, result of study, facilitating its reading and in the last phase of construction of results corresponds to the elaboration of the manual. Results: Specialized care in neonatal nursing is essential to ensure that neonates, especially those facing health challenges, receive the necessary treatment to overcome their disease and develop healthily, thus avoiding possible long-term complications.
A manual for managing evidence-based care allows NICU staff to have more comprehensive interventions for their day-to-day practice.Estudiante
Minorités linguistiques au programme de recherche du Centre Æquatoria
No full textPar ce bref exposé, l’auteur se propose d’abord de montrer comment, en menant leur lutte contre les influences du français et du lingála par la promotion sur tous les plans du lonkundó, une variété du lomongo parlée principalement dans les environs de Mbandaka, chef-lieu de la Province de l’Equateur en RDC et classée sous le sigle C.61 par Guthrie, les Pères E. Boelaert, G. Hulstaert et A. De Rop, tous trois missionnaires du Sacré-Coeur, sont parvenus à sauver une bonne partie du patrimoine culturel du bassin central congolais du danger d’une déperdition totale. Il s’agit ensuite d’une reprise sommaire de ce qu’il a déjà pu écrire luimême sur la situation actuelle des minorités linguistiques dans le bassin central congolais et enfin de quelques témoignages sur l’intérêt que présentent aujourd’hui les langues parlées par des communautés minoritaires pour la reconstitution de l’histoire pré-coloniale africaine. Dans ses conclusions, l’auteur s’interroge sur les types d’actions qu’il est encore possible de mener pour garantir la protection de ce patrimoine culturel menacé d’extinction depuis plusieurs décennies pour l’intérêt à la fois de ces petites communautés et de la recherche scientifique.Mots-clés: Æquatoria; lingala; lonkundó; lomongo; Boelaert; Hulstaert; De Rop; minorités linguistiques.By this brief description the author proposes to show how, by through their fight against the influences of French and Lingála by promotion on all levels of the lonkundó language, a variety of the lomongo spoken mainly in the surroundings about Mbandaka, in DRC and classified under the C.61 initials by Guthrie, Fathers E Boelaert, G Hulstaert and A. De Rop, missionaries of Sacred Heart, managed to save a good part of the cultural inheritance of the Congolese central basin of the danger of total loss. Follows a summary of what the author wrote already himself on the current situation of the linguistic minorities in the Congolese basin central and finally of some testimonies on the interest of the languages presently spoken by minority communities for the reconstitution of the African pre-colonial history. In its conclusions, the author wonders about the types of actions which can still be carried out in order to guarantee the protection of this cultural inheritance, in the interest both of these small communities and of scientific research.Keywords: Æquatoria; lingala; lonkundó; lomongo; Boelaert; Hulstaert; De Rop; linguisticminorities
A coordenação de atores da ajuda humanitária internacional e as expressões de desnacionalização
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Programa de Pós-Graduação em Relações Internacionais, Florianópolis, 2014.A presente dissertação objetiva investigar se a coordenação de atores da Ajuda Humanitária Internacional, analisada no âmbito do UNOCHA - United Nations Office for the Coordination of Humanitarian Affairs, constitui uma Classe Global Emergente, promotora da Desnacionalização, conforme tipologia analítica de Saskia Sassen. Esta autora apresenta o conceito de Desnacionalização vinculado ao fenômeno da globalização e caracteriza as Classes Globais Emergentes por: serem arranjos sociais identificáveis, possuírem vinculação nacional e global, não serem cosmopolitas e apresentarem um referencial sistêmico no capitalismo global. Entende-se que é possível identificar elementos constitutivos e operacionais na conjugação dos atores da Ajuda Humanitária Internacional, a partir da lógica de coordenação do UNOCHA, que permitem verificar a plausibilidade da hipótese central desta pesquisa. Este é um estudo de Política Internacional e seu caráter é descritivo e exploratório. A sua delimitação temporal situa-se entre a década de 1980 e os dias atuais. Para a compreensão do contexto desta investigação serão utilizadas as teorias das Relações Internacionais do Institucionalismo Neoliberal e da Sociologia Histórica. A socióloga Saskia Sassen pertence à última escola.Abstract : This dissertation aims to investigate if the coordination of the International Humanitarian Aid actors, examined under UNOCHA - United Nations Office for the Coordination of Humanitarian Affairs, is a Global Emerging Class, promoter of denationalization according to the analytical typology of Saskia Sassen. This author presents the concept of Denationalization linked to the phenomenon of globalization and characterizes the Emerging Global Class by: being identifiable social arrangements, having national and global binding, not being cosmopolitans and presenting a systemic reference in global capitalism. It is understood that it is possible to identify constitutive and operational elements in the conjugation of the International Humanitarian Aid actors, based on the coordination logic of UNOCHA, which allow to verify the plausibility of the central hypothesis of this research. This is a International Politics study whose character is descriptive and exploratory. Its temporal boundary is between the 1980s and the current days. To understand the context of this research the theories of International Relations of Neoliberal Institutionalism and Historical Sociology will be used. The sociologist Saskia Sassen belongs to the latter school
Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study
No full text© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Purpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP).
Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed.
Results: A total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (p < 0.001), hemoglobin (p < 0.001), hematocrit (p < 0.001), mean corpuscular hemoglobin concentration (p < 0.001), lymphocytes (p = 0.035), and platelets (p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (p = 0.044), red blood cell distribution width (RDW) (p < 0.001), erythroblasts (p < 0.001), neutrophils (p = 0.030), neutrophils-lymphocytes ratio (p = 0.028), and basophils (p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression.
Conclusion: In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP.Open access funding provided by FCT|FCCN (b-on). This work was supported by the Laboratório de Genética and the Instituto de Saúde Ambiental (ISAMB) of the Faculdade de Medicina of Universidade de Lisboa and the Instituto de Investigação Científica Bento da Rocha Cabral. The writing of the manuscript was also supported by funds from Fundação para a Ciência e a Tecnologia to ISAMB (ref. UIDB/04295/2020 and UIDP/04295/2020). This work was also part of a doctoral project funding by the company CUF with a PhD grant in Medicine awarded in 2021 and by the Portuguese Society of Ophthalmology with a PhD grant awarded in 2019.info:eu-repo/semantics/publishedVersio
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