48,370 research outputs found
Evolution of the G+C content frontier in the rat cytomegalovirus genome
No full textWithin the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%. A region of extremely low G+C content (33.8%) is found in the 5 kb immediately to the right of the frontier, in which there are no predicted coding sequences. To the right of position 147501, the G+C content rises and predicted coding sequences reappear. However, these genes are much shorter (average 848bp, 50% G+C) than those in the left two-thirds of the genome (average 1462bp, 70% G+C). Whole genome alignment of several viruses indicates that the initial ultra-low G+C region appeared in the common ancestor of the genera Cytomegalovirus and Muromegalovirus, and that the lowering of G+C in the right third has been a subsequent process in the lineage leading to RCMV. The left two-thirds of RCMV has stop codon occurrences at 67.5% of their expected level, based on a modified Markov chain model of stop codon distribution, and the corresponding figure for the right third is 78%. Therefore, despite heavy mutation pressure, selective constraint has operated in the right third of the RCMV genome to maintain a degree of gene length unusual for such low G+C sequences
Evaluating the Factor Structure of the Emotion Dysregulation Scale-Short (EDS-s): A Preliminary Study
No full textEmotion dysregulation (ED) can be considered a psychopathological transdiagnostic dimension, the presence of which should be reliably screened in clinical settings. The aim of the current study was to validate the Italian version of the Emotion Dysregulation Scale-short (EDS-s), a brief self-report tool assessing emotion dysregulation, in a non-clinical sample of 1087 adults (768 women and 319 men). We also assessed its convergent validity with scales measuring binge eating and general psychopathology. Structural equation modeling suggested the fit of a one-factor model refined with correlations between the errors of three pairs of items (χ2 = 255.56, df = 51, p < 0.001, RMSEA = 0.08, CFI = 0.94, TLI = 0.93, SRMR = 0.04). The EDS-s demonstrated satisfactory internal consistency (ordinal alpha = 0.94). Moreover, EDS-s scores partly explained the variance of both binge eating (0.35, p < 0.001) and general psychopathology (0.60, p < 0.001). In conclusion, the EDS-s can be considered to be a reliable and valid measure of ED
Italian validation of the social anxiety scale for social media users (SAS-SMU) in a non-clinical sample
No full textPrior research has suggested that the use of social media could be associated with psychopathology (e.g., depression and anxiety symptoms). To measure social anxiety associated
with social media use, Alkis et al. (2017) developed the Social Anxiety Scale for Social
Media Users (SAS-SMU). The aims of the present study were to investigate the factor
structure of the SAS-SMU in a nonclinical sample of Italian adults and to analyze its
psychometric properties. Three hundred and eighty participants (222 women and 158 men)
were administered Italian versions of the SAS-SMU, the Social Phobia Inventory, the
Bergen Social Media Addiction Scale, the Obsessive-Compulsive Inventory Revised, the
General Anxiety Disorder-7, the Patient Health Questionnaire-9, and the Satisfaction with
Life Scale. The original hierarchical model, with four first-order factors and one second
order factor had good fit to the data (χ2
185=405.81, RMSEA=0.06, 95%CI 0.05–0.06,
CFI=0.99, TLI=0.98, SRMR=0.04). SAS-SMU had satisfactory internal consistency
(ordinal α=0.94) as well as good convergent and divergent validity. Finally, different
SAS-SMU scores were associated with different level of social anxiety. The SAS-SMU
is, therefore, a reliable and valid measure of social anxiety in relation to social media use
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
FIGURE 4. AC in Two new freshwater rhabdocoels, Austrodalyellia gen. nov. and Haplodidymos gen. nov. (Platyhelminthes), from Queensland, Australia
No full textFIGURE 4. AC. Austrodalyellia ariena gen. nov. sp. nov. A, Frontal section through dorsal body region. Scale bar = 100 µm. B, Frontal section through posterior body region, approximately medial. Scale bar = 80 µm. C, Frontal section through ventral body region. Scale bar = 30 µm. CO, copulatory organ; EG, egg; GL, glands around gonopore; GP, gonopore; GT, gut lumen; PH, pharynx; UT, uterus; VI, vitellaria.Published as part of Hochberg, Rick & Cannon, Lester R. G., 2002, Two new freshwater rhabdocoels, Austrodalyellia gen. nov. and Haplodidymos gen. nov. (Platyhelminthes), from Queensland, Australia, pp. 1-15 in Zootaxa 44 on page 6, DOI: 10.5281/zenodo.15607
Kir channel expression differs in distinct types of hippocampalastrocytes and is altered in epilepsy
No full textKir channel expression differs in distinct types of hippocampalastrocytes and is altered in epilepsy
No full textPsychometric properties of the modified Yale Food Addiction Scale Version 2.0 in an Italian non-clinical sample
No full textPurpose: To assess the dimensionality and psychometric properties of the modified Yale Food Addiction Scale 2.0 (mYFAS 2.0) in an Italian non-clinical sample.
Methods: 262 adults (184 women) were administered the Italian versions of the mYFAS 2.0, and questionnaires measuring binge eating severity, anxiety and depression symptoms, and emotional dysregulation.
Results: 15 individuals (5.7%) met the criteria for a diagnosis of food addiction according to the mYFAS 2.0. Bayesian confirmatory factor analysis supported a single-factor solution for the mYFAS 2.0. The mYFAS 2.0 had good internal con- sistency (Ordinal α = 0.91), and convergent validity with binge eating severity (r = 0.67, p < 0.001), both anxiety (r = 0.31, p < 0.001) and depressive (r = 0.35, p < 0.001) symptoms, and difficulties in emotion regulation (r = 0.35, p < 0.001). Finally, both discriminant validity with dietary restraint (Gamma = 0.11; p = 0.52) and incremental validity in predicting binge eating severity over emotion dysregulation and psychopathology (b = 0.52; t = 11.11; p < 0.001) were confirmed.
Conclusions: The Italian mYFAS 2.0 has satisfactory psychometric properties and can be used as a brief instrument for the assessment of addictive eating behaviors when time constraints prevent the use of the original version.
Level of Evidence: Level V, cross-sectional descriptive study
The association between adult ADHD and food addiction: A mediation analysis
No full textObjectives: The aim of this study was to investigate the association between food addiction severity (FA) and ADHD symptomatology. Furthermore, we investigated whether emotional distress, and the mentalization deficits could mediate this relationship.
Methods: Three hundred eighty-five Italian adults (307 women and 78 men) participated in the study and completed the Italian versions of the Modified Yale Food Addiction Scale version 2.0, the Adult ADHD Self- Report Scale, the Depression Anxiety Stress Scales 21 and the Mentalization Questionnaire.
Results: ADHD symptoms severity and general distress were significantly and independently associated with FA. Emotional distress partly mediated the relationship between FA and ADHD symptoms severity. In addition, mentalization deficits partly mediated this relationship only when evaluating the influence of FA on ADHD symptoms severity.
Limitations: This is a cross-sectional study and causal interpretations of the relationships among the variables are speculative.
Conclusions: It is important to assess emotional distress and mentalization deficits in individuals at risk of ADHD and FA because these conditions could increase the risk for the presence of disordered eating patterns
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