2,017,365 research outputs found
The effect of polystyrene sodium sulfonate grafting on polyethylene terephthalate artificial ligaments on in vitro mineralisation and in vivo bone tissue integration
No full textThis study investigates the impact of polystyrene sodium sulfonate (PolyNaSS) grafting onto the osseointegration of a polyethylene terephthalate artificial ligament (Ligament Advanced Reinforcement System, LARS ) used for Anterior Cruciate Ligament (ACL). The performance of grafted and non-grafted ligaments was assessed in vitro by culturing human osteoblasts under osteogenic induction and this demonstrated that the surface modification was capable of up-regulating the secretion of ALP and induced higher level of mineralisation as measured 6 weeks post-seeding by Micro-Computed Tomography. Grafted and non-grafted LARS were subsequently implanted in an ovine model for ACL reconstruction and the ligament-to-bone interface was evaluated by histology and biomechanical testings 3 and 12 months post-implantation. The grafted ligaments exhibited more frequent direct ligament-tobone contact and bone formation in the core of the ligament at the later time point than the nongrafted specimens, the grafting also significantly reduced thefibrous encapsulation of the ligament 12 months post-implantation. However, this improved osseo-integration was not translated into a significant increase in the biomechanical pull-out loads. These results provide evidences that PolyNaSS grafting improved the osseo-integration of the artificial ligament within the bone tunnels. This might positively influence the outcome of the surgical reconstructions, as higher ligament stability is believed to limit micro-movement and therefore permits earlier and enhanced healing.Programme ANR LIGAR
Diktarnas furste, diktarnas narr? Bilden av Lars Forssell och hans författarskap
No full textAn analysis of the critical reception of the poetry of Swedish writer Lars Forssel
The Shape of Things to Come. An Interview with Lars Bernaerts
No full textIn this interview, Lars Bernaerts discusses narratology as a tool to analyze the form, functioning, and circulation of narrative, introduces his current research project on the novelistic cycle, and explains what we can learn from “narratological science fiction.
Molnskådaren Lars Järlestad
No full textTexten är ett förord till ett urval av Lars Järlestads lyriska produktion.</p
Reptricket. Förord till Lars Gustafsson: Mot noll
No full textIntroduction to a collection of philosophical essays by Swedish author Lars Gustafsson (b. 1936)
«Everything is intermedial». A Conversation with Lars Elleström
No full textLars Elleström needs no introduction to intermediality and comparative literature scholars. Massimo Fusillo and Mattia Petricola had a conversation with him just a few weeks before the publication of his new, major theoretical work. The conversation discusses the evolution of Elleström’s theory over the last decade, his formation and influences, Peirce’s semiotics, the history of intermediality, and the notion of media literacy
Biological and Biomechanical Evaluation of the Ligament Advanced Reinforcement System (LARS AC) in a Sheep Model of Anterior Cruciate Ligament Replacement: A 3-Month and 12-Month Study
No full textPurposeThe purposes of this study were to assess tissue ingrowth within the Ligament Advanced Reinforcement System (LARS) artificial ligament (LARS AC; LARS, Arc sur Tille, France) and to study the biomechanical characteristics of the reconstructed knees in a sheep model of anterior cruciate ligament (ACL) replacement.MethodsTwenty-five female sheep underwent excision of the proximal third of the left ACL and intra-articular joint stabilization with a 44-strand polyethylene terephthalate ligament (mean ultimate tensile failure load, 2,500 N). Animals were killed either 3 or 12 months after surgery. Explanted knees were processed for histology (n = 10) or mechanical tests including tests of laxity and loading to failure in tension (n = 15).ResultsWell-vascularized tissue ingrowth within the artificial ligament was only observed in the portions of the ligament in contact with the host's tissues (native ligament and bone tunnels). Ligament wear was observed in 40% of explanted knees. The ultimate tensile failure loads of the operated knees at both time points were inferior to those of the contralateral, intact knees (144 ± 69 N at 3 months and 260 ± 126 N at 12 months versus 1,241 ± 270 N and 1,218 ± 189 N, respectively) (P < .01). In specimens with intact artificial ligaments, failure occurred by slippage from the bone tunnels in all specimens explanted 3 months postoperatively and in half of the specimens explanted 12 months postoperatively.ConclusionsThis study provides evidence that the LARS AC has a satisfactory biointegration but that it is not suitable for ACL replacement if uniform tissue ingrowth is contemplated. Despite good clinical performance up to 1 year after implantation, none of the reconstructions approached the mechanical performance of the normal ACL in the ovine model. Partial tearing of the artificial ligament, which led to a significant decrease in ultimate tensile strength, was observed in 40% of cases in the ovine model.Clinical RelevanceThe LARS is not a suitable scaffold for ACL replacement. Further animal studies are needed to evaluate its potential for augmentation of ligament repair.Agence Nationale pour la Recherche (ANR), France [Grant LIGART 06-TECSAN-006-01
Att vara Lars: Några tankar om språkteknologi och socioonomastik
No full textSince the SweClarin project began in 2015 its resources in terms of data and tools have been used in many different projects including linguistics. A research area where they have been less employed is the study of names. In this paper I suggest that language technology and general corpora can be used to contribute to the sociological study of personal names and offer a few examples. As is fit for the occasioin I take Lars as the point of departure.
Att vara Lars: Några tankar om språkteknologi och socioonomastik
No full textSince the SweClarin project began in 2015 its resources in terms of data and tools have been used in many different projects including linguistics. A research area where they have been less employed is the study of names. In this paper I suggest that language technology and general corpora can be used to contribute to the sociological study of personal names and offer a few examples. As is fit for the occasioin I take Lars as the point of departure.
Author Functions in Lars Kepler\u27s The Hypnotist: An Analysis
No full textThis paper examines Foucault\u27s notion of the author function as it pertains to Lars Kepler\u27s bestselling 2011 crime thriller, The Hypnotist. Lars Kepler is the pseudonym of a Swedish husband-wife writing duo, making him the perfect subject for analysis centering on illusory notion of the author. This paper will answer these questions: Who is the true author of The Hypnotist? What factors influence the author function of this bestelling novel? And what can The Hypnotist phenomenon tell us about the relationships between authors and their readers? This paper will demonstrate that no literary works may be ascribed to an individual person, and that authors hold no privileged knowledge of the works they produce, because authors cease to be authors the moment pen is lifted from page
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