128 research outputs found
Berdinen arteko harremanak Lehen Hezkuntzan: Kasu baten azterketa
No full text46 p. : il. -- Bibliogr.: p. 35-37[EUS] Ikerketa honek hiru helburu nagusi ditu: (1) berdinen arteko harremanetan oinarrituriko unitate didaktiko bat diseinatzea; (2) diseinaturiko unitate didaktikoa aurrera eramatea; (3) eta tailerraren ostean ikasleen arteko harremanak deskribatzea. Lana aurrera eramateko, 5. mailako 20 ikaslek parte hartu dute (9 mutil eta 11 neska). Parte hartzaileak, Lapurdi probintzian kokatzen den Urruña herriko ikastolakoak dira. Emaitzei dagokienez, (1) Harremanak sendotzen: elkar ezagutu, sentitu eta entzun unitate didaktikoa diseinatu da; (2) hortik, denboralizazioan eta haurren arteko elkarrekintza gatazkatsuak eman direla ikusi da; eta bukatzeko, (3) argi geratu da beraien arteko harreman dinamikak zeintzuk diren. Lan honetan ere emaitza horiek baloratu dira eta etorkizunerako hobekuntza proposamenak egin dira.[ES] Esta investigación ha tenido tres objetivos principales: (1) diseñar una unidad de enseñanza que promueve las relaciones entre iguales; (2) llevar a cabo la unidad didáctica diseñada; (3) y describir la relación entre los alumnos después del taller. Para llevar a cabo el trabajo, participaron 20 estudiantes de 5º de primaria (9 niños y 11 niñas). Las personas participantes son alumnos y alumnas de Educación Primaria de Urruña, un pueblo ubicado en la provincia de Lapurdi. Con respecto a los resultados, (1) se ha diseñado una unidad didáctica llamada Harremanak sendotzen: elkar ezagutu, sentitu eta entzun [Fortaleciendo relaciones: conocer, sentir y escuchar]; (2) se ha visto que han habido interacciones conflictivas entre el alumnado y que se han encontrado dificultades para gestionar el tiempo durante los talleres; y para concluir, (3) ha quedado claro cuáles son las dinámicas de relación que se dan en el grupo. En este trabajo también se evalúan los resultados y se llevan a cabo propuestas de mejora en el futuro.[FRE] Cette recherche a trois objectifs principaux: (1) concevoir une unité d’enseignement basée sur l’enseignement mutuel; (2) réaliser l'unité didactique conçue; (3) et décrire la relation entre les élèves après l’atelier. Pour effectuer ce travail, 20 élèves du CM2 ont participé (9 garçons et 11 filles). Les participants viennent de l'Ikastola d'Urrugne, située dans la province de Lapurdi. En ce qui concerne les résultats, (1) l'unité d'enseignement Harremanak sendotzen: elkar ezagutu, sentitu eta entzun [Améliorer les relations: se connaître, se sentir, s'écouter] a été conçue; (2) À partir de là, on a constaté des interactions conflictuelles entre les élèves et des difficultés ont été rencontrées dans la gestion du temps pendant les ateliers; et pour conclure (3), il est évident que leur dynamique relationnelle est restée la même. Dans ce travail, les résultats ont également été évalués et des propositions d’amélioration ont été réalisées à l’avenir.[EN] The main objectives of this study are (1) to design a teaching unit that promotes relationships among peers; (2) to carry out the designed teaching unit; (3) and to describe the relationship among pupils after the workshop. To begin with, 20 pupils in a 5th grade class participated (9 boys and 11 girls). Participants are from a Primary school in Urruña, located in the province of Lapurdi. In regards to the results, (1) the teaching unit Harremanak sendotzen: elkar ezagutu, sentitu eta entzun [Strengthening relationships: to know, feel and listen to each other] was designed; (2) conflicting interactions were found among children, as well as difficulties in time management during the workshop; finally, (3) it was obvious the relationship dynamics among the group stayed the same. In this work, results are discussed and evaluated with suggestions for future improvement
Opioide-hartzaileen deskribapena saguen gametoetan: morfinak obozitoen in vitro heltzean duen eragina
No full textGaur egun, ugarkotasun ezaren arazoa dela eta, geroz eta gehiago dira haurdunaldia lortzearren lagunduriko ugalketa tekniketara (ART, assisted reproductive technology) jo behar duten pertsonak; baina, oraindik, teknika horien arrakasta ez da oso handia eta batez beste, %50eko arrakasta duela esan ohi da(SEF erregistroa 2013). ART guztien artean, obozitoen in vitro heltzea (IVM, in vitro maturation) oso teknika berria da baina duen arrakasta txikiagatik, gutxien erabiliena da. Hala ere, in vitro ernalketaren (IVF, in vitro fertilization) hasieran eragingo litekeenez, ARTen arrakasta asko igoko litzateke
Cholangiocarcinoma biomarkers in biofluid extracellular vesicles: a new liquid biopsy strategy
No full text220 p.bioDonosti
Identification of taxonomic changes in the fecal bacteriome associated with colorectal polyps and cancer: potential biomarkers for early diagnosis
No full textColorectal cancer (CRC) commonly arises in individuals with premalignant colon lesions known as polyps, with both conditions being influenced by gut microbiota. Host-related factors and inherent characteristics of polyps and tumors may contribute to microbiome variability, potentially acting as confounding factors in the discovery of taxonomic biomarkers for both conditions. In this study we employed shotgun metagenomics to analyze the taxonomic diversity of bacteria present in fecal samples of 90 clinical subjects (comprising 30 CRC patients, 30 with polyps and 30 controls). Our findings revealed a decrease in taxonomic richness among individuals with polyps and CRC, with significant dissimilarities observed among the study groups. We identified significant alterations in the abundance of specific taxa associated with polyps (Streptococcaceae,
Lachnoclostridium
, and
Ralstonia
) and CRC (Lactobacillales, Clostridiaceae,
Desulfovibrio
, SFB,
Ruminococcus
, and
Faecalibacterium
). Clostridiaceae exhibited significantly lower abundance in the early stages of CRC. Additionally, our study revealed a positive co-occurrence among underrepresented genera in CRC, while demonstrating a negative co-occurrence between
Faecalibacterium
and
Desulfovibrio
, suggesting potential antagonistic relationships. Moreover, we observed variations in taxonomic richness and/or abundance within the polyp and CRC bacteriome linked to polyp size, tumor stage, dyslipidemia, diabetes with metformin use, sex, age, and family history of CRC. These findings provide potential new biomarkers to enhance early CRC diagnosis while also demonstrating how intrinsic host factors contribute to establishing a heterogeneous microbiome in patients with CRC and polyps
La voz en los ensayos audiovisuales de Carolina Astudillo. Análisis de El Gran Vuelo (2014) y Ainhoa, yo no soy esa (2018)a partir del esquema comunicativo de Julia Kristeva
No full textThis article studies the voice in Carolina Astudillo’s cinema by analysing her two feature films El gran vuelo (2014) and Ainhoa, yo no soy esa (2018). Her works contain charactertistics of an essay film, such as using different techniques and materials, an asystematic discourse, and self-reflective speech. This form of filmmaking is particularly suitable for exploring themes that concern the author. We will apply the communicative scheme developed by Julia Kristeva in Semiotics (1969) to identify the different voices in these two films. Thus, we will demonstrate how the director’s voice is filtered through her characters, establishing a dialogue with them while at the same time turning it into a mirrorlike technique for self-exploration.Este artículo estudia la voz en el cine de Carolina Astudillo a través del análisis de sus dos largometrajes El gran vuelo (2014) y Ainhoa, yo no soy esa (2018). Sus trabajos contienen características atribuidas al ensayo audiovisual, como es el uso de técnicas y materiales diversos, el desarrollo de un discurso asistemático y la autorreflexividad. Esta forma de hacer cine resulta especialmente adecuada para la exploración de temáticas que preocupan a la autora. Aplicaremos el esquema comunicativo desarrollado por Julia Kristeva en su Semiótica (1969) para identificar las diferentes voces en estas dos películas. Con esto probaremos que la voz de la directora se filtra a través de las de sus personajes, estableciendo un diálogo con ellos y al mismo tiempo convirtiéndolo en una técnica de exploración de sí misma a modo de espejo
Liver GPBAR1 Associates With Immune Dysfunction in Primary Sclerosing Cholangitis and Its Activation Attenuates Cholestasis in Abcb4-/- Mice
No full textBackground and Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterised by progressive biliary inflammation and fibrosis, leading to liver cirrhosis and cholangiocarcinoma. GPBAR1 (TGR5) is a G protein-coupled receptor for secondary bile acids. In this study, we have examined the therapeutic potential of BAR501, a selective GPBAR1 agonist in a PSC model. Methods: Single-cell analysis of healthy human liver samples and gene expression analysis of PSC liver samples were conducted. In vitro studies on a human cholangiocyte cell line (NHC), U937 and human hepatic stellate cells (hSteCs) were performed. Additionally, Abcb4−/− mice were treated with BAR501 for 12–24 weeks. Results: Single-cell analysis demonstrated that GPBAR1 is expressed by macrophages, NK cells, sinusoidal cells and to a lesser extent by cholangiocytes. Total liver expression of GPBAR1 increases in PSC patients compared to that in healthy controls and positively correlates with markers for monocytes and NK cells and cytokeratin 19. In vitro treatment of NHCs with BAR501 reversed the acquisition of a pro-inflammatory phenotype and the downregulation of GPBAR1 expression promoted by LPS in an NF-κB-dependent manner. Treating Abcb4−/− mice reduced bile duct inflammation and liver fibrosis and prevented the downregulation of GPBAR1 expression. Treating mice with BAR501 also modulated the bile acid pool composition and reduced the dysbiosis-associated gut permeability, and intestinal and systemic inflammation. Ex vivo experiments using conditioned media from BAR501-treated cholangiocytes mitigated the activation of macrophages. Conclusions: Our study provides evidence for the therapeutic potential of selective GPBAR1 agonists in intestinal inflammation–associated cholestasis, warranting the evaluation of BAR501 in PSC patients
Fabre, Bonaparte et Duvoisin
No full textEn un artículo anterior se menciona que Bonaparte pudo haber pedido a Fabre que le tradujese al labortano de Ainhoa, el catecismo de Astete. El autor cree que fue Duvoisin quien se lo pidió y luego aconsejó a Bonaparte que le mandase unos candelabros para pagar la traducciónIn a previous article it is said that Bonaparte may have requested Fabre to translate Astete's catechism to Basque from Labourd of Ainhoa. The author believes that it was Duvoisin who made this request and then asked Bonaparte to send him some candelabras to pay for the translatio
Defence signalling marker gene responses to hormonal elicitation differ between roots and shoots
No full text15 p., 5 tablas, 3 figurasPhytohormones such as jasmonic acid (JA), salicylic acid (SA), ethylene (ET) and abscisic acid (ABA) play a key role in regulation of plant immune responses to different attackers. Extensive research over recent years has led to the identification of molecular markers for specific hormonal-regulated defence pathways. However, most of our current knowledge on the regulation of plant immunity derives from studies focused on above-ground organs, mainly on the model plant Arabidopsis thaliana. Therefore, it is unclear whether the paradigms based on experiments on above-ground organs are entirely transferable to roots. Here, we used the non-model plant Brassica rapa to study the regulation dynamics of hormonal-related marker genes in both roots and shoots. These markers were identified in Arabidopsis shoots after elicitation of the JA-, SA-, ET- or ABA-signalling pathways, and are commonly used to study induced responses. We assessed whether the regulation of those genes by hormonal elicitation differs between roots and shoots. To discern whether the differences in marker gene expression between roots and shoots are related to differences in hormone production or to differential responsiveness, we also measured actual hormone content in the treated tissue after elicitation. Our results show that some of the widely used markers did not show specific responsiveness to single hormone applications in B. rapa. We further found that hormonal elicitation led to different response patterns of the molecular markers in shoots and roots. Our results suggest that the regulation of some hormonal-related marker genes in B. rapa is organ specific and differs from the Arabidopsis-derived paradigms.This research was supported by the German Centre
for Integrative Biodiversity Research (iDiv) Halle-Jena-
Leipzig funded by the German Research Foundation
Downloaded from https://academic.oup.com/aobpla/article-abstract/10/3/ply031/4996589 by 81263630 user on 16 April 2019
Papadopoulou et al. – Hormonal marker genes in shoots and roots
AoB PLANTS https://academic.oup.com/aobpla © The Author(s) 2018 13
(FZT 118). A.M.-M. further acknowledges the support by
the programme to support junior researchers to obtain
third-party funding from Friedrich-Schiller-Universität
Jena (DRM/2015-02). The authors acknowledge support
from the iDiv Open Science Publication Fund.Peer reviewe
Ecología trófica y estructura de la comunidad de peces mesopelágicos del Mediterráneo Occidental
No full textMemoria de tesis doctoral presentada por Ainhoa Bernal Bajo para optar al grado de Doctora en Ciencias del Mar por la Universitat Politècnica de Catalunya (UPC), realizada bajo la dirección de la Dra. Mª Pilar Olivar Bueradel Institut de Ciències del Mar (ICM-CSIC) y de la Dra. Mª Luz Fernández de Puelles del Centre Oceanogràfic de Balears (IEO).-- 307 pages[EN] Mesopelagic fish populations from the orders Myctophiformes and Stomiiformes were investigated to determine the potential effects of physical and biological factors on their trophic ecology, and characterize the ecological role that have in an oligotrophic system such as the western Mediterranean. The relevance of the mesopelagic fish community is connected to the great biomass that they represent worldwide, constituting common dietary resources for large pelagic fishes of commercial interest, marine birds and marine mammals. Myctophids are also key components of the trophic webs since they perform extensive diel vertical migrations throughout the water column, acting as vectors of matter and energy fluxes. This study was developed in a region off the Balearic Islands during two seasonal periods, late autumn (water mixing period) and summer (stratification of the water column). The trophic behaviour and vertical distribution of mesopelagic fishes were analysed, and ontogenetic dietary shifts from young individuals to adulthood were described. These aspects have been hardly reported in juveniles and adults of Mediterranean mesopelagic fishes. The present study comprises the most abundant and frequent species of myctophids (Ceratoscopelus maderensis, Notoscopelus elongatus, Benthosema glaciale, Hygophum hygomii, H. benoiti, Lampanyctus crocodilus, L. pusillus, Lobianchia dofleini, and Myctophum punctatum) and stomiiforms (mainly, the gonostomatid Cyclothone braueri and the sternoptychid Argyropelecus hemigymnus) of the Mediterranean Sea. The first objective of this thesis was to confirm whether the classical larval identification based on morphological and pigmentation characters, for both myctophids and stomiiforms, was supported by using barcoding genetic techniques. [...][ES] En esta tesis doctoral se ha estudiado la relación de las poblaciones de peces mesopelágicos pertenecientes a los órdenes Myctophiformes y Stomiiformes con el medio pelágico, analizando el posible efecto de factores físicos y biológicos en su ecología trófica, y caracterizando su papel ecológico en un ecosistema oligotrófico de la cuenca occidental del Mar Mediterráneo. La importancia de estos peces mesopelágicos subyace a su elevada biomasa en todos los océanos, constituyendo una base alimenticia para peces pelágicos de carácter comercial, así como aves y mamíferos marinos. Los mictófidos son elementos claves de las cadenas tróficas al efectuar extensas migraciones diarias verticales, actuando como vectores de flujo de materia orgánica y energía. El presente estudio se desarrolló en las proximidades del archipiélago balear en dos períodos, final del otoño (período de mezcla de la columna de agua) y en verano (estratificación). Se ha investigado el comportamiento trófico y la distribución vertical de peces mesopelágicos, describiendo los cambios en la dieta a lo largo del desarrollo ontogénico. Estos aspectos han sido apenas estudiados en juveniles y adultos de los peces mesopelágicos en el Mediterráneo occidental. El estudio abarca las especies más abundantes y frecuentes de mictófidos (Ceratoscopelus maderensis, Notoscopelus elongatus, Benthosema glaciale, Hygophum hygomii, H. benoiti, Lampanyctus crocodilus, L. pusillus, Lobianchia dofleini, y Myctophum punctatum) y stomiiformes (principalmente el gonostomátido Cyclothone braueri y el sternoptíquido Argyropelecus hemigymnus). El primer objetivo de esta tesis consistió en comprobar si la clásica identificación de estadios larvarios de mictófidos y stomiiformes en base a caracteres morfológicos y de pigmentación era confirmada utilizando técnicas moleculares de barcoding. [...]The author has been granted with a FPI pre-doctoral scholarship of the Ministry of Economy and Competitiveness from December 2009 to October 2013. This thesis has been developed within the framework of the IDEADOS project (CTM2008-04489-C03-01/MAR and -02/MAR) funded by the Spanish governmentPeer Reviewe
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