182,521 research outputs found
William H. Allen Letter
No full textLetter written from Camp Hamilton (or Fort Monroe) by Col. William H. Allen, 1st New York Infantry, to Captain J. Frederick Pierson regarding the arrest of a husband and wife on susision of treason. The following is a transcription of the letter: "You will at once proceed to the residence of Mr. Mussey residing within these lines & search his house and arrest himself and wife or any others whom you may have just cause to suspect of conveying information to the enemy"
Hundreds of variants clustered in genomic loci and biological pathways affect human height
No full textMost common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways
Personal Papers (MS 80-0002)
No full textLetter from Allen Kimberly to I. H. Kempner discussing Kempner's postponed trip to Hawaii and Kimberly's upcoming trip to Washington D.C. and inquiring about Clark Thompson
Personal Papers (MS 80-0002)
No full textLetter from I. H. Kempner to Allen Kimberly discussing Herbert Kempner's health condition, Clark Thompson's political campaigns and office, and Kempner's deferred trip to Hawaii
Personal Papers (MS 80-0002)
No full textLetter from Allen Kimberly to I. H. Kempner discussing Kempner's upcoming visit to Los Angeles and providing instructions for meeting at Kimberly's Hollywood home
Personal Papers (MS 80-0002)
No full textLetter from I. H. Kempner to Allen Kimberly discussing Herbert Kempner's recovery progress and I. H. and Henrietta Leonora Kempner's Los Angeles visit on the way to Hawaii
The herbarium of Paul h. Allen
No full textEl herbario privado de Paul h. Allen, unos cinco o seis mil ejemplares, ha sido comprado por la escuela agrícola panamericana
- …
