103,896 research outputs found
Análise histórica progressiva e caracterização geotécnica de aterro sobre solo mole executado com cinza pesada, localizado no Complexo Termelétrico Jorge Lacerda, Tubarão - SC
No full textTCC (Engenharia Civil) - Universidade Federal de Santa Catarina. Centro Tecnológico. Engenharia Civil.O crescimento urbano nas últimas décadas, no Brasil, contribuiu para a redução da disponibilidade de solos competentes nas regiões de maior desenvolvimento econômico, levando a ocupação em solos de baixa capacidade de suporte. A ocorrência deste tipo de solo é comum no país, principalmente na costa e nas várzeas de rios no interior. Portanto, vê-se a necessidade de estudar o comportamento do aterro sobre solo mole, que requer métodos que solucione ou minimize os problemas de recalque e estabilidade. Desta forma, o trabalho pretende caracterizar um aterro localizado no município de Tubarão – SC. A peculiaridade do estudo é o tipo de material utilizado como corpo de aterro, utilizou-se a cinza pesada proveniente da queima do carvão do Complexo Termelétrico Jorge Lacerda. A análise da área inicia desde seu emprego como depósito de cinzas até a ocupação do espaço pelas usinas fotovoltaica e eólica. Em função destas obras foi realizada uma extensa investigação geotécnica para a caracterização do solo de fundação e da cinza pesada, o estudo irá avaliar estes ensaios. Os resultados apontam para a confirmação do solo de fundação de baixa capacidade, há indícios que o depósito de cinza contribuiu para o ganho de resistência da camada de argila subjacente a cinza. E por ser um resíduo do carvão, a cinza contém materiais pesados prejudiciais à saúde, portanto requer atenção no seu manejo. Por fim, os métodos empregados garantiram a resistência para considerar um solo adequado a algumas obras de engenharia
Personal Papers (MS 80-0002)
No full textLetter from H. Kempner Cotton Company to José Q. Lacerda discussing his expense accounts and a bill incurred by Harris Leon Kempner
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
T cell numbers relate to bone involvement in Gaucher disease
No full textBlood Cells Mol Dis. 1999 Apr;25(2):130-8.
T cell numbers relate to bone involvement in Gaucher disease.
Lacerda L, Arosa FA, Lacerda R, Cabeda J, Porto G, Amaral O, Fortuna A, Pinto R, Oliveira P, McLaren CE, Sá Miranda C, de Sousa M.
Department of Genetics Neurobiology, Porto University, Portugal.
Abstract
The major elements of bone pathology in Gaucher disease are a failure of osteoclast and osteoblast function, resulting in osteopenia and also osteonecrosis. T lymphocytes have recently been found to be involved in the regulation of osteoblast/osteoclast activity in vitro. In the present report the peripheral blood T major lymphocyte subsets were investigated in a group of genotyped type 1 Gaucher disease patients. A total of 31 patients were studied: 21 non-splenectomized (5 N370S homozygotes) and 10 splenectomized (of whom 1 was a N370S homozygote). The results show that non-splenectomized patients present a decrease in absolute numbers of peripheral blood T lymphocytes, specially the CD4+ T subset. However, when patients were analyzed with respect to the presence of bone disease, the number of CD8+ T lymphocytes was found to be statistically significantly lower in patients presenting bone involvement. Furthermore, lower numbers of CD8+ T lymphocytes were significantly correlated with higher levels of plasma tartrate resistant acid phosphatase (TRAP) activity, a putative marker of osteoclast cell activity. These in vivo findings are in agreement with the results reached in vitro by others. They provide an additional marker of disease severity in Gaucher disease. In the group of genotyped Gaucher disease patients, the majority of the N370S homozygous patients presented a clinically milder phenotype, including the absence of bone involvement, confirming earlier reports predicting that a number of these patients may remain undiagnosed. Collectively the homozygosity for the N370S mutation and normal T cell numbers may provide additional markers for the clinical heterogeneity of Gaucher disease.
PMID: 10389595 [PubMed - indexed for MEDLIN
On social impact and its appraisal in favela-based organisations
No full textt is not enough to have good intentions when deploying social interventions in favela territories. In this post, Daniel S. Lacerda discusses the importance of assessing social impact in context, explaining why favela-based NGOs must ensure their actions and objectives respond to the material space where they operate
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
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