263,348 research outputs found
Leslie T. C. Kuo, The technical transformation of agriculture in communist China
No full textÉtienne Gilbert. Leslie T. C. Kuo, The technical transformation of agriculture in communist China. In: Tiers-Monde, tome 14, n°53, 1973. Politiques et planifications de la santé. p. 210
Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
No full textCellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of caspase-8 and is required for macrophage survival. Recent studies have revealed a selective role of caspase-8 in noncanonical IL-1 beta production that is independent of caspase-1 or inflammasome. Here we demonstrated that c-FLIPL is an unexpected contributor to canonical inflammasome activation for the generation of caspase-1 and active IL-1 beta. Hemizygotic deletion of c-FLIP impaired ATP-and monosodium uric acid (MSU)-induced IL-1 beta production in macrophages primed through Toll-like receptors (TLRs). Decreased IL-1 beta expression was attributed to a reduced activation of caspase-1 in c-FLIP hemizygotic cells. In contrast, the production of TNF-alpha was not affected by downregulation in c-FLIP. c-FLIPL interacted with NLRP3 or procaspase-1. c-FLIP is required for the full NLRP3 inflammasome assembly and NLRP3 mitochondrial localization, and c-FLIP is associated with NLRP3 inflammasome. c-FLIP downregulation also reduced AIM2 inflammasome activation. In contrast, c-FLIP inhibited SMAC mimetic-, FasL-, or Dectin-1-induced IL-1 beta generation that is caspase-8-mediated. Our results demonstrate a prominent role of c-FLIPL in the optimal activation of the NLRP3 and AIM2 inflammasomes, and suggest that c-FLIP could be a valid target for treatment of inflammatory diseases caused by over-activation of inflammasomes
Comparison of anterior cingulate and primary somatosensory neuronal responses to noxious laser-heat stimuli in conscious, behaving rats.
No full textMeasurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
Get PDFThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Constructing Sobol' sequences with better two-dimensional projections
No full textDirection numbers for generating Sobol' sequences that satisfy the so-called Property A in up to 1111 dimensions have previously been given in Joe and Kuo [ACM Trans. Math. Software, 29 (2003), pp. 49–57]. However, these Sobol' sequences may have poor two-dimensional projections. Here we provide a new set of direction numbers alleviating this problem. These are obtained by treating Sobol' sequences in d dimensions as (t, d)-sequences and then optimizing the t-values of the two-dimensional projections. Our target dimension is 21201
Kuo-2014-Genetics-Fig3
No full textThese primary data are summarized and discussed in Kuo et al., Genetics (2014).
Data in this file are from the P{wa} assay, first published in Adams et al., Science (2002), DOI: 10.1126/science.1077198 .
The first tab has counts of progeny from each vial. As in other uses of this assay, only daughters that did not recieve the transposase
chromosome (Cy+) were scored. Since the Df(3R)ED6058 chromosome has w+ on it, only progeny that recieved a Sbchromosome were scored.
f red = frequency of red-eyed flies
f yellow = frequency of yellow-eyed flies
The last tab has molecular analysis of synthesis and/or deletion in the yellow-eyed daughters. Each row represents presence (+) or absence (-)
of a PCR product in white-eyed sons of yellow-eyed progeny. Each yellow-eyed progeny came from a different vials (f numbers are Fancm,
c numbers are control). Distance of furthers primer from left or right end of the element is indicated. Primers used are listed
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