54,179 research outputs found
Categorisation of clauses in conjunctive normal forms: minimally unsatisfiable sub-clause-sets and the lean kernel
No full text1ST MEASUREMENT OF GAMMA(D(S)(+)-]MU+NU)/GAMMA(D(S)(+)-]PHI-PI+)
No full textComplete Author List:
ACOSTA D, ATHANAS M, MASEK G, PAAR H, BEAN A, GRONBERG J, KUTSCHKE R, MENARY S, MORRISON RJ, NAKANISHI S, NELSON HN, NELSON TK, RICHMAN JD, RYD A, TAJIMA H, SCHMIDT D, SPERKA D, WITHERELL MS, PROCARIO M, YANG S, BALEST R, CHO K, DAOUDI M, FORD WT, JOHNSON DR, LINGEL K, LOHNER M, RANKIN P, SMITH JG, ALEXANDER JP, BEBEK C, BERKELMAN K, BESSON D, BROWDER TE, CASSEL DG, CHO HA, COFFMAN DM, DRELL PS, EHRLICH R, GALIK RS, GARCIASCIVERES M, GEISER B, GITTELMAN B, GRAY SW, HARTILL DL, HELTSLEY BK, JONES CD, JONES SL, KANDASWAMY J, KATAYAMA N, KIM PC, KREINICK DL, LUDWIG GS, MASUI J, MEVISSEN J, MISTRY NB, NG CR, NORDBERG E, OGG M, PATTERSON JR, PETERSON D, RILEY D, SALMAN S, SAPPER M, WORDEN H, WURTHWEIN F, AVERY P, FREYBERGER A, RODRIGUEZ J, STEPHENS R, YELTON J, CINABRO D, HENDERSON S, KINOSHITA K, LIU T, SAULNIER M, SHEN F, WILSON R, YAMAMOTO H, ONG B, SELEN M, SADOFF AJ, AMMAR R, BALL S, BARINGER P, COPPAGE D, COPTY N, DAVIS R, HANCOCK N, KELLY M, KWAK N, LAM H, KUBOTA Y, LATTERY M, NELSON JK, PATTON S, PERTICONE D, POLING R, SAVINOV V, SCHRENK S, WANG R, ALAM MS, KIM IJ, NEMATI B, ONEILL JJ, SEVERINI H, SUN CR, ZOELLER MM, CRAWFORD G, DAUBENMIER CM, FULTON R, FUJINO D, GAN KK, HONSCHEID K, KAGAN H, KASS R, LEE J, MALCHOW R, MORROW F, SKOVPEN Y, SUNG M, WHITE C, WHITMORE J, WILSON P, BUTLER F, FU X, KALBFLEISCH G, LAMBRECHT M, ROSS WR, SKUBIC P, SNOW J, WANG PL, WOOD M, BORTOLETTO D, BROWN DN, FAST J, MCILWAIN RL, MIAO T, MILLER DH, MODESITT M, SCHAFFNER SF, SHIBATA EI, SHIPSEY IPJ, WANG PN, BATTLE M, ERNST J, KROHA H, ROBERTS S, SPARKS K, THORNDIKE EH, WANG CH, DOMINICK J, SANGHERA S, SHELKOV V, SKWARNICKI T, STROYNOWSKI R, VOLOBOUEV I, ZADOROZHNY P, ARTUSO M, HE D, GOLDBERG M, HORWITZ N, KENNETT R, MONETI GC, MUHEIM F, MUKHIN Y, PLAYFER S, ROZEN Y, STONE S, THULASIDAS M, VASSEUR G, ZHU G, BARTELT J, CSORNA SE, EGYED Z, JAIN V, SHELDON P, AKERIB DS, BARISH B, CHADHA M, CHAN S, COWEN DF, EIGEN G, MILLER JS, OGRADY C, URHEIM J, WEINSTEIN A
Novel mutations of Kir2.1 underlying Andersen’s syndrome are non-functional and have a dominant negative effect on the wild –type allele
No full textN-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes
No full textAntibodies to the N-methyl-d-aspartate subtype of glutamate receptor have been associated with a newly-described encephalopathy that has been mainly identified in young females with ovarian tumours. However, the full clinical spectrum and treatment responses are not yet clear. We established a sensitive cell-based assay for detection of N-methyl-d-aspartate receptor antibodies in serum or cerebrospinal fluid, and a quantitative fluorescent immunoprecipitation assay for serial studies. Although there was marked intrathecal synthesis of N-methyl-d-aspartate receptor antibodies, the absolute levels of N-methyl-d-aspartate receptor antibodies were higher in serum than in cerebrospinal fluid. N-methyl-d-aspartate receptor antibodies were of the immunoglobulin G1 subclass and were able to activate complement on N-methyl d-aspartate receptor-expressing human embryonic kidney cells. From questionnaires returned on 44 N-methyl-d-aspartate receptor antibody-positive patients, we identified a high proportion without a detected tumour (35/44, 80%: follow-up 3.6-121 months, median 16 months). Among the latter were 15 adult females (43%), 10 adult males (29%) and 10 children (29%), with four in the first decade of life. Overall, there was a high proportion (29%) of non-Caucasians. Good clinical outcomes, as defined by reductions in modified Rankin scores, correlated with decreased N-methyl-d-aspartate receptor antibody levels and were associated with early (<40 days) administration of immunotherapies in non-paraneoplastic patients (P < 0.0001) and earlier tumour removal in paraneoplastic patients (P = 0.02). Ten patients (23%) who were first diagnosed during relapses had no evidence of tumours but had received minimal or no immunotherapy during earlier episodes. Temporal analysis of the onset of the neurological features suggested progression through two main stages. The time of onset of the early features, characterized by neuropsychiatric symptoms and seizures preceded by a median of 10-20 days, the onset of movement disorders, reduction in consciousness and dysautonomia. This temporal dichotomy was also seen in the timing of cerebrospinal fluid, electroencephalographic and in the rather infrequent cerebral imaging changes. Overall, our data support a model in which the early features are associated with cerebrospinal fluid lymphocytosis, and the later features with appearance of oligoclonal bands. The immunological events and neuronal mechanisms underlying these observations need to be explored further, but one possibility is that the early stage represents diffusion of serum antibodies into the cortical grey matter, whereas the later stage results from secondary expansion of the immunological repertoire within the intrathecal compartment acting on subcortical neurons. Four patients, who only had temporal lobe epilepsy without oligoclonal bands, may represent restriction to the first stag
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
Exclusive and inclusive semileptonic decays of B mesons to D mesons
No full textcomplete author list: Fulton R.; Jensen T.; Johnson D.; Kagan H.; Kass R.; Morrow F.; Whitmore J.; Wilson P.; Bortoletto D.; Chen W.; Dominick J.; McIlwain R.; Miller D.; Ng C.; Schaffner S.; Shibata E.; Shipsey I.; Yao W.; Battle M.; Sparks K.; Thorndike E.; Wang C.; Alam M.; Kim I.; Li W.; Romero V.; Sun C.; Wang P.; Zoeller M.; Goldberg M.; Haupt T.; Horwitz N.; Jain V.; Mestayer M.; Moneti G.; Rozen Y.; Rubin P.; Sharma V.; Skwarnicki T.; Thulasidas M.; Zhu G.; Csorna S.; Letson T.; Alexander J.; Artuso M.; Bebek C.; Berkelman K.; Browder T.; Cassel D.; Cheu E.; Coffman D.; Crawford G.; Dewire J.; Drell P.; Ehrlich R.; Galik R.; Garcia-Sciveres M.; Geiser B.; Gittelman B.; Gray S.; Halling A.; Hartill D.; Heltsley B.; Honscheid K.; Kandaswamy J.; Katayama N.; Kreinick D.; Lewis J.; Ludwig G.; Masui J.; Mevissen J.; Mistry N.; Nandi S.; Nordberg E.; O'Grady C.; Peterson D.; Pisharody M.; Riley D.; Sapper M.; Selen M.; Silverman A.; Stone S.; Worden H.; Worris M.; Sadoff A.; Avery P.; Besson D.; Garren L.; Yelton J.; Kinoshita K.; Pipkin F.; Procario M.; Wilson R.; Wolinski J.; Xiao D.; Zhu Y.; Ammar R.; Baringer P.; Coppage D.; Davis R.; Haas P.; Kwak N.; Lam H.; Ro S.; Kubota Y.; Nelson J.; Perticone D.; Poling R.; Fulton R.; Poling R.; Perticone D.; Nelson J.; Fulton R.</p
Lentiviral expression of GAD67 and CCK promoter-driven opsins to target interneurons in vitro and in vivo
No full textBackground: The ability to manipulate the activity of interneurons with optogenetic tools offers the possibility of interfering with diseases caused by altered neuronal inhibition and synchrony, including epilepsy and schizophrenia. To develop vectors for therapeutic approaches, targeting optogenetic constructs to interneurons is therefore a key requirement. We investigated whether the interneuron-specific promoters glutamic acid decarboxylase (GAD)67 and cholecystokinin (CCK) allowed targeted lentiviral delivery of opsins to interneurons as a whole, or specifically CCK+ interneurons. Methods: We generated lentiviral (LV) plasmids encoding channelrhodopsin (ChR2) and halorhodopsin (NpHR) tagged with fluorophores and driven by GAD67 or CCK promoters. Adeno-associated virus (AAV) and LV vectors carrying opsins driven by pyramidal cell promoters were used as controls. We transduced neuronal cultures and rodent brain in vivo, immunostained specimens 6-8 weeks after in vivo injection and 7-14 days after in vitro transduction, and evaluated volume and specificity of expression by confocal microscopy. Results: In vitro, 90% (19/21) of LV-CCK-NpHR2.0-EYFP expressing neurons were CCK+. In vivo, LV-GAD67-ChR2-mCherry was expressed in 2.6% (5/193), LV-GAD67-NpHR2.0-EYFP in approximately 15% (43/279) and LV-CCK-NpHR2.0-EYFP in 47% (9/19) of hippocampal GABA+ interneurons. GAD67 vectors expressed in larger volumes than CCK-driven constructs. AAV vector controls achieved the largest expression volumes. Conclusions: LV-CCK-NpHR2.0-EYFP may be useful for targeting CCK+ interneurons in culture. GAD67/CCK-driven lentiviral constructs are expressed in vivo, although expression is not specific for interneurons. Overall, expression levels are low compared to opsins driven by pyramidal cell promoters. A better understanding of GAD67 and CCK promoter structure or alternative techniques is required to reliably target opsins to interneurons using viral vectors
Erosie door open taludbekledingen. Samenvattend verslag + Bijlage A t/m D
No full textOpen taludbekledingen die bestaan uit in verband geplaatste betonblokken met gaten, bieden de mogelijkheid vegetatie te doen groeien, waardoor mogelijk een milieuvriendelijke oever kan worden verkregen. In het pioniersstadium van de vegetatie is het evenwel ongewenst dat de gatvulling uitspoelt. Teneinde de relatie tussen waterbeweging en erosie van de gatvulling vast te stellen, is door de Dienst Weg- en Waterbouwkunde van Rijkswaterstaat per brief d.d. 16 maart 1987 (kenmerk WB 570), opdracht verleend aan het Waterloopkundig Laboratorium tot het uitvoeren van onderzoek naar de erosie door open taludbekledingen. Het doel van het onderzoek is het ontwikkelen van ontwerprichtlijnen voor taludbekledingen met gaten die groter zijn dan de zand- of filterkorrels eronder. Hiertoe dient de kritieke waterbeweging bij een oever- of dijkbekleding te worden vastgesteld, waarbij nog toelaatbare erosie is te verwachten. De toelaatbare erosie mag daarbij maximaal gelijk zijn aan de hoeveelheid sediment in de gaten. Filter- of basismateriaal gelegen onder de elementen mag dus niet uitspoelen. Bij oeverbekledingen waar vegetatie een rol moet gaan spelen, is de toelaatbare erosie kleiner, dat wil zeggen in de gaten dient sediment achter te blijven.Steenzettingen - TAW/EN
Measurement of the B̄→D*lν̄ branching fractions and -Vcb-
No full textcomplete author list:
Barish B.; Chadha M.; Chan S.; Cowen D.; Eigen G.; Miller J.; O'Grady C.; Urheim J.; Weinstein A.; Acosta D.; Athanas M.; Masek G.; Paar H.; Gronberg J.; Kutschke R.; Menary S.; Morrison R.; Nakanishi S.; Nelson H.; Nelson T.; Qiao C.; Richman J.; Ryd A.; Tajima H.; Sperka D.; Witherell M.; Procario M.; Balest R.; Cho K.; Daoudi M.; Ford W.; Johnson D.; Lingel K.; Lohner M.; Rankin P.; Smith J.; Alexander J.; Bebek C.; Berkelman K.; Bloom K.; Browder T.; Cassel D.; Cho H.; Coffman D.; Crowcroft D.; Drell P.; Ehrlich R.; Gaidarev P.; Galik R.; Garcia-Sciveres M.; Geiser B.; Gittelman B.; Gray S.; Hartill D.; Heltsley B.; Jones C.; Jones S.; Kandaswamy J.; Katayama N.; Kim P.; Kreinick D.; Ludwig G.; Masui J.; Mevissen J.; Mistry N.; Ng C.; Nordberg E.; Patterson J.; Peterson D.; Riley D.; Salman S.; Sapper M.; Würthwein F.; Avery P.; Freyberger A.; Rodriguez J.; Yang S.; Yelton J.; Cinabro D.; Henderson S.; Liu T.; Saulnier M.; Wilson R.; Yamamoto H.; Bergfeld T.; Eisenstein B.; Gollin G.; Ong B.; Palmer M.; Selen M.; Thaler J.; Edwards K.; Ogg M.; Bellerive A.; Britton D.; Hyatt E.; MacFarlane D.; Patel P.; Spaan B.; Sadoff A.; Ammar R.; Ball S.; Baringer P.; Bean A.; Besson D.; Coppage D.; Copty N.; Davis R.; Hancock N.; Kelly M.; Kotov S.; Kravchenko I.; Kwak N.; Lam H.; Kubota Y.; Lattery M.; Momayezi M.; Nelson J.; Patton S.; Perticone D.; Poling R.; Savinov V.; Schrenk S.; Wang R.; Alam M.; Kim I.; Nemati B.; Ling Z.; O'Neill J.; Severini H.; Sun C.; Wappler F.; Crawford G.; Daubenmier C.; Fulton R.; Fujino D.; Gan K.; Honscheid K.; Kagan H.; Kass R.; Lee J.; Malchow R.; Skovpen Y.; Sung M.; White C.; Zoeller M.; Butler F.; Fu X.; Kalbfleisch G.; Ross W.; Skubic P.; Wood M.; Fast J.; Mcilwain R.; Miao T.; Miller D.; Modesitt M.; Payne D.; Shibata E.; Shipsey I.; Wang P.; Battle M.; Ernst J.; Gibbons L.; Kwon Y.; Roberts S.; Thorndike E.; Wang C.; Dominick J.; Lambrecht M.; Sanghera S.; Shelkov V.; Skwarnicki T.; Stroynowski R.; Volobouev I.; Wei G.; Zadorozhny P.; Artuso M.; Goldberg M.; He D.; Horwitz N.; Kennett R.; Mountain R.; Moneti G.; Muheim F.; Mukhin Y.; Playfer S.; Rozen Y.; Stone S.; Thulasidas M.; Vasseur G.; Xing X.; Zhu G.; Bartelt J.; Csorna S.; Egyed Z.; Jain V.; Gibaut D.; Kinoshita K.; Kinoshita K.; Barish B
Measurement of the D+/- production asymmetry in 7 TeV pp collisions
No full textThe asymmetry in the production cross-section \sigma of D+/- mesons, A_P = (\sigma(D+) - \sigma(D-))/(\sigma(D+) + \sigma(D-)), is measured in bins of pseudorapidity \eta and transverse momentum p_T within the acceptance of the LHCb detector. The result is obtained with a sample of D+ -> K_S pi+ decays corresponding to an integrated luminosity of 1.0 fb^-1, collected in pp collisions at a centre of mass energy of 7 TeV at the Large Hadron Collider. When integrated over the kinematic range 2.0 K_S pi+ decay is negligible. No significant dependence on \eta or p_T is observed
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