20 research outputs found
Material management without forecasting: From MRP to demand driven MRP
No full textPurpose: Efficient Operations and Supply Chain Management is key to building sustainable competitive edge for companies. However, the achievement of this goal is becoming challenging in the present dynamic production environment, as traditional Manufacturing Planning and Control systems were not developed to work in this context. The Demand-Driven Material Requirement Planning (DDMRP) methodology was developed with the aim of addressing this need and deal efficiently with material management. The present work, therefore analyzes the evolution of a company after converting from MRP to DDMRP.
Design/methodology/approach: To achieve an in depth understanding of the case study a qualitative approach was taken. Data was collected from semi-structured interviews, documents and archival records enabling triangulation. The results from before and after the implementation of DDMRP were compared, and the evolution of the performance of the company was evaluated.
Findings: The results clearly show that using DDMRP the company increased visibility in the supply chain. In addition, the inventory level was reduced by 52.53% while material consumption was increased by 8.7%. These results were achieved while maintaining the high service level.
Originality/value: DDMRP is a relatively new methodology and for this reason there is little published data in this field. In addition the few studies found in the literature analyze the performance of DDMRP in simulated environments. The present work aims to go one step further and analyzes the implementation of DDMRP in a real company.Peer Reviewe
Demand Driven MRP – The need to standardise an implementation process
No full text[EN] Since the creation of the demand-driven material requirement planning (DDMRP) model, numerous studies have analysed the methodology’s significant impact on different organisations. Several successful cases and research studies into DDMRP have demonstrated that the methodology is beneficial to organisations because it increases their service level and stock adjustments; however, there is a dearth of literature regarding the steps necessary to implement this model successfully. This document delivers a systematic review of the literature based on the work done by Kitchenham (2004) with the aim of analysing studies that investigate the standardization of the process of implementing the model. Once the lack of research has been demonstrated, a possible line of future research can be outlined to standardise the implementation process of the DDMRP model to achieve its full potential.Orue, A.; Lizarralde, A.; Kortabarria, A. (2020). Demand Driven MRP – The need to standardise an implementation process. International Journal of Production Management and Engineering. 8(2):65-73. https://doi.org/10.4995/ijpme.2020.12737OJS657382Bahu, B., Bironneau, L., Hovelaque, V. (2019). Compréhension du DDMRP et de son adoption: Premiers éléments empiriques. Logistique & Management, 1-13. https://doi.org/10.1080/12507970.2018.1547130De La Calle, A., Grus, M.E., Álvarez, E. (2017). Value creation through demand and supply chains: Evidences from Spanish companies. Direccion y Organizacion, 61, 4-11.Dessevre, G., Martin, G., Pellerin, R., Lamothe, J., Lauras, M. (2019). Decoupled Lead Time in finite capacity flowshop: A feedback loop approach. 2019 International Conference on Industrial Engineering and Systems Management (IESM), 1-6. https://doi.org/10.1109/IESM45758.2019.8948198Favaretto, D., Marin, A. (2018). An Empirical Comparison Study Between DDMRP and MRP in Material Management. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3305114Fomin, V., Lyytinen, K. (2000). How to Distribute a Cake before Cutting It into Pieces: Alice in Wonderland or Radio Engineers' Gang in the Nordic Countries?. In Jakobs, K. (Ed.), Information Technology Standards and Standardization: A Global Perspective (pp. 222-239). IGI Global. https://doi.org/10.4018/978-1-878289-70-4.ch014Gupta, M.C., Boyd, L.H. (2008). Theory of constraints: A theory for operations management. International Journal of Operations & Production Management, 28(10), 991-1012. https://doi.org/10.1108/01443570810903122Ihme, M., Stratton, R. (2015). Evaluating Demand Driven MRP: A case based simulated study. In International Conference of the European Operations Management Association (1-10). Retrieved from http://irep.ntu.ac.uk/id/eprint/26668/ISO, I. S. O. (2005). 9000-Quality management systems-Fundamentals and vocabulary. Quality Management Systems, Berlin: Beuth Verlag GmbH, 22-25.Jang, Y., Lee, J. (1998). Factors influencing the success of management consulting projects. International Journal of Project Management, 16(2), 67-72. https://doi.org/10.1016/S0263-7863(97)00005-7Jiang, J., Rim, S.C.C. (2017). Strategic WIP Inventory Positioning for Make-to-Order Production with Stochastic Processing Times. Mathematical Problems in Engineering, 2017, 1-7. https://doi.org/10.1155/2017/8635979Jiang, J., Rim, S. C. (2016). Strategic Inventory Positioning in BOM with Multiple Parents Using ASR Lead Time. Mathematical Problems in Engineering, 2016, 1-9. https://doi.org/10.1155/2016/9328371Kitchenham, B. (2004). Procedures for performing systematic reviews. Keele, UK, Keele University.Koren, Y. (2010). The global manufacturing revolution: product-process-business integration and reconfigurable systems (Vol. 80). John Wiley & Sons. https://doi.org/10.1002/9780470618813Kortabarria, A., Apaolaza, U., Lizarralde, A., Amorrortu, I. (2018). Material management without forecasting: From MRP to demand driven MRP. Journal of Industrial Engineering and Management, 11(4), 632. https://doi.org/10.3926/jiem.2654Lee, C.J., Rim, S.C. (2019). A Mathematical Safety Stock Model for DDMRP Inventory Replenishment. Mathematical Problems in Engineering, 2019, 1-10. https://doi.org/10.1155/2019/6496309Lizarralde, A., Apaolaza, U., Mediavilla, M. (2020). A Strategic Approach for Bottleneck Identification in Make-to-Order Environments: A Drum-Buffer-Rope Action Research Based Case Study. Journal of Industrial Engineering and Management, 13(1), 18-37. https://doi.org/10.3926/jiem.2868Martin, G., Baptiste, P., Lamothe, J., Miclo, R., Lauras, M., & Albi, M. (2018). A process map for the Demand Driven Adaptive Enterprise model: Towards an explicit cartography 3. The cartography: how to represent the complete Demand Driven Adaptive. In 7 th International Conference on Information Systems, Logistics and Supply Chain (664-672). Retrieved from https://hal-mines-albi.archives-ouvertes.fr/hal-01883504/Miclo, R., Fontanili, F., Lauras, M., Lamothe, J., Milian, B. (2016a). An empirical comparison of MRPII and Demand-Driven MRP. IFACPapersOnLine, 49(12), 1725-1730. https://doi.org/10.1016/j.ifacol.2016.07.831Miclo, R., Fontanili, F., Lauras, M., Lamothe, J., Milian, B. (2016b). MRP vs. Demand-driven MRP: Towards an objective comparison. Proceedings of 2015 International Conference on Industrial Engineering and Systems Management, IEEE IESM 2015, (October), 1072-1080. https://doi.org/10.1109/IESM.2015.7380288Miclo, R., Lauras, M., Fontanili, F., Lamothe, J., Melnyk, S.A. (2019). Demand Driven MRP: Assessment of a new approach to materials management. International Journal of Production Research, 57(1), 166-181. https://doi.org/10.1080/00207543.2018.1464230Münstermann, B., Weitzel, T. (2008). What Is Process Standardization? (Vol. 64). Retrieved from http://aisel.aisnet.org/confirm2008/64Pretorius, P. (2014). Introducing in-between decision points to TOC ' s five focusing steps. International Journal of Production Research, (November), 37-41. https://doi.org/10.1080/00207543.2013.836612Ptak, C.A., Smith, C. (2016). Demand Driven Material Requirements Planning (DDMRP). Industrial Press, Incorporated.Ramakumar, A., Quality, B.C. (2004), U. (n.d.). Process standardization proves profitable: the demand for higher product quality has resulted in an increasingly complex value chain. BNP Media. Retrieved from https://scholar.google.es/scholar?hl=es&as_sdt=0%2C5&q=ramakumar+y+cooper+2004&btnG=Shofa, M.J., Moeis, A.O., Restiana, N. (2018). Effective production planning for purchased part under long lead time and uncertain demand: MRP Vs demand-driven MRP. In IOP Conference Series: Materials Science and Engineering (Vol. 337, p. 012055). IOP Publishing. https://doi.org/10.1088/1757-899X/337/1/012055Shofa, M.J., Widyarto, W.O. (2017). Effective production control in an automotive industry: MRP vs. demand-driven MRP. In AIP Conference Proceedings (Vol. 1855, p. 020004). AIP Publishing LLC. https://doi.org/10.1097/01.ju.0000143904.17666.0bSmith, B.D., Smith, C. (2013, November 1). Becoming demand-driven: How to change from push and promote to position and pull. Strategic Finance, 95(November), 37-45. Retrieved from https://go.galegroup.com/ps/i.do?p=AONE&sw=w&u=googlescholar&v=2.1&it=r&id=GALE%7CA349741171&sid=googleScholar&asid=052f118fStevenson, M., Hendry, L.C., Kingsman, B.G. (2005). A review of production planning and control: The applicability of key concepts to the maketo-order industry. International Journal of Production Research, 43(5), 869-898. https://doi.org/10.1080/0020754042000298520Swaminathan, J.M. (2001). Enabling Customization Using Standardized Operations. California Management Review, 43(3), 125-135. https://doi.org/10.2307/41166092Trojan, J., Pekarčíková, M., Kliment, M., Trebuňa, P. (2019). Demand driven material requirements planning. Some methodical and practical comments. Management and Production Engineering Review, 10(2), 50-59. https://doi.org/10.24425/mper.2019.129568Velasco Acosta, A.P., Mascle, C., Baptiste, P. (2019). Applicability of Demand-Driven MRP in a complex manufacturing environment. International Journal of Production Research, 0(0), 1-13. https://doi.org/10.1080/00207543.2019.165097
Implementing Management Systems and Demand Driven MRP concepts: A Project Based Learning experience in Industrial Organization Engineering
No full text[EN] This research work presents an experience of the Faculty of Engineering of Mondragon Unibertsitatea using Project Based Learning (PBL) with the students of 4th semester of Bachelor's Degree in Industrial Organization Engineering (IOE). The PBL delved into the concepts developed in the subjects of Management Systems and Production Logistics. The project was contextualized in a company that produced parts for the automotive sector. Teams of students implemented a management system that enabled the efficient management of materials and the production process using tools such as Demand Driven MRP (DDRMP). As a result, they had to solve the proposed problem, develop a simulation and choose the proposal that best met the needs of the company. In order to assess PBL performance a survey was carried out. The results confirmed that the experience was positive since the achieved knowledge provided a meaningful learning experience for the students, while facilitating the development of both technical and transversal competences. http://ocs.editorial.upv.es/index.php/HEAD/HEAD18Kortabarria, A.; Elizburu, A. (2018). Implementing Management Systems and Demand Driven MRP concepts: A Project Based Learning experience in Industrial Organization Engineering. Editorial Universitat Politècnica de València. 543-550. https://doi.org/10.4995/HEAD18.2018.8033OCS54355
DDMRP - The need to standardise an implementation process
No full textInternational Conference on Industrial Engineering and Industrial Management (13th. 2019. Gijón
Learnig SCRUM: a POPBL-based experience
No full textAgile project management methods have played a prominent role in recent years. Certain aspects as adaptability or orientation toward action characterize agile methods, making them especially interesting in high uncertainty and unpredictability contexts. Thus, some agile methods have transcended the software development context thereby reaching a remarkable expansion in various industries. It is the case of Scrum, which also requires the participants' know-how. In the case of people without a professional background, the starting point is different. Besides, learning agile methods is aimed at application, which requires practice. Lack of experience and fictitious application context hinder this purpose. Consequently, the learning process must overcome these obstacles. This study addresses the abovementioned problem when it comes to learning Scrum through the Project Based Learning approach. Eight teams of students competed to develop the best solution through a project to be managed with Scrum. As a result, we reached interesting findings and conclusions that we believe may be applicable in other methods beyond Scrum.Los métodos ágiles de gestión de proyectos han jugado un papel destacado en los últimos años. Caracterizados por aspectos como la adaptabilidad o la orientación a la acción, son especialmente interesantes en contextos de alta incertidumbre e imprevisibilidad. Así, algunos métodos ágiles han trascendido el contexto original de desarrollo de software, alcanzando una
notable expansión. Es el caso de Scrum, requiere además conocimientos por parte de de los participantes. En el caso de personas sin experiencia, el punto de partida es diferente. Además, el aprendizaje de métodos ágiles tiene como objetivo la aplicabilidad, lo que requiere práctica. La falta de experiencia y la el uso de un contexto de aplicación ficticio dificultan este propósito. En consecuencia, el proceso de aprendizaje debe superar estos obstáculos. Este estudio aborda esta problemática para el caso de Scrum, basándose en un enfoque de aprendizaje basado en proyectos. Ocho equipos de estudiantes compitieron para desarrollar la mejor solución mediante un proyecto gestionado con Scrum. Este trabajo ha dado lugar a hallazgos conclusiones de interés que, además, consideramos que pueden ser aplicables en otros métodos, más allá de Scrum
Mataró, una ciutat de "15 minuts". La proximitat pedestre als serveis urbans aplicada a la capital maresmenca
No full textLa ubiqüitat, la hiperconnexió, la descarbonització, la terciarització, entre moltes altres realitats, han vingut a canviar la manera de viure a les ciutats d'avui en dia. En aquest context, neix un model teòric en el replanteig de la ciutat actual titulat "la ciutat dels 15 minuts", terme encunyat i desenvolupat per Carlos Moreno. A fi de crear ciutats sostenibles, resilients i habitables, Moreno vetlla per una organització urbana on cada ciutadà pot trobar tot el que necessita per habitar en bones condicions en un radi territorial de menys de 15 minuts a peu al voltant del seu domicili. El present treball avalua la posada en pràctica d'aquest model a Mataró. S'analitza la proximitat practicable a peu a un seguit de serveis i comerços agrupats en 6 grans blocs, prenent de referència algunes de les funcions socials urbanes que anomena l'autor: mobilitat, aprovisionament, cura, educació, oci i altres. L'estudi s'ha basat en un procés metodològic de georeferenciació de dades, la posterior anàlisi de xarxes d'àrees de servei a partir d'eines SIG i l'elaboració d'indicadors que quantifiquen l'accessibilitat dels serveis sobre la base d'un rang temporal òptim establert. L'estudi és reforçat per una diagnosi comparativa a escala de barris i el plantejament d'una proposta d'actuació urbanística.La ubicuidad, la hiperconexión, la descarbonización, la terciarización, entre otras muchas realidades, han venido a cambiar la manera de vivir en las ciudades de hoy en día. En este contexto, nace un modelo teórico en el replanteo de la ciudad actual titulado "la ciudad de los 15 minutos", término acuñado y desarrollado por Carlos Moreno. A fin de crear ciudades sostenibles, resilientes y habitables, Moreno velatorio por una organización urbana donde cada ciudadano puede encontrar todo el que necesita para habitar en buenas condiciones en un radio territorial de menos de 15 minutos a pie alrededor de su domicilio. El presente trabajo evalúa la puesta en práctica de este modelo a Mataró. Se analiza la proximidad practicable a pie a una serie de servicios y comercios agrupados en 6 grandes bloques, tomando de referencia algunas de las funciones sociales urbanas que denomina el autor: movilidad, aprovisionamiento, cura, educación, ocio y otros. El estudio se ha basado en un proceso metodológico de georreferenciación de datos, el posterior análisis de redes de áreas de servicio a partir de herramientas SIG y la elaboración de indicadores que cuantifican la accesibilidad de los servicios en base a un rango temporal óptimo establecido. El estudio es reforzado por una diagnosis comparativa a escala de barrios y el planteamiento de una propuesta de actuación urbanística.Ubiquity, hyperconnection, decarbonization, tertiarization, among many other realities, have come to change the way of living in today's cities. In this context, a theoretical model was born in the rethinking of the current city entitled "15-minute city", a term coined and developed by Carlos Moreno. In order to create sustainable, resilient and livable cities, Moreno called for an urban organization where each citizen can find everything they need to live in good conditions within a territorial radius of less than 15 minutes on foot around their home. This document evaluates the implementation of this model in Mataró. The practicable proximity on foot to a series of services and shops grouped into 6 large blocks is analysed, taking as a reference some of the urban social functions that the author calls: mobility, provisioning, healing, education, leisure and others. The study has been based on a methodological process of georeferencing data, the subsequent analysis of networks of service areas based on GIS tools and the development of indicators that quantify the accessibility of services based on an established optimal time range. The study is reinforced by a comparative diagnosis at the scale of neighbourhoods and the proposal for urban action
El lèxic de Nicolau Primitiu Gómez Serrano en relació amb el seu ideari nacional. Un tast del vocabulari emprat al dietari Varia I (1934-1935)
No full textEl model lingüístic de l’humanista valencià del segle XX Nicolau Primitiu Gómez Serrano (1877-1971) és encara una incògnita tant per la manca d’estudis que s’hi dediquen com per la naturalesa de les seues formes gramaticals i lèxiques, força heterogènies i peculiars: localismes, arcaismes, castellanismes, creacions lèxiques de collita pròpia... En el present treball ens encareguem, doncs, d’oferir un tast del lèxic emprat pel patrici durant la dècada dels anys trenta, període d’efervescència del valencianisme cultural, a partir del seu dietari inèdit Varia I (1934-1935), època en la qual fou president d’importants entitats com Lo Rat Penat i Proa.The linguistic model of the Valencian humanist of the twentieth century Nicolau Primitiu Gómez Serrano (1877-1971) is still a mystery due to the lack of studies that are devoted to it and because of the nature of its grammatical and lexical forms, quite heterogeneous and peculiar: localisms, Archaisms, Castilianisms, lexical creations... In this work, we want to offer a summary of the lexicon used by the author during the thirties, a period of effervescence of cultural Valencianism, based on its unpublished dietary Varia I (1934-1935), when he was president of important entities such as Lo Rat Penat and Proa
Walforf pedagogia, hezkuntzan espiritualtasunari leku bat egiten
No full text32,16 p.-- Bibliogr.: p. 27-32[EUS] GRAL honetan Waldorf pedagogiara hurbilketa bat egiten da, hala nola pedagogia horren iturri
filosofiko-espiritualetara. Pedagogia horren sortzaileak, Rudolf Steiner-ek, proposatzen dituen
printzipio horien bidez, bai teorikoki zein praktikoki, espiritualtasunak eta irakasleek lehen
haurtzaroan duten garrantzia aztertzen da. Horretarako eta printzipio pedagogiko horietan
oinarrituta, Haur Hezkuntzan 39 urtetako esperientzia duen, Waldorf prestakuntza duen eta
oso bestelakoa den Haurreskolaren egunerokotasunean pedagogia honen printzipioak
gauzatzea lortzen duen hezitzaile baten ibilbide eta ezagutza aztertzen da. Haur Hezkuntzako
irakaslearen esperientzia, GRAL- aren autorea den eta Haur Hezkuntzako Graduko ikaslearen
praktika-aldian burututako behaketa partehartzailearekin elkarrizketan jarri eta metodo
kualitatiboen bidez aztertzen da. Emaitzen eztabaida eta ondorioek espiritualtasunari
haurtzaroan, irakasleon prestakuntzan, eta Haurreskoletan integratzeko klabeak identifikatu
eta zehazten ditu. Gainera, ikerketak irakaslegaiaren hazkuntza prozesuan izan duen inpaktua
identifikatu eta irakaslegaien garapen pertsonalean egin ditzakeen ekarpenak antzematen
ditu.[ES] En este GRAL se hace una aproximación a la pedagogía Waldorf, así como a las fuentes
filosófico-espirituales de dicha pedagogía. A través de estos principios que propone su
creador, Rudolf Steiner, se analiza, tanto teórica como practicamente, la importancia de la
espiritualidad y de la figura docente en la primera infancia. Para ello y en base a estos
principios pedagógicos, se analiza la trayectoria y el conocimiento de una educadora con 39
años de experiencia en Educación Infantil, que tiene formación en pedagogía Waldorf y que
aún trabajando en un contexto muy diferente, logra incorporar en la cotidianeidad de la
Escuela Infantil principios de dicha pedagogía. La experiencia de la profesora de Educación
Infantil es puesta en diálogo y analizada mediante métodos cualitativos con la observación
participativa realizada durante el periodo de prácticas de la alumna del Grado en Educación
Infantil, autora del GRAL. El debate y las conclusiones de estos resultados identifican y definen
las claves de integración de la espiritualidad en la infancia, en la formación de este
profesorado y en las Escuelas Infantiles, así como el impacto de la investigación en el proceso
de crecimiento del profesorado y sus posibles aportaciones al desarrollo personal de los
mismos.[EN] This dissertation it is intended to make an approach to Waldorf pedagogy, as well as the
philosophical-spiritual principles from which this pedagogy draws. Through these principles
that the founder of this pedagogy; rudolf steiner, proposes both theoretically and practically,
spirituality and the importance of teachers in early childhood are analyzed. For this, and based
on these pedagogical principles, the trajectory and knowledge of an educator with 39 years of
experience in Early Childhood Education, who has training in Waldorf education, and who even
working in a very different context, manages to incorporate the principles of this pedagogy in
the daily life of the Kindergarten. The experience of the Early Childhood Education teacher is
put into dialogue and analyzed through qualitative methods with the participant observation
carried out during the student's internship period of the Degree in Early Childhood Education,
author of this dissertation. The debate and the conclusions of these results identify and define
the keys to integrating spirituality in childhood, in the training of these teachers and in
Kindergarten, as well as the impact of research on the growth process of teachers and their
possible contributions to their personal development
Walforf pedagogia, hezkuntzan espiritualtasunari leku bat egiten
No full text32,16 p.-- Bibliogr.: p. 27-32[EUS] GRAL honetan Waldorf pedagogiara hurbilketa bat egiten da, hala nola pedagogia horren iturri
filosofiko-espiritualetara. Pedagogia horren sortzaileak, Rudolf Steiner-ek, proposatzen dituen
printzipio horien bidez, bai teorikoki zein praktikoki, espiritualtasunak eta irakasleek lehen
haurtzaroan duten garrantzia aztertzen da. Horretarako eta printzipio pedagogiko horietan
oinarrituta, Haur Hezkuntzan 39 urtetako esperientzia duen, Waldorf prestakuntza duen eta
oso bestelakoa den Haurreskolaren egunerokotasunean pedagogia honen printzipioak
gauzatzea lortzen duen hezitzaile baten ibilbide eta ezagutza aztertzen da. Haur Hezkuntzako
irakaslearen esperientzia, GRAL- aren autorea den eta Haur Hezkuntzako Graduko ikaslearen
praktika-aldian burututako behaketa partehartzailearekin elkarrizketan jarri eta metodo
kualitatiboen bidez aztertzen da. Emaitzen eztabaida eta ondorioek espiritualtasunari
haurtzaroan, irakasleon prestakuntzan, eta Haurreskoletan integratzeko klabeak identifikatu
eta zehazten ditu. Gainera, ikerketak irakaslegaiaren hazkuntza prozesuan izan duen inpaktua
identifikatu eta irakaslegaien garapen pertsonalean egin ditzakeen ekarpenak antzematen
ditu.[ES] En este GRAL se hace una aproximación a la pedagogía Waldorf, así como a las fuentes
filosófico-espirituales de dicha pedagogía. A través de estos principios que propone su
creador, Rudolf Steiner, se analiza, tanto teórica como practicamente, la importancia de la
espiritualidad y de la figura docente en la primera infancia. Para ello y en base a estos
principios pedagógicos, se analiza la trayectoria y el conocimiento de una educadora con 39
años de experiencia en Educación Infantil, que tiene formación en pedagogía Waldorf y que
aún trabajando en un contexto muy diferente, logra incorporar en la cotidianeidad de la
Escuela Infantil principios de dicha pedagogía. La experiencia de la profesora de Educación
Infantil es puesta en diálogo y analizada mediante métodos cualitativos con la observación
participativa realizada durante el periodo de prácticas de la alumna del Grado en Educación
Infantil, autora del GRAL. El debate y las conclusiones de estos resultados identifican y definen
las claves de integración de la espiritualidad en la infancia, en la formación de este
profesorado y en las Escuelas Infantiles, así como el impacto de la investigación en el proceso
de crecimiento del profesorado y sus posibles aportaciones al desarrollo personal de los
mismos.[EN] This dissertation it is intended to make an approach to Waldorf pedagogy, as well as the
philosophical-spiritual principles from which this pedagogy draws. Through these principles
that the founder of this pedagogy; rudolf steiner, proposes both theoretically and practically,
spirituality and the importance of teachers in early childhood are analyzed. For this, and based
on these pedagogical principles, the trajectory and knowledge of an educator with 39 years of
experience in Early Childhood Education, who has training in Waldorf education, and who even
working in a very different context, manages to incorporate the principles of this pedagogy in
the daily life of the Kindergarten. The experience of the Early Childhood Education teacher is
put into dialogue and analyzed through qualitative methods with the participant observation
carried out during the student's internship period of the Degree in Early Childhood Education,
author of this dissertation. The debate and the conclusions of these results identify and define
the keys to integrating spirituality in childhood, in the training of these teachers and in
Kindergarten, as well as the impact of research on the growth process of teachers and their
possible contributions to their personal development
Targeting CD38 with monoclonal antibodies disrupts key survival pathways in paediatric Burkitt's lymphoma malignant B cells
No full textObjectives: Paediatric Burkitt's lymphoma (pBL) is the most common childhood non-Hodgkin B-cell lymphoma. Despite the encouraging survival rates for most children, treating cases with relapse/resistance to current therapies remains challenging. CD38 is a transmembrane protein highly expressed in pBL. This study investigates the effectiveness of CD38-targeting monoclonal antibodies (mAbs), daratumumab and isatuximab, in impairing crucial cellular processes and survival pathways in pBL malignant cells. Methods: In silico analyses of patient samples, combined with in vitro experiments using the Ramos cell line, were conducted to assess the impact of daratumumab and isatuximab on cellular proliferation, apoptosis and the phosphoinositide 3-kinase (PI3K) pathway. Results: Isatuximab was found to be more effective than daratumumab in disrupting B-cell receptor signalling, reducing cellular proliferation and inducing apoptosis. Additionally, isatuximab caused a significant impairment of the PI3K pathway and induced metabolic reprogramming in pBL cells. The study also revealed a correlation between CD38 and MYC expression levels in pBL patient samples, suggesting CD38 involvement in key oncogenic processes. Conclusion: The study emphasises the therapeutic potential of CD38-targeting mAbs, particularly isatuximab, in pBL. CC BY 4.0© 2024 The Author(s). Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.Correspondence Address: A. Camponeschi; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; email: [email protected] work was supported by the Swedish Research Council (2018-03128), the Swedish Cancer Foundation (19 0464), the Swedish Childhood Cancer Fund (PR2018-0170, PR2020-0147), Assar Gabrielsson’s Foundation (FB21-104, FB22-70, BGR23-03), Reumatikerförbundet, ALF (agreement between the Swedish government and the county council), Kungl. Vetenskaps- och Vitterhets-Samhället, Adlerbertska stiftelsen, Stiftelsen Apotekare Hedbergs fond för medicinsk forskning, Åke Wibergs Stiftelse, Lundgrens Stiftelse, Göteborgsregionens Stiftelse för Reumatologisk Forskning and Ingabritt och Arne Lundbergs Forskningsstiftelse. The German Research Foundation (Deutsche Forschungsgemeinschaft [DFG]) through TRR130 to MR and Roche Innovation Center Zurich.</p
