192 research outputs found
Etude du lien entre l'exposition aux perturbateurs endocriniens (PE) et l'endométriose : une approche intégrative
No full textLes humains sont exposés quotidiennement à des mélanges complexes de polluants chimiques, dont certains sont susceptibles de perturber nos fonctions endocriniennes et de contribuer à des maladies reproductives comme l'endométriose. L'endométriose est une maladie peu connue qui touche environ 5 à 15 % des personnes ayant leurs règles. Elle se caractérise par la présence de tissus endométriaux en dehors de l'utérus, et peut présenter des symptômes graves et coûteux. Malgré les preuves épidémiologiques de plus en plus nombreuses qui confirment l'association entre certains produits chimiques perturbateurs endocriniens (PE) et l'endométriose, les mécanismes pathogéniques exacts par lesquels les expositions chimiques contribuent à l'apparition ou à l'aggravation de la maladie restent largement inconnus. Des preuves mécanistes permettant d'identifier les voies potentiellement perturbées soutiennent la plausibilité biologique de l'impact des facteurs environnementaux sur l'endométriose. En outre, des analyses à haute résolution des biomarqueurs d'exposition et d'effet sont nécessaires pour explorer le profil métabolomique perturbé des patientes atteintes d'endométriose. L'intégration des données d'exposition avec les biomarqueurs métaboliques peut être la clé pour élucider les voies moléculaires sous-jacentes par lesquelles les expositions chimiques peuvent contribuer à l'endométriose. Les outils statistiques actuellement utilisés en épidémiologie environnementale ne permettent pas de représenter de manière réaliste les effets de mélanges complexes d'expositions sur les effets sur la santé, ni de gérer des données de biomarqueurs colinéaires de haute dimension. Un cadre statistique robuste est nécessaire pour intégrer des données multipolluants et métaboliques de haute dimension dans une analyse multibloc. Dans ce contexte, cette thèse vise à caractériser le lien entre l'exposition aux polluants environnementaux et l'endométriose en découvrant les mécanismes d'action sous-jacents qui médient la relation par une synthèse des preuves mécanistiques et une analyse métabolomique à haute résolution, en développant un cadre statistique robuste pour répondre aux limites des modèles traditionnellement utilisés, et enfin en intégrant les biomarqueurs d'exposition et d'effet dans une analyse statistique multibloc appliquée d'une étude cas-témoins.Humans are exposed daily to complex mixtures of chemical pollutants, some of which have the potential to disrupt our bodies’ natural endocrine functions, and contribute to reproductive diseases like endometriosis. Endometriosis is a little understood disease which impacts an estimated 5-15% of individuals who menstruate. It is characterised by the presence of endometrial tissues outside of the uterus, and may have severe and costly symptoms. Despite growing epidemiological evidence thatsupports the association between some endocrine disrupting chemicals (EDCs) and endometriosis, the exact pathogenic mechanisms by which chemical exposures contribute to the onset or aggravation of the disease remain largely unknown. Mechanistic evidence to identify potential perturbed pathways to support the biological plausibility of the impact of environmental factors on endometriosis. Furthermore, high resolution analyses of biomarkers of exposure and effect are needed to explore the disrupted metabolomics profile of endometrosis patients. Integration of exposure data with metabolic biomarkersmay be the key to elucidating the underlying molecular pathways by which chemical exposures may contribute to endometriosis. The statistical tools currently used in environmental epidemiology fall short of being able to realistically represent the effects of complex exposure mixtures on health effects, and to manage high dimensional, collinear biomarkers data. A robust statistical framework is needed to integrate high dimensional multipollutant and metabolic data in a multiblock analysis. In this context, this thesis aims to characterise the link between exposure to environmental pollutants and endometriosis by uncovering the underlying mechanismsof action that mediate the relationship through a synthesis of mechanistic evidence and a high resolution metabolomics analysis, developing a robust statistical framework to address the limitations of traditionally used models, and finally integrating biomarkers of exposure and effect in an applied multiblock statistical analysis of acase-control study
Diasporic narratives and migrant memories in 'The Teak Almirah' by Indian Jewish author Jael Silliman
No full textDiasporic literature posits itself as a space of vision in which to prompt ruptures, go beyond prescriptive and proscriptive limits, and imagine new ways to identify and belong (Parmar 2016). This is what makes the novels by Jael Silliman worth reading and apprehending in the contested and complex scenario of contemporary Indian literatures in English, further allowing an analysis of the role of English in constructing historically complex communities of readers in a transnational and transcultural perspective. At the crossroads of literature, anthropology and history, Silliman’s novel The Teak Almirah (2016) evokes times and places of colonial India, re-casting them in a new performance where both the characters and the readers are compelled to follow the shadows, the rumours, the hints and the traces that are defined an emotional geography and a “cartography of diaspora” (Brah 1996)
Special issue on Terra Matta
No full textIn 2007 Einaudi published a book entitled Terra matta, by an unknown Sicilian author, Vincenzo Rabito, which would rapidly become a bestseller. In 2012 a film derived from the book, Terramatta; Il Novecento italiano di Vincenzo Rabito analfabeta siciliano, was presented at the Venice Film Festival to great acclaim. In introducing our analyses of that cultural phenomenon, I describe the nature of the typescript and set it in the context of other writings by Italy's diversamente colti. I chart the passage from typescript to book to film and outline the interventions – explored in detail by the protagonists in the contributions that follow – shaping its successive incarnations
Serving temperature viscosity measurements of nectar and honey-thick liquids
No full textThis study reports the viscosity (thickness) of nectar- and honey-thick liquids measured at a typical serving temperature. Centipoise (cP) measurements were compared for three products (two starch and one gum-based thickener) mixed with five beverages that set for three time intervals (manufacturer recommended time to thicken, 10 and 30 minutes). The serving temperature of the cold beverages was 4º C (water, apple juice, orange juice, and milk), and the hot beverage (coffee) was measured at 70º C. Statistical analysis showed that all factors interacted with one another, meaning that the viscosity of a nectar- or honey-like liquid varies greatly depending on the type of thickening agent and beverage combination in relation to the amount of time its thickens. Simply Thick, the gum-based thickener, typically produced samples that were the least viscous but they maintained a more consistent level of thickness over time. Serving temperature results are contrasted with viscosity measurements collected at room temperature, showing variable thickening patterns especially related to the type of thickening agent
ntervention as a mode of artistic implementation: Analysis of Gordon Matta-Clark's Day's End
No full textilustracionesEn esta investigación se analiza una parte de la obra artística de Gordon Matta-Clark (1943-1978) y su impacto disruptivo en el ámbito artístico. El objetivo principal es examinar el uso de la intervención en el arte contemporáneo y el discurso teórico de este artista, quien es reconocido por su combinación de teoría y práctica artística. Se busca comprender las referencias históricas de la intervención artística y el uso del espacio urbano en su obra, a través de investigaciones acerca de la obra de este artista, textos escritos por el propio artista, así como estudios posteriores a su muerte, videos y fotografías. También se examina el método utilizado por Matta-Clark para intervenir en el espacio urbano, así como las herramientas teóricas y conceptuales presentes en su obra Day's End (1975). Se busca establecer una relación entre los procesos analizados en su obra y la producción artística contemporánea. Esta investigación resalta la relevancia de las prácticas de Matta-Clark y sus implicaciones en el arte actual. De igual forma, este análisis es un basamento para la creación de la serie Relleno del autor de este trabajo de titulación.This research analyzes a part of the artistic work of Gordon Matta-Clark (1943-1978) and its disruptive impact on the artistic field. The main objective is to examine the use of intervention in contemporary art and the theoretical discourse of this artist, who is recognized for his combination of theory and artistic practice. It seeks to understand the historical references of artistic intervention and the use of urban space in his work, through research on the work of this artist, texts written by the artist himself, as well as studies after his death., videos and photographs. The method used by Matta-Clark to intervene in urban space is also examined, as well as the theoretical and conceptual tools present in his work Day's End (1975). It seeks to establish a relationship between the processes analyzed in his work and contemporary artistic production. This research highlights the relevance of Matta-Clark's practices and his implications for contemporary art. In the same way, this analysis is a foundation for the creation of the Relleno series of the author of this degree project
Energy Saving Opportunities and Value of Information: A Trade-off in a Production Line
No full textAbstractA general framework for switching the machine off/on has been recently proposed in literature for single machines. However, the amount of information available along the production system is often limited and it might be not trivial to understand which information provides more benefits. This paper studies the performance of a production line when several control policies are applied at machine level. The amount of information at machine level varies and the trade-off with energy reduction is investigated. The considered performance measures are the energy consumed per part and the system throughput. Numerical results are based on discrete event simulation
Barrio Matta Sur, Chile: Un Modelo de Transformación Urbana Sostenible /
No full text6.7 MB : 87 páginas ; imagenesEsta investigación está dirigida a resaltar la importancia de intervenir zonas urbanas obsoletas y
deterioradas para revitalizarlas y contribuir con el desarrollo de las ciudades. La investigación se
realiza sobra la línea de “Revitalización Urbana” y un enfoque de “Ciudad sostenible” abordando
conceptos encontrados en proyectos emplazados tanto fuera de Latinoamérica como dentro de
ella, entendiendo el impacto de la inactividad económica de un barrio completo en el contexto
del barrio Matta Sur (comuna de Santiago), específicamente en la ciudad de Santiago de Chile.
El proyecto se desarrolla analizando el sitio a partir de un estudio, a modo de diagnóstico, del
entorno urbano comprendido por aspectos concernientes a la población, a los equipamientos
actuales y a la movilidad y conectividad, lo cual evidenció el deterioro social y espacial que
presentaba el barrio a causa de la ausencia de espacios y actividades convocantes. La
elaboración de una tabla de resultados (llámese matriz DOFA) y su explicación gráfica
complementa la investigación al permitir el planteamiento de estrategias de diseño y, finalmente,
una propuesta urbana sostenible cuyo objetivo sería la revitalización de barrio Matta Sur.
El trabajo.This research is aimed at highlighting the importance of obsolete and deteriorated urban areas to
revitalize them and contribute to the development of cities. The research is carried out on the
“Urban Revitalization” line and a “Sustainable City” approach, addressing concepts found in
projects located both outside and within Latin America, understanding the impact of the
economic inactivity of a complete neighborhood in the context of Matta Sur neighborhood
(commune of Santiago), specifically in the city of Santiago de Chile. The project is developed by
analyzing the site from a study, a diagnostic mode, the urban environment comprised of aspects
of concern to the population, current equipment and mobility and connectivity, which
demonstrates the social and spatial development that neighborhood presents cause of the absence
of spaces and convening activities. The elaboration of a table of results (call DOFA matrix) and
its graphic explanation would complement the investigation by allowing the design strategies
approach and, finally, a sustainable urban proposal whose objective would be the revitalization
of the Matta Sur neighborhood.
El trabajo.PregradoArquitectoTrabajo de grado(Arquitecto) --Corporación Universitaria del Caribe – CECAR. Facultad de Ciencias Básicas Ingeniera y Arquitectura, Programa de Arquitectura. Sincelejo-Sucre, 2019
Presentación de "Espacio. Casa, calle y otro mundo: el caso de Brasil", de Roberto Da Matta
No full textPresentation of "Space. House, Street and other World: the Case of Brazil", by Roberto Da Matta. Ana Doldan, Julia Donley, Harol Gonzalez Duque, Denis Merklen and Maïwenn Raoul translated Roberto DaMatta’s work entitled "Espaço. Casa, rua e outro mundo: o caso do Brasil" published in the book by the Rocco Publishing House of Rio de Janeiro, in 1997. We truly thank the authorization for this translation and publication to the author and the publishing house.; Presentación de "Espacio. Casa, calle y otro mundo: el caso de Brasil", de Roberto Da Matta. Ana Doldan, Julia Donley, Harol Gonzalez Duque, Denis Merklen y Maïwenn Raoul realizaron la traducción del trabajo de Roberto DaMatta titulado "Espaço. Casa, rua e outro mundo: o caso do Brasil" que fue publicado en el libro A casa e a rua. Espaço, cidadania, mulher e morte no Brasil por la editorial Rocco de Rio de Janeiro, en 1997. Agradecemos al autor y a la editorial habernos dado los permisos para su traducción y publicación
Presentación de "Espacio. Casa, calle y otro mundo: el caso de Brasil", de Roberto Da Matta
No full textPresentación de "Espacio. Casa, calle y otro mundo: el caso de Brasil", de Roberto Da Matta. Ana Doldan, Julia Donley, Harol Gonzalez Duque, Denis Merklen y Maïwenn Raoul realizaron la traducción del trabajo de Roberto DaMatta titulado "Espaço. Casa, rua e outro mundo: o caso do Brasil" que fue publicado en el libro A casa e a rua. Espaço, cidadania, mulher e morte no Brasil por la editorial Rocco de Rio de Janeiro, en 1997. Agradecemos al autor y a la editorial habernos dado los permisos para su traducción y publicación.Presentation of "Space. House, Street and other World: the Case of Brazil", by Roberto Da Matta. Ana Doldan, Julia Donley, Harol Gonzalez Duque, Denis Merklen and Maïwenn Raoul translated Roberto DaMatta’s work entitled "Espaço. Casa, rua e outro mundo: o caso do Brasil" published in the book by the Rocco Publishing House of Rio de Janeiro, in 1997. We truly thank the authorization for this translation and publication to the author and the publishing house
El padre copto-ortodoxo Matta Al-Miskīn: Una aproximación introductoria a su vida, su obra y su teología
No full textThis article is intended to provide an answer to the following questions: Who was the Coptic-Orthodox father Matta Al-Miskīn (1919-2006) and what were his theories and his most important ideas? In order to offer a detailed answer to these questions, and to introduce succinctly the author who is considered —rightly— one of the Coptic-Orthodox theology leading representatives of the 20th century, same as one of key-figures of the Arab Christianity, today. The proposed structure has two main parts, an introduction and some final remarks. Firstly, a brief account of the life of the Coptic-Orthodox theologian is described, as well as a general presentation of his writings. Secondly, a synthesis of his spiritual, monastic-mystical, biblical, patristic and dogmatic-theological thought is proposed.El presente artículo pretende dar respuesta a los siguientes interrogantes: ¿quién fue el padre copto-ortodoxo Matta Al-Miskīn (1919-2006)? ¿Cuáles fueron sus teorías e ideas más importantes? Con el objetivo de ofrecer una respuesta detallada a estas preguntas y presentar de forma sucinta a quien se considera —con razón— uno de los máximos representantes de la teología copto-ortodoxa del siglo XX y del cristianismo árabe de hoy, la estructura propuesta tiene dos partes principales, además de una introducción y algunas observaciones finales. En primer lugar, se realiza un breve recuento de su vida y una presentación general de sus obras. En segundo lugar, se propone una síntesis de su pensamiento espiritual, monástico-místico, bíblico, patrístico y dogmático-teológico
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