76,921 research outputs found
Klein, T C (Thomas Charles), WX4692
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/397521Surname: KLEIN. Given Name(s) or Initials: T C (THOMAS CHARLES). Military Service Number or Last Known Location: WX4692. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 5847.235753
Item: [2016.0049.29814] "Klein, T C (Thomas Charles), WX4692
Global analysis of gene expression identifies C/EBP and TEF-1 as major p38 alpha MAP kinase-regulated transcription factors in proliferating cardiomyocytes.
No full textp38 MAPKs (mitogen-activated protein kinases) play important
roles in the regulation of cellular responses to environmental
stress. Recently, this signalling pathway has also been implicated
in the regulation of processes unrelated to stress, for example, in
T lymphocytes and cardiomyocytes. In order to identify molecular
targets responsible for the housekeeping functions of p38
MAPKs, we have analysed the differences in the transcriptomes
of normally proliferating wild-type and p38α knockout immortalized
embryonic cardiomyocytes. Interestingly, many potential components of the myocardium extracellular matrix were found
to be upregulated in the absence of p38α. Further analysis of
the microarray data identified TEF-1 (transcriptional enhancer
factor-1), a known regulator of heart-specific gene expression,
and C/EBPβ (CCAAT/enhancer-binding protein β), as the two
transcription factors the binding sites ofwhich were most enriched
in the promoters of p38α-regulated genes. We have focused on
the study of the extracellular matrix component COL1A1 (α1
chain of type I collagen) and found evidence for the involvement
of both TEF-1 and C/EBPβ in the p38α-dependent inhibition of
COL1A1 transcription. Our data therefore show that p38 MAPKs
regulate TEF-1 andC/EBPβ transcriptional activity in the absence
of environmental stress and suggests a role for p38α in the expression of extracellular matrix components that maintain organ
architecture
C. T. Sheats, Mrs. James Leonard and Allan S. Klein
No full textMrs. James Leonard, secretary of the Tarrant County Chapter, National Foundation for Infantile Paralysis, accepts a $250 check from the National Fashion Exhibitors of America with C. T. Sheats, left, exhibitors\u27 manager, and Allan S. Klein, president, representing the fashion organization.https://mavmatrix.uta.edu/specialcollections_startelegram1950s/23787/thumbnail.jp
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Lactobacillus curvatus subsp. curvatus subsp. nov. and Lactobacillus curvatus subsp. melibiosus subsp. nov. and Lactobacillus sake subsp. sake subsp. nov. and Lactobacillus sake subsp. carnosus subsp. nov., new subspecies of Lactobacillus curvatus Abo-Elnaga and Kandler 1965 and Lactobacillus sake Katagiri, Kitahara, and Fukami 1934 (Klein et al. 1996, emended descriptions), respectively
No full textLactobacillus curvatus and Lactobacillus sake are each genetically homogeneous species, as indicated by the high levels of DNA homology (≤76%) exhibited by strains of these taxa. However, the results of a numerical analysis of total soluble cell protein patterns and biochemical test data revealed that there are two phenotypic subgroups within L. curvatus and two phenotypic subgroups within L. sake. The overall randomly amplified polymorphic DNA (RAPI)-PCR band patterns obtained for the majority of L. curvatus strains corresponded well to the pattern obtained for the type strain of L. curvatus (strain DSM 20019). However, six strains of L. curvatus had different, but similar, RAPD-PCR profiles and grouped in a separate genetic cluster, which was linked to one of the clusters of L. sake strains. On the basis of these results, differences in biochemical and physiological characteristics, and total soluble cell protein profiles, we describe the subspecies L. curvatus subsp. curvatus subsp. nov. and L. curvatus subsp. melibiosus subsp. nov. for L. curvatus Abo-Elnaga and Kandler 1965 (Klein et al. 1996, emended description). Strains of L. sake grouped in two RAPD-PCR clusters, which was consistent with previous reports of phenotypic heterogeneity. Strains of Lactobacillus bavaricus, including type strain LMG 9844, clustered with the type strain of L. sake (strain NCFB 2714), indicating that these organisms belong to the same genetic group. We propose that strains of L. sake Katagiri, Kitahara, and Fukami 1934 (Klein et al. 1996, emended description) should be reclassified as members of L. sake subsp. sake subsp. nov. and L. sake subsp. carnosus subsp. nov. Strains of L. bavaricus are reclassified as members of L. sake subsp. sake, and the name L. bavaricus Stetter and Stetter 1980 is rejected
Transcriptional targeting of B cells for induction of peripheral CD8 T cell tolerance
No full textSeveral mechanisms are in place to neutralize autoimmune CD8 T cells by tolerance induction. Developing self-specific CD8 T cells are eliminated in the thymus by Ag-presenting epithelial and dendritic cells (DCs). However, CD8 T cells escaping thymic central tolerance can also be inactivated by tolerance mechanisms in peripheral organs. In contrast to DCs, the role of B cells in generating CD8 T cell tolerance is not well-characterized. To investigate this question in more detail, we transcriptionally targeted Ag to B cells using B cell-specific retroviral vectors in vivo. Although Ag expression could be detected in B cells of thymus, lymph nodes, and spleen, B cells were unable to induce central tolerance of CD8 thymocytes. In contrast, in peripheral organs, we could identify clonal deletion and functional inhibition (anergy) of CD8 T cells as tolerance-inducing mechanisms. Although Ag expressed by B cells was acquired and cross-presented by DCs, B cells were also sufficient to tolerize CD8 T cells directly. These findings suggest exploitation of B cells for Ag-specific immunotherapy of CD8 T cell-mediated autoimmune diseases
T.E.D. Klein: "Certain Things Associated With Night"
No full textThis record consists of a transcript of an interview with T.E.D. Klein
A numerical study of the small dispersion limit of the Korteweg–de Vries equation and asymptotic solutions
No full textWe study numerically the small dispersion limit for the Korteweg-de Vries (KdV) equation u(t) + 6uu(x) + epsilon(2)u(xxx) = 0 for epsilon << 1 and give a quantitative comparison of the numerical solution with various asymptotic formulae for small epsilon in the whole (x, t)-plane. The matching of the asymptotic solutions is studied numerically
Numerical solution of the small dispersion limit of the Camassa-Holm equation and Whitham equations and Multiscale expansion
No full textThe small dispersion limit of solutions to the Camassa-Holm (CH) equation is characterized by the appearance of a zone of rapid modulated oscillations. An asymptotic description of these oscillations is given, for short times, by the one-phase solution to the CH equation, where the branch points of the corresponding elliptic curve depend on the physical coordinates via the Whitham equations. We present a conjecture for the phase of the asymptotic solution. A numerical study of this limit for smooth hump-like initial data provides strong evidence for the validity of this conjecture. We present a quantitative numerical comparison between the CH and the asymptotic solution. The dependence on the small dispersion parameter ϵ is studied in the interior and at the boundaries of the Whitham zone. In the interior of the zone, the difference between CH and asymptotic solution is of the order ϵ, at the trailing edge of the order ϵ√ and at the leading edge of the order ϵ1/3. For the latter we present a multiscale expansion which describes the amplitude of the oscillations in terms of the Hastings-McLeod solution of the Painlev\'e II equation. We show numerically that this multiscale solution provides an enhanced asymptotic description near the leading edge
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