44,975 research outputs found
Hold on: physical restraint in residential child care
No full textGuidance for developing best practice, policy and improved outcomes for children and young people in residential child care. Children in residential care can exhibit disturbed and violent behaviour which can result in them being aggressive to themselves and to others. Over many years practitioners, managers and policy-makers have tried to find ways of dealing with children whose behaviour is dangerous with a range of interventions such as crisis intervention and crisis de-escalation, as well as the use of sanctions such as restricting leisure activities and control of pocket money. There has also been some debate about the use of physical restraint by residential child care staff when the child or those around him or her need to be protected from the child's aggression without hurting or humiliating the child
Nitric oxide can differentially modulate striatal neurotransmitter concentrations via soluble guanylate cyclase and peroxynitrite formation
No full textInvolvement of cGMP and ONOO- formation in the neuromodulatory effects of nitric oxide in the central nervous system
No full textAre neuromodulatory effects of nitric oxide in the striatum mediated cGMP or peroxynitrite formation?
No full text
Role of cGMP and peroxynitrite formation on neuromodulatory effects of nitric oxide in the rat striatum
No full textMeasurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
The effect of different precursors on the synthesis of ultramarine blue using a modified test furnace
No full textThe industrial pigment, ultramarine blue, has been prepared using a modified laboratory-scale test furnace. A study to investigate the reproducibility between runs of the test furnace, in terms of the colour properties of the products and impurities present in the products, has been performed using predensified precursor mix taken from an ultramarine plant. A second set of experiments was performed in single runs in the furnace to show the effect of different types of sulfur source and feldspar on the quality and colour of ultramarine blue produced. Colour measurements indicate that the ultramarine with the best colour properties is produced when sodium sulfide is used as the sulfur source in the starting mixture. Analyses of products washed with different alkali solutions show that while washing with potassium hydroxide improves the colour properties of the pigment, it is less effective than sodium hydroxide at removing impurities in the product. The structures of the ultramarine blue products have been investigated using the Rietveld refinement of powder X-ray diffraction data. A strong correlation between structural parameters and colour parameters has not been found
Soluble amyloid beta(1-42) reduces dopamine levels in rat prefrontal cortex: relationship to nitric oxide.
No full textSeveral studies suggest a pivotal role of amyloid beta (Ab)1-42 and nitric oxide (NO) in the pathogenesis of Alzheimer’s disease. NO also possess central neuromodulatory properties. To study the soluble Ab1-42 effects on dopamine
concentrations in rat prefrontal cortex, microdialysis
technique was used. We showed that i.c.v. injection or retrodialysis Ab1-42 administration reduced basal and K-stimulated dopamine levels, measured 2 and 48 h after peptide administration. Immunofluorescent experiments revealed that after 48 h from i.c.v. injection Ab1-42 was no longer detectable in the ventricular space. We then evaluated the role of NO on Ab1-42-induced reduction in dopamine concentrations. Subchronic L-arginine administration decreased basal dopamine levels, measured either 2 h after i.c.v. Ab1-42 or on day 2 post-injection, whereas subchronic 7-nitroindazole administration increased basal dopamine concentrations, measured 2 h after i.c.v. Ab1-42 injection, and decreased them when measured on day 2 post-Ab1-42-injection. No dopaminergic response activity was observed after K stimulation in all groups. These results suggest that the dopaminergic system seems to be acutely vulnerable to soluble Ab1-42 effects. Finally, the opposite role of NO occurring at different phases might be regarded as a possible link between Ab1-42-induced effects and dopaminergic dysfunction
Soluble amyloid beta1-42 reduces dopamine levels in rat prefrontal cortex. Relationship to nitric oxide
No full textSeveral studies suggest a pivotal role of amyloid beta (Abeta)(1-42) and nitric oxide (NO) in the pathogenesis of Alzheimer's disease. NO also possess central neuromodulatory properties. To study the soluble Abeta(1-42) effects on dopamine concentrations in rat prefrontal cortex, microdialysis technique was used. We showed that i.c.v. injection or retrodialysis Abeta(1-42) administration reduced basal and K(+)-stimulated dopamine levels, measured 2 and 48 h after peptide administration. Immunofluorescent experiments revealed that after 48 h from i.c.v. injection Abeta(1-42) was no longer detectable in the ventricular space. We then evaluated the role of NO on Abeta(1-42)-induced reduction in dopamine concentrations. Subchronic L-arginine administration decreased basal dopamine levels, measured either 2 h after i.c.v. Abeta(1-42) or on day 2 post-injection, whereas subchronic 7-nitroindazole administration increased basal dopamine concentrations, measured 2 h after i.c.v. Abeta(1-42) injection, and decreased them when measured on day 2 post-Abeta(1-42)-injection. No dopaminergic response activity was observed after K(+) stimulation in all groups. These results suggest that the dopaminergic system seems to be acutely vulnerable to soluble Abeta(1-42) effects. Finally, the opposite role of NO occurring at different phases might be regarded as a possible link between Abeta(1-42)-induced effects and dopaminergic dysfunction
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