1,720,973 research outputs found
Methylene blue ameliorates colonic injury in acetic acid-induced colitis model
Full text linkAim: Inflammatory bowel disease (IBD) is a serious health problem affecting the quality of life. IBDs caused by various pathophysiological mechanisms, including genetic, immunological, inflammatory, and environmental factors. Although it has been widely investigated, treatment of IBDs remains a difficult clinical problem. We aimed to investigate the healing of mucosal damage and anti-inflammatory effects of methylene blue (MB) in experimental colitis model. Material and Methods: Twenty-eight rats were randomly divided into four equal groups: group 1 (Sham), group 2 (control), group 3 (topical treatment), and group 4 (topical and systemic treatment). In groups 2, 3, and 4, acetic acid-induced colitis model was created. Normal saline to group 2, topical MB to group 3, and topical and systemic MB to group 4 were given. Results: The levels of hydroxyproline were lower in the treatment groups than in the control group (p=0.017 for group 3 and p=0.004 for group 4). There was no difference between groups according to the TNF- alpha levels. The results of macroscopic scores were significantly lower in treatment groups (group 3-4) than In the control group (group 2) (p=0.005 for group 3 and p=0.002 for group 4). There was a significant difference between the treatment groups and the control group according to the epithelial loss and inflammatory infiltrate (p=0.022 for group 3, p=0.026 for group 4 for both histopathological values). Discussion: MB ameliorates colonic injury in acetic acid-induced colitis model This effect of MB was observed both locally and with local + systemic administration
Scan statistics and some applications
No full textScan statistics originated from the differences of contigious order statistics is used at time and space dimensions to analyze of the clustering of random occurences. It can be used in industry, medicine, epidemiology, biology, especially genetic researches, mining and meteorology. The aim of this study is to give information about scan statistics and to present a source to researchers also by giving some examples.Sıra istatistikleri arasındaki ardışık farklardan hareketle tanımlanan tarama istatistikleri, zaman ve konum boyutlarında rasgele oluşların kümelenmesinin analizinde son yıllarda kullanılmaktadır. Kullanım alanları arasında endüstri, tıp, epidemiyoloji, biyoloji ve özellikle genetik araştırmalar, madencilik, meteoroloji sayılabilir. Bu çalışmanın amacı, tarama istatistiklerinin tanıtımını yapmak ve kullanımlarına örnekler vererek ihtiyaç duyabilecek araştırmacılara bir kaynak sunmaktır
Tarama istatistikleri ve bazı uygulamaları
No full textSıra istatistikleri arasındaki ardışık farklardan hareketle tanımlanan tarama istatistikleri, zaman ve konum boyutlarında rasgele oluşların kümelenmesinin analizinde son yıllarda kullanılmaktadır. Kullanım alanları arasında endüstri, tıp, epidemiyoloji, biyoloji ve özellikle genetik araştırmalar, madencilik, meteoroloji sayılabilir. Bu çalışmanın amacı, tarama istatistiklerinin tanıtımını yapmak ve kullanımlarına örnekler vererek ihtiyaç duyabilecek araştırmacılara bir kaynak sunmaktır
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Effects Of Garlic Oil (Allium Sativum) On Acetic Acid-Induced Colitis in Rats: Garlic Oil And Experimental Colitis
Full text linkUlusal Travma ve Acil Cerrahi DergisiBACKGROUND: Inflammatory bowel disease (IBD) is an important health problem. The most important hypotheses for the pathogenesisof this disease are the deterioration of immune responses and loss of tolerance against bacteria in the enteric flora. AlthoughIBD has been widely investigated, its treatment remains difficult. This study aims to investigate the effects of garlic oil (GO) on anexperimental colitis model.METHODS: Twenty-eight rats were randomly divided into four equal groups as follows: group 1 (sham), group 2 (control), group 3(topical treatment) and group 4 (topical and systemic treatment). An acetic acid-induced colitis model was produced in groups 2, 3 and4 and was administered normal saline, topical GO and topical and systemic GO, respectively.RESULTS: Hydroxyproline levels were lower in the treatment groups than in the control group. TNF-α levels were significantlylower in group 3 than in group 2. Macroscopic scores were significantly lower in group 4 than in group 2. Significant differences wereobserved between the treatment and control groups according to their epithelial loss.CONCLUSION: GO can reduce colonic damage and inflammation in the acetic acid-induced colitis model, with effects on both localand systemic treatments, but with a more pronounced effect in local treatment
The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study
No full textBACKGROUND: In developing countries, esophageal burns are quite common. They are caused by the ingestion of corrosive substances that may lead to esophageal perforation in the short-term and stricture formation in the long-term. Prevention of stricture progression in the esophagus is the main aim of the treatment for corrosive esophageal burns. We aimed to investigate the protective and anti-inflammatory effects of methylene blue (MB) treatment on corrosive esophageal burns. METHODS: Twenty-eight rats were used in the study and randomly divided into four equal groups; group 1 (Sham), group 2 (control), group 3 (topical treatment), and group 4 (topical plus systemic treatment). Except for group 1 (Sham group), all three groups received sodium hydroxide (NaOH) in order to generate esophageal burns. In addition, group 2 was given normal saline, group 3 topical MB, and group 4 topical and systemic MB. RESULTS: Hydroxyproline levels were found to be lower in each of the treatment groups as compared to the control group (p=0.005 for group 3 and p=0.009 for group 4). There were no differences in the tumor necrosis factor-α (TNF-α) levels between the groups. The stenosis index (SI) in the treatment groups was also lower than the control group (p=0.016 for group 3 and p=0.015 group 4). The histopathologic damage score (HDS) was prominently lower in group 4 as compared to the control group (p=0.05). CONCLUSION: MB is effective in treating tissue damage caused by corrosive esophageal burns and in preventing esophageal stenosis. Complication rates of corrosive esophageal burns may be decreased by using MB in the initial treatment stage. © 2019 Turkish Association of Trauma and Emergency Surgery
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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