242 research outputs found
Abstract 1472: The role of the BAF complex in Wnt signaling-mediated transcriptional regulation in colorectal cancer
No full textAbstract Recent genome- and exome-wide sequencing studies have revealed a close association between the epigenome and the pathogenesis of cancer. Not only were chromatin regulators found to be commonly mutated in a wide range of cancers, but a class of these regulators, the ATP-dependent chromatin remodelers, especially subunits of the mammalian BAF complex, were among the most frequently mutated group of genes across cancer types, mutated in over 20% of cancers. Among these subunits, loss of function mutations in ARID1A (AT-rich interactive domain-containing protein 1A) are most frequent across cancer types including 10% of colorectal cancer (CRC). Very interestingly, a recent publication described the pivotal role of the loss of ARID1A in driving CRC wherein its inactivation alone led to the formation of invasive adenocarcinomas in mice. However, surprisingly, in contrast to the expected tumor suppressive role of ARID1A in CRC, we observe that the knockout (KO) of ARID1A in CRC cell lines leads to impaired proliferation. Moreover, subcutaneous xenografts in SCID/SHO mice using ARID1A KO CRC cells did not form more aggressive tumors than their wild type counterparts. One of the most commonly occurring mutations in CRC is in the APC gene, which leads to hyperactive Wnt signaling. Thus CRC progression is typically highly dependent on this pathway. Notably, it is reported that loss of ARID1A in the context of APC mutations results in diminished tumor formation in mice and increased differentiation. This led us to hypothesize that ARID1A is required for Wnt signaling-mediated transcriptional (de)regulation in CRC. To uncover this further, we utilized several publically available ChIP-seq, RNA-seq and ATAC-seq datasets as well as our own ChIP-seq data for ARID1A in the HCT116 cell line. We observe a substantial co-localization of the BAF complex with TCF7L2, a downstream effector of the Wnt signaling pathway, suggesting cooperation between these factors. Further, these sites are also co-occupied by AP1 transcription factors. A crosstalk between the TCF7L2 and AP1 factors has been reported in intestinal tumors. From data available in the ARID1A KO system, we observe a downregulation of potential target genes which are co-occupied at neighboring sites by these factors. Therefore, we suggest that ARID1A plays an important role in the regulation of colorectal cancer relevant genes that are targets of TCF7L2/AP1, thus facilitating a pathway that is most commonly hijacked in colorectal cancer. Citation Format: Madhobi Sen, Feda H. Hamdan, Xin Wang, Jacobe Rapp, Steven A. Johnsen. The role of the BAF complex in Wnt signaling-mediated transcriptional regulation in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1472
New York State's Recycling Agricultural Plastics Project (RAPP): Hurdles and High Points
No full textThe Northeast United States supports a vibrant and diversified agriculture that generates lots of different types of plastic waste.
This presentation focuses on logistical decision points in developing a sustainable recycling infrastructure and viable recycling markets suited for agriculture and non-organic agricultural wastes.
The Recycling Agricultural Plastics Project (RAPP) is a Cornell University initiative working in collaboration with agricultural producers, and with organizations, agencies and businesses that support agriculture, environmental protection, regional economic development and recycling
IMAGE Love Your Body Day Speaker Emily Rapp discusses "Disabilities and Body Image"
No full textIncludes descriptive metadata provided by producer in MP3 file: "Politics, Economics and Social Issues - Podcasts - IMAGE Love Your Body Day Speaker Emily Rapp discusses 'Disabilities and Body Image'." Rapp, the author of the book Poster Child, speaks on Oct. 15, 2008, drawing partially on her experiences living with a prosthetic leg and with anorexia nervosa. She reads a passage from her book. The event was sponsored by the activist organization IMAGE and was a celebration of Love Your Body Day. Part of the address at the beginning is missing
Emily Rapp Black, 41st Annual ODU Literary Festival
No full textEmily Rapp Black is the author of Poster Child: A Memoir, and The Still Point of the Turning World, which was a New York Times bestseller. Her next book, Sanctuary, is forthcoming from Random House in 2019. She was recently awarded a Guggenheim Fellowship and is associate professor of creative writing at the University of California-Riverside
Chicago or/oder Berlin: Grootstedelijk ensemble van Kollhoff en Rapp + Rapp in Den Haag
No full textMet de drie imposante torens van de Duitsers Prof. Hans Kollhoff Architekten en Rapp + Rapp architecten in het Wijnhavenkwartier lijkt het hoogtepunt van de 'compacte stad' en 'Den Haag Nieuw Centrum' voltooid. Eindelijk heeft Den Haag het stadsbeeld van een metropool, maar tegen welke prijs?UrbanismArchitecture and The Built Environmen
La edición de obras electroacústicas del compositor Jorge Rapp
No full textResumen: Luego de una breve referencia a la vida y obra de Jorge Rapp, la autora se enfoca en la edición de dos CDs conteniendo obras electroacústicas de dicho compositor.Abstract: After a brief reference to the life and work of Jorge Rapp, the author focuses on the two CD edition containing electroacustic works of the composer
Keynote – Universal Design for Learning: Applications for Higher Education
No full textUniversal Design for Learning: Applications for Higher Education
In this presentation, Dr. Rapp provides an overview of the principles of universal design for learning (UDL) and the application of each principle to the college setting. Dr. Rapp outlines the responsibility of higher education institutions for providing supports in coursework and field-based experiences while maintaining high expectations for knowledge and skill acquisition. She shares several specific strategies for universally-designed learning environments that help prepare a more diverse group of people for success in their chosen fields.
Biography
Dr. Rapp is Associate Professor of Inclusive Education at St. John Fisher College, where she teaches courses on inclusive education pedagogy, assessment, and classroom management. Dr. Rapp holds a bachelor’s degree in elementary education and psychology from the State University of New York at Potsdam and master’s and doctoral degrees in special education from Michigan State University. Dr. Rapp’s current research interests include universal design for learning (UDL) throughout the school years and college, as well as strategies for executive functioning. She is the author of the textbook Universal Design for Learning: 100 Ways to Teach All Learners (2014) and coauthor of the textbooks Teaching Everyone: An Introduction to Inclusive Education (2012, with K. L. Arndt) and Picture Inclusion! Snapshots of Successful Diverse Classrooms (Feb. 2019, with K. L. Arndt and S. M. Hildenbrand). Dr. Rapp presents at local, state, national, and international conferences on UDL and inclusive education pedagogy
Visual Branding as Communication Strategy Used by PT. RAPP Through Website
No full textThe aim of the research is to identify the visual brand elements used visual communication on the RAPP website. The author conducted descriptive-qualitative research in try to understand the data and material on this website. Data collection technique in this study was observation on a website. The object of this research is the RAPP website. The results of the study show that visual brand elements are used consistently and with great care to produce a distinctive brand identity. The colors and typography complement the company's brand values and personality, and the prominently. This website uses high quality images, giving a professional impression
Sindrome di Rapp-Hodgkin. Espressivita fenotipica diversa in membri della stessa famiglia
No full textA 23-year old woman with narrow nose, maxillary hypoplasia, cleft lip and palate, hypodontia, dystrophic nails and hypohidrosis is described. Her scalp hair was coarse, dry and wiry. Microscopic examination of hair showed longitudinal twisting at irregular intervals, typical of pili torti. Her mother presented only dystrophic nails and hypohidrosis. Rapp-Hodgkin syndrome is an uncommon, autosomal dominant condition characterized by distinctive craniofacial anomalies and cleft lip and palate. In the patients observed, the phenotypical manifestations were different. In fact, the proband showed all the major features of the syndrome, while her mother only onychodysplasia and hypohidrosis. The differential diagnosis between Rapp- Hodgkin syndrome and other forms of ectodermal dysplasia are discussed.
Author keyword
Analisis Perjanjian Kerja Bersama Dalam Pemutusan Hubungan Kerja Akibat Kesalahan Berat Berdasarkan Undang-undang Nomor 13 Tahun 2003 Tentang Ketenagakerjaan (studi : Pt Rapp Pangkalan Kerinci)
No full textAn employment agreement is a relationship between someone who acts as a laborer or worker and someone who acts as an employer. Work plays a vital role in human life, so it qualifies as a means of generating income to meet needs. One of the inalienable human rights that needs to be upheld is the freedom to work and receive rights in the form of wages to meet daily needs. Based on the author's background, here are several problem formulations raised by the author, first, how can an employee be fired for committing serious violations in accordance with applicable rules and regulations. Second, what is the legal protection for employees whose employment relationship is terminated due to making serious mistakes at work. The research used by the author is empirical research, namely conducting research directly at the research location to obtain accurate data which is carried out by means of interviews and documentation. The nature of the research used by the author is sociological law, by consistently expressing facts in the field. The location of the author's research is PT RAPP, Pangkalan Kerinci District, Pelalawan Regency. The method of drawing conclusions used by the author uses a deductive method, which involves conclusions from general to specific matters. From the results of the research and discussion, the author found that employees can be fired if they make serious mistakes in the form of making double gate passes without PT RAPP permission and taking action to ask PT RAPP employees for additional money. Legal protection for employees whose employment relationship is terminated is by taking legal action by conducting bipartite negotiations and the final effort by workers is by registering an industrial relations dispute lawsuit in the industrial relations court
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