791 research outputs found
Effect of Hingulamrutadi malahara in the management of dushta vrana
No full text Dustavrana is a common and frequently encountered problem faced in surgical practice. The presence of Dushtavrana(1) worsens the condition of the patient with different complications and may become fatal. Local factors on wound like slough, infection and foreign body, affect the normal process of healing. A healthy wound in a normal body heals earlier with a minimum scar as compared to a contaminated wound. Therefore in this study all the efforts are made to make a Dustvrana into a shuddhavrana. (2) Once the vrana becomes shuddha, ropana of the vrana will start. The objective of the study was to evaluate the Shodhana and Ropana effect of HingulamrutadiMalahara in Dushtavrana compared with standard Jatyadi Ghrita. Clinically diagnosed 40 Patients of Dushtavrana were randomly divided into two groups, each consisting of 20 Patients. H group were treated with the HingulamrutadiMalahara treated group. J Group as a control group was treated by JatyadiGhrita. On the basis of assessment criteria and overall result of treatment, the patients of Hingulamrutadi Malahara group showed better results when compared to Jatyadi Ghrita group. Hingulamrutadi Malahara has provided good relief in most of the signs and symptoms of the patients of Dushtavrana, in comparison to Jatyadi Ghrita. Its overall effects were good in comparison to Jatyadi Ghrita. 
The Chronology of the Priors of the Monastery in Vrana (1333–1391) and its Corrections
No full textAutor donosi korekciju kronologije vranskih priora, odnosno poglavara ivanovaca u Ugarskoj provinciji. Korekcija obuhvaća period od godine prvoga spomena priora u Vrani (1333.) do godine smrti Ivana Paližne (1391.), nakon koje Ugarska provincija nepopravljivo slabi. U dosadašnjim kronologijama vranskih priora bilo je grešaka u prepisivanju prethodnih kronologija i izostavljanju određenih dokumenata, a u međuvremenu su iznjedrile i neke nove spoznaje.The author makes a correction of the chronology of the priors of the monastery in Vrana (the chiefs of the Order of the St. John/Hospitallers in the Hungarian province). The correction covers the period from the first mention of the prior in Vrana (1333) to the year of the death of prior John Palisna (1391), after which Hospitallers in the Hungarian province became irreparably weak. Previous chronologies of the priors of the monastery in Vrana have made mistakes in rewriting previous chronologies and omitting certain documents. In the meantime, there are also some new insights introduced
Nombramiento de Kent E. Vrana como Profesor Honorario
No full textPor Resolución Rectoral 42-08, de fecha 5 de diciembre de 2008, el guatemalteco Kent E. Vrana fue nombrado Profesor Honorario de la Universidad Peruana de Ciencias Aplicadas. Profesor y exdirector del Departamento de Farmacología en la Facultad de Medicina de Penn State, ha liderado importantes investigaciones. Su legado incluye más de 200 publicaciones científicas y la coautoría de dos libros de texto. En 2024, fue honrado con el Premio Alpha Omega Alpha Robert J. Glaser al Maestro Distinguido, otorgado por la Asociación de Facultades de Medicina de Estados Unidos, reconociendo su excelencia en la enseñanza médica
ROLE OF PALASH (BUTEA MONOSPERMA) KSHARA IN THE MANAGEMENT OF DUSTA VRANA (CHRONIC ULCERS) WITH SPECIAL REFERENCE TO INFECTED WOUND
No full textWound infection is one of the most important factors that cause delayed wound healing. Wound healing occurs as a fundamental response to tissue injury. Several natural products have been shown to accelerate the healing process. Dusta vranas (chronic ulcers) are a frequently encountered problem in present era produced commonly as a complication of trauma or pathological insult and it causes long term agony to the patient. The present study was undertaken to determine the efficacy of topical administration of Kshara of stem bark of Palash (Butea monosperma (Lam.) Taub.) on Dusta vrana with special reference to infected wound. These drugs possess Vrana shodhana and Ropana properties. It was used topically in chronic or infected wound once daily for 14 days or till the wound bed is prepared whichever is earlier. It is a clinical study wherein 30 patients were selected and divided in three equal groups of ten patients each. It was found to reduce pain, discharge and slough tissue. It also helped in improved floor and granulation tissue formation that is to prepare wound bed as compared to control group. Hence it can be speculated that Palash kshara possess sufficient efficacy in Vrana shodhana (wound debridement) and Vrana ropana without producing any adverse affects
Microbial-Based Bioremediation of Selenium and Tellurium Compounds
No full textThe chalcogens selenium (Se) and tellurium (Te) are rare earth elements, which are mainly present in the environment as toxic oxyanions, due to the anthropogenic activities. Thus, the increased presence of these chalcogen-species in the environment and the contamination of wastewaters nearby processing facilities led to the necessity in developing remediation strategies aimed to detoxify waters, soils and sediments. Among the different decontamination approaches, those based on the ability of microorganisms to bioaccumulate, biomethylate or bioconvert Se- and/or Te-oxyanions are considered the leading strategy for achieving a safe and eco-friendly bioremediation of polluted sites. Recently, several technologies based on the use of bacterial pure cultures, bacterial biofilms or microbial consortia grown in reactors with different configurations have been explored for Se- and Te-decontamination purposes. Further, the majority of microorganisms able to process chalcogen-oxyanions have been described to generate valuable Se- and/or Te-nanomaterials as end-products of their bioconversion, whose potential applications in biomedicine, optoelectronics and environmental engineering are still under investigation. Here, the occurrence, the use and the toxicity of Se- and Te-compounds will be briefly overviewed, while the microbial mechanisms of chalcogen-oxyanions bioprocessing, as well as the microbialbased strategies used for bioremediation approaches will be extensively described
Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand
No full textInternational audienceEarlier studies have described promising antitumor activity of a large-ring chelate complex [PtCl(-1,4-DACH)] (DACH = diaminocyclohexane). Encouraging antitumor activity of this analogue of cisplatin prompted us to perform studies focused on the mechanistic basis of pharmacological effects of this complex. Four early steps in the mechanism of biological activity of cisplatin have been delineated: cell entry, reactions with sulfur-containing compounds, platinum–DNA binding along with processing platinated DNA by proteins (enzymes) and DNA repair. Here, we describe comparative experiments (involving also cisplatin) revealing: (i) improved cytotoxicity (3.4 – 5.4-fold) of [PtCl(-1,4-DACH)] in human tumor ovarian cell lines; (ii) enhanced cellular uptake (∼1.5-fold) of [PtCl(-1,4-DACH)]; (iii) somewhat enhanced rate of reactions of [PtCl(-1,4-DACH)] with glutathione (∼1.5-fold), but a similar rate of reactions with metallothionenin-2; (iv) enhanced rate of DNA binding of [PtCl(-1,4-DACH)] in cell-free media (∼2-fold); (v) similar sequence preference of DNA binding of [PtCl(-1,4-DACH)] in cell-free media; (vi) identical DNA interstrand crosslinking efficiency (6%); (vii) similar bending (32 °) and enhanced local unwinding (∼1.5-fold) induced in DNA by the major 1,2-GG-intrastrand crosslink; (viii) markedly enhanced inhibiting effects of DNA adducts of [PtCl(-1,4-DACH)] on processivity of DNA polymerase; and (ix) a slightly lower efficiency of DNA repair systems to remove the adducts of [PtCl(-1,4-DACH)] from DNA
Barriers for Fast Matrix Multiplication from Irreversibility
No full textDetermining the asymptotic algebraic complexity of matrix multiplication, succinctly represented by the matrix multiplication exponent omega, is a central problem in algebraic complexity theory. The best upper bounds on omega, leading to the state-of-the-art omega <= 2.37.., have been obtained via the laser method of Strassen and its generalization by Coppersmith and Winograd. Recent barrier results show limitations for these and related approaches to improve the upper bound on omega.
We introduce a new and more general barrier, providing stronger limitations than in previous work. Concretely, we introduce the notion of "irreversibility" of a tensor and we prove (in some precise sense) that any approach that uses an irreversible tensor in an intermediate step (e.g., as a starting tensor in the laser method) cannot give omega = 2. In quantitative terms, we prove that the best upper bound achievable is lower bounded by two times the irreversibility of the intermediate tensor. The quantum functionals and Strassen support functionals give (so far, the best) lower bounds on irreversibility. We provide lower bounds on the irreversibility of key intermediate tensors, including the small and big Coppersmith - Winograd tensors, that improve limitations shown in previous work. Finally, we discuss barriers on the group-theoretic approach in terms of "monomial" irreversibility
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