International Journal of Ayurvedic Medicine
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In-vitro and randomised pilot clinical study to analyse the impact of Vijayasara (Pterocarpus Marsupium Roxb.) and Vrikshamla (Garcinia Indica Choisy.) in Sthoulya (Obesity)
Full text linkObesity, a major global health issue, is marked by abnormal fat accumulation and linked to conditions like type 2 diabetes, cardiovascular diseases, and metabolic syndrome. It results from a chronic imbalance between calorie intake and expenditure, commonly caused by sedentary lifestyles, high-fat diets, and stress. In Ayurveda, obesity—known as Sthoulya—is considered a disorder stemming from an imbalance of Medo Dhatu, often associated with aggravated Kapha and Vata doshas. Factors such as improper diet (Ahara), lack of physical activity (Avyayama), and impaired digestive fire (Agnimandya) contribute to its development. The growing prevalence of obesity correlates strongly with increased risks of lifestyle-related diseases like hypertension, diabetes, cardiovascular disease, and certain cancers. According to NFHS-5 (2019–21), overweight or obesity (BMI ≥25 kg/m²) increased among Indian adults: men from 18.9% to 22.9% and women from 20.6% to 24.0%. (1) A 2021 Indian study showed an overall obesity prevalence of 40.3%, higher in urban populations (about 44%), and more common in women (41.9%) than men (38.7%). (2) This preliminary in-vitro and clinical pilot study explores the potential of Vijayasara (Pterocarpus Marsupium) and Vrikshamla (Garcinia Indica) in managing obesity. MTT assay results demonstrated that both extracts effectively reduced adipocyte activity without cellular toxicity. Twenty-four patients with Sthoulya were randomized into two groups: Group A received Vijayasara, and Group B received Vrikshamla for six weeks. Both groups showed improvements in body weight, BMI, and waist circumference, with Vrikshamla showing more pronounced benefits. The study suggests that Vrikshamla has stronger anti-lipogenic effects, indicating greater potential in obesity management
A Comparative Study of Triphala Ghrita Pana and Tarpana in Medashrita Patalagata Dushti w.s.r. to Vitreous Opacity (Asteroid Hyalosis)
Full text linkBackground: Medashrita Patalagata Dushti, as referenced in Ayurveda, correlates with vitreous opacity (Asteroid Hyalosis) in modern ophthalmology. This condition results in floaters and visual disturbances. Triphala Ghrita Pana and Netra Tarpana have been traditionally indicated for ocular disorders, but their efficacy in managing vitreous opacity remains underexplored. Aims and Objectives: To assess the effectiveness of Triphala Ghrita Pana and Netra Tarpana in managing Medashrita Patalagata Dushti (Vitreous Opacity/Asteroid Hyalosis) by evaluating their impact on distant visual acuity, pinhole vision, and fundus examination over a 45-day period. Methods: This open-label, randomized controlled clinical study included 60 patients with vitreous opacity. Group 1 received Triphala Ghrita Pana (10g daily, empty stomach) along with Netra Tarpana (three sittings of 10 minutes each at seven-day intervals for 45 days), while Group 2 received only Triphala Ghrita Pana (10g daily, empty stomach) for 45 days. Primary outcomes measured changes in distant visual acuity, pinhole vision, and fundus examination at baseline, 15, 30, and 45 days using paired t-tests and ANOVA. Results: Both groups showed significant improvement in distant visual acuity and pinhole vision (p < 0.05). However, no significant changes were observed in near vision, colour vision, foveal reflex, or macular and optic disc clarity. No statistically significant difference was noted between the two groups. Conclusion: Triphala Ghrita Pana improved distant visual acuity and pinhole vision in vitreous opacity, but Netra Tarpana did not provide additional benefit. Further studies with larger sample sizes and extended assessment parameters are recommended to confirm these findings
Advancing Type 2 Diabetes Mellitus Treatment with Computer Aided Drug Design
Full text linkDiabetes Mellitus is a worldwide chronic metabolic disorder characterized by pancreatic cell damage, or insulin resistance, and relative insulin insufficiency. Diabetes is also known as the third killer in humans after cancer and heart attack. This project seeks to tackle the prevalent global health challenge of diabetes mellitus through the application of in silico methods, a promising avenue in drug discovery and development. Our primary objective is to identify therapeutic targets for diabetes treatment, with a specific focus on Peroxisome Proliferators Activated Receptor Gamma (PPAR-γ) and Glycogen Phosphorylase (GP). Utilizing in silico techniques, we aim to explore the interaction of these targets with potential therapeutic agents to develop more potent treatments. Our project is centered on investigating the therapeutic potential of Organo Sulfur Compounds and understanding their interaction mechanisms with receptors using in silico techniques. The overarching aim is to expedite the discovery of novel, efficient, and safe treatments for diabetes mellitus. Computational tools like PyRx, SwissADME, Biovia Discovery Studio, ADMET SAR were used to check the binding and drug forming abilities of ligands under study. It is a faster and more accurate process as compared to the actual experimental trial and error method. Databases like PubChem, PDB and NCBI were also used. In addition to these the other software that were used are SwissADME, Marwin Sketch and OSIRIS data explorer.
Analytical assessment of Sukumara Ghrita using HPTLC and GCMS: Exploring its phytoconstituents and probable mode of action
Full text linkBackground: Sukumara Ghrita an Ayurvedic ghee-based formulation is renowned for its efficacy in addressing various ailments. Objective: This study employs advanced analytical techniques, specifically High-Performance Thin-Layer Chromatography (HPTLC) and Gas Chromatography-Mass Spectrometry (GC-MS), to comprehensively characterize Sukumara Ghrita and to explore bioactive principles present in Sukumara Ghrita and understand their probable mode of action in treating various ailments. Materials and Methods: The medicine was procured from GMP certified Sitaram Ayurveda Pharma and was subjected to HPTLC and GC–MS analysis after due processing. The methanolic extracts were used for HPTLC and GCMS studies. HPTLC fingerprints for methanolic extracts of Sukumara Ghrita was established with good separation and resolution in solvent system Toluene: Ethyl acetate: Hexane (6:3:1). Results: GC-MS analysis of Sukumara Ghrita revealed the presence of 11 phytochemical compounds. HPTLC analysis detected the presence of 9 and 14 active biological constituents at 254 nm and 366 nm respectively, which remains to be identified. Conclusion: The probable mode of action of Sukumara ghrita can be understood through the action of phytoconstituents screened through HPTLC and GC-MS. The phytoconstituents screened are said to have Anti-oxidant, Anti-hypercholesterolemic, Antihypertriglyceridemic, Anti-inflammatory etc actions
Efficacy of oral Musalyapamarga churna in improving hearing threshold: A randomized controlled clinical trial in Badhirya w.s.r. to Sensory neural hearing loss (SNHL)
Full text linkIntroduction: The sense of hearing, crucial yet often overlooked, profoundly impacts life. Hearing loss, whether slight or profound in one or both ears, detrimentally affects social, professional, and personal aspects. Modern treatments like hearing aids and implants are effective but can be financially challenging. In underdeveloped regions, Ayurvedic therapies such as Musalyapamarga Churna, known for its Vata-hara and Rasayana properties, offer a potentially accessible and cost-effective alternative. The study aims to explore the efficacy of Musalyapamarga Churna in treating sensory neural hearing loss (Badhirya), leveraging Ayurveda\u27s holistic approach to improve public health outcomes.
Methods: This study aims to evaluate the efficacy of Musalyapamarga Churna in Badhirya,in this study 30 patients were enrolled and randomized into two groups Group A (Musalyapamarga Churna) and Group B (Sarivadi Vati), 15 in each group.
Results: Statistical analysis using paired t-tests within groups and unpaired t-tests between groups showed significant improvement in both the trial and control groups (p=0.001).
Conclusion: In the present study Musalyapamarga Churna was effective in the management of Badhirya. Both groups were equally effective in the management of Badhirya.
 
Quantification of the Ethnomedicine Data Collected from the Kanikkars in Kanyakumari District, Tamil Nadu, India
Full text linkThis study aims to explore the traditional medicinal plants used by the Kanikkar community, which resides in 26 villages within the Petchiparai Panchayat area of Kanyakumari District, Tamil Nadu, India. These plants are crucial in treating various health issues the community faces. To gather ethnomedicinal information, we conducted interviews and group discussions with 252 participants, including 146 men and 106 women aged 20 to 60. Our research identified 215 species of medicinal plants belonging to 179 genera across 75 families, documenting each species and its medicinal uses. We analyzed the ethnomedicinal data using several quantitative metrics, including the Frequency of Citation Percentage (FC%), which tracks how often a plant is referenced for specific ailments; the Relative Frequency of Citation (RFC), which measures a plant\u27s popularity; the Fidelity Level (FL), indicating the consistency of its use for certain conditions; and the Informant Consensus Factor (FIC), which assesses the agreement among informants regarding the uses of specific plants. We employed Direct Matrix Ranking (DMR) and Preference Ranking (PR) techniques to emphasize the importance of various plant species. This comprehensive evaluation highlights the rich ethnomedical knowledge of the Kanikkar community and stresses the significance of protecting their traditional practices along with the biodiversity that supports them.
Quantitative estimation of secondary metabolites, in-vitro antioxidant, anti-inflammatory and anti-sickling activity of leaf of Ficus virens Aiton.
Full text linkSickle cell anaemia is a severe global disease marked by oxidative stress and painful episodes. This study evaluates the antioxidant, anti-inflammatory, and anti-sickling properties of the ethanolic extract of Ficus virens Aiton leaves. Total phenolic (TPC), tannin (TTC), and flavonoid (TFC) contents were assessed spectrophotometrically, while antioxidant activity was measured using DPPH, anti-inflammatory activity via the HRBC method, and anti-sickling effects through Emmel and reversibility tests. The extract showed high TPC (79.84±2.77 µg/mg GAE), TTC (10.51±0.62 µg/mg GAE), and TFC (132.62±6.69 µg/mg QE). It significantly reduced haemolysis (12.19±1.84% at 2000 µg/ml) and exhibited strong antioxidant activity (89.34±0.56% DPPH scavenging at 75 µg/ml, IC50: 22.76±1.01 µg/ml). The extract also demonstrated a high sickle cell reversal rate (84.13±0.25% at 10 mg/ml after 150 min), comparable to phenylalanine (85.71%). These results highlight Ficus virens Aiton as a promising candidate for treating inflammation and sickle cell anaemia
Dermal wound healing contribution of aqueous extracts of Acalypha indica, Calotropis gigantea, Bacopa monnieri and their combination
Full text linkWound healing is a complex process that requires a well-orchestrated integration of an array of molecular events such as cell migration and proliferation, deposition and remodelling of extracellular matrix components for restoring the structural and functional integrity of the injured tissue. Ayurveda suggests wound healing herbs can achieve enhanced therapeutic effect with reduced toxicity when they are optimally combined in a specific ratio as polyherbal formulation (PHF). The present study was aimed to evaluate the combinatorial wound healing efficacy (in vivo wound closure and histological changes) of aqueous extracts of three medicinal plants (Bacopa monnieri, Acalypha indica and Calotropis gigantea). This study also explored how the combination influenced the overall quality of healed wound. Individual wound closure kinetic performance of aqueous plant extracts in C57B/6J mice was assessed using safe concentrations obtained from human adult dermal fibroblast viability assay. The aqueous plant extract combination optimized using response surface methodology was tested for in vivo wound closure effectiveness. Quality of healed wound was assessed via Haematoxylin & Eosin and immunohistochemical staining of markers (K1, K5, Loricrin, Ki67, CD31 and collagen1). The combination treatment (B.monnieri-15μg/ml, A.indica-11.59μg/ml, C.gigantea-1μg/ml) contributed to faster wound closure (11 days), improved collagen type I remodelling and angiogenesis, complete re-epithelialization, similar epidermal differentiation pattern as that of individual and control treatments. Ki67 staining revealed no significant increase in cell proliferation in combination compared to individual and control. Findings from the study validates the polyherbal combination’s impressive capability to promote wound healing
The Kumbh 2025: Bestower of Sarvasiddhi (All Attainments) and Divine Enlightenment
Full text linkThe tradition of Mahakumbh has flourished from Indian great spiritual and cultural heritage. Mahakumbh is the vibration of cultural and spiritual consciousness of India. It is a divine and lively glimpse of \u27One India-Great India-Inclusive India\u27. Maha Kumbh is a eternal and integrated victory cry of unity in diversity of India. Skanda Purana and Vishnu Purana are emphasizing importance of bathing in Mahakumbh. This event deepens the experience of spirituality and is a confluence of astrology, astronomy, tradition, rituals, social and cultural perspectives. Mahakumbh indicates that antiquity should not only be preserved but also rediscovered. For Mahakumbh 2025 various public accommodations were arranged. A special plan was prepared for security and convenience on special bathing festivals like Paush Purnima, Makar Sankranti, Mauni Amavasya, Basant Panchami, Magh Purnima, and Mahashivratri. The Kumbh Mela, with its uninterrupted flow of faith, is a centre of attraction for the whole world. This Kumbh mela is often regarded as \u27Sarvasiddhipradah Kumbh,\u27 the Kumbh that grants all achievements. The 2025 Mahakumbh highlighted the U.P. Government\u27s exceptional organization, utilizing infrastructure efficiently for a well-executed event
Evaluation and method development for quantification of Piperine in Balchaturbhadra Churna by RP- HPLC
Full text linkAim and Objective: This study aimed to prepare Balchaturbhadra Churna in the laboratory and evaluate its Pharmacognostic, physicochemical, and phytochemical properties, including developing an RP-HPLC method for estimating Piperine as a marker compound. Methods: The prepared Balchaturbhadra Churna was analysed using WHO guidelines for macroscopic, physical, and chemical parameters. The methanolic extract was used for Piperine estimation through RP-HPLC. Results: The macroscopic characteristics, such as colour, odour, and taste were recorded. Physical parameters were determined, including loss on drying, ash value, extractive value, swelling index, foaming index, and powder properties (angle of repose, bulk density, tapped density, and compressibility index). Additionally, total phenolic, flavonoid and preliminary phytochemical screening were performed. The results were compared with a marketed formulation of Balchaturbhadra Churna. The retention time of standard Piperine was 4.50 minutes, while the Piperine in the laboratory and marketed formulations was detected at 4.478 and 4.480 minutes, respectively. The Piperine concentration in the laboratory and marketed formulations was 0.19% w/w and 0.21% w/w, respectively. The developed HPLC method was successfully validated. Conclusion: The laboratory-prepared and marketed formulations of Balchaturbhadra Churna were systematically evaluated and compared. The findings contribute to the standardization of Balchaturbhadra Churna, an Ayurvedic formulation