International Journal of Ayurvedic Medicine
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An experimental study of different types of edible oils with reference to Cholesterol level in Albino Rats
Full text linkThe aim of this study is to evaluate the effect of Sunflower Oil, Safflower Oil and Sesame Oil on the lipid profile of wister albino rats. Twenty Four healthy wister albino rats weighing between 96-110 g and aged between 6weeks to 8weeks were used. The rats were placed randomly into four groups of six animals each. Group 1 served as Normal control and no oil was fed. Group 2 animals were given Sunflower oil in 1ml quantity (1) each daily through oral route. Group 3 Animals were given Safflower Oil (1ml each) daily orally and the group 4 Animals were given Sesame oil (1ml) orally as well. The experiment lasted for 14 days. The results showed that the animals had significant increase in body weight compared with the control. Triacylglycerol, phospholipid and total cholesterol level were also significantly decreased in case of Sunflower and Sesame Oil while the same parameters got increased in Safflower Oil Very Low Density Lipoprotein (VLDL) and Low Density Lipoprotein (LDL) were also significantly Decreased in Sunflower and Sesame Oil Groups while increased in Safflower Control Oils. However High Density Lipoprotein (HDL) showed significant increase in both Sunflower And Sesame Oil Groups. Cholesterol, triacylglycerol and fatty acids are significant and independent risk factors of adverse cardiovascular events. The clinical and nutritional implication of these results is discussed through ayurvedic point of view
A Comparative Clinical Study to Evaluate The Efficacy of Lekhana Basti in Chaturbhadra Kalpa Basti Krama and Yoga Basti Krama in the Management of Sthoulya w.s.r to Obesity
Full text linkThis clinical study aims to compare the efficacy of Lekhana Basti administered through two different protocols—Yoga Basti Krama and Chaturbhadra Kalpa Basti Krama —in managing Sthoulya (obesity). Obesity, characterized by excessive adiposity, poses significant global health challenges and has been traditionally addressed in Ayurveda through Shodhana Chikitsa, including various Basti therapies. Yoga Basti Krama involves alternating Anuvasana and Niruha Basti treatments, while Chaturbhadra Kalpa Basti Krama employs a sequence of continuous Anuvasana and Niruha Basti treatments. Conducted at Parul Ayurved Hospital with 40 diagnosed cases of Sthoulya , the study assessed the impact of these interventions on weight, BMI, body circumference, and lipid profiles. Results indicated both treatment protocols were effective in reducing weight and improving lipid profiles, with Chaturbhadra Kalpa Basti Krama showing more pronounced improvements in body composition and subjective symptoms of obesity compared to Yoga Basti Krama
A Comparative Analysis of Balaguduchyadi and Erandamooladi Niruha Basti: Insights and Outcomes
Full text linkAyurveda aims to preserve health and alleviate ailments through two main types of treatments: Shodhana Karma and Shamana Karma. Shodhana Karma includes purification therapies like Niruha Basti, which is particularly effective for Vata-predominant disorders. This retrospective study assesses the immediate outcomes of two improvised Niruha Basti formulations—Balaguduchyadi Basti (BNB) and Erandamuladi Basti (ENB)—in achieving Samyaka Niruha Lakshana, focusing on dosage ranges, voiding patterns, and Retention Period (RP). Forty Assessment formats for Basti karma of patients with various medical conditions were categorized into two groups. Group A consisted of 20 patients (both male and female) who received BNB, while Group B comprised 20 patients (both male and female) who received ENB. Results indicated that BNB achieved its highest average score for Samyaka Niruha Lakshana with a dosage range of 601-650 ml with an average RP of 14.9 minutes, whereas ENB reached its optimal score at a slightly lower dosage range of 551-600 ml (average RP of 5.9 minutes). The lowest average scores for BNB were observed at a dosage range of 401-450 ml (average RP of 8.5 minutes), while ENB showed the lowest scores at a dosage range of 501-550 ml (average RP of 6.3 minutes)
Management of penn maladu (female infertility) due to tubal block in Siddha medicine-A case report
Full text linkWomen will have a blissful and complete life after having a child. The inability to conceive a child will adversely impact a women’s life. Infertility has also been proposed as a major contributor to emotional problems and reduced quality of life. There are many factors causing infertility- ovarian, tubal, cervical and peritoneal factors. Tubal factors account for about 25-30% of female infertility. Tubal block occurs due to sexually transmitted infections, previous abdominal surgeries, past ectopic pregnancy, pelvic inflammatory diseases and pelvic adhesions or endometriosis in which scarring occur inside the lining of fallopian tubes. Siddha medicine plays a vital role in promoting reproductive health in both male and female partners. The medicines act well on clearing the tubal block and restoring the tubal functions. In this case study a Siddha regimen comprising Aadutheendapalai ennai and Pachapashana chenduram are proven beneficial in treating the tubal block. The study describes about a twenty -five-year old female patient visiting Ayothidoss pandithar Hospital, National Institute of Siddha for the management Penn maladu (Female Infertility) due to Tubal block by Siddha medicine. The patient was under treatment for two months. Hysterosalpingography was taken before and after treatment which showed clearance of block on the Right fallopian tube. In Allopathy treatment IVF is suggested for this condition. IVF is proven to be economically costly procedure and the success rate is also low. So this Siddha regimen can be given to the patients for managing female infertility due to tubal block
A Clinical Study to Evaluate the Antihypertensive Effect of Herbal Formulation (Cap Punarnavadi Mishran) in Management of Primary Hypertension
Full text linkThe present clinical study aimed to evaluate the antihypertensive efficacy of a polyherbal formulation, Capsule Punarnavadi Mishran, in the therapeutic management of primary hypertension. A total number of 30 patients diagnosed with primary hypertension were enrolled from both outpatient and inpatient departments of Dr. D. Y. Patil Ayurved College and Hospital, Pimpri, Pune (Maharashtra). All participants received Capsule Punarnavadi Mishran as a part of their treatment regimen over a defined study period. The effectiveness of the intervention was assessed using both objective parameters primarily changes in systolic and diastolic blood pressure and subjective clinical symptoms. Blood pressure measurements were recorded at baseline and at regular intervals during the course of treatment. The results demonstrated a statistically significant reduction in both systolic and diastolic blood pressure among all 30 participants. Based on clinical assessment, 6 patients (20%) exhibited excellent improvement, 14 patients (46.7%) showed moderate improvement, while 10 patients (33.3%) demonstrated mild to moderate symptomatic relief. The formulation was well-tolerated, and no adverse events were reported during the trial. These findings suggest that Capsule Punarnavadi Mishran may offer a promising adjunct or alternative in the management of primary hypertension. Further large-scale, randomized controlled studies are recommended to validate these preliminary results and elucidate the underlying pharmacological mechanisms
Protective effects of Cassia fistula on epididymal histopathology, oxidative stress and reproductive performance in streptozotocin-induced Diabetic male Wistar rats
Full text linkBackground: Diabetes mellitus (DM) negatively affects normal sperm function and male fertility. Medicinal plants, known for their rich antioxidant properties, can help mitigate male infertility induced by diabetes. Objective: This research is designed to explore the ameliorative effects of ethanolic (70%) extract of Cassia fistula Linn. pods on epididymal histopathology, oxidative stress, sperm quality, and fertility in diabetic rats. Materials and Methods: Type-I diabetes was induced in male Wistar rats by administering a single injection (i.p.) of streptozotocin (60 mg/kg body mass). The diabetic rats were then administered oral doses of Cassia fistula pod extract at different amounts (100, 250, and 500 mg/kg body weight per day) for a duration of 60 days. The outcomes were compared to those of diabetic rats administered the antidiabetic drug glibenclamide (5 mg/kg body weight per day). Sperm quality (count, motility, and viability), lipid peroxidation, and markers of antioxidant defense (catalase, glutathione, superoxide dismutase and ascorbic acid) in the epididymis were analyzed. Additionally, epididymal histopathology, fertility index, and litter size were assessed. Results: The oral administration of Cassia fistula pod extract or glibenclamide in diabetic rats notably improved sperm vitality, fertility rate, and progeny number. The treatment also enhanced epididymal antioxidant levels and reversed histopathological abnormalities in comparison to the untreated diabetic group. These outcomes were similar to those seen with the standard glibenclamide treatment. Conclusions: The findings of this study demonstrate that Cassia fistula pod extract exhibit potent antioxidant properties and provides significant benefits for alleviating epididymal dysfunction in diabetic male rats
Integrated approach in managing necrotizing spider bite wound – A case report
Full text linkBackground: Spider bites from venomous species may result in progressive necrosis and delayed wound healing due to cytotoxic and hemotoxic effects of the venom. Conventional management includes antiseptics, antibiotics, and debridement, but outcomes are often unsatisfactory. Ayurveda describes Lūṭā Viṣha and offers detoxification and tissue-regenerative approaches that may complement modern care. CasePresentation: A 21-year-old female presented with a necrotizing ulcer on the inner thigh following a spider bite. The wound worsened after initial allopathic treatment, showing increasing necrosis, pain, swelling, and secondary infection. Interventions: Initial first aid involved irrigation with hydrogen peroxide, povidone-iodine application, and sterile dressing. An integrative protocol was then adopted. Internal medicines included Triphala Guggulu for detoxification, Zinc–Vitamin C–Vitamin D supplementation for collagen synthesis, and Guduchi–Manjistha decoction for immunomodulation. External applications comprised Triphala Kwath wash with Neem and Haridra for antisepsis, Yashtimadhu Ghrita for regeneration, and Dashanga Lepa for wound healing. Outcomes: The wound was assessed with the Bates–Jensen Wound Assessment Tool. Within 15 days there was near-complete resolution of necrotic tissue, significant reduction in infection, well-formed granulation tissue, and accelerated epithelialization. The patient reported marked pain relief and improved satisfaction. Conclusion: This case demonstrates the potential benefits of an integrative approach that combines modern first aid with Ayurvedic interventions in managing necrotizing spider bite wounds. Broader clinical studies are warranted to validate these findings and support evidence-based integration
Pharmacological Insights and Phyto-Chemical Profiling of Dhanyaka (Coriandrum Sativum Linn) for Therapeutic Applications
Full text linkThe Dhanyaka (Coriander) is botanically identified as Coriandrum sativum Linn belongs to Apiaceae (Shatapushpa Kula) family. It is a commonly used spices and medicine in Ayurveda. In Ayurveda, Ardha Dhanyaka (wet coriander), Sushka Dhanyaka (dry coriander), and Dhanyaka Shaka (fresh coriander leaves) are different forms of coriander used for their medicinal properties.
Dhanyaka (Coriandrum sativum Linn) beeja (seeds) consists of, kashaya, tikta rasa (astringent and bitter taste), snigdha laghu guna (unctuous, light properties), ushna veerya (hot in potency) and madhura vipaka (undergoes sweet metabolism). It acts as tridhosha shamaka (mitigates vata, pitta and kapha), deepana (appetizer), pachana (enhances digestion), mutrala (diuretics), jwaraghna (anti-pyretic), grahi (absorbent), trishnanigrahana (subsides excessive thirst), dahahara (cooling), chardighna (antiemetic), swasahara (anti-asthmatic), krimighna (anti-microbial), and hridya (cardiac tonic). Observations and results: The qualitative and quantitative analysis shows oil yield 7.89% and 9.25%, odour- pleasant, colour- greenish brown, taste- spicy, acid value - 8.569 & 7.568, iodine value - 42.12 & 82.39, saponification value - 285.36 & 236.23, ester value- 265.35 &226.521 in aqueous & methanol respectively. Phytochemical analysis of Dhanyaka extract shows presence of carbohydrates, alkaloids, flavonoids, glycosides, tannins, gas chromatography and mass spectrometric analysis indicates the presence of β-linalool as major chemical constituent along with other essential components, which is widely used in the markets of food, pharmaceutical, cosmetic and aromatherapy
Phytochemical Screening and Thin Layer Chromatography of Successive Solvent Extracts of the Medicinal Plant Maytenus emarginata
Full text linkMedicinal plants have long been recognized for their therapeutic potential, with phytochemical screening serving as a crucial step in understanding their bioactive constituents. Maytenus emarginata, a member of the Celastraceae family, has garnered attention for its diverse secondary metabolites. This study aimed to analyze the phytochemical composition of M. emarginata leaves through qualitative screening and thin-layer chromatography (TLC). Extraction was performed using chloroform, methanol, and aqueous solvents, followed by the identification of compounds such as flavonoids, alkaloids, tannins, and sterols. TLC profiling provided insights into compound separation, revealing varied retention factor (Rf) values across different extracts. The qualitative analysis of M. emarginata leaf extracts identified the presence of secondary metabolites. Alkaloids were detected in chloroform and aqueous extracts, while flavonoids and sterols were present across all extracts. Among the three solvents used, aqueous extraction yielded the highest extractive content (6.03%), followed by methanolic (3.95%) and chloroform (1.44%). TLC confirmed the presence of multiple phytoconstituents across extracts. The chloroform extract exhibited 6 spots under normal and short-wave UV and 7 under long-wave UV, indicating a broad range of compounds with Rf values from 0.62 to 1.0. The methanolic extract showed up to 4 spots under long-wave UV, while the aqueous extract displayed a single UV-active compound (Rf = 0.68). Qualitative phytochemical screening of M. emarginata suggests a complex chemical makeup, underscoring the need for quantitative HPLC analysis. Further research should emphasize the isolation and structural characterization (NMR, MS) of individual compounds
Formulation And Evaluation of Herbal Emulgel for Treatment of Psoriasis
Full text linkOne of the most prevalent skin conditions in humans, psoriasis is thought to have strong genetic roots. It is characterized by abnormal keratinocyte differentiation and excessive development, however with the right treatment, it is completely curable. The development of psoriatic plaques is associated with environmental triggers and other factor such as streptococcal infection, physical trauma (such as tattoos and surgical incisions), smoking and alcohol abuse, as well as certain medications such as antidepressant drugs, anti-hypertensive drugs, anti-cytokine medication. The formulation goal is to develop an emulgel infused with a combination of herbs such as Neem oil, Coconut oil and Aloevera gel, that can help to alleviate the symptoms of Psoriasis and also to cure the condition. The prepared gel formulations were evaluated for pH, viscosity, drug content uniformity, physical characterization, phytochemical screening and by also evaluating it’s effect on psoriasis affected skin. Aloevera and neem oil, and coconut oil containing emulgel exhibited the drug content within the optimum range 87.56%-90.45% which concluded efficient drug loading in the formulation