International Journal of Ayurvedic Medicine
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Exploring the role of Kantavallabha rasa in Polycystic ovarian syndrome management: A pilot Study
Full text linkPolycystic Ovary Syndrome (PCOS) is a complex hormonal disorder affecting the reproductive system, metabolism, and skin. Since modern treatments often focus on individual symptoms, there is a need for a more holistic approach. Kantavallabha rasa, a classical Ayurvedic medicine traditionally indicated in the conditions like Mandagni, Gulma,moola roga and bhagandara , was studied for its potential role in managing PCOS. A pilot study was conducted with 10 women of PCOS, diagnosed using the Rotterdam criteria. Symptoms such as irregular periods (amenorrhoea/oligomenorrhoea), pain in menstruation, hair fall, oily skin, acne, hirsutism (excess facial hair), acanthosis nigricans (dark skin patches), and BMI were monitored. Hormone levels (especially AMH) and ultrasound findings (ovarian volume and follicle count) were also assessed. Statistical analysis was done using paired t-test to evaluate the outcomes. The results showed notable improvements. Women, who had been suffering from PCOS for 3 to 20 years, experienced a significant reduction in the gap between menstrual cycles, pain during menstruation, and ovarian size. There was also clear improvement in hirsutism (unwanted hair growth), acanthosis nigricans, and the number of ovarian follicles. Remarkably, even participants, who had not menstruated for over a year, saw the return of their periods before the treatment ended. This suggests that Kantavallabha rasa may be a promising Ayurvedic solution for managing PCOS
A Randomized Controlled Clinical Study on the Effect of Swarnaprashan (Gold Electuary) on Serum IgG, Anthopometry, and Morbidity Status in Children in Recurrent Upper Respiratory Tract Infections (URTI)
Full text linkBackground: Recurrent upper respiratory tract infections (URTIs) in children represent a major public health concern, especially in developing countries. These infections are among the leading causes of morbidity in immunocompromised and susceptible pediatric populations. In India, respiratory infections contribute to nearly 15% of deaths occurring during infancy and childhood. Aim of the study: To study the Effect of Swarnaprashan (Gold Electuary) on Serum IgG, Anthopometry, and Immune status in Children. Methods: A randomized, open-label clinical study was conducted on 120 children aged 6 to 12 years of both sexes, having low immunity and frequent upper respiratory tract infections. Participants were randomly allocated into two groups of 60 each. Group A received the trial drug SP, while Group B was administered Madhu and Ghrita as the control for a duration of two months. Evaluation Parameters: The study parameters included the incidence of recurrent upper respiratory tract infections (URTI) as reported by participants, the duration and severity of each episode, serum IgG levels, and anthropometric measures. Results: Group A showed significant improvement in morbidity scores(<0.0001), and serum IgG levels (0.0424) whereas Group B demonstrated insignificant changes (>0.05). Conclusion: This clinical trial indicates that SP may serve as an effective intervention for enhancing immune status, reducing the recurrence of upper respiratory tract infections, and promoting the overall growth of children
Microwave assisted extraction of Carica papaya leaves for the formulation of herbal shampoo
Full text linkThe present study aimed to extract Carica papaya(C. papaya) leaves by microwave-assisted extraction(MAE), formulate a shampoo from the extract using a suitable base, and evaluate its properties. The MAE of C. papaya leaves was carried out using water as the solvent. The extracts were dried and tested qualitatively for tannin constituents. After the quantification, extracts were formulated as shampoo using different shampoo bases, namely liquid cream shampoo, clear liquid shampoo, surfactant base shampoo, and gel shampoo, and compatibility was checked. The extract was found to be compatible with surfactant-based shampoo. The four different concentrations of shampoo were formulated by varying the concentrations of surfactant and thickening agent. The four formulations F1-F4 were evaluated for physicochemical parameters such as wetting, foaming, cleansing activity, and wig tests and compared with BIS standards. The optimised formulation was evaluated for viscosity and in vitro fungal activity using agar diffusion. And a stability study. The MAE of the C. papaya leaves yield was 30%. The qualitative test confirmed the presence of tannin. The surfactant-based shampoo showed compatibility in terms of physical nature and stability. F1 also showed maximum detergency (79.23±0.43%) and minimum wetting time (177 sec) required for an ideal shampoo. The wig test with the prepared formulations showed shiny and smooth hair without the fizziness method. The viscosity was checked, and pseudo-plastic behaviour was followed. The minimum inhibitory concentration of the test shampoo(F1) showed 14mm of inhibition, and the marketed ketoconazole shampoo showed 13mm. The F1 shampoo was stable for 3 months, and there was no change in the physicochemical properties of the shampoo. The MAE extraction procedure yielded a higher yield than the traditional extraction method. The extract had high quantities of tannin, responsible for its antifungal activity. The result of F1 was as per the BIS certification for shampoo. Moreover, it inhibited the growth of Candida albicans, providing the anti-dandruff activity against Seborrheic dermatitis. It can also be used for anti-dandruff shampoo. This method of extraction and formulation makes the scale-up process easier. Further, a study needs to be done on the toxicity of shampoo in a cell line, and it can be easily scaled up for technology transfer
Ayurveda Management of Diabetes Mellitus: A Comprehensive Evidence-Based Narrative Review
Full text linkDiabetes mellitus (DM) remains a key worldwide health issue due to its rising prevalence, significant morbidity, high economic burden. Conventional medical approaches often struggle to achieve optimal control in many patients, leading to growing interest in complementary therapies such as Ayurveda. This narrative review explores the clinical evidence supporting Ayurveda management of Type 2 Diabetes mellitus and prediabetes. A comprehensive literature search spanning PubMed, AYUSH Research portal and Google scholar from 2015 to 2025 identified 16 clinical studies, including randomized controlled trials, pilot studies, and single case report. The interventions evaluated ranged from classical and polyherbal formulations, herbo-mineral compounds, and Panchakarma therapies to integrated lifestyle strategies incorporating yoga, therapeutic fasting, and Ayurvedic dietary protocols. Ayurvedic therapy consistently improved glycemic indices (HbA1c, FBS, PPBS), insulin resistance, lipid profiles, BMI, and quality of life. Notably, integrative treatments that combined Ayurveda with Western medicines, including Metformin, resulted with improved outcomes with fewer adverse events. Panchakarma therapies such as Vamana, Virechana, and Basti have also shown promise for correcting early diabetes conditions. The findings underscore Ayurveda\u27s holistic, individualized framework as a possible supplement or alternative in diabetes treatment and management. However, additional large-scale, standardized trials are required to corroborate these findings and promote wider clinical implementation
Dematoglyphic analysis in Jatyaandh: A case-control study
Full text linkIntroduction: Dermatoglyphics stands as one of humanity\u27s oldest and most enduringly useful techniques. Dermatoglyphics has historically been employed for identification since ancient times, its application in diagnosing various diseases gained attention as early as the 17th century. In recent decades, there has been a growing global interest in epidermal ridges, especially as it became apparent that individuals with chromosomal abnormalities often exhibit unusual ridge formations. Significant advancements have been achieved in researching and comprehending the connections between dermatoglyphics and various medical conditions. Consequently, dermatoglyphic analysis has gained acceptance as a valuable diagnostic tool in numerous diseases, particularly in disorders arising from chromosomal abnormalities. These conditions often coincide with alterations in patterns, highlighting the diagnostic utility of dermatoglyphic analysis. Materials and Methods: The objective of this study is to investigate the correlation between dermatoglyphics and Jatyaandh. In this study, 250 children diagnosed with Jatyaandh underwent examination, comparing their dermatoglyphic patterns with those of age and sex-matched controls. Dermatoglyphics prints were taken by ‘Ink method’ described by Cummins and Mildo. Results: Significant variances were noted in several dermatoglyphic traits among the cases. Specifically, the case group displayed differences in Finger Ridge Count, Total Finger Ridge Count, Absolute Finger Ridge Count, as well as an elevated atd angle, and a greater prevalence of whorl patterns on their digits
A clinical evaluation of Siddha herbal formulation Panchathaarai kuzhambu (Internal medicine) and Ottrai thalaivali thylam (External medicine) in the management of Ottrai thalaivali (Migraine)
Full text link Migraine is a syndrome of headache which is benign and re-occurring, along with various neurological dysfunctions, nausea/vomiting etc, affecting about 20% of females and 6% of males at some point in life. It affects over one billion people worldwide. According to Siddha, Ottrai thalaivali (migraine) is characterized as unilateral headache, lacrimation, irritability, sighing, fatigue, tremor, startling, loss of appetite and tingling sensation. Research studies regarding Migraine was searched in databases like PubMed, Google scholar, scopus, web of science, using keywords Migraine and siddha, Migraine AND Panchathaarai kuzhambu, Ottrai thalaivali and Clinical trial. Eventhough, there are a few papers proving the effectiveness of ayurvedic treatment regimens for migraine, No works have been found relating siddha clinical trials and migraine. Also as the disease requires long term management, there is a need to look for herbal formulations that can be effective in the management of Migraine. The herbal formulations Panchathaarai kuzhambu and Ottrai thalaivali thylam have been taken for the study to prove its effectiveness on Migraine. A Clinical trial was conducted on 10 patients diagnosed with Ottrai thalaivali(Migraine). The trial drugs Panchathaarai kuzhambu was given in a dose of 2gms twice daily along with cow’s milk and Ottrai thalaivali, 70ml as bath oil twice in a week, given for 48 days. The results using HIT-6 Score and Headache diary showed that there was significant relief in the patients and there was no untoward side-effects in any patients
Formulation, Development and In-vitro evaluation of Anti-inflammatory Polyherbal Transdermal Patch
Full text linkBackground: Inflammation is a tissue response to any infection associated with pain, increased vascular permeability, protein denaturation & membrane alteration. Non-steroidal and steroidal anti-inflammatory drugs (NASIDs) and SAIDs are commonly used medications for inflammation but have adverse side-effects. Dashmool, an ayurvedic polyherbal formulation shows significant anti-inflammatory properties with no severe side-effects. Objective: This study aims to develop and evaluate a transdermal patch containing Dashmool extract, leveraging the benefits of transdermal drug delivery to manage inflammation and pain effectively. Methods: The aqueous extract of Dashmool was prepared and standardised. Anti-inflammatory activity was assessed using albumin denaturation inhibition. Various formulations of transdermal patches were created using cassava starch as a natural polymer and different ratios of hydroxypropyl methylcellulose (HPMC) and plasticisers. Physicochemical properties, including thickness, folding endurance, moisture content, and surface pH, were evaluated. Results: The aqueous extract of Dashmool exhibited significant anti-inflammatory activity, with the highest inhibition of protein denaturation observed at 400 µg/ml. Among the formulations, F1 (cassava starch-based) showed the best overall performance with good adhesive properties, flexibility, and moisture content. The patches demonstrated uniform thickness, acceptable folding endurance, and low moisture content, indicating stability. Conclusion: The developed Dashmool transdermal patch, offers a promising alternative for pain management with better stability
Chemical profiling of Mandak - A novel polyherbal combination
Full text linkIntroduction: In Ayurveda, drug formulation adheres to two principles: single-drug use and compound drug use, the latter known as polyherbalism. Mandak, a Novel Polyherbal combination of six drugs have shown better efficacy individually in the management of twak vikaras. Methods: This study aimed to evaluate raw and end product’s (Mandak) organoleptic, physicochemical, and phytochemical properties, along with chromatographic screenings via Thin Layer Chromatography (TLC) and High-Performance Thin Layer Chromatography (HPTLC), and Fourier Transform Infrared Spectroscopy (FTIR) to assess the synergistic effects of this novel combination. Results and Discussion: The microbial load of both the raw drugs and the compound mixture was within permissible limits. Physicochemical and phytochemical analyses confirmed the presence of compounds such as flavonoids, alkaloids, and tannins, recognised for their antioxidant, anti-inflammatory, anti-allergic, and antimicrobial properties. HPTLC profiling identified berberine (Rf ~0.36) and gallic acid (Rf ~0.59), with colour bands indicating various phytoconstituents such as red and yellow for alkaloids and blue for flavonoids and tannins etc. FTIR analysis detected hydroxyl groups linked to alcohols and phenols, which exhibit antioxidant properties, and carboxyl groups associated with lipids and proteins synthesis. The phytoconstituent composition may vary due to geographical distribution and time of collection. The compound drug’s components might work synergistically, enhancing antioxidant, anti-inflammatory, and wound healing activities. Conclusion: The diverse pharmacological activities of Mandak stem from its phytoconstituents, which could help create standard monographs for this novel combination. This study emphasises the importance of Mandak by evaluating its phytochemical properties and potential benefits in Ayurvedic practice
To ascertain the prevalence of diabetic retinopathy among the different dehaprakriti - A cross sectional study
Full text link Diabetic retinopathy (DR) is a common cause of vision problems worldwide. One in three diabetics has symptoms of diabetic retinopathy. Dehaprakriti is a unique concept of Ayurved. By knowing the concept of Dehaprakriti one can maintain homeostasis. Aim: Determination of the prevalence of diabetic retinopathy in the different Dehaprakriti. Materials and Methods: A simple randomisation study was conducted at SGR Ayurved College & Hospital Solapur, Maharashtra with appropriate consent. According to inclusion criteria, people with Diabetes Mellitus were screened. Fundoscopy was performed on all diabetic patients. Each patient with Diabetes Mellitus underwent funduscopy. The presence or absence of changes in diabetic retinopathy was noted in each patient. Identified subjects with diabetes retinopathy underwent detailed examination by Dehaprakriti. The study of Dehaprakriti was based on a proforma approved by the Maharashtra University of Health Sciences, Nashik. Result: For the study, 106 individuals with Diabetes Mellitus in total were enrolled. Of them, sixty patients exhibited signs of diabetic retinopathy. The overall prevalence of 56.6 percent was associated with diabetic retinopathy. 25% of people in Kaphavaat Dehaprakriti had diabetic retinopathy. Pittakapha is the Dehaprakriti that is least impacted. The group\u27s prevalence was 10%. Conclusion: Changes in DR are observed to a greater extent in Kaphvaat Dehaprakriti individuals
Evidence based Management of Pittaj Mutrakruchhra (Urinary Tract Infection) through Ayurvedic Medicine – A Single Case Report
Full text linkIntroduction: Urinary tract or UTI infections, are extremely frequent and can have a negative impact on the individual\u27s well-being and standard of life. The overall rate of UTI prevalence was 33.54%, with 66.78% of cases occurring in females and can be correlated to Mutrakruchhra. Aim- To study the effect of Vidariyadi Vati on the management of Pittaj Mutrakruchha. Case Report-- A 38 years old female came to OPD of Dr. D Y Patil College of Ayurved and Research Center resident of Pune, Maharashtra. She had Peet Mutrapravrutti (yellowish discolouration of urine), Sadaha Mutrapravrutti (burning sensation during micturition), Sashul mutrapravrutti (pain during/after micturition), Muhur muhur Mutrapravrutti at night (increased frequency of micturition at night). She was treated with Vidariyadi Vati 250 mg for first 5 days 4 times a day then 6th to 8th day 3 times a day and after that 9th to 12th day 2 times a day. Results after 12 days was found satisfactory. With no negative side effects, Observation and Results : Vidariyadi Vati act as Vatpittashamak and helps to distruct the samprapti of Mutrakruchha. Vidariyadi Vati was helpful to get rid of symptoms and prevents recurrence of symptoms in patient Conclusion: The treatment of Pittaj Mutrakruchhra by Ayurvedic measures has been thoroughly examined and discussed here. Her progression is also shown here, step by step. This case study will encourage further research and aid in the development of an ayurvedic treatment protocol for Pittaj Mutrakruchhra.