162,413 research outputs found
Fluorination And Deoxygenation As Chemical Tools To Study The Conformational Preferences Of Hexopyranoses: A Journey From Gas Phase To Solution
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The 3D-arrangement of carbohydrates and, particularly, the orientation of their hydroxymethyl groups are structural features crucial for their biological activities. In this work, we investigate the influence of water on the conformational preferences of model hexopyranoses by performing a comprehensive analysis in the gas phase via microwave spectroscopy\footnote{C. Calabrese, I. Uriarte, A. Insausti, M. Vallejo-Lopez, F. J. Basterretxea, S. A. Cochrane, B. G. Davis, F. Corzana and E. J. Cocinero \textit{ACS Cent. Sci.}, \textbf{6}, 293-303, 2020.}\footnote{E. J. Cocinero, A. Lesarri, P. Ecija, F. J. Basterretxea, J.-U. Grabow, J. A. Fernandez, F. Castaño \textit{Angew. Chem. Int. Ed.}, \textbf{51}, 3119, 2012.} of different fluorinated and deoxygenated carbohydrate analogues and comparing the results with those obtained in solution using a combination of NMR data and molecular dynamics simulations. The gg conformation is stabilized in the gas phase by intra molecular HBs that lock this conformation when oriented clockwise. However, and contrary to previously reported data, the conformation of the hydroxymethyl group in D-gluco and D-mannopyranose series follows a similar tendency in the gas phase and in solution, indicating the importance of stereo electronic and minimizing the importance of competing water molecules against stabilizing intra molecular HBs
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
La Mancomunitat de les Valls. Fragilidad, paisaje y desarrollo
No full textEste libro es la continuación de la serie editada por la UPV a propuesta del Taller de Urbanismo y Paisaje. Está compuesto por cinco artículos de investigación que invitan a la reflexión sobre la necesidad de difusión de ideas sobre las estrategias de rehabilitación urbana más aconsejables, que contribuyan al desarrollo sostenible y favorezcan las formulas de intervención sobre tejidos, perfiles urbanos y espacios verdes.En definitiva, se trata de un libro que versa sobre la fragilidad, como define su título, la fragilidad de lo belloAguilar Alonso, MD.; Alonso Salvador, M.; Blasco Sánchez, MDC.; Ramón Huidobro, J.; Insausti Machinandiarena, P.; Martínez Pérez, FJ.; Vigil De Insausti, A. (2016). La Mancomunitat de les Valls. Fragilidad, paisaje y desarrollo. Editorial Universitat Politècnica de València. https://riunet.upv.es/handle/10251/74592EDITORIA
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
Impact of the oh-to-f replacements in monosaccharides
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Bioisosteric OH-to-F replacements, concretely those produced in saccharides, have become a cornerstone in the development of novel drugs and tracers for the non-invasive imaging modalities, like \mbox{(F-MR/MRI)} and (F-PET). F and OH groups are isoelectronic and possess similar polarity and steric impact. Despite its remarkable purposes, there is a lack of knowledge about the structural non-covalent interactions involving F in their native context, which are the key in the activities that they develop. By means of high resolution rotational spectroscopy in combination with a laser ablation\footnote{C. Calabrese, I.Uriarte, A. Insausti, M. Vallejo-López, F.J. Basterretxea, S.A. Cochrane, B.G. Davis*, F. Corzana*, E.J. Cocinero*. \textit{ACS Cent. Sci.} \textbf{2020}, \underline{6}, 2, 293-303}\footnote{C. Calabrese, P. Écija, I. Compañón, M. Vallejo-López, A. Cimas, M. Parra, F.J. Basterretxea, J.I. Santos, J. Jiménez-Barbero, A. Lesarri, F. Corzana*, E.J. Cocinero*. \textit{J. Phys. Chem. Lett.} \textbf{2019}, \underline{10}, 12, 3339-3345}, we are able to isolate and characterize the intrinsic conformational structures of these fluorinated saccharides, obtaining valuable information about their structure and connection with their biological properties
A Tripartite Post-Recession Rebalancing
No full textIn this latest Advance & Rutgers Report, entitled “A Tripartite Post-Recession Rebalancing,” Dean James W. Hughes and Professor Joseph J. Seneca deliver an incisive assessment of the current market conditions and obstacles in the path of our economic recovery. They offer a statistical cautionary tale that the private and public sector need to hear and acknowledge in order for the economy to make continued progress.This report was published as Issue Paper Number 7, November 2011, in Advance & Rutgers Report
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
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