649 research outputs found
Rational use of Jatropha curcas L. in food and medicine: from toxicity problems to safe applications
No full textJatropha curcas L. is natural sources of biodiesel. It has high potential economic values. Different parts of J. curcas have their own potencies, unfortunately these were not known by the farmers. The aim of this thesis is to give an overview of the additional values of Jatropha curcas L. by characterization of its natural products that can be used as a safe pharmaceutical product. In addition the detoxification of the plant cake allowing it to be used for animal stock has been researched. This thesis is a part of larger project for valorization Jatropha curcas L. plantation, especially in Indonesia. From the latex of J. curcas L. two cyclic peptides were isolated and synthesized. Curcacycline A inhibited the growth of Pseudomonas aeruginosa and Bacillus subtillis. Both curcacyclines did not cause mutagenicity and cytotoxicity. From the pressed cake of J. curcas L, it can be utilized as animal feed, because its protein content is the same as FAO requirement, but the utilization is limited due to the toxic components. Because of that, detoxification process became an interesting object. We developed analytical method using tandem mass spectrometer to differentiate α, β phorbol myristic acetate (PMA) and dehydroxy phorbol ester (DHPEs). With this method we can detect the PMA in low amount (1 µg/mL). We also validated the detoxification results using ecotoxicity, cytotoxicity and mutagenicity tests. Based on those results J. curcas cake was not cytotoxic and mutagenic. These data will be essential to develop the use of J. curcas as new drug candidate and for animal food application
Artikel ADM Muhamad Rido
No full textStudents are a very important element in educational and teaching activities in schools. Educational institutions are established for the benefit of students. Therefore it needs to get enough attention from the implementation of education in order to achieve the objectives of national education as a whole.Therefore, as a prospective educator later, in order to be able to administer for students so that the learning process runs well it is necessary to understand about the administration of students / students. Therefore, the author tries to make a paper that discusses the administration of students
Rational use of Jatropha curcas L. in food and medicine: from toxicity problems to safe applications
No full textJatropha curcas L. is natural sources of biodiesel. It has high potential economic values. Different parts of J. curcas have their own potencies, unfortunately these were not known by the farmers. The aim of this thesis is to give an overview of the additional values of Jatropha curcas L. by characterization of its natural products that can be used as a safe pharmaceutical product. In addition the detoxification of the plant cake allowing it to be used for animal stock has been researched. This thesis is a part of larger project for valorization Jatropha curcas L. plantation, especially in Indonesia. From the latex of J. curcas L. two cyclic peptides were isolated and synthesized. Curcacycline A inhibited the growth of Pseudomonas aeruginosa and Bacillus subtillis. Both curcacyclines did not cause mutagenicity and cytotoxicity. From the pressed cake of J. curcas L, it can be utilized as animal feed, because its protein content is the same as FAO requirement, but the utilization is limited due to the toxic components. Because of that, detoxification process became an interesting object. We developed analytical method using tandem mass spectrometer to differentiate α, β phorbol myristic acetate (PMA) and dehydroxy phorbol ester (DHPEs). With this method we can detect the PMA in low amount (1 µg/mL). We also validated the detoxification results using ecotoxicity, cytotoxicity and mutagenicity tests. Based on those results J. curcas cake was not cytotoxic and mutagenic. These data will be essential to develop the use of J. curcas as new drug candidate and for animal food application
Rational use of Jatropha curcas L. in food and medicine: from toxicity problems to safe applications
No full textJatropha curcas L. is natural sources of biodiesel. It has high potential economic values. Different parts of J. curcas have their own potencies, unfortunately these were not known by the farmers. The aim of this thesis is to give an overview of the additional values of Jatropha curcas L. by characterization of its natural products that can be used as a safe pharmaceutical product. In addition the detoxification of the plant cake allowing it to be used for animal stock has been researched. This thesis is a part of larger project for valorization Jatropha curcas L. plantation, especially in Indonesia. From the latex of J. curcas L. two cyclic peptides were isolated and synthesized. Curcacycline A inhibited the growth of Pseudomonas aeruginosa and Bacillus subtillis. Both curcacyclines did not cause mutagenicity and cytotoxicity. From the pressed cake of J. curcas L, it can be utilized as animal feed, because its protein content is the same as FAO requirement, but the utilization is limited due to the toxic components. Because of that, detoxification process became an interesting object. We developed analytical method using tandem mass spectrometer to differentiate α, β phorbol myristic acetate (PMA) and dehydroxy phorbol ester (DHPEs). With this method we can detect the PMA in low amount (1 µg/mL). We also validated the detoxification results using ecotoxicity, cytotoxicity and mutagenicity tests. Based on those results J. curcas cake was not cytotoxic and mutagenic. These data will be essential to develop the use of J. curcas as new drug candidate and for animal food application
Rational use of Jatropha curcas L. in food and medicine: from toxicity problems to safe applications
No full textJatropha curcas L. is natural sources of biodiesel. It has high potential economic values. Different parts of J. curcas have their own potencies, unfortunately these were not known by the farmers. The aim of this thesis is to give an overview of the additional values of Jatropha curcas L. by characterization of its natural products that can be used as a safe pharmaceutical product. In addition the detoxification of the plant cake allowing it to be used for animal stock has been researched. This thesis is a part of larger project for valorization Jatropha curcas L. plantation, especially in Indonesia. From the latex of J. curcas L. two cyclic peptides were isolated and synthesized. Curcacycline A inhibited the growth of Pseudomonas aeruginosa and Bacillus subtillis. Both curcacyclines did not cause mutagenicity and cytotoxicity. From the pressed cake of J. curcas L, it can be utilized as animal feed, because its protein content is the same as FAO requirement, but the utilization is limited due to the toxic components. Because of that, detoxification process became an interesting object. We developed analytical method using tandem mass spectrometer to differentiate α, β phorbol myristic acetate (PMA) and dehydroxy phorbol ester (DHPEs). With this method we can detect the PMA in low amount (1 µg/mL). We also validated the detoxification results using ecotoxicity, cytotoxicity and mutagenicity tests. Based on those results J. curcas cake was not cytotoxic and mutagenic. These data will be essential to develop the use of J. curcas as new drug candidate and for animal food application
Design maintenance for lighthouse / Muhamad Rashid Ab Aziz
No full textAs lighthouses have become less essential to navigation, many of their historic structures have faced demolition or neglect. So, this final project will enlighten with more detail regarding the maintenance works for lighthouse. This research of the study will involves marine department of Malaysia as a government organization that responsible to manage lighthouses. The aim of this final project is to investigate the implementation of marine department to maintain the lighthouse and suggest the best design maintenance for lighthouse. To support this research, four lighthouses have been taken as case studies. The data gathered from observation, condition survey and interview conducted at the site. It is hoped that the overall findings of the study will be beneficial for further research that can be developed in this particular area. Besides that, the analysis is made to achieve the objective of this study. Conclusion and recommendation also made in the last chapter to achieve the objective of the study. From this study, the author hopes that it would give clear awareness to us why the important of lighthouse to be maintain
PENAPISAN FITOKIMIA DAN KARAKTERISASI SIMPLISIA DAUN JAMBU MAWAR (Syzygium jambos Alston)
No full textSyzygium jambos Alston adalah tumbuhan dari suku Myrtaceae. Secara tradisional daun dan awetan bunga biasanya digunakan sebagai obat penenang, kulit kayu dan bijinya dapat mengobati demam, diare dan disentri. Buah dan kulit batang mengandung saponin, flavonoid dan tannin, di samping itu daun dan buahnya mengandung polifenol. Namun penelitian kandungan kimia tumbuhan yang bermanfaat tersebut di Indonesia masih sedikit dilaporkan. Tujuan penelitian ini adalah untuk menetapkan senyawa fitokimia dan mengkarakterisasi simplisia daun S. jambos. Dilakukan pengambilan sampel dan pengolahan simplisia daun jambu mawar kemudian dilakukan ekstraksi dengan metode maserasi menggunakan pelarut dengan kepolaran bertingkat (n-heksana, etil asetat, dan metanol). Dilakukan karakterisasi serbuk simplisia meliputi penetapan kadar air, penetapan kadar abu total dan kadar abu tidak larut asam, penetapan susut pengeringan serta penetapan kadar sari larut air dan etanol. Pemeriksaan kandungan kimia alkaloid: menggunakan pereaksi Dragendroff dan Mayer; flavonoid: menggunakan pereaksi serbuk magnesium, HCl 2 N serta amil alcohol; tannin : diberikan pereaksi FeCl3, larutan gelatin 1% dan Steasny; fenol : ditetesi larutan FeCl3 10%; saponin: ditambahkan beberapa tetes asam klorida 2 N; steroid/triterpenoid: diteteskan pereaksi Liebermann-Burchard. Diperoleh nilai kadar air 8,33 ±1,52, kadar abu total 7,64 ±0,08 dan kadar abu tidak larut asam 5,41 ±0,15, susut pengeringan 15,33 ±4,04, kadar sari larut air 20,90 ±0,56 serta kadar sari larut etanol 22,43 ±1,35. Penapisan fitokimia ekstrak daun S. jambos mengandung fenol, flavonoid, dan steroid/triterpenoid
ANTIOXIDANT ACTIVITIES OF VARIOUS SEED EXTRACTS FROM FOUR VARIETIES OF RAMBUTAN (Nephelium lappaceum) USING DPPH AND ABTS ASSAYS
No full textObjectives: The objectives of this research were to study antioxidant activities from various seed extracts of four varieties of rambutan using2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2\u27-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) methods and correlation of total flavonoidcontent (TFC), total phenolic content (TPC), and total carotenoid content (TCC) with inhibitory concentration 50 (IC50) of DPPH and ICMethods: Antioxidant activities, TFC, TPC, and TCC of various seed extracts were performed by ultraviolet -visible spectrophotometry and theircorrelation with IC50 of DPPH and IC50 of ABTS antioxidant activities were analyzed by Pearson\u27s method.Results: Ethanolic seed extract of lebak bulus variety had the lowest IC of DPPH scavenging activity 7 µg/ml, while ethyl acetate seed extract of rajahvariety had the lowest IC5050 of ABTS scavenging activity 7.34 µg/ml. The highest TFC, TPC, and TCC were given by ethyl acetate extract of binjai variety,ethanolic extract of rapiah variety, and ethanolic extract of rajah variety, respectively. There were negatively high correlation between TFC, TPC,, TCCin seed extracts of rapiah variety with their IC50 of DPPH and IC50 of ABTS scavenging activities.Conclusions: All of ethyl acetate and ethanolic seed extracts of four varieties of rambutan were very strong antioxidant by DPPH and ABTS methods.Flavonoid, phenolic, and carotenoid compound in seed extracts of rapiah variety were contributor in their antioxidant activities by DPPH and ABTSmethods. The IC50 of DPPH and IC50 of ABTS scavenging activities in seed extracts of lebak bulus, rajah, and rapiah varieties gave linear result.Keywords: Antioxidant, 2,2-diphenyl-1-picrylhydrazyl, 2,2\u27-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid, Seed, Four varieties, Rambutan,Flavonoid, Phenolic, Carotenoid
SOSIOTEKNOLOGI Kearifan Lokal: Komoditas Era Revolusi Industri 5.0
No full textBook Title : SOSIOTEKNOLOGI Kearifan Lokal: Komoditas Era Revolusi Industri 5.0
Author Names : Dicky R. Munaf dan Susanto
Year of Publication : 2021
Publisher : ITB Press, Gedung Perpustakaan Pusat ITB, Jl. Ganesa No. 10 Bandung 40132, Jawa Barat
Number of pages : 293 pages
ISBN Number : 978-623-297-131-8
Book review by : Muhamad Firman Al-Faha
ISOLATION OF 8-HIDROXY-6,7-DIMETHOXY COUMARIN FROM JARAK TINTIR STEM (Jatropha multifida L.) AND ITS TOXICITY VALUE USING BRINE SHRIMP LETHALITY TEST (BSLT)
No full textJatropha multifida L. (jarak tintir) was a shrub, annual, and had ± 2 m high. Empirically jarak tintir sap was used as traditional medicine by Indonesian people for a long time. Only limited studies were conducted regarding its chemical compound. It was reported that multifidone (diterpenoid compound from the stem) had an activity against cancer cells in vitro. This study aimed to test the toxicity of various extracts (n-hexane, ethyl acetate, and methanol) with Brine Shrimp Lethality Test (BSLT) of Jatropha multifida L. stem. A Fraxidin (8-hidroxy-6,7-dimethoxy coumarin) has been isolated from ethyl acetate fraction based on highest cytotoxic with LC50 value 3.69 µg/mL. The isolated compound was elucidated to gain chemical structure base on spectroscopic data (UV-Vis Spectrofotometric, IR Spectrofotometric, and NMR). Toxicity of fraxidin was tested on BSLT and showed no potential activity with LC50 value > 500 μg/mL
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