217 research outputs found
Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomas
No full textA single nucleotide polymorphism-chip analysis of 98 cases of aggressive B-cell lymphomas revealed a recurrent deletion at 19p13 in nine of the cases. Six further cases with deletions encompassing this region were found in array-comparative genomic hybridization data of 295 aggressive B-cell lymphomas from a previous study. Three cases even showed a homozygous deletion, suggesting a tumor suppressor gene in the deleted region. Two genes encoding members of the tumor necrosis factor superfamily (TNFSF) were located in the minimally deleted region, that is, TNFSF7 and TNFSF9. As no mutations were found within the coding exons of the remaining alleles in the lymphomas with heterozygous deletions, we speculate that the deletions may mostly function through a haploinsufficiency mechanism. The cases with deletions encompassed both diffuse large B-cell lymphomas and Burkitt lymphomas, and a deletion was also found in a Hodgkin lymphoma cell line. Thus, TNFSF7 and TNFSF9 deletions are recurrent genetic lesions in multiple types of human lymphomas
Primary acinar cell carcinoma of the ampulla of Vater.
No full textAcinar cell carcinoma of the pancreatobiliary system is a relatively rare malignant neoplasm arising usually in the pancreatic parenchyma. We experienced a 68-year-old woman who presented with obstructive jaundice due to an ampullary mass 1.0 cm in diameter, detected by abdominal computed tomography and endoscopic examination. The patient underwent a curative surgical operation, and histopathological examination revealed that the tumor was confined to the ampulla of Vater with no continuity to the pancreatic parenchyma. The tumor cells showed acinar or tubular arrangement with eosinophilic to basophilic granular cytoplasm, findings identical to those of acinar cell carcinoma of the pancreas. Immunohistochemically, the tumor cells were positive for lipase. From these findings, we concluded that the tumor was primary acinar cell carcinoma arising in the ampulla of Vater, probably originating from heterotopic pancreatic tissue. This is the first reported case of primary acinar cell carcinoma in the ampulla of Vater
Zwischen Vater und Tochter
No full textDie vorliegende Arbeit begibt sich auf die Suche nach Mechanismen der Distanz im Kontext
der Vater – Tochter Beziehung.Als Ausgangspunkt diente das Modell der
Generationenbeziehungen, auf dessen Basis sich eine Definition von Distanz ableiten lässt:
Distanz soll charakterisiert werden als Abweichung von einer dynamischen Bewegung
zwischen Nähe-herstellenden und Abstand-haltenden Tendenzen, als Resultat einer Erstarrung
und Ausdruck einer Leerstelle im Kontakt zwischen Vater und Tochter. Im Anschluss geht es
darum, einer Genese dieser erstarrten Distanz auf die Spur zu kommen. Dabei wird unter
Berücksichtigung psychoanalytischer und bindungstheoretischer Ansätze die Aufmerksamkeit
sowohl auf emotionale, als auch auf sinnlich-körperbezogene Austauschprozesse zwischen
Vater und Tochter gelegt. So kann ein Bogen vom Konzept des väterlichen „holdings“ – das
neben spielerisch-herausfordernden Anteilen vor allem auch die zärtliche Fürsorge des Vaters
berücksichtigt - über das Prinzip einer „Anerkennung mit dem Körper“ bis hin zur Theorie
der intersubjektiven Anerkennung gespannt werden. Die zunehmende Fokussierung der
Körperlichkeit des Vaters mündet schließlich in eine Auseinandersetzung mit dem
Themenkomplex Sexualität und Geschlecht. Hier geht es vor allem darum, welche
Hintergründe und Konsequenzen eine unangemessene Haltung des Vaters gegenüber der
kindlichen Sexualität der Tochter haben kann. In einem letzten Schritt wird das Thema auf
eine kulturell-gesellschaftliche Ebene geführt, um zu verdeutlichen, dass eine von kollektiven
Mechanismen isolierte Beleuchtung distanzimmanenter Momente immer zu kurz greifen muss
– so kann etwa die Vater – Tochter Beziehung nicht unabhängig von einem Weiblichkeits-/
Männlichkeitsdualismus gesetzt werden, der nicht nur in den Geschlechterbeziehungen
wirksam wird, sondern darüber hinaus auch – in Form einer Spaltung zwischen männlichem
und weiblichem Bezugssystem - das gesamte westliche Denken durchzieht.The present paper, deals with mechanism of distance between father and daughter. distance is characterized as a deviance of dynamic movement between tendencies of space and tendencies of closeness. To get on the track of the genesis of distance the author focusses psychoanalytic theories - especially the theory of intersubjectivity - and attachment theory. In a last step the subject is lifted on a cultural level to prove that there is a connection between individualistic and collective mechanism of distance
JOHANN SEVERIN VATER AND SAMOYEDS
No full textThe purpose of the article is to show the process of formatting a new kind of linguistics,
a contribution by A. Schlözer and I. S. Vater of their version of modern linguistics
based on the Samoyed (Nenets) language research. The article demonstrates the way
the researchers have arrived at their conclusions through careful selection of sources, both published and archived. The 18th century, the “age of systematics”, complete with
a new division of sciences, arrived at the transformation of ethnography and linguistics
into independent disciplines. Those were prerequisites for the emergence of comparative-
historical linguistics. Using the Samoyed language studies as an example, the article
examines Schlözer and Vater’s solution of the problems arising in identifying linguistic
kinship: the lack of grammatical descriptions and the difficulties of reliable fixation
of a non-written language. The works by Vater are the most significant precursors for
the first grammar of the Samoyed language, i. e. The Samoyed Grammar by M. Castrén
(1854). Schlözer insisted that the Samoyeds were an independent people, and that the
section of his Northern History devoted to their community was a traditional comprehensive
description of history, geography, customs, and language. The author determines
the place of the Samoyed language among the neighboring peoples, critically analyzing
the sources while offering a thematic Latin-Samoyed dictionary. Schlözer’s materials
were later referred to in the Comparative Dictionaries… by P. S. Pallas. I. S. Vater, realizing
the need for a new classification of sciences, headed the department of ethnography
and linguistics, thus re-defining the object of linguistics. Regularly addressing the
Samoyed language, as well as publishing texts, dictionaries and grammar notes in it,
both addressing his informants and actively cooperating with the international academic
community, Vater placed the Samoyed language into a rich academic context.
The activities of the conscientious and impartial authors in their particular academic
field demonstrates a long process of introducing their new information into circulation,
together with changes of visual description: from a mixed description (by Schlözer) to
the distinction between ethnography and linguistics (Vater). Refs 12
Christine Nöstlinger for French children. An analysis of the translation of "Einen Vater hab' ich auch"
No full textChristine Nöstlinger für französische Kinder. Eine Übersetzungsanalyse des Romans ?Einen Vater hab ich auch?Diese Diplomarbeit beschäftigt sich mit der Analyse eines deutschen Ausgangstextes und dessen Übersetzung in das Französische. Als Untersuchungsgegenstand wurde Christine Nöstlingers Roman ?Einen Vater hab ich auch? aus dem Jahre 1994 gewählt. Die französische Übersetzung ?J´ai aussi un père? wurde von Jeanne Étoré übersetzt und erschien 1997. "Einen Vater hab ich auch? enthält viele österreichische Kulturspezifika und Nöstlingers cha-rakteristische Ad-hoc-Schöpfungen und ist deshalb sehr aufschlussreich für eine Übersetzungsanalyse. Bei der Analyse nach Antoine Bermans ?tendances déformantes? wird das Hauptaugenmerk darauf gerichtet, wie die Übersetzerin Kulturspezifika übersetzt und inwie-fern Nöstlingers spezifischer Humor im französischen Text erhalten bleiben kann.Christine Nöstlinger for French children. An analysis of the translation of the novel ?Einen Vater hab ich auch?This diploma thesis deals with the analysis of a German source text and its French translation. The subject-matter is the novel ?Einen Vater hab ich auch?, written by Christine Nöstlinger and published in 1994. The French translation is entitled ?J´ai aussi un père? and was released in 1997. It was translated by Jeanne Étoré. The novel ?Einen Vater hab ich auch? contains a lot of Austrian cultural specifics as well as funny neologisms created by the author, which makes it quite interesting and illuminating for an analysis of source text and target text. The analysis according to Antoine Berman´s ?deforming tendencies? concentrates on the translation of cultural specifics and neologisms and describes, in which degree the author´s characteristic humour could be preserved in the French target text.vorgelegt von Karin BachnerAbweichender Titel laut Übersetzung der Verfasserin/des VerfassersGraz, Univ., Dipl.-Arb., 2009Text dt., teilw. franz
Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability
No full textabstract: Background
Recent advances in the treatment of cancer have focused on targeting genomic aberrations with selective therapeutic agents. In rare tumors, where large-scalec linical trials are daunting, this targeted genomic approach offers a new perspective and hope for improved treatments. Cancers of the ampulla of Vater are rare tumors that comprise only about 0.2% of gastrointestinal cancers. Consequently, they are often treated as either distal common bile duct or pancreatic cancers.
Methods
We analyzed DNA from a resected cancer of the ampulla of Vater and whole blood DNAfrom a 63 year-old man who underwent a pancreaticoduodenectomy by whole genomesequencing, achieving 37× and 40× coverage, respectively. We determined somatic mutations and structural alterations.
Results
We identified relevant aberrations, including deleterious mutations of KRAS and SMAD4 as well as a homozygous focal deletion of the PTEN tumor suppressor gene. These findings suggest that these tumors have a distinct oncogenesis from either common bile duct cancer or pancreatic cancer. Furthermore, this combination of genomic aberrations suggests a therapeutic context for dual mTOR/PI3K inhibition.
Conclusions
Whole genome sequencing can elucidate an oncogenic context and expose potential therapeutic vulnerabilities in rare cancers.The electronic version of this article is the complete one and can be found online at: http://genomemedicine.biomedcentral.com/articles/10.1186/gm35
Les deux « grammaires générales » de Johann Severin Vater sont-elles « générales »
No full textABSTRACT: In 1801, Johann Severin Vater published «Versuch einer allgemeinen Sprachlehre» («An Essay of a General Grammar») and in 1805,
Lehrbuch der allgemeinen Grammatik
(«A Manual of General Grammar»). Both titles include the qualitative adjective «general» by which Vater explicitly refers to the tradition of general grammars, initiated by Port-Royal. Moreover, Vater underlines several times in both texts the «general» nature of his analysis. Today however, both grammars are often described as entirely or at least partially historical and comparative works. This article deals with the principles of Vater’s analysis, his conception of general grammar and its application to linguistic facts. It seems possible to show, in accordance with the conviction of their author, that the two grammars actually fit in the tradition of general grammars and that «An Essay of a General Grammar» in particular represents a remarkable example of it.</jats:p
Les deux « grammaires générales » de Johann Severin Vater sont-elles « générales »
No full textABSTRACT: In 1801, Johann Severin Vater published «Versuch einer allgemeinen Sprachlehre» («An Essay of a General Grammar») and in 1805,
Lehrbuch der allgemeinen Grammatik
(«A Manual of General Grammar»). Both titles include the qualitative adjective «general» by which Vater explicitly refers to the tradition of general grammars, initiated by Port-Royal. Moreover, Vater underlines several times in both texts the «general» nature of his analysis. Today however, both grammars are often described as entirely or at least partially historical and comparative works. This article deals with the principles of Vater’s analysis, his conception of general grammar and its application to linguistic facts. It seems possible to show, in accordance with the conviction of their author, that the two grammars actually fit in the tradition of general grammars and that «An Essay of a General Grammar» in particular represents a remarkable example of it.RÉSUMÉ: En 1801 Johann Severin Vater publie Versuch einer allgemeinen Sprachlehre («Essai d’une grammaire générale») et en 1805, Lehrbuch der allgemeinen Grammatik («Manuel de la grammaire générale»). Dans les deux titres Vater qualifie donc son étude de «générale», qualification que, de plus, il revendique plusieurs fois dans les deux textes et par laquelle il renvoie à la tradition des grammaires générales ou rationnelles qui fut inaugurée par les Messieurs de Port-Royal. Néanmoins, plusieurs commentateurs modernes ont considéré que ces deux ouvrages relèvent seulement en partie ou même ne relèvent pas du tout de cette tradition mais s’inscrivent — au moins partiellement — dans le courant des grammaires historiques et comparées qui prend son essor à cette époque. L’étude cherche alors à élucider les principes d’analyse de Vater dans ces deux ouvrages, la conception de la grammaire générale de l’auteur et sa mise en application. Il nous semble possible de démontrer que, conformément à la conviction de l’auteur, aussi bien l’Essai que le Manuel relèvent bel et bien de la tradition des grammaires générales et que notamment l’Essai en constitue une illustration remarquable.Spitzl-Dupic Friederike. Les deux « grammaires générales » de Johann Severin Vater sont-elles « générales ». In: Histoire Épistémologie Langage, tome 25, fascicule 1, 2003. Politiques linguistiques (2/2) pp. 129-150
Supplementary movies of the dynamic rupture and tsunami models published in Ulrich et al. (2019)
No full text<p>Supplementary movies of the dynamic rupture and tsunami models published in Ulrich et al. (2019)</p>
<p>movie_Sulawesi_SR-cp.mov: Absolute slip rate (m/s) across the fault network during the earthquake. Author: Thomas Ulrich</p>
<p>movie_Sulawesi_wavefield-cp.mov: Absolute slip rate (m/s) and wavefield (absolute particle velocity in m/s) across the fault network during the earthquake. Author: Thomas Ulrich</p>
<p>SulawesiTanioka.mp4: Sea surface height (m) predicted by the tsunami scenario. Author: Stefan Vater</p>
<p>reference: Ulrich, T., Vater, S., Madden, E. H., Behrens, J., van Dinther, Y., van Zelst, I., Fielding, E. J., Liang, C. & Gabriel, A. A. (2019). Coupled, Physics-based Modeling Reveals Earthquake Displacements are Critical to the 2018 Palu, Sulawesi Tsunami. doi: 10.31223/osf.io/3bwqa.</p>
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