12 research outputs found
Isolasi dan Elusidasi Struktur Kimia Senyawa Flavonoid sebagai Inhibitor Enzim Α-Glukosidase dari Ekstrak Etanol Kulit Batang Raru (Vatica pauciflora Blume)
No full textRaru (Vatica pauciflora Blume) is a wild plant grows enormously in Central Tapanuli forest area.
Barks of this plant are utilized for antidiabetic medicine by boiling and consuming the decoction. The aim
of this study is to determine the chemical structure of bioactive compound from ethanolic extract of barks
of Raru (Vatica pauciflora Blume) that act as α-glucosidase enzyme inhibitor. Isolation was done by
extracting the barks using n-hexane, ethylacetate, ethanol, and water as solvents. The ethanolic extract
then were partitioned and run to column chromatography using SiO3 asd stationary phase. Compound
VpEt-9-4-4-1 isolated from ethanol extract showed α-glucosidase enzyme inhibition with IC50 93.46.
Based on spectral data of UV, FTIR. 1D NMR, 2D NMR (COSY, HMQC, HMBC) we got 2 methoxies,
1aromatic, and 1 carbonyl moieties. Compared to IUPAC data, compound VpEt-9-4-4-1 was determined
as as 3,4,9-trihydroxy-2-(hydroxymethyl)-8,10-dimethoxy-2,3,4-tetrahydropyrano-(3,2-c)-isochromen-6-
(10bH)-one with molecular formula C15H18O9. Mass measurement using HR-MS gave mass weight
341.087.Raru (Vatica pauciflora Blume) adalah tumbuhan yang banyak tumbuh liar di daerah hutan
Tapanuli Tengah. Kulit batang tanaman ini dimanfaatkan sebagai obat antidiabetes dengan cara merebus
dan meminumnya. Tujuan penelitian ini adalah untuk menentukan struktur kimia dari senyawa bioaktif
dari ekstrak etanol kulit batang Raru (Vatica pauciflora Blume) yang memiliki aktivitas sebagai
penghambat enzim α-glucosidase. Isolasi dilakukan dengan mengekstrak kulit batang menggunakan
pelarut n-heksan, etilasetat, etanol, dan air. Ekstrak etanol kemudian dipartisi dan dikromatografi kolom
menggunakan SiO3 sebagai fase diam. Senyawa VpEt-9-4-4-1yang diisolasi dari ekstrak etanol
memperlihatkan aktivitas penghambatan enzim α-glucosidase dengan IC50 93.46. Berdasarkan data
spektra UV, FTIR, NMR 1D, NMR 2D (COSY, HMQC, HMBC) diperoleh 2 metoksi, 1aromatik, dan 1
karbonil. Berdasarkan perbandingan data dengan IUPAC, senyawa VpEt-9-4-4-1 ditetapkan sebagai
3,4,9-trihidroksi-2-(hidroksmetil)-8,10-dimetoksi-2,3,4-tetrahidropirano-(3,2-c)-isokromen-6-(10bH)-
onedengan rumus molekul C15H18O9. Pengukuran massa menggunakan HR-MS memberikan bobot massa
341.087.104 HalamanDisertasi Dokto
Isolasi dan Elusidasi Struktur Kimia Senyawa Flavonoid sebagai Inhibitor Enzim Α-Glukosidase dari Ekstrak Etanol Kulit Batang Raru (Vatica pauciflora Blume)
No full textRaru (Vatica pauciflora Blume) is a wild plant grows enormously in Central Tapanuli forest area.
Barks of this plant are utilized for antidiabetic medicine by boiling and consuming the decoction. The aim
of this study is to determine the chemical structure of bioactive compound from ethanolic extract of barks
of Raru (Vatica pauciflora Blume) that act as α-glucosidase enzyme inhibitor. Isolation was done by
extracting the barks using n-hexane, ethylacetate, ethanol, and water as solvents. The ethanolic extract
then were partitioned and run to column chromatography using SiO3 asd stationary phase. Compound
VpEt-9-4-4-1 isolated from ethanol extract showed α-glucosidase enzyme inhibition with IC50 93.46.
Based on spectral data of UV, FTIR. 1D NMR, 2D NMR (COSY, HMQC, HMBC) we got 2 methoxies,
1aromatic, and 1 carbonyl moieties. Compared to IUPAC data, compound VpEt-9-4-4-1 was determined
as as 3,4,9-trihydroxy-2-(hydroxymethyl)-8,10-dimethoxy-2,3,4-tetrahydropyrano-(3,2-c)-isochromen-6-
(10bH)-one with molecular formula C15H18O9. Mass measurement using HR-MS gave mass weight
341.087.Raru (Vatica pauciflora Blume) adalah tumbuhan yang banyak tumbuh liar di daerah hutan
Tapanuli Tengah. Kulit batang tanaman ini dimanfaatkan sebagai obat antidiabetes dengan cara merebus
dan meminumnya. Tujuan penelitian ini adalah untuk menentukan struktur kimia dari senyawa bioaktif
dari ekstrak etanol kulit batang Raru (Vatica pauciflora Blume) yang memiliki aktivitas sebagai
penghambat enzim α-glucosidase. Isolasi dilakukan dengan mengekstrak kulit batang menggunakan
pelarut n-heksan, etilasetat, etanol, dan air. Ekstrak etanol kemudian dipartisi dan dikromatografi kolom
menggunakan SiO3 sebagai fase diam. Senyawa VpEt-9-4-4-1yang diisolasi dari ekstrak etanol
memperlihatkan aktivitas penghambatan enzim α-glucosidase dengan IC50 93.46. Berdasarkan data
spektra UV, FTIR, NMR 1D, NMR 2D (COSY, HMQC, HMBC) diperoleh 2 metoksi, 1aromatik, dan 1
karbonil. Berdasarkan perbandingan data dengan IUPAC, senyawa VpEt-9-4-4-1 ditetapkan sebagai
3,4,9-trihidroksi-2-(hidroksmetil)-8,10-dimetoksi-2,3,4-tetrahidropirano-(3,2-c)-isokromen-6-(10bH)-
onedengan rumus molekul C15H18O9. Pengukuran massa menggunakan HR-MS memberikan bobot massa
341.087.104 HalamanDisertasi Dokto
ASSESSMENT OF THE QUALITY OF CRUDE PALM OIL FROM ELAEIS GUINEENSIS GROWING AREAS OF THE PT. LANGKAT NUSANTARA KEPONG-PTPN II NORTH SUMATERA
No full textPalm oil is one of the major fats and oils produced in Indonesia, which is of great value in the diet of many people. The quality of palm oil could be affected by various factors ranging from improper postharvest handling, processing and storage. Recently, there has been wide spread speculation that palm oil is adulterated in order to maximize profit (Madubuike et al., 2015). The quality parameters of palm oil are generally determined by the moisture content, impurity, specific gravity, percentage of free fatty acid (FFA), iodine value, peroxide value and saponification values. The objective of this research therefore was to evaluate the quality of palm oil samples obtained from elaeis guineensis growing areas of the PT. Langkat Nusantara Kepong-PTPN II North Sumatera. The results showed that mean value of the quality parameters are 0.15% moisture content; 5.71% impurity level; 0.935 specific gravity;8.43% FFA; 52.13 iodine value; 13.71meq/kg peroxide value; and 181,89 mg KOH/g saponification value. The quality parameters are associated with the method of processing.Keywords: Moisture Content, Impurity, Specific Gravity, Percentage Of Free Fatty Acid, Iodine Value, Peroxide Value And Saponification Values
Identification Of Chemistry Bioactivity Structure Of Α- Glucosidase Inhibitor From Ethanol Extract Of The Stem Bark Raru (Vatica Pauciflora Blume)
No full textAntidiabetic Activity of Methoxy Bergenin Isolated from Ethanol Extract of Raru Stem Bark (Vatica pauciflora Blume) in Alloxan Induced Diabetic Wistar Rats
No full textDevelopment of Chemistry Practical Guide Book Innovative on General Chemistry Integrated Problem Based Learning Models
No full textAntimicrobial Activities of Some Indonesian Medicinal Plants against Propionibacterium acnes (ATCC 27853) and Staphylococcus epidermis (ATCC 12228) causing Acne
No full textEfektivitas Minyak Atsiri dan Ekstrak N-Heksana Daun Beluntas sebagai Insektisida Alami dengan Bioindikator Ulat Hongkong: Efektivitas Minyak Atsiri dan Ekstrak N-Heksana Daun Beluntas sebagai Insektisida Alami dengan Bioindikator Ulat Hongkong
No full textNatural insecticides are pest control materials derived from natural sources such as plants. The use of natural insecticides is very important because it has a lower cost, is safe for living things and does not pollute the environment, so this study aims to determine the activity of essential oils and n-hexane extracts of beluntas leaves (Pluchea indica L.) as natural insecticides with bioindicators of Hong Kong caterpillars (Tenebrio molitor). Isolation of essential oils was carried out using the steam distillation method and extraction using the maceration method. Insecticide activity tests used the contact poison method and the residue method, with variations in extract and essential oil concentrations of 1%, 3%, 5%, 7%, 10%, 20%, 30% (v/v) and positive controls, namely Hippo insecticide and negative control tween 80. The results of the isolation of essential oils from beluntas leaves produced a yield of 2%, while extraction using the maceration method produced a yield of 1.84%. The results of the insecticide activity test using the contact poison method were more effective than the residue method. The insecticidal activity and n-hexane extract are more effective than essential oils, this is due to the differences in the content of secondary metabolite compounds contained in the extract and essential oil.Insektisida alami adalah bahan pengendali hama yang berasal dari sumber – sumber alami seperti tanaman. Penggunaan insektisida alami sangat penting karena memiliki biaya yang lebih murah, dan keamanan bagi makhluk hidup dan tidak mencemari lingkungan sehingga penelitian ini bertujuan untuk mengetahui aktivitas minyak atsiri dan ekstrak n-heksana daun beluntas (Pluchea indica L.) sebagai insektisida alami dengan bioindikator ulat hongkong (Tenebrio molitor). Isolasi minyak atsiri dilakukan dengan menggunakan metode destilasi uap dan ekstraksi dengan metode maserasi. Uji aktivitas insektisida menggunakan metode racun kontak dan metode residu, dengan variasi konsentrasi ekstrak dan minyak atsiri sebesar 1%, 3%, 5%, 7%, 10%, 20%, 30% (v/v) serta kontrol positif yaitu insektisida Hippo dan kontrol negatif tween 80. Hasil isolasi minyak atsiri daun beluntas menghasilkan 2% rendemen, sedangkan ekstraksi dengan menggunakan metode maserasi menghasilkan 1,84% rendemen. Hasil uji aktivitas insektisida metode racun kontak lebih efektif dibandingkan metode residu. Aktivitas insektisida dan ekstrak n-heksana lebih efektif dibandingkan minyak atsiri dikarenakan perbedaan kandungan senyawa metabolit sekunder yang terkandung dalam ekstrak dan minyak atsiri
Bioactivity of Ginger (Zingiber officinale Rosc), Citronella (Cymbopogonnardus (L.) and Cinnamon (Cinnamomum burmannii B) Against Decreased Blood Sugar Levels of Alloxan-induced (Rattus Novergicus)
No full textPurpose: To see the potency of mixed extracts of Ginger (Zingiber officinal Rosc.), Citronella (Cymbopogon nardus (L.) Randle, Cinnamon (Cinnamomum burmanii B.) Against blood sugar levels in alloxan-induced Novergicus Rattus male rats.
Theoretical reference: Insulin resistance is necessary to maintain dysglycemia, where insulin levels are higher than usual. Insulin resistance often occurs in people who are overweight, commonly known as obesity. 2. Pancreatic B Cell Dysfunction, decreased pancreatic beta cell function, and continued increase in insulin resistance, causing chronic hyperglycemia and stage liver disease. 3. Environmental factors are individuals who consume excessive carbohydrates and sugars.
Method: Using Complete Randomized Design (RAL) consisting of 7 groups with 4 repetitions, namely K0 (Normal group), K- (Negative group), K+ (Positive group given meformin), K1, K2, K3 and K4 (mixed extracts of ginger, lemongrass, cinnamon 100, 200, 300 and 400mg/kg bw), The data obtained were analyzed using ANOVA with a sig < 0.05.
Results and conclusion: It showed that the administration of mixed extracts of Ginger (Zingiber officinal Rosc.), Citronella (Cymbopogon nardus (L.) Randle, Cinnamon (Cinnamomum burmanii B.) affected reducing blood glucose levels and improving pancreatic histology. A mixed extract dose of Ginger (Zingiber officinal Rosc.), Citronella (Cymbopogon nardus (L.) Randle, Cinnamon (Cinnamomum burmanii B.) 400 mg/kg bw was most effective in lowering blood glucose levels and improving alloxan-induced pancreatic histology.
Implications of the research: When you want to control blood sugar, you can use a mixture of Ginger (Zingiber officinale Rosc), Citronella (Cymbopogonnardus (L.), and Cinnamon (Cinnamomum burmannii B) extracts in balanced portions).
Originality/Value: Ginger (Zingiber officinale Rosc), Citronella (Cymbopogon Nardus (L.), and Cinnamon (Cinnamomum burmannii B) have potential as herbal medicine ingredients
PENGARUH TEKNOLOGI IT PADA MODEL PEMBELAJARAN DISCOVERY CONSTRUCTIVE LEARNING UNTUK MENINGKATKAN PEMAHAMAN SISWA MENGENAI ZAT ADITIF MAKANAN DI KELAS VIII SMP KALAM KUDUS MEDAN
No full textThis research aims for knowing is there is difference enhancement results study chemistry SMP Kalam Kudus Medan using flash animation media with Ms. Power Point on the Discovery Constructive Learning model. The population in this study were students class VIII-B and VIII-C SMP Kalam Kudus Medan. Taking sample study taken by purposive sampling consisting of from class learning Discovery Constructive Learning with flash animation media and in class learning Discovery Constructive Learning with Ms. Power Point media. Type this research is research experiment pseudo . Based on the results of the data requirements test , it is known that both the result data study student class learning Discovery Constructive Learning with flash animation media and class Discovery Constructive Learning with Ms. Power Point media is stated is normally distributed and has uniform variance (homogeneous) . Based on the normalized gain data , the increase in results learn using _ learning Discovery Constructive Learning with flash animation media is 84.43% and an increase results learn using _ Discovery Constructive Learning with Ms. Power Point media is 71.06 %. The size difference enhancement results study chemical students is 13.37%. Test results hypothesis , obtained t < -t½α and t > t½α by using t test two party namely 0.0437 < -0.025 and 0.0437 > 0.025 at the level significance = 0.025. This means that H0 is rejected and Ha is accepted , where Ha = exists difference enhancement results study chemistry SMP Kalam Kudus Medan using flash animation media with Ms. Power Point on the Discovery Constructive Learning model for class VIII SMP Kalam Kudus Medan on the subject discussion substance additive food 2013/2014.
Keywords: Discovery Constructive Learning model, IT media , SMP Kalam Kudus Meda
