4,875 research outputs found
Proliferating cell nuclear antigen as a molecular biomarker for spermatogenesis in PTU-induced hypothyroidism of rats
No full textThe thyroid hormone has few serious effects on the testes except during the neonatal stage. There is little knowledge concerning the prolonged effect of thyroid hormone deficiency throughout the rat's life span and its effect on spermatogenesis. Proliferating cell nuclear antigen (PCNA) is a nuclear matrix protein, which is essential for multiple cell cycle pathways. Here we used PCNA immunohistochemistry as a marker to differentiate between the testes of control and hypothyroid rats. About 20 rats were equally divided into 2 groups; the first group was the control group, while the second group was the experimental group in which rats were fed 0.05% 6-n-propyl thiouracil (PTU) in drinking water for 6 weeks. Immunohistochemistry, using an antibody against PCNA, showed at least 3 differences in the pattern of PCNA immunoreactivity (PCNA-ir). First, PCNA-ir was not detected in Sertoli and Leydig cells in the testes of control rats and detected in some of the hypothyroid rats. Second, in the control group more than 96% of spermatogonia were PCNA-positive cells; however, hypothyroidism caused the reduction to approximately 25% PCNA staining in spermatogonia. The third difference was in the abnormal distribution of spermatogonia seen in the hypothyroid rat testis, not in the control one. These results suggest that prepubertal hypothyroidism affects the proliferation of spermatogenic cells leading to impaired spermatogenesis and that PCNA index is a useful marker for assessing germ cell kinetics and spermatogenesis in prepubertal hypothyroidism
UPAYA MENANGGULANGI TERJADINYA KETERLAMBATAN DALAM PROSES PEMBONGKARAN MUATAN PUPUK CURAH DI ATAS MV. IBRAHIM ZAHIER
No full textTri Cahyo Nugroho, NIT. 49124431. N, 2017, “effort of overcome the delay unloading process of bulk fertilizer on MV. Ibrahim Zahier”, Program Diploma IV, Nautika, Politeknik Ilmu Pelayaran Semarang, Pembimbing I: Capt. Didi Sumadi, M.M., M.Mar dan Pembimbing II: Achmad Wahyudiono, M.M., M.Mar.E,
The development of sea transportation is now advancing so rapidly, especially in terms of port. If talking about the port, then talking about ship. In addition to being used as a means of sea transportation, the vessel is also used in the process of loading and unloading at the port. In the implementation of constraints in the process of loading and unloading is still exist. The obstacle that occur in process unloading, among others, the occurrence of damage to the unloading equipment and clumping on the load carried the bulk fertilizer. Then through these obstacles, the author takes the title “effort of overcome the delay unloading process of bulk fertilizer on MV. Ibrahim Zahier”. In the theoretical foundation contains some theory which is like the definition of loading and unloading which is an activity of load or unload with using crane/conveyor or the other equipment. In accordance with scientific principles, in the writing of this essay, the author uses the method of research that is USG method ((Urgency, seriously, growth) with using data collection techniques, i.e. by observation, interview and literature study on the MV. Ibrahim Zahier during the implementation sea project. Form the results of research during the implementation of sea project on vessel, the authors found an obstacle which result in delay in the process of loading and unloading of bulk fertilizer. The damage to unloading equipment is due to lack of regular maintenance and company delay in spending spare part. For clumping on the load caused by contaminated loads with water and poorly maintained fertilizer quality. The conclusion of the research is that the process of unloading the cargo on MV. Ibrahim Zahier is not always running smoothly. The delay constraints caused by the damage to unloading equipment and clumping on the load. For that by doing regular maintenance and compacting the existing load, then the process of unloading is expected run smoothly.
Key word : delay time, tool breakdown
Treatment with folic acid ameliorated the histopathological alterations caused by propylthiouracil-induced hypothyroid rat testes
No full textHypothyroidism is an underactive thyroid gland that cannot make enough thyroid hormone to keep the body running normally. Here we studied the histopathological, immunohistochemical, and ultrastructural changes in the hypothyroid rat testes at the postpubertal stage, in addition to the ameliorating role of folic acid in enhancing spermatogenesis, boosting sperm concentration and building up the antioxidant status against the oxidants. A total of 50 male albino rats were equally divided into 5 groups; the first and second groups comprised the control and folic acid groups, respectively; while the third group comprised the hypothyroid group in which rats received 6-n-propyl-2-thiouracil in drinking water for 6 weeks to induce hypothyroidism. The fourth and fifth groups comprised hypothyroid rats treated with folic acid for 4 weeks and dissected after 6 and 10 weeks, respectively. Testes in the hypothyroid rats showed marked morphological and histological changes in the seminiferous tubules with a reduction in sperm count. Our results indicate that hypothyroidism adversely affects spermatogenesis, suggesting that thyroid hormone might play an important role not only in controlling normal testicular development but also in maintaining normal testicular function and spermatogenesis. Further, we suggested an ameliorating role of folic acid in the relief of testicular tissue from changes due to hypothyroidism. However, we found that the best results were found in cases where folic acid was used as an adjuvant therapy for returning to the euthyroid state
Authority and Personality in M.M. Bakhtin\u27s Author and Hero in Aesthetic Activity
No full textM.M. Bakhtin\u27s fundamental claim in his seminal essay Author and Hero in Aesthetic Activity situates verbal action as the most essential constituent of human personality. A careful reading of this text reveals important truths about the relationship between free individual personhood and the nature of the speech utterance. Bakhtin connects the human experience of speech to the life and person of Jesus Christ emphasizing the incarnation and the Trinitarian view of God as essential principles for understanding the creative power of the word and consequent liabilities. Bakhtin develops these theological and philosophical coordinates around a discussion of the author-hero relationship in the novel asserting that the verbal utterance is creatively involved in building and sustaining the inner personhood of those it addresses. Bakhtin\u27s critical conclusion substantiates that from whom a word is received, and to whom the spoken word appeals has weighty influence on the type and character of human personality, and that personality\u27s relationship to authority
Documento Bancario, M.M. Mayence & Cie., Paris, 1908 Junio 14
No full textabstract: Handwritten letter from Rubén Darío to M.M. Mayence & Cie, informing about one meeting with the Spain's King and the location of Nicaraguan legation in Madrid.The original Rubén Darío Papers 1882-1945 (MSS-339) are located at ASU Libraries Archives & Special Collections. For more information about visiting the collection see http://hdl.handle.net/2286/L.A.0.The top margin has the hand written word "Particular" ("Private, Personal").In the left top margin apparently are written the words "Documento 267" ("Documento 267").Heading the letter there is a reference to a person called Santiago, whose last name hasn't been identified
M.M. Arkas: through the correlation between professional and patriotic
No full textУ статті розглянуто проблему співвідношення у творчому спадку М.М. Аркаса,
композитора, історика, громадського діяча, професійних і патріотичних засад. Проаналізовано
життєдіяльність М.М. Аркаса та виявлені основні чинники, що вплинули на формування його
світоглядних уявлень і врешті сприяли становленню у представника грецького роду українського
менталітету.В статье рассматривается проблема соотношения в творческом наследии Н.Н. Аркаса, композитора,
историка и общественного деятеля, профессионализма и патриотизма. Анализируется жизнедеятельность
Н.Н. Аркаса и выявляются основные компоненты, что способствовали формированию его духовного космоса
и становлению у представителя греческого рода украинского менталитета.The article examines the issues of rating the professional and patriotic constituents in the creative legacy of
M.M. Arkas, - the composer, historian and social activist. By researching into the life of M.M. Arkas, the author uncovers
the key factors and events that influenced the formation of his spiritual cosmos and thus eventually conduced
to moulding the Ukrainian mentality in a member of the Greek kinship
M.M. Arkas: through the correlation between professional and patriotic
No full textУ статті розглянуто проблему співвідношення у творчому спадку М.М. Аркаса,
композитора, історика, громадського діяча, професійних і патріотичних засад. Проаналізовано
життєдіяльність М.М. Аркаса та виявлені основні чинники, що вплинули на формування його
світоглядних уявлень і врешті сприяли становленню у представника грецького роду українського
менталітету.В статье рассматривается проблема соотношения в творческом наследии Н.Н. Аркаса, композитора,
историка и общественного деятеля, профессионализма и патриотизма. Анализируется жизнедеятельность
Н.Н. Аркаса и выявляются основные компоненты, что способствовали формированию его духовного космоса
и становлению у представителя греческого рода украинского менталитета.The article examines the issues of rating the professional and patriotic constituents in the creative legacy of
M.M. Arkas, - the composer, historian and social activist. By researching into the life of M.M. Arkas, the author uncovers
the key factors and events that influenced the formation of his spiritual cosmos and thus eventually conduced
to moulding the Ukrainian mentality in a member of the Greek kinship
M.M. Arkas: through the correlation between professional and patriotic
No full textУ статті розглянуто проблему співвідношення у творчому спадку М.М. Аркаса,
композитора, історика, громадського діяча, професійних і патріотичних засад. Проаналізовано
життєдіяльність М.М. Аркаса та виявлені основні чинники, що вплинули на формування його
світоглядних уявлень і врешті сприяли становленню у представника грецького роду українського
менталітету.В статье рассматривается проблема соотношения в творческом наследии Н.Н. Аркаса, композитора,
историка и общественного деятеля, профессионализма и патриотизма. Анализируется жизнедеятельность
Н.Н. Аркаса и выявляются основные компоненты, что способствовали формированию его духовного космоса
и становлению у представителя греческого рода украинского менталитета.The article examines the issues of rating the professional and patriotic constituents in the creative legacy of
M.M. Arkas, - the composer, historian and social activist. By researching into the life of M.M. Arkas, the author uncovers
the key factors and events that influenced the formation of his spiritual cosmos and thus eventually conduced
to moulding the Ukrainian mentality in a member of the Greek kinship
Plant introduction, conservation and enrichment of biodiversity in M.M. Gryshko National Botanical Garden of the NAS of Ukraine
No full textThe paper deals with the main achievements of scientists of M.M. Gryshko National Botanical Garden of the NAS of Ukraine (NBG) in scientific, conservation, cultural and educational activities. The results of researches on biodiversity, conservation, plants protection, introduction, acclimatization and selection, allelopathy, medical botany, landscape design, bioindication and hemosystematycs are given. It is noted that over 14 thousands species, forms and varieties of plants, are collected in NBG, and the most unique collections attributed to the objects of national heritage. Breeders have obtained more than 300 certificates or author ship on plant varieties. NBG carries out extensive international cooperation, several new exposition of plant collection appeared in Botanical Garden. In recent years the achievements of NBG scientists were awarded by two State Awards in the field of science and technology of Ukraine
Perception of M.M. Bakhtin in the West: some general remarks
No full textIn the present work is a translation of the short introductory work of Turin’s Professor Roberto Salizzoni dedicated to the analysis of art of M.M. Bakhtin and some reflections of the author of the translation, which led him to assess creativity Russian thinker, present in this book of the Italian scientist. First of all, the author of the translation does not agree with the disparaging assessment of creativity of Bakhtin how unoriginal and more abounding plagiarism. The author of the translation argues injustice exaggerated influence on the concept of Bakhtin from literary trends and ideas, including by the media those of the so-called “circle of Bakhtin”. The necessity of considering of creativity of Russian thinker as philosophical, creativity independent and original. Such a conclusion can fail and approval of Neokantian origin of “philosophical roots” of Bakhtin’s concept of philosophy of culture
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