121,609 research outputs found
Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease
No full textTo date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic determinants shared among these involved tissues. To characterize these T cells at the molecular level, we compared the T cell antigen receptor (TcR) variable (V) region gene usage in thyroid, retroorbital, pretibial tissue, and peripheral blood mononuclear cells of two patients with Graves' disease, ophthalmopathy, and pretibial dermopathy. Ribonucleic acid was extracted, reverse transcribed, and amplified using the PCR and 22 V alpha and 23 V beta gene-specific oligonucleotide primers. The resulting TcR V alpha and V beta transcripts were verified by Southern hybridization analysis using TcR C region-specific, digoxigenin-labeled oligonucleotide probes. In addition, complementarity determining regions 3 and junctional regions of TcR V beta genes were sequenced. Marked similarities of intrathyroidal, retroorbital, and pretibial TcR V alpha and V beta gene repertoires were noted with respect to the degree of TcR V gene restriction and the patterns of individual V genes expressed. Sequence analysis of junctional domains of V beta families revealed oligoclonality of intrahyroidal, retroorbital, and pretibial T cells. In addition, certain conserved junctional motifs were shared by T cells derived the thyroid gland and the extrathyroidal sites. Our results suggest that in the two patients with Graves' disease and extrathyroidal manifestations studied, similar antigenic determinants may have contributed to the recruitment and oligoclonal expansion of T cells both within the thyroid gland and at the involved extrathyroidal sites
Marilyn Graves interview, 2001
No full textGraves, Marilyn - Audio Oral History Interview - CSWA ❧ Interviewed by Katherine Schlottman on March 29, 2001. An interview with Marilyn Graves as she discusses her early interest in social work; the development of the Crippled Children's society; various positions held; and participation in commissions and committees focused on children and adults with disabilities. ❧ Marilyn Graves. Interviewed by Katherine Schlottman. Date of interview: 3-29-01. Length of interview: 45 minutes. Transcript of interview: 29 pp. CD containing interview and transcript. ❧ ADDITIONAL MATERIALS: 1.Curriculum Vitae. 2. Photograph
To Live Amongst the Dead: an Ethnographic Exploration of Mass Graves in Cambodia
No full textThis thesis uses mass graves as a lens through which to examine how people in contemporary Cambodia use the Khmer Rouge period (1975 – 1979) to reconstitute and re-imagine the world they live in. Based on sixteen months of multisited ethnographic fieldwork, this thesis will argue that the Khmer Rouge regime was a critical event (Das 1997) in Cambodian life, and as such has triggered a re-shaping of relationships between local and the national, and the national and the global, leading to new forms of social and community life and action in post Khmer Rouge Cambodia. As physical markers of violence and political instability, mass graves are inherently political and articulate these re-imaginations on the state, community, and individual level. The Cambodian state exercises and legitimates its authority by constructing modern history in reference to a narrative of liberation from the Khmer Rouge, and the ‘innocent suffering’ of Cambodia and its people, while local communities use Buddhism and animism to narrate and conceptualise the period, bringing it into expected and understandable events within Khmer Buddhist cosmology. These approaches are not necessarily in opposition to one another, but rather represent the overlapping plurality of connections with mass graves.
This thesis provides a unique exploration of social relationships to mass graves in Cambodia contributing to debates within the anthropology of politics, violence and collective memory by examining how moments of national mass violence re-shape the state and relationships within it, and how destructive periods of violence nonetheless create new fields for the imagination of the political, the religious, and the social. It also contributes to the emerging field of Cambodian ethnography that combines local considerations with wider national and geo-political discourses and how these are played out at the local level
author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Ocorrência de carcinoma de tireóide em pacientes com doença de graves submetidos à tireoidectomia para controle do hipertireoidismo
No full textTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Médica, Curso de Medicina, Florianópolis, 200
The rs1990760 polymorphism within the IFIH 1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease
No full textBackground: Three genes have been confirmed as major joint susceptibility genes for endocrine autoimmune disease:human leukocyte antigen class II, cytotoxic T-lymphocyte antigen 4 and protein tyrosine phosphatase non-receptor type 22. Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD). Methods: The aim of the present study was to investigate the role of the rs1990760 polymorphism within the IFIH1 gene in German patients with GD (n=258), Hashimoto's thyroiditis (HT,n=106), Addison's disease (AD,n=195) and healthy controls (HC,n=227) as well as in 55 GD families (165 individuals, German) and 100 HT families (300 individuals, Italian). Furthermore, the interaction between rs1990760 polymorphism with human leukocyte antigen (HLA) risk haplotype DQ2(DQA*0501-DQB*0201), the risk haplotypes DQ2/DQ8 (DQA*0301-DQB*0302) and the status of thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb) and TSH receptor antibody (TRAb) in patients and families were analysed. Results:No significant differences were found between the allele and genotype frequencies for rs1990760 IFIH1 polymorphism in patients with GD, HT, AD and HC. Also no differences were observed when stratifying the IFIH1 rs1990760 polymorphism for gender, presence or absence of thyroid antibodies (GD:TRAb and HT:TPOAb/TgAb) and HLA risk haplotypes (DQ2:for GD and HT, DQ2/DQ8:for AD). Furthermore the transmission analysis in GD and HT families revealed no differences in alleles transmission for rs1990760 IFIH1 from parents with or without HLA risk haplotype DQ2 to the affected offspring. In contrast, by dividing the HT parents according to the presence or absence of thyroid Ab titers, mothers and fathers both positive for TPOAb/TgAb overtransmitted the allele A of IFIH1 rs1990760 to their HT affected offspring (61.8% vs 38.2%;p=0.05;corrected p [pc]=0.1). However, these associations did not remain statistically significant after correction of the p-values. Conclusion: In conclusion, our data suggest, no contribution from IFIH1 rs1990760 polymorphism to the pathogenesis of either Graves' disease, Hashimoto's thyroiditis or Addison's disease in our study populations. However, in order to exclude a possible influence of the studied polymorphism in specified subgroups within patients with autoimmune thyroid disease, further investigations in larger populations are needed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Introduction to Special Issue "War Graves / Die Bauaufgabe Soldatenfriedhof, 1914-1989"
No full textCommemoration of the dead is intricately linked to the history of civilization itself. Consequently, art history (understood in a broad sense, encompassing architectural history, social history of art, aesthetics, political iconography, etc.) is characterized by a long tradition of paying minute attention to Christian and profane iconography of chapels, epitaphs, and death dances; and to memorials, tombs, and other manifestations, particularly with regard to the Middle Ages and Early Modern Times. Twentieth century war graves, war cemeteries, memorial shrines, and burial sites of the fallen, however, have received only little attention. This assessment was the starting point of our joint endeavor: If the history of conflicts and wars, and the history of war death in particular, is such a major topic for the humanities at large, and especially for contemporary and cultural history, memory studies, etc., then the question arises to what degree art history can contribute to that ongoing discourse.
Sketching a Potentially Global Field of Research
Table of Contents
Acknowledgements
Sources and Materials
Basic Research on War Graves and War Cemeteries in The Political Archive of the Federal Foreign Office in Berlin / Kriegsgräber im Politischen Archiv des Auswärtigen Amtes in Berlin
The Archive of the German War Graves Commission in Kassel / Das Archiv des Volksbundes Deutsche Kriegsgräberfürsorge e. V. in Kassel
War Graves, War Cemeteries, and Memorial Shrines since 1914: A Selected Bibliography
Selected Printed Source Materia
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