4,754 research outputs found
The rs1990760 polymorphism within the IFIH 1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease
No full textBackground: Three genes have been confirmed as major joint susceptibility genes for endocrine autoimmune disease:human leukocyte antigen class II, cytotoxic T-lymphocyte antigen 4 and protein tyrosine phosphatase non-receptor type 22. Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD). Methods: The aim of the present study was to investigate the role of the rs1990760 polymorphism within the IFIH1 gene in German patients with GD (n=258), Hashimoto's thyroiditis (HT,n=106), Addison's disease (AD,n=195) and healthy controls (HC,n=227) as well as in 55 GD families (165 individuals, German) and 100 HT families (300 individuals, Italian). Furthermore, the interaction between rs1990760 polymorphism with human leukocyte antigen (HLA) risk haplotype DQ2(DQA*0501-DQB*0201), the risk haplotypes DQ2/DQ8 (DQA*0301-DQB*0302) and the status of thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb) and TSH receptor antibody (TRAb) in patients and families were analysed. Results:No significant differences were found between the allele and genotype frequencies for rs1990760 IFIH1 polymorphism in patients with GD, HT, AD and HC. Also no differences were observed when stratifying the IFIH1 rs1990760 polymorphism for gender, presence or absence of thyroid antibodies (GD:TRAb and HT:TPOAb/TgAb) and HLA risk haplotypes (DQ2:for GD and HT, DQ2/DQ8:for AD). Furthermore the transmission analysis in GD and HT families revealed no differences in alleles transmission for rs1990760 IFIH1 from parents with or without HLA risk haplotype DQ2 to the affected offspring. In contrast, by dividing the HT parents according to the presence or absence of thyroid Ab titers, mothers and fathers both positive for TPOAb/TgAb overtransmitted the allele A of IFIH1 rs1990760 to their HT affected offspring (61.8% vs 38.2%;p=0.05;corrected p [pc]=0.1). However, these associations did not remain statistically significant after correction of the p-values. Conclusion: In conclusion, our data suggest, no contribution from IFIH1 rs1990760 polymorphism to the pathogenesis of either Graves' disease, Hashimoto's thyroiditis or Addison's disease in our study populations. However, in order to exclude a possible influence of the studied polymorphism in specified subgroups within patients with autoimmune thyroid disease, further investigations in larger populations are needed
Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease
No full textTo date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic determinants shared among these involved tissues. To characterize these T cells at the molecular level, we compared the T cell antigen receptor (TcR) variable (V) region gene usage in thyroid, retroorbital, pretibial tissue, and peripheral blood mononuclear cells of two patients with Graves' disease, ophthalmopathy, and pretibial dermopathy. Ribonucleic acid was extracted, reverse transcribed, and amplified using the PCR and 22 V alpha and 23 V beta gene-specific oligonucleotide primers. The resulting TcR V alpha and V beta transcripts were verified by Southern hybridization analysis using TcR C region-specific, digoxigenin-labeled oligonucleotide probes. In addition, complementarity determining regions 3 and junctional regions of TcR V beta genes were sequenced. Marked similarities of intrathyroidal, retroorbital, and pretibial TcR V alpha and V beta gene repertoires were noted with respect to the degree of TcR V gene restriction and the patterns of individual V genes expressed. Sequence analysis of junctional domains of V beta families revealed oligoclonality of intrahyroidal, retroorbital, and pretibial T cells. In addition, certain conserved junctional motifs were shared by T cells derived the thyroid gland and the extrathyroidal sites. Our results suggest that in the two patients with Graves' disease and extrathyroidal manifestations studied, similar antigenic determinants may have contributed to the recruitment and oligoclonal expansion of T cells both within the thyroid gland and at the involved extrathyroidal sites
A 0.96-mW dB-Linear Variable Gain Amplifier With 0.4-dB Linearity Error Over a 62.4-dB Gain Tuning Range
No full textThis letter presents a low-power dB-linear variable gain amplifier (VGA) with a small linear-in-dB error over a wide gain tuning range. An exponential current ratio is realized in the linear-in-dB control circuit based on the subthreshold I-V characteristic. The VGA is built with subthreshold common-gate transistors as current steering, accurately replicating the exponential current ratio and forming a tunable gain. Implemented in 55-nm CMOS technology, the proposed VGA occupies a compact active area of 0.011 mm2 excluding the buffer. It achieves a linear-in-dB error of 0.4 dB over a gain tuning range of 62.4 dB, corresponding to the state-of-the-art relative error of 0.6%. The proposed design shows constant 80-MHz bandwidth with a power consumption of 0.96 mW. Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic Instrumentatio
DB 2020: Analyzing and Forecasting DB Market Trends
No full textabstract: Over the last two decades, Alternative Project Delivery Methods (APDM), such as Design-Build (DB), have become more popular in the construction industry, specifically in the U.S., and the competition for APDM projects has risen among construction companies. The Engineering News Record (ENR) magazine analyzes DB firms and publishes the list of the top 100 every year. According to ENR articles and many scientific papers, the implementation of DB method has grown drastically over the last decade, however, information about growth trends depending on firm size and segment is lacking. Also missing is knowledge the future market trends over the next five years. Furthermore, public agencies and DB firms may be worried that DB projects do not distribute wealth equally among DB firms. Using the top 100 firms deemed representative of the DB market, the author has divided the market into volumes based on rankings to analyze the total DB market revenue growth. A comparison between international and domestic revenues indicated that the top five DB firms have 64% more involvement in the international market compared to the domestic market. Furthermore, while the research shows increasing market share only for the top five firms, the author has found that (1) a large portion of their market share is due to a large growth in their international market, and (2) revenues for all volumes of the DB market have increased. Moreover, regression and time series analyses allow for the forecasting of the DB market growth, which the author anticipate to move from about 150B in 2020.Dissertation/ThesisMasters Thesis Construction 201
A -109.1 dB/-98 dB THD/THD+N Chopper Class-D Amplifier with >83.7 dB PSRR Over the Entire Audio Band
No full textThis paper reports a chopper Class-D audio amplifier that obtains high PSRR over the entire audio band. A chopping scheme is proposed to minimize intermodulation distortion between pulse-width modulation (PWM) and chopping in the audio band. A high-voltage chopper is developed to handle a 14.4 V PWM signal. Timing matching techniques are proposed to minimize chopping nonidealities which ensure good PSRR and THD. Fabricated in a 180nm BCD process, the prototype obtains a PSRR >109 dB at 217 Hz and >83.7 dB over the entire audio band. It also achieves -109.1 dB/-98 dB THD/THD+N and can deliver a maximum of 13 W to an 8-Ω load.Accepted author manuscriptElectronic Instrumentatio
A - 121.5-dB THD Class-D Audio Amplifier With 49-dB LC Filter Nonlinearity Suppression
No full textClass-D audio amplifiers produce electromagnetic interference (EMI), which often needs to be suppressed by an external LC filter. However, due to component nonlinearity, this filter can itself cause significant distortion. This article presents a class-D amplifier that suppresses LC filter nonlinearity by 49 dB and is robust to ±30% variations in its cutoff frequency. This is achieved by a dual-loop architecture, in which an inner loop provides stability, while an outer loop provides the high gain needed to suppress the LC filter and output-stage nonlinearity. A prototype, implemented in a 180-nm BCD process, achieves -121.5-dB total harmonic distortion (THD) and -107.1-dB THD+N, which is maintained to within 3 dB even as the LC filter cutoff frequency is varied from 62 to 106 kHz. It can deliver a maximum of 21 W into a 4-Ω load with 87% efficiency and 12 W into an 8-Ω load with 91% efficiency, measured at 10% THD. Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
Ocorrência de carcinoma de tireóide em pacientes com doença de graves submetidos à tireoidectomia para controle do hipertireoidismo
No full textTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Médica, Curso de Medicina, Florianópolis, 200
A Dynamic Zoom ADC with 109-dB DR for Audio Applications
No full textThis paper presents the first dynamic zoom ADC. Intended for audio applications, it achieves 109-dB DR, 106-dB signal-to-noise ratio, and 103-dB SNDR in a 20-kHz bandwidth, while dissipating only 1.12 mW. This translates into the state-of-the-art energy efficiency as expressed by a Schreier FoM of 181.5 dB. It also achieves the state-of-the-art area efficiency, occupying only 0.16 mm2 in the 0.16- μm CMOS. These advances are enabled by the use of concurrent fine and coarse conversions, dynamic error-correction techniques, and a dynamically biased inverter-based operational transconductance amplifier.Accepted author manuscriptElectronic Instrumentation(OLD)Applied Quantum ArchitecturesMicroelectronic
A 280 <i>μ</i>W Dynamic Zoom ADC With 120 dB DR 118 dB SNDR in 1 kHz BW
No full textThis paper presents a dynamic zoom analog-to-digital converter for use in low-bandwidth (&lt;1 kHz) instrumentation applications. It employs a high-speed asynchronous successive approximation register (SAR) ADC that dynamically updates the references of a fully differential &#x0394; &#x03A3; ADC. Compared to previous zoom ADCs, faster reference updates relax the loop filter requirements, thus allowing the adoption of energy-efficient amplifiers. Fabricated in a 0.16-&#x03BC;m CMOS process, the prototype occupies 0.26 mm&#x00B2; and achieves 119.1-dB peak signal-to-noise ratio (SNR), 118.1-dB peak signal-to-noise-and-distortion-ratio (SNDR), and 120.3-dB dynamic range (DR) in a 1-kHz bandwidth while consuming 280 &#x03BC;W. This results in a Schreier figure of merit (FoM) of 185.8 dB.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic Instrumentation(OLD)Applied Quantum ArchitecturesMicroelectronic
A 590 μw, 106.6 dB SNDR, 24 kHz BW Continuous-Time Zoom ADC with a Noise-Shaping 4-bit SAR ADC
No full textThis paper presents a continuous-Time zoom ADC for audio applications. It combines a 4-bit noise-shaping coarse SAR ADC and a fine delta-sigma modulator with a tail-resistor linearized OTA for improved linearity, energy efficiency, and handling of out-of-band interferers compared to previous designs. In 160 nm CMOS, the prototype chip occupies 0.36 mm2, achieves 107.2 dB SNR, 106.6 dB SNDR, and 107.3 dB dynamic range in a 24 kHz bandwidth while consuming 590 μW from a 1.8 V supply. This translates into a Schreier figure-of-merit (FoMs) of 183.4 dB and a FoMSNDR of 182.7 dB. Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
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