1,721,008 research outputs found
Coeficiente de correlación de Spearman
No full textCoeficiente de correlación de Spearman de indicadores bibliométricos</p
Fuentes primarias Producción Científica sobre Cáncer Bucal
No full textFuentes primarias Producción Científica sobre Cáncer Bucal</p
Papel de los inhibidores de la proteasa en la patogénesis de la neuropatía alcohólica
Full text linkBackground: Alcoholic neuropathy is a common complication among patients with alcohol abuse disorder. It is often asymptomatic and the frequency of occurrence varies. We propose that the deficit of protease inhibitors could be a causal factor of alcoholic neuropathy. If this is true, it would contribute to understanding of the pathophysiology, explain variability in individual response, and explain variability in individual response, and facilitate the search for prevention therapy.Development: Alcoholic neuropathy is characterized by a pattern of symmetrical polyneuropathy with great involvement of the lower extremities. The mechanisms of axonal degeneration due to alcohol consumption are still unclear. It is known that alcohol inhibits protection mechanisms of the nervous system. Here, we discuss that the deficit of protease inhibitors could be a causal factor in the pathogenesis of alcoholic neuropathy. If this is true, it would contribute to an understanding of the pathophysiology, explain variability in individual response, and facilitate the search for prevention therapy.Conclusions: The protease inhibitors play a significant role in the origin of peripheral neuropathies. There is strong evidence to suggest that proteases and their inhibitors are related to processes that allow the development and maintenance of peripheral nerves, and alterations in their proportions favor the development of anomalies in such structures. The mechanisms through which these molecules trigger the disease are unclear in most cases. An increase in the number of investigations in this area would undoubtedly contribute to preventing and combating a disease which strikes a significant number of people.Antecedentes: La neuropatía alcohólica es una complicación común entre los pacientes con trastorno por abuso de alcohol. Suele ser asintomática y su frecuencia de aparición es variable. Proponemos que el déficit de inhibidores de la proteasa podría ser un factor causal de la neuropatía alcohólica. Si esto es cierto, contribuiría a la comprensión de la fisiopatología, explicaría la variabilidad en la respuesta individual y facilitaría la búsqueda de una terapia de prevención.
Desarrollo: La neuropatía alcohólica se caracteriza por un patrón de polineuropatía simétrica con gran afectación de las extremidades inferiores. Los mecanismos de degeneración axonal debidos al consumo de alcohol aún no están claros. Se sabe que el alcohol inhibe los mecanismos de protección del sistema nervioso.
Conclusiones: Los inhibidores de la proteasa juegan un papel importante en el origen de las neuropatías periféricas. Existen fuertes evidencias que sugieren que las proteasas y sus inhibidores están relacionados con los procesos que permiten el desarrollo y mantenimiento de los nervios periféricos, y las alteraciones en sus proporciones favorecen el desarrollo de anomalías en dichas estructuras. Los mecanismos por los que estas moléculas desencadenan la enfermedad no están claros en la mayoría de los casos. Un aumento de las investigaciones en este ámbito contribuiría sin duda a prevenir y combatir una enfermedad que afecta a un número importante de personas
History and Philosophy of Science in Latin America
Full text linkIntroduction: The countries of Latin America have a common history in which they share languages, roots and traditions, and this is a major milestone in their unique way of progress.
Objective: To characterise the communication patterns and impact of Latin American scientific output in the category “History and Philosophy of Science”.
Methods: A bibliometric study was conducted where the documents belonging to the category "History and Philosophy of Science" from the period between 1996 and 2016 were analysed, using as tools Scival and Scimago Country and Journal Rank.
Results: While the regional scientific output showed an annual growth, especially after 2009, this growth was less noticeable at a global level, which indicates the scientific community’s interest towards this type of studies. More than half of the documents were cited, with a citation average of 28 cites per document. More than 30% of the communications involved international collaboration. Different studies have proven that the works which involved collaboration had a greater impact, at the expense of their visibility.
Conclusions: The analysis of the Latin-American field of History and Philosophy of Science is characterised by a sustained growth, with Brazil as its greater producer. The region has high indicators for scientific leadership and citation. They show their potential based on the recovery of the historical memory of Latin-American people in a new context related to the recognition of scientific heritage as an essential part of our people’s culture, economy, politics and society.Introducción: Los países de América Latina presentan una historia común en la que comparten lenguas, raíces y tradiciones, y que ha marcado su singular vía de progreso.
Objetivo: Caracterizar los patrones de comunicación e impacto de la producción científica Latinoamericana en la categoría Historia y Filosofía de la Ciencia.
Métodos: Se realizó un estudio bibliométrico donde se analizaron los documentos pertenecientes a la categoría “History and Philosophy of Science” en el período comprendido entre 1996 y 2016, utilizando como herramientas el Scival y el portal del Scimago Country and Journal Rank.
Resultados: Mientras la producción científica regional ostentó un crecimiento anual, especialmente luego de 2009, a nivel global sin embargo este crecimiento fue menos marcado, lo que denota el interés de la comunidad científica por este tipo de estudios. Más de la mitad de los documentos recibieron al menos una cita, con un promedio de 28 citas por documentos. En más del 30% de las comunicaciones existió colaboración internacional, estudios han demostrado que los estudios donde existe colaboración poseen un impacto superior, a expensas de su visibilidad.
Conclusiones: El análisis del dominio Latinoamericano en la categoría Historia y Filosofía de la Ciencia se caracterizó por un crecimiento sostenido, sobresaliendo Brasil como mayor productor. La región ostenta elevados indicadores de liderazgo científico y citación muestran su potencialidad en función recuperar la memoria histórica de los pueblos latinoamericanos en un nuevo contexto, el del reconocimiento de un patrimonio científico, parte integral de la cultura, economía, política y sociedad de nuestros pueblos
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Medical Applications and Challenges of Cell Culture Systems
No full textIntroduction: cell culture systems allow investigation of physiological, pathological, and pharmacological processes under controlled conditions, tracing back to techniques developed since the early 20th century and enhanced by the discovery of induced pluripotent stem cells in 2006.Methods: a total of 16 articles in Spanish and English were retrieved from Scopus, Science, and Springer using the keywords “2D cell culture,” “3D cell culture,” “regenerative medicine,” and “drug screening,” with more than 60 % published in the last five years.Results: two-dimensional cultures are characterized by simplicity, low cost, and scalability in cytotoxicity assays and drug screening, although they exhibit low biological fidelity. Three-dimensional systems better reproduce tissue architecture, generate nutrient and oxygen gradients, and promote more physiological gene expression profiles, making them suitable for tissue engineering, organoid development, and regenerative medicine. Identified applications include monoclonal antibody production, vaccines, cell therapies, and viral diagnostics. However, technical complexity, matrix standardization, and reproducibility remain limiting factors.Conclusions: cell culture techniques enable in vitro study of cellular physiology and pathology. Two-dimensional monolayers and three-dimensional constructs offer distinct advantages and limitations. Their applications include drug screening, regenerative medicine, vaccine production, and diagnostics
Patterns in Leadership and Management Research: A Bibliometric Review
Full text linkoai:hl.ageditor.ar:article/1Introduction: the direction and management of an institution represents one of the most dynamic functions that any individual can perform. Its purpose, in the case of the manager of the entity or institution, is to mesh each of the departments, personnel involved and/or resources in order to fulfill the social function it performs.Objective: characterize the scientific production related to Leadership and Management in the medical sciencesMethod: an observational, descriptive, bibliometric and quantitative research was developed. A total of 35,286 articles published in the SCOPUS database were analyzed. Bibliometric indicators were analyzed. Descriptive statistics were applied.Results: articles published in Q2 predominated with 12,381 works for 35.08%. The United States and the United Kingdom stood out with the highest number of articles published with 14,556 (41.25%) and 3,184 (9.02%) works respectively. Articles with national collaboration stood out (13,540; 38.4%). The largest number of articles were located in thematic areas related to medical sciences: medicine, nursing and health in general.Conclusions: scientific production on leadership and management in health sciences has shown increasing growth and interest among researchers. It has been positioned in important scientific journals in correlation with the main research and scientific production centers. In turn, the contributions made between the authors focus on the different areas of knowledge of medical sciences in matters of management and organization
Use of virtual reality in rehabilitation
Full text linkIntroduction: virtual reality is a promising medical rehabilitation tool, offering patients a safe and interactive experience to improve their quality of life. Scientific studies support its effectiveness in improving balance, coordination, and cognitive function in various conditions.
Methods: PubMed was searched for information using descriptors related to virtual reality and physical and mental rehabilitation. Twenty-nine clinical and observational trial articles published in the last 10 years in English and Spanish were selected, and the PRISMA methodology was used for systematic reviews.
Results: the results indicate that virtual reality therapy can improve motor, cognitive and psychological function in diverse patient populations. However, the effectiveness of different virtual reality approaches may vary depending on the population and rehabilitation goals.
Conclusion: virtual reality therapy improves motor function and quality of life in patients with various medical conditions. Combining it with other therapies can enhance outcomes and shows benefits in treating neurological and psychological conditions
Procedimientos para el cálculo de indicadores bibliométricos a partir de metadatos
No full textLos indicadores bibliométricos calculados a partir de los metadatos de indexación de los artículos analizados. En algunos casos (países por ejemplo) fueron normalizados los nombres a los cuales correspondía
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