2,145 research outputs found
Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility
No full text14 pags., 7 figs., 3 tabs.Hybrids of RNA with arabinonucleic acids 2′F-ANA and ANA have very similar structures but strikingly different thermal stabilities. We now present a thorough study combining NMR and other biophysical methods together with state-of-the-art theoretical calculations on a fully modified 10-mer hybrid duplex. Comparison between the solution structure of 2′F-ANA•RNA and ANA•RNA hybrids indicates that the increased binding affinity of 2′F-ANA is related to several subtle differences, most importantly a favorable pseudohydrogen bond (2′F-purine H8) which contrasts with unfavorable 2′-OH-nucleobase steric interactions in the case of ANA. While both 2′F-ANA and ANA strands maintained conformations in the southern/eastern sugar pucker range, the 2′F-ANA strand's structure was more compatible with the A-like structure of a hybrid duplex. No dramatic differences are found in terms of relative hydration for the two hybrids, but the ANA•RNA duplex showed lower uptake of counterions than its 2′F-ANA•RNA counterpart. Finally, while the two hybrid duplexes are of similar rigidities, 2′F-ANA single strands may be more suitably preorganized for duplex formation. Thus the dramatically increased stability of 2′F-ANA•RNA and ANA•RNA duplexes is caused by differencesin at least four areas, of which structure and pseudohydrogen bonding are the most important. © The Author(s) 2010. Published by Oxford University Press.Spanish Ministerio de Ciencia e Innovacion (grants
CTQ2007-68014-C02-02 to CG and BIO2009-10964 to
MO); Fundacion Marcelino Botin (grant to MO);
Canadian Institutes for Health Research (grant to
M.J.D.); Natural Sciences and Engineering Research
Council of Canada (postgraduate scholarship to
J.K.W.). Funding for open access charge: Canadian
Institutes for Health Research
A multi-institution analysis of outcomes of liver-directed surgery for metastatic renal cell cancer
No full textObjectives: Management of liver metastasis (LM) from a non-colorectal, non-neuroendocrine primary carcinoma remains controversial. Few data exist on the management of hepatic metastasis from primary renal cell carcinoma (RCC). This study sought to determine the safety and efficacy of surgery for RCC LM. Methods: A total of 43 patients who underwent surgery for RCC hepatic metastasis between 1994 and 2011 were identified in a multi-institution hepatobiliary database. Clinicopathologic, operative and outcome data were collected and analysed. Results: Mean patient age was 62.4 years and most patients (67.4%) were male. The mean tumour size of the primary RCC was 6.9 cm and most tumours (72.1%) were designated as clear cell carcinoma. Nine patients (20.9%) presented with synchronous LM. Among the patients with metachronous disease, the median time from diagnosis of the primary RCC to treatment of LM was 17.2 months (range: 2.1189.3 months). The mean size of the RCC LM was 4.0 cm and most patients (55.8%) had a solitary metastasis. Most patients (86.0%) underwent a minor resection (up to three segments). Final pathology showed margin status to be negative (R0) in 95.3% of patients. Postoperative morbidity was 23.3% and there was one perioperative death. A total of 69.8% of patients received perioperative chemotherapy. Overall 3-year survival was 62.1%. Three-year recurrence-free survival was 27.3% and the median length of recurrence-free survival was 15.5 months. Conclusions: Resection of RCC hepatic metastasis is safe and is associated with low morbidity and near-zero mortality. Although recurrence occurs in up to 50% of patients, resection can be associated with long-term survival in a well-selected subset of patients
Viajantes ex-cêntricas nas histórias de Ana Miranda
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Literatura.No conjunto das narrativas ficcionais da escritora brasileira Ana Miranda, a temática da viagem # considerada uma das mais férteis da literatura ocidental de todos os tempos # ocupa um espaço de centralidade, podendo até mesmo ser vista como o mais importante eixo de estruturação de suas obras. O estudo realizado pela presente tese tem por objetivo analisar o tratamento dado ao tema da viagem nos romances Desmundo, O retrato do rei, Dias & Dias e Amrik, evidenciando que por intermédio das narradora-viajantes # Oribela, Mariana, Feliciana e Amina # a autora promove um diálogo entre diferentes culturas, gêneros, etnias e gerações, ao mesmo tempo em que estabelece um profícuo diálogo com o passado em sua invariante problematização concernente aos limites e cruzamentos entre o discurso ficcional e os discursos narrativos extraliterários que o cercam, sobretudo o histórico e o biográfico. In the whole of Brazilian writer Ana Miranda#s fictional narrative, the travel thematic # considered one of the most fertile themes of the western literature of all times # occupies a central space, and can even been seen as the most important structuring axis of Miranda#s works. The aim of the present thesis is to analyze the treatment given to the travel subject in the novels Desmundo, O retrato do rei, Dias & Dias and Amrik, emphasizing that, through the traveling narrators, Oribela, Mariana, Feliciana and Amina, the author promotes a connection between different cultures, genders, ethnics and generations, at the same time that establishes a profitable dialogue with the past in her invariant problematization concerning the limits and crossings between the fictional and the extra-literary narrative discourses that surrounds it, mainly the historical and the biographic ones
NASKAH QAWA'IDU L-ISLAM WA L-IMAN (Suntingan Teks dan Kajian Pragmatik)
No full textMuna, Ana Fauzul. 2018. Qawa'idu l-Islam wa l-iman’s Manuscript (Editing teks and pragmatic studies). Skripsi. Faculty of Humanities, Diponogoro University. Leaders I Dr. M. Abdullah, M.A, II Drs. M. Muzakka, M.Hum.
Qawa'idu l-Islam wa l-iman’s Manuscript (QII) is the ancient manuscript who has an Arabic letter and Malay. QII is manuscript that saved in Nasional Library of Indonesian Republic with manuscript number BR 418. This manuscript has three teks among others: fiqh, Friday prayer, and tauhid. The author count heavely on the first teks which is fiqh.
This research has a purpose for present editing teks and explain advantage in teks based on pragmatic studies. The author use two theory among others: philology and pragmatic. This research use some methods which is: collection, analysis, and present the data inside. Data analysis divided in two part which is philology and pragmatic. And then the data presented by discriptive method.
The result of analysis from QII manuscript contain two function which is: religion function and education function. The religion function in QII manuscript contain pillars of Islam among others: Syahadat, prayer, obligatory charity, fasting, hajj trip. Thaharah include istinja, wudu, take a bath, menstruation, nifas, and tayamum. Pillars of faith is believe to Allah, while education function in the QII manuscript contain advice to study hard, pray when go and out from bathroom.
Key word: Qawa'idu l-Islam wa l-iman’s manuscript, philology, pragmatic
First person – Ana Cecilia Aliaga Fandino
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Ana Cecilia Aliaga Fandino is first author on ‘Reprogramming of the cambium regulators during adventitious root development upon wounding of storage tap roots in radish (Raphanus sativus L.)’, published in BIO. Ana conducted the research described in this article while a Master's student in Ji-Young Lee's lab at Seoul National University, Republic of Korea. She is now a PhD student in the lab of Christian Hardtke at the University of Lausanne, Switzerland, investigating developmental genetics in the root vascular system
On the sensitivity of Von Neuman and Morgenstern abstract stable sets : the stable and the individual stable bargaining set
No full textScientometric Portrait of Nobel Laureate S. Chandrasekhar
No full textScientometric analysis of the publications productivity of Nobel Laureate S. Chandrasekhar is documented
Stages for the More Sustainable Farm
No full textCurrently, agricultural farm units are faced with a double and most times contradictory challenge, in order to be successful: on the one hand the invested capital has to be profitable and the economic performance has to be maximised. On the other hand, given the socio-environmental situation, it is necessary to preserve and to protect the environment and natural resources. Given the potential conflict of the two aims, since the satisfaction of one implies the underperformance of the other (and vice versa), the question then is: which is the solution to choose? We intend, in this work, to formulate a farm plan with the purpose of reconciling the criteria of environmental sustainability with that of economic competitiveness. For this achievement we proceed to the comparative study of sustainability of different groups of farms identified in the study area (first evaluation cycle) through MESMIS (“Marco para la Evaluación de Sistemas de Manejo de Recursos Naturales Mediante Indicadores de Sustentabilidad” - Framework for Evaluation of Natural-Resource Systems Handling through Sustainability Indicators) methodology, that allowed to select the more sustainable group of farms. Based on the found potentialities and weakness on these production systems, we stepped to the planning of a production unit of bovine meat, which obeys simultaneously to economic and environmental objectives, using Multicriteria Decision. We finished the work with the sustainability evaluation between groups of farms identified previously and the planned farms (second evaluation cycle), based, again, in the MESMIS methodology, to confirm (or not) the greatest sustainability of the last ones. Analyses of the results allow us to confirm the greatest relative sustainability of the planned farm, for the diverse traced scenarios.Decision taking, planning, sustainability, Environmental Economics and Policy, Farm Management,
Tagging of Biomedical Articles on CiteULike: A Comparison of User, Author and Professional Indexing
No full textThis paper examines the context of online indexing from the viewpoint of three different groups: users, authors, and professional indexers. User tags, author keywords and descriptors were collected from academic journal articles, which were both indexed in Pubmed and tagged on CiteULike, and analysed. Descriptive statistics, informetric measures, and thesaural term comparison shows that there are important differences in the use of keywords between the three groups in addition to similarities which can be used to enhance support for search and browse. While tags and author keywords were found that matched descriptors exactly, other terms which did not match but provided important expansion to the indexing lexicon were found. These additional terms could be used to enhance support for searching and browsing in article databases as well as to provide invaluable data for entry vocabulary and emergent terminology for regular updates to indexing systems. Additionally, the study suggests that tags support organisation by association to task, projects and subject while making important connections to traditional systems which classify into subject categories
Ichthyologists of the Argentine: Ana Luis Thormählen.
No full textThis series will include all those people who, by means of their contributions, greatand small, played a part in the consolidation of ichthyology in Argentina.The general plan of this work consists of individual factsheets containing a list ofworks by each author, along with reference bibliography and, whenever possible,personal pictures and additional material.The datasheets will be published primarily in chronological order, although this issubject to change by the availability of materials for successive editions.This work represents another approach for the recovery and revalorization of thosewho set the foundations of Argentine ichthyology while in diverse historicalcircumstances.I expect this to be the beginning of a major work that achieves the description ofsuch a significant part of the history of natural sciences in Argentina. (PDF has 30 pages.)ProBiota: Programa para el estudio y uso sustentable de la biota australDebe citarse:
LÓPEZ, H. L., L. C. PROTOGINO & J. PONTE GÓMEZ. 2009. Ictiólogos de la Argentina: Ana Luisa Thormählen. ProBiota, FCNyM, UNLP, Serie Técnica y Didáctica, La Plata, Argentina, 14: 1-30. ISSN 1515-9329
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