108,990 research outputs found
Pymes : ¿Acciones planificadas o reacciones improvisadas? : Las estrategias de trabajadores y directivos frente a períodos de crisis y crecimiento socioeconómico
No full textFil: Gimenez, Natalia G.. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina
I calcestruzzi ad alte prestazioni nei riguardi delle azioni di natura chimico-fisica e della durabilità
No full textA G protein-biased designer G protein-coupled receptor useful for studying the physiological relevance of Gq/11-dependent signaling pathways
No full textDesigner receptors exclusively activated by a designer drug (DREADDs) are clozapine-N-oxide-sensitive designer G protein-coupled receptors (GPCRs) that have emerged as powerful novel chemogenetic tools to study the physiological relevance of GPCR signaling pathways in specific cell types or tissues. Like endogenous GPCRs, clozapine-N-oxide-activated DREADDs do not only activate heterotrimeric G proteins but can also trigger β-arrestin-dependent (G protein-independent) signaling. To dissect the relative physiological relevance of G protein-mediated versus β-arrestin-mediated signaling in different cell types or physiological processes, the availability of G proteinand β-arrestin-biased DREADDs would be highly desirable. In this study, we report the development of a mutationally modified version of a non-biased DREADD derived from the M3muscarinic receptor that can activate Gq/11 with high efficacy but lacks the ability to interact with β-arrestins. We also demonstrate that this novel DREADD is active in vivo and that cell type-selective expression of this new designer receptor can provide novel insights into the physiological roles of G protein (Gq/11)-dependent versus β-arrestin-dependent signaling in hepatocytes. Thus, this novel Gq/11-biased DREADD represents a powerful new tool to study the physiological relevance of Gq/11-dependent signaling in distinct tissues and cell types, in the absence of β-arrestin-mediated cellular effects. Such studies should guide the development of novel classes of functionally biased ligands that show high efficacy in various pathophysiological conditions but display a reduced incidence of side effects
The shrimp mitochondrial FoF1-ATPase inhibitory factor 1 (IF1)
No full textThe whiteleg shrimp species Litopenaeus vannamei is exposed to cyclic changes of the dissolved oxygen concentration of seawater and must neutralize the adverse effects of hypoxia by using ATP as energy source. In crustaceans, the mitochondrial FOF1-ATP synthase is pivotal to the homeostasis of ATP and function prevalently as a FOF1-ATPase. Hitherto, it is unknown whether these marine invertebrates are equipped with molecules able to control the FOF1-ATPase inhibiting the ATP consumption. In this study, we report two variants of the mitochondrial FOF1-ATPase Inhibitory Factor 1 (IF1) ubiquitously expressed across tissues of the Litopenaeus vannamei transcriptome: the IF1_Lv1 and the IF1_Lv2. The IF1_Lv1, with a full-length sequence of 550 bp, encodes a 104 aa long protein and its mRNA amounts are significantly affected by hypoxia and re-oxygenation. The IF1_Lv2, with a sequence of 654 bp, encodes instead for a protein of 85 aa. Both proteins share a 69 % homology and contain a conserved minimal inhibitory sequence (IATP domain) along with a G-rich region on their N-terminus typical of the invertebrate. In light of this characterization IF1 is here discussed as an adaptive mechanism evolved by this marine species to inhibit the FOF1-ATPase activity and avoid ATP dissipation to thrive in spite of the changes in oxygen tension.Fil: Chimeo, Cindy. Centro de Investigacion en Alimentacion y Desarrollo; MéxicoFil: Fernandez Gimenez, Analia Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencia Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Campanella, Michelangelo. University of London; Reino Unido. University College London; Estados UnidosFil: Mendez Romero, Ofelia. Centro de Investigacion en Alimentacion y Desarrollo; MéxicoFil: Muhlia Almazan, Adriana. Centro de Investigacion en Alimentacion y Desarrollo; Méxic
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
Des voix à la parole
No full textInternational audienceA partir du cas d'un patient schizophrène, Jacques, je présenterai deux types d'hallucinations auditives, et étudierai leur évolution au cours de cinq ans de théra-pie: des hallucinations auditives non verbales (chocs dans les oreilles, accompagnés de la sensation que le tympan se crève), et des hallucinations auditives ver-bales, ordres tyranniques que Jacques entend dans son oreille droite et auxquels il ne peut qu'obéir. J'essaierai de montrer en quoi l'hallucination auditive non verbale se scénarise dans la relation, et permet ainsi que se représente ce qui ne pouvait encore être mis en pensée. Nous étudierons ensuite comment les hallucinations psychomotrices verbales de Jacques, qui sont appréhendées comme des ordres venant du dehors (mots prononcés dans les oreilles), se transfor-ment progressivement, d'abord en mots prononcés dans sa tête par un autre, puis en pensées étrangères, en pensées personnelles, et enfin en mots qu'il peut GIMENEZ, G., 1997. Des Voix à la parole. In GREEN, A., BOTELLA, S., BOTELLA, C., BOUBLI, M., GIMENEZ, G., AULAGNIER, P., FONAGY, J., PINOL-DOURIEZ, M., Pulsions, représentations, langage. Théorie et clinique psychanalytiques. Delachaux et Nieslé, 93-133. Mots clefs : Hallucinations auditives (psychomotrices verbales), scénarisation transférentielle des hallucinations (transférentialisation des hallucinations). Transformation, dans la relation clinique, en mots prononcés dans la tête d'un autre puis en pensées étrangèes, en pensée personnelles, enfin en mots qu'il peut adresser à quelqu'un (représentation de paroles). Hallucination et arrière du corps. Hallucination et mécanismes négatifs. Démétaphorisation (ou mise en équation symbolique coporéisée), hallucination fondées sur des inscriptions d'expériences non inscrite symboliquement (représentation chose). Hallucination et signifiant formel (pré-scénario), et pictogramme. Hallucination comme figuration démétaphorisée d'un scénario encore impensable. Temps du transfert psychotique : exclusion, pseudopode narcissique, investi comme double, tiers potentiel
Análisis esclerocronológicos de Glycymeris longior (Sowerby, 1832) : edad, estructura poblacional y evaluación de su potencial como archivo ambiental del Golfo San Matías (Mar Argentino)
No full textEl presente trabajo de tesis se focaliza en la almeja Glycymeris longior. Los objetivos son: 1) determinar la periodicidad con la que se forman las bandas de crecimiento en las valvas de G. longior; 2) estudiar la estructura demográfica y la longevidad de la población de El Sótano (Golfo San Matías); 3) modelar la tasa de crecimiento individual a partir de los incrementos de crecimiento y construir un registro esclerocronológico para el Golfo San Matías; y 4) analizar el posible vínculo entre la cronología y la variabilidad de los factores ambientales que podrían influenciarla.Fil: Gimenez, Lucas Hernán. Universidad Nacional del Comahue. Escuela Superior de Ciencias Marinas; Agentin
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