15 research outputs found
Adaptive Optics of Kyrieleis Plaques in Varicella Zoster Virus-Associated Posterior Uveitis: A Multimodal Imaging Analysis
No full textKyrieleis plaques (KP) represent a peculiar type of vasculitis affecting retinal arterial branches in a beaded segmental pattern that can be found in several posterior inflammatory ocular conditions. The nature and precise location of KP is unclear. Adaptive Optics (AO) provides an in vivo visualization of retinal vasculature on a microscopic level, thus permitting a more detailed characterization of KP as compared to traditional imaging techniques. This study aims to report AO imaging of KP in Varicella Zoster virus (VZV)-associated posterior uveitis and to correlate the findings with traditional imaging techniques. Three patients diagnosed with VZV posterior uveitis underwent adaptive optics (AO) imaging and traditional multimodal imaging techniques, including fundus photography, fluorescein angiography, indocyanine green angiography and optical coherence tomography. In all subjects, AO imaging revealed segmental hyporeflectivity confined to the vessel wall, with no evidence of arterial wall disruption or extravascular involvement. In our series, AO findings support the view that KP are localized within the inner arterial wall, possibly at the endothelial level
Unknown artworks and further considerations regarding Paolo de Matteis, Giuseppe Simonelli, Lorenzo Ruggi and other followers of Luca Giordano
No full textCientos de pinturas napolitanas de los siglos XVII y XVIII han sido generalmente atribuidas a la escuela de Luca Giordano, quien tuvo un largo número de alumnos cuyos nombres han sido transmitidos por las principales fuentes de la historiografía artística. A algunos de ellos, como Franceschitto o Monsù Anselmo, no les podemos asociar ni siquiera con una obra. Por el contrario, hay casos de seguidores anónimos de Giordano con un estilo reconocible, como el autor de las dos versiones de Santiago el Mayor, una conservada en Casalnuovo de Nápoles y la otra en Lecce. Otras obras siguen fielmente el estilo de Giordano y llevan la firma de pintores que serían de otro modo desconocidos, caso de Lorenzo Ruggi, que firma una hermosa Inmaculada en la iglesia de S. Franciscode Aversa. Otro notable artista seguidor de Giordano es el «G. Fatteruso» que firma el Milagro de San Biagio en la iglesia de San Biagio en Mugnano de Nápoles. Es sin duda plausible la identificación con Giuseppe Fattorusso, recordado como discípulo de Vaccaro y luego de Beinaschi, si bien la comparación con sus obras documentadas plantea algunas dudas. Por último, una revisión de obras de diversa calidad, atribuidas con reserva a Luca Giordano o a su taller, puede arrojar una nueva luz sobre la cuestión de las numerosas imitaciones de las obras del maestro. La calificación de copias sería la más adecuada, por ejemplo, para las dos versiones de la Bendición de Isaac aparecidas en el mercado anticuario de Nueva York y en una colección privada en Sant’Arpino.Hundreds of 17th- and 18th-century Neapolitan paintings have been generically attributed to the school of Luca Giordano, who had many pupils, whose names have become known to us thanks to the leading historiographical sources of Neapolitan art. The work of some of these artists, such as Franceschitto and Monsu Anselmo, is unknown, although there are some anonymous Giordano followers who can easily be identified by their style, among them the author of two versions of St James the Greater, one of which is kept in Casalnuovo di Napoli and the other in Lecce. In addition, there are other works that are heavily influenced by Giordano and signed by hitherto unknown artists. These include Lorenzo Ruggi, who painted the wonderful Immaculate adorning St Francis Church in Aversa. Recent documentary research has revealed some information on the painter. Another leading follower of Giordano’s is one “G. Fatteruso”, who completed the majestic Miracle of St Blaise at St Blaise Church in Mugnano di Napoli. Though there are obvious grounds for identifying this artist as Giuseppe Fattorusso,remembered as a pupil of Vaccaro and later of Beinaschi, comparisons with the latter’s documentedworks suggest that this is not the case. Finally, newly conducted analysis of poorer-quality paintings that are cautiously attributed to Giordano or his studio, has enabled more detailed investigation into the problem regarding copies of Giordano’s famous works. Examples of this are two depictions of The Blessing of Isaac, one sold in New York and another in Sant’Arpino (near Naples), both of which can only be regarded as copies of a lost Giordano composition
In Vivo Correlation Between Macular Pigment Optical Volume and Retinal Layers Thickness
No full textPurpose. This study aims to investigate the potential in vivo relationship between macular pigment (MP) and retinal layers thickness in healthy subjects and dry, non-advanced age-related macular degeneration (AMD). Methods. An observational, cross-sectional study was conducted. Healthy subjects >40 years and patients with early or intermediate AMD were recruited. Structural OCT and macular pigment optical volume (MPOV) were collected for each subject. Retinal layers parameters were calculated based on the standard early treatment diabetic retinopathy study (ETDRS) map. Additionally, MPOV within 1 degrees, 2 degrees, and 9 degrees of eccentricity was assessed and associated with retinal layers thickness and volume. Linear mixed-effects models were used to test the relationship between MP and structural OCT parameters, while adjusting for known possible confounding factors. Results. A total of 144 eyes of 91 subjects (60.4% females) were evaluated, comprising 43% normal eyes and 57% with early/intermediate AMD. Among the retinal layers, only the outer nuclear layer (ONL) thickness and volume appeared to be associated to higher MP levels. Specifically, the central ONL thickness was identified as a significant predictor of the MPOV 1 degrees(P = 0.04), while the parafoveal ONL thickness (inner ETDRS subfield) was identified as a significant fixed effect on the MPOV 9 degrees (P = 0.037). Age and the presence of drusen or subretinal drusenoid deposits were also tested without showing significant correlations. Conclusions. Among the retinal layers examined, only the ONL thickness demonstrated a significant association with MPOV. Consequently, ONL thickness might serve as a potential biomarker related to MP levels
Visual performance after bilateral implantation of 2 new presbyopia-correcting intraocular lenses: Trifocal versus extended range of vision
No full textUn modello di riprogettazione del percorso nascita: strumenti di empowerment delle donne e di supporto decisionale clinico e manageriale
No full text2020 - 2021Pregnancy and childbirth symbolize a period of decisions during which the woman feels
the need to express her needs and to receive correct information leading to conscious
choices.
Over the years the theme of the birth path has become relevant due to the increase in the
number of parts carried out by caesarean section, a surgical practice capable of
compromising the health of women and children if performed without real medical needs
and with a strong impact on the health system from an organizational, social, clinical and
economic point of view.
In many territorial contexts the choice of opting for surgery rather than favouring natural
childbirth is conditioned not so much by the presence of real differences in the health
status of the population, as many factors of different nature that lead to decisions
increasingly inappropriate from the clinical and organizational point of view.
Focusing the interest on the birth path is the most appropriate way to study a phenomenon
on which it is necessary to intervene with an integrated approach that connects the
different moments of the path, the actors who are part of it, the modalities with which the
services are delivered, the criticalities that are found and the hypotheses of participation.
The following study aims to support the formulation of clinical and managerial decisions
appropriate to the mode of childbirth, promote a conscious and rational use of the practice
of Caesarean section and realize an effective process of patient empowerment.
On the basis of data and information obtained from the main sources of information
relating to the birth event, a dataset has been built in which clinical and extra-clinical
variables have been reported clinics that correlate with the modalities of childbirth in
order to carry out a descriptive study on the multidimensional nature of the phenomenon.
The project activity included a cognitive investigation of the organizational and
procedural aspects applied at the two units under investigation, the Departments of
Gynecology and Obstetrics of the Clinica Mediterranea S.p.A. of Naples and the Hospital
Company- University of San Giovanni di Dio and Ruggi d'Aragona of Salerno.
The study has interesting practical and policy implications. First, it identifies the aspects
of the organizational process useful for the construction of an integrated care path that
promotes the synergy between hospital and territory, aimed at an effective management
of patients both in terms of appropriateness of care and clinical governance. Secondly, it
defines methodological tools useful for clinical and governance decision support
to enhance patient education, increase women’s empowerment in decision-making and
provide an economically sustainable health service.
Finally, it contributes to the literature on the theme of the birth path in public and private
health facilities, identifying factors useful for the creation of an innovative model of
redesign of the care path. [edited by Author]La gravidanza e il parto simboleggiano un periodo di decisioni durante i quali la donna
avverte la necessità di esprimere i propri bisogni e di ricevere informazioni corrette che
conducano a scelte consapevoli.
Nel corso degli anni il tema del percorso nascita è divenuto rilevante a causa dell’aumento
del numero di parti effettuati con taglio cesareo, una pratica chirurgica in grado di
compromettere la salute della donna e del bambino se eseguita senza reali necessità mediche
e con un forte impatto sul sistema sanitario dal punto di vista organizzativo, sociale, clinico
ed economico.
In molti contesti territoriali la scelta di optare per l’intervento chirurgico piuttosto che
favorire il parto naturale è condizionata non tanto dalla presenza di reali differenze nello
stato di salute della popolazione, quanto da molteplici fattori di diversa natura che conducono
a decisioni sempre più inappropriate dal punto di vista clinico ed organizzativo.
Focalizzare l’interesse sul percorso nascita è il modo più appropriato per studiare un
fenomeno su cui occorre intervenire con un approccio di tipo integrato che mette in relazione
i diversi momenti del percorso, gli attori che ne fanno parte, le modalità con cui i servizi
sono erogati, le criticità che vengono riscontrate e le ipotesi di intervento.
Il seguente studio mira a supportare la formulazione di decisioni cliniche e manageriali
appropriate rispetto alla modalità di parto, promuovere un uso consapevole e razionale della
pratica del taglio cesareo e realizzare un efficace processo di patient empowerment.
Sulla base dei dati e delle informazioni ricavate dalle principali fonti informative relative
all’evento nascita, è stato costruito un dataset in cui sono state riportate variabili cliniche ed
extra-cliniche che correlano con le modalità di parto al fine di realizzare uno studio
descrittivo sulla natura multidimensionale del fenomeno.
L’attività progettuale ha previsto un’indagine conoscitiva degli aspetti organizzativi e
procedurali applicati presso le due unità oggetto di indagine, i Reparti di Ginecologia ed
Ostetricia della Clinica Mediterranea S.p.A. di Napoli e dell’Azienda OspedalieroUniversitaria San Giovanni di Dio e Ruggi d’Aragona di Salerno.
Lo studio ha interessanti implicazioni pratiche e di policy. In primo luogo, identifica gli
aspetti del processo organizzativo utili alla costruzione di un percorso assistenziale integrato
che favorisca la sinergia tra ospedale e territorio, volta ad una efficace presa in carico delle
pazienti sia in termini di appropriatezza delle cure che di governo clinico. In secondo luogo,
definisce gli strumenti metodologici utili al supporto decisionale clinico e di governance al
fine di potenziare la patient education, accrescere l’empowerment delle donne nel
processodecisionale e fornire un servizio sanitario economicamente sostenibile.
Infine, contribuisce alla letteratura sul tema del percorso nascita nelle strutture sanitarie
pubbliche e private, identificando fattori utili alla creazione di un innovativo modello di
riprogettazione del percorso assistenziale. [a cura dell'Autore]XXXIII cicl
Erratum: Search for gravitational waves from compact binary coalescence in LIGO and Virgo data from S5 and VSR1 (Physical Review D - Particles, Fields, Gravitation and Cosmology)
No full textThis paper was published online on 5 November 2010 with an omission in the Collaboration author list. S. Dwyer has
been added as of 12 April 2012. The Collaboration author list is incorrect in the printed version of the journal
Erratum: All-sky search for gravitational-wave bursts in the first joint LIGO-GEO-Virgo run (Physical Review D - Particles, Fields, Gravitation and Cosmology (2010) 81 (102001))
No full textThis paper was published online on 5 May 2010 with an omission in the Collaboration author list. S. Dwyer has been
added as of 12 April 2012. The Collaboration author list is incorrect in the printed version of the journal
Publisher's Note: Search for gravitational waves from binary black hole inspiral, merger, and ringdown
No full textThis paper was published online on 6 June 2011 with an omission in the Collaboration author list. S. Dwyer has been
added as of 12 April 2012. The Collaboration author list is incorrect in the printed version of the journal
Author Correction: Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial (Nature Medicine, (2021), 27, 8, (1451-1457), 10.1038/s41591-021-01455-x)
No full textCorrection to: Nature Medicine, published online 12 August 2021. In the version of this article initially published, members of the PASSPORT Study Group were listed in Supplementary information but not included in the main article. The contributors are listed below for inclusion in authorship. PASSPORT Study Group Ikuko Aiba1, Angelo Antonini2, Diana Apetauerova3, Jean-Philippe Azulay4, Ernest Balaguer Martinez5, Jee Bang6, Paolo Barone7, Matthew Barrett8, Danny Bega9, Daniela Berg10, Koldo Berganzo Corrales11, Yvette Bordelon12, Adam L. Boxer13, Moritz Brandt14, Norbert Brueggemann15, Giovanni Castelnovo16, Roberto Ceravolo17, Rosalind Chuang18, Sun Ju Chung19, Alistair Church20, Jean-Christophe Corvol21, Paola Cudia2, Marian Dale22, Luc Defebvre23, Sophie Drapier24, Erika D Driver-Dunckley25, Georg Ebersbach26, Karla M Eggert27, Aaron Ellenbogen28, Alexandre Eusebio4, Andrew H Evans29, Natalia Fedorova30, Elizabeth Finger31, Alexandra Foubert-Samier32, Boyd Ghosh33, Lawrence Golbe34, Francisco Grandas Perez35, Murray Grossman36, Deborah Hall37, Kyoko Hamada38, Kazuko Hasegawa39, Guenter Hoeglinger40, Lawrence Honig41, David Houghton42, Xuemei Huang43, Stuart Isaacson44, SeongBeom Koh45, Jaime Kulisevsky Bojarski46, Anthony E. Lang47, Peter Nigel Leigh48, Irene Litvan49, Juan Jose Lopez Lozano50, Jose Luis Lopez-Sendon Moreno51, Albert Christian Ludolph52, Ma Rosario Luquin Piudo53, Irene Martinez Torres54, Nikolaus McFarland55, Wassilios Meissner32, Tiago Mestre56, Pablo Mir Rivera57, Eric Molho58, Britt Mollenhauer59, Huw R Morris60, Miho Murata61, Tomokazu Obi62, Fabienne Ory Magne63, Padraig O’Suilleabhain64, Rajesh Pahwa65, Alexander Pantelyat6, Nicola Pavese66, Dmitry Pokhabov67, Johannes Prudlo68, Federico Rodriguez-Porcel22, James Rowe69, Joseph Savitt70, Alfons Schnitzler71, Joerg B Schulz72, Klaus Seppi73, Binit Shah8, Holly Shill74, David Shprecher75, Maria Stamelou76, Malcolm Steiger77, Yuji Takahashi61, Hiroshi Takigawa78, Carmela Tartaglia79, Lars Toenges80, Daniel Truong81, Winona Tse82, Paul Tuite83, Dieter Volc84, Anne-Marie A Wills85, Dirk Woitalla86, Tao Xie87, Tatsuhiko Yuasa88, Sarah Elizabeth Zauber89 and Theresa Zesiewicz901Department of Neurology, National Hospital Organization Higashinagoya National Hospital, Nagoya, Japan. 2San Camillo Hospital IRCCS, Venice Lido, Italy. 3Lahey Hospital and Medical Center, Burlington, MA, USA. 4Assistance Publique Hapitaux De Marseille, Marseille, France. 5Hospital General de Catalunya, Barcelona, Spain. 6The Johns Hopkins University, Baltimore, MD, USA. 7AOU San Giovanni di Dio e Ruggi d’Aragona University di Salerno, Salerno, Italy. 8University of Virginia Health System, Charlottesville, VA, USA. 9Northwestern University, Chicago, IL, USA. 10UKSH - Campus Kiel, Kiel, Germany. 11Hospital De Cruces, Barakaldo, Spain. 12University of California, Los Angeles, CA, USA. 13Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA. 14Universitatsklinikum Carl Gustav Carus Dresden, Dresden, Germany. 15University Hospital Schleswig-Holstein, Luebeck, Germany. 16Centre Hospitalier Universitaire de Nimes - Hopital Universitaire Caremeau, Nimes, France. 17University Hospital of Pisa, Pisa, Italy. 18Swedish Health Services, Seattle, WA, USA. 19Asan Medical Center, Seoul, Republic of Korea. 20Aneurin Bevan University Health BoardClinical Research and Innovation Centre - St Woolos Hospital, Newport, UK. 21Sorbonne Université, Assistance Publique Hôpitaux de Paris, INSERM, CNRS, Institut du Cerveau – Paris Brain Institute – ICM, Hôpital Pitié-Salpêtrière, Paris, France. 22Medical University of South Carolina, Charleston, SC, USA. 23Centre Hospitalier Regional Universitaire) de Lille - Hopital Roger Salengro, Lille, France. 24CHU de Rennes - Hopital de Pontchaillou, Rennes, France. 25Mayo Clinic Arizona - Scottsdale, Scottsdale, AZ, USA. 26Movement Disorders Clinic, Beelitz-Heilstatten, Germany. 27Philipps Universitat Marburg, Marburg, Germany. 28QUEST Research Institute, Farmington Hills, MI, USA. 29The Royal Melbourne Hospital (RMH)-Flemington Neurology - North Melbourne, North Melbourne, Australia. 30Russian Medical Academy of Postgraduate Education, Moscow, Russia. 31Parkwood Institute, London, Ontario, Canada. 32CHU De Bordeaux Parkinson Expert Centre, IMNC Hopital Pellegrin, Bordeaux, France. 33University Hospital Southampton NHS Foundation Trust, Southampton UK. 34 Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. 35Hospital General Universitario Gregorio Maranon, Madrid, Spain. 36Hospital of the University of Pennsylvania, Philadelphia, PA, USA. 37Rush University Medical Centre Chicago, IL USA. 38Shinsapporo Neurosurgical Hospital, Sapporo, Japan. 39National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan. 40Department of Neurology, Technische Universität München, Munich, Germany. 41Columbia University College of Physicians and Surgeons - Gertrude H. Sergievsky Center, New York, NY, USA. 42Ochsner Medical Center, New Orleans, LA, USA. 43Penn State University-Milton S. Hershey Medical Center, Hershey, PA USA. 44Parkinson’s Disease And Movement Disorder Center Of Boca Raton, Boca Raton, FL, USA. 45Korea University Guro Hospital, Seoul, Republic of Korea. 46Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. 47 Edmond J. Safra Program in Parkinson’s Disease and the Rossy PSP Centre, Toronto Western Hospital and the University of Toronto, Toronto, Ontario, Canada. 48Brighton and Sussex Medical School Trafford Centre for Biomedical Research, Brighton, UK. 49University of California, Parkinson and Other Movement Disorders Center, San Diego, CA, USA. 50Clinica Ruber Internacional, Madrid, Spain. 51Hospital Universitario Ramon y Cajal, Madrid, Spain. 52Universitats- und Rehabilitationskliniken Ulm, Ulm, Germany. 53Clinica Universidad De Navarra, Pamplona, Spain. 54Hospital la FE, Valencia, Spain. 55University of Florida Center For Movement Disorders and Neurorestoration, Gainesville, FL, USA. 56The Ottawa Hospital - Civic Campus, University of Ottawa, Ottawa, Canada. 57Hospital Universitario Virgen del Rocio, Sevilla, Spain. 58Albany Medical College, Albany, NY, USA. 59Paracelsus-Elena-Klinik Kassel, Kassel, Germany. 60National Hospital for Neurology and Neurosurgery, London, UK. 61Musashi Hospital, Kodaira-Shi, Japan. 62National Hospital Organization - Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan. 63Hopital Purpan - Batiment Pierre Paul Riquet, Toulouse, France. 64University of Texas Southwestern Medical Center - Clinical Center For Movement Disorders, Dallas, TX, USA. 65The University of Kansas Medical Center - Parkinson’s Disease and Movement Disorder Center, Kansas City, KS, USA. 66The Newcastle upon Tyne Hospitals NHS Foundation Trust - Campus for Ageing and Vitality, Newcastle upon Tyne, UK. 67Federal State Budgetary Institution, Federal Siberian Scientific Clinical Center of Federal Medical-Biological Agency, Krasnoyarsk, Russia. 68Universitaet Rostock - Universitaetsmedizin Rostock, Rostock, Germany. 69Cambridge University, Cambridge, UK. 70University of Maryland School of Medicine, Baltimore, MD, USA. 71Center for Movement Disorders and Neuromodulation-University Hospital Dusseldorf, Dusseldorf, Germany. 72Uniklinik RWTH Aachen Medizinische Klinik III, Aachen, Germany. 73Medizinische Universitaet Innsbruck, Innsbruck, Austria. 74St. Joseph’s Hospital and Medical Center/Barrow Neurology Clinics, Phoenix, AZ, USA. 75Banner Sun Health Research Institute, Sun City, AZ, USA. 76Hygeia Hospital, Marousi, Greece. 77The Walton Center - NHS Foundation Trust, Liverpool, UK. 78Tottori University Hospital, Yonago, Japan. 79Toronto Western Hospital, University Health Network Movement Disorders Centre, Toronto, Canada. 80St. Josef - Hospital Bochum, Kardiologische Studienambulanz, Bochum, Germany. 81The Parkinson’s and Movement Disorder Institute, Fountain Valley, CA, USA. 82Mount Sinai Movement Disorders Center, New York,NY, USA. 83University of Minnesota Medical Center - Fairview - Neurology Clinic, Minneapolis, MN, USA. 84Prosenex Ambulatoriumsbetriebs GmbH – Studienzentrum, Vienna, Austria. 85Massachusetts General Hospital Cancer Center, Boston, MA, USA. 86St. JosefKrankenhaus, Essen-Kupferdreh, Essen, Germany. 87The University of Chicago Medicine - Center for Parkinson’s Disease and Movement Disorders, Chicago, IL, USA. 88Kamagaya General Hospital, Kamagaya-City, Japan. 89Indiana University Health Physicians - Neurology – Indianapolis, Indianapolis, IN, USA. 90University of South Florida - Morsani College of Medicine, Tampa, FL, USA
Commissioning status of the Virgo interferometer
No full textAn Erratum for this article has been published in 2010 Class. Quantum Grav. 27 149801 (The full author list for this article was omitted in error).International audienceThe Virgo interferometer is one of the big observatories aimed at detecting gravitational waves. This paper will describe the Virgo + upgrades and the commissioning work performed between the first Virgo science run (VSR1) and the second Virgo science run (VSR2). Some first results of VSR2 will be discussed, which was recently started with a good duty cycle and an inspiral range for the detection of binary neutron-star inspirals of 10 Mpc. To conclude, an outlook will be given on some future upgrades of the detector
