201,669 research outputs found
Ventes. Citation de Jean Genet : Pompes Funèbres, Gallimard
No full textGenet Jean. Ventes. Citation de Jean Genet : Pompes Funèbres, Gallimard . In: Sorcières : les femmes vivent, n°5, 1976. Odeurs. p. 35
Citation de Jean Genet : Le miracle de la rose, Gallimard
No full textGenet Jean. Citation de Jean Genet : Le miracle de la rose, Gallimard . In: Sorcières : les femmes vivent, n°15, 1978. Mouvements. p. 46
A paixão segundo Jean Genet: labirintos e barroquismos
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Gaduação em Literatura.Esta dissertação tem como título: A Paixão segundo Jean Genet: Labirintos e Barroquismos e se estende em dois intentos principais: o primeiro, consiste no estudo da arte e da estética de Genet pelo qual se procura dar fundamentação ou sustentação ao pressuposto de que sua arte revela certa tendência barroquizante. Esse intento contém também duas compreensões a saber: a do processo de escrita denominado - O labirinto de Genet e a análise dessa arte cotejando diferentes conceitos relativos ao Barroco, sobretudo aqueles fundamentados em Walter Benjamin, Heinrich Wölfflin e Eugenio D'Ors e, ainda, contemplando a poética e a estética de Genet sob o pensar filosófico de Hegel, Gaston Bachelard e Herbert Marcuse. Essas duas compreensões correspondem respectivamente aos três primeiros capítulos. O segundo intento, a leitura da paixão, se faz alicerçada em Foucault e em Bataille. Trata-se então do erotismo, da transgressão e da paixão presentes na Arte de Genet, em que os jogos de sedução, desejo e poder se realizam nas relações eróticas, ou simplesmente na intimidade e na cumplicidade entre homens. Considera-se que esse segundo intento atravessa toda a dissertação. E, ainda, no desdobre desse propósito se compõe e se atinge o quarto capítulo, nele se reflete de modo particular o homoerotismo em Genet. Segue-se a conclusão, que se apresenta antes como um descortino da arte, da paixão e do erotismo em Genet do que como concluimento ou mero desfecho
Hundreds of variants clustered in genomic loci and biological pathways affect human height
No full textMost common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways
AFLP reveals structural details of genetic diversity within cultivated olive germplasm from the Eastern Mediterranean
No full textAmplified fragment length polymorphism (AFLP) analysis was used to assess genetic inter-relationships among olive varieties cultivated in the Eastern Mediterranean Basin. The genotypes sampled included most of the important cultivars from Turkey, Greece and the Middle East and selected genotypes from the Western Mediterranean area. A total of 119 polymorphic markers were generated from five selective primer-pair combinations. The combined data sets generated by just two primer-pairs were adequate to discriminate between all 65 genotypes, while each primer-pair could individually identify up to 64 genotypes. A factorial correspondence analysis (FCA) plot indicated that the cultivars clustered into two relatively modestly defined groups. The first broad group was dominated by cultivars from Turkey but also included genotypes originating from the Middle East (Syria and Lebanon) that collectively formed a tight subcluster. The second group comprised Greek cultivars and those originating from the Western Mediterranean. A significant genetic distance value between Greek and Turkish cultivars was provided by an analysis of molecular variance (amova). There was also evidence of substructure here, with an apparent separation of most Spanish and Italian clones. These findings are in general accordance to previous suggestions of an East-West divergence of olive cultivars, although the dichotomy is less extensive than reported previously and complicated by regional variation within each group. © Springer-Verlag 2004.Angiolillo A, 1999, THEOR APPL GENET, V98, P411, DOI 10.1007-s001220051087; Banilas G, 2003, GENOME, V46, P370, DOI 10.1139-G03-011; BASSAM BJ, 1991, ANAL BIOCHEM, V196, P80, DOI 10.1016-0003-2697(91)90120-I; Belaj A, 2003, EUPHYTICA, V130, P387, DOI 10.1023-A:1023042014081; Belaj A, 2002, THEOR APPL GENET, V105, P638, DOI 10.1007-s00122-002-0981-6; Belaj A, 2003, THEOR APPL GENET, V107, P736, DOI 10.1007-s00122-003-1301-5; Belaj A, 2001, J AM SOC HORTIC SCI, V126, P64; Benzecri J.P., 1982, ANAL DONNEES, V2; Besnard G, 2001, THEOR APPL GENET, V102, P251, DOI 10.1007-s001220051642; Besnard G, 2000, CR ACAD SCI III-VIE, V323, P173, DOI 10.1016-S0764-4469(00)00118-9; Besnard G, 2002, THEOR APPL GENET, V104, P1353, DOI 10.1007-s00122-001-0832-x; Besnard G, 2002, THEOR APPL GENET, V105, P139, DOI 10.1007-s00122-002-0868-6; Blondel J, 1995, MEDITERRANEAN TYPE E, P43; Cipriani G, 2002, THEOR APPL GENET, V104, P223, DOI 10.1007-s001220100685; Contento A, 2002, THEOR APPL GENET, V104, P1229, DOI 10.1007-s00122-001-0799-7; de Caraffa VB, 2002, THEOR APPL GENET, V104, P1209, DOI 10.1007-s00122-002-0883-7; DICE LR, 1945, ECOLOGY, V26, P297, DOI 10.2307-1932409; EXCOFFIER L, 1992, GENETICS, V131, P479; FABBRI A, 1995, J AM SOC HORTIC SCI, V120, P538; Hatzopoulos P, 2002, EUR J LIPID SCI TECH, V104, P574, DOI 10.1002-1438-9312(200210)104:9-1057451635
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
No full textGenetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10<sup>−11</sup>; odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28–1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes
Fast identification of biological pathways associated with a quantitative trait using group lasso with overlaps.
No full textWhere causal SNPs (single nucleotide polymorphisms) tend to accumulate within biological pathways, the incorporation of prior pathways information into a statistical model is expected to increase the power to detect true associations in a genetic association study. Most existing pathways-based methods rely on marginal SNP statistics and do not fully exploit the dependence patterns among SNPs within pathways.We use a sparse regression model, with SNPs grouped into pathways, to identify causal pathways associated with a quantitative trait. Notable features of our "pathways group lasso with adaptive weights" (P-GLAW) algorithm include the incorporation of all pathways in a single regression model, an adaptive pathway weighting procedure that accounts for factors biasing pathway selection, and the use of a bootstrap sampling procedure for the ranking of important pathways. P-GLAW takes account of the presence of overlapping pathways and uses a novel combination of techniques to optimise model estimation, making it fast to run, even on whole genome datasets.In a comparison study with an alternative pathways method based on univariate SNP statistics, our method demonstrates high sensitivity and specificity for the detection of important pathways, showing the greatest relative gains in performance where marginal SNP effect sizes are small
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
No full textUsing the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10−4). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 × 10−8), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals
Jean Genet ou la danse macabre du bien et du mal
No full textIn this paper the author focuses the question of the search for lay sanctity in the work of Jean Genet considering the literary expression of his relationship with «Good» and «Evil». This topic brings in the problem of liberty in the dramatic work of Genet, which in turn is related to the question of (im)morality and religiosity. For this reason, in the second part of the essay, the author discusses Genet's anguished preoccupation with the problem of the relationship between Morality and Aesthetics; which could be described as a «danse macabre»
J. Heffer, J.-L. Robert, P. Saly, Outils statistiques pour les historiens, Publications de la Sorbonne, Paris, 1981
No full textGenet Jean-Philippe. J. Heffer, J.-L. Robert, P. Saly, Outils statistiques pour les historiens, Publications de la Sorbonne, Paris, 1981. In: Le médiéviste et l'ordinateur, N°6, automne 1981. p. 22
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