1,015 research outputs found
Loneliness and social media: A qualitative investigation of young people's motivations for use and perceptions of social networking sites
No full textThis is an accepted manuscript of an article published by Palgrave MacMillan in Emotions and Loneliness in a Networked Society on 09/11/2019, available online: https://link.springer.com/chapter/10.1007/978-3-030-24882-6_16
The accepted version of the publication may differ from the final published version.The democratisation of Internet access has incrementally changed every domain of activity and has created new business and economic models. From answering work emails to learning a new language, shopping, booking medical appointments or managing one’s finances, almost everything is attainable at the click of a button. The added implications of the rapid rise of social networking websites (SNSs), such as Facebook, Twitter, Instagram or Snapchat, have further contributed to changing the way we communicate and build new friendships. Indeed most of our social relationships are now being ‘increasingly developed and maintained online’ (Nowland, Necka & Cacioppo, 2017: 1). Ostensibly, despite improved Internet access and enhanced social connectedness, modern societies are struggling to combat loneliness. It is reported to affect people of all ages, especially young adults (16-24 and 25-34 years old) who are avid Internet and social media users (see Office for National Statistics, 2018)
Envolvimento dos receptores neurocinérgicos NK1 do septo lateral na modulação da ansiedade experimental avaliada no teste do odor de gato
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.O presente estudo investigou a participação dos receptores NK1 do septo lateral de ratos avaliados no modelo experimental de odor de gato. Para realizar este objetivo primeiramente o teste foi padronizado nas condições experimentais do nosso laboratório. Nesta etapa foi feita a padronização farmacológica do teste do odor de gato com o benzodiazepínico midazolam, sendo escolhida a dose de 0,25 mg/Kg i.p. a mais eficaz em inibir os comportamentos de defesa dos animais após a exposição ao odor. Na etapa seguinte, foi realizada uma curva dose-resposta ao antagonista de receptores taquicinérgicos do tipo NK1, o WIN51,708. A dose de 10 pmol, administrada centralmente (icv) antes da exposição ao odor, mostrou-se eficaz na diminuição do comportamento defensivo de ratos frente ao odor de gato. A última etapa de nosso trabalho consistiu na administração de 10 pmol do WIN51,708 no septo lateral de ratos antes da exposição ao odor. Este tratamento foi capaz de modificar todos os parâmetros comportamentais dos ratos expostos ao odor de gato, indicando uma atividade do tipo ansiolítica. Este resultado evidencia a participação dos receptores NK1 presentes no septo lateral na modulação do comportamento de defesa de ratos e um papel tônico da substância P endógena na modulação destes comportamentos
Bianca Garavelli studiosa e scrittrice
No full textBianca Garavelli (Vigevano, 1958-2021) was a highly regarded figure in the literary world, both on the critical and creative side. Author of important critical studies on Dante and of a successful commentary on the Commediam (begun under the supervision of Maria Corti but then continued independently), as well as critic and reviewer for newspapers and periodicals, Garavelli also wrote and published poems, novels and short stories. This article offers an exhaustive bio-bibliographical profile of Bianca Garavelli, whose literary work in various fields is reconstructed and critically examined
Platelet progenitors: the hidden drug target
No full textPlatelets are central players in haemostasis and atherothrombosis.1
Their nucleated progenitors, the megakaryocytes (MKs), reside in
the bone marrow and have unique features
Let´s (watch me) play : which factors relate to Let´s Play addiction?
No full textAuthor Bianca Haun, BScZusammenfassungen in englischer SpracheMasterarbeit Universität Linz 201
Longitudinally persisting KCNA2-autoantibodies in mild amnestic dementia with Alzheimer´s pathology – Report and literature review
No full textA combined intervention for executive deficits and anxiety in Parkinson's patients: a case study
No full textParkinson’s disease (PD) is a neurodegenerative disorder most commonly associated with motor symptomatology, yet often presenting with deficits in attention, executive functioning (EF; e.g., planning, mental flexibility, complex attention), anxiety, and depression, with debilitating effects on patients’ quality of life. Current interventions, including pharmacological and surgical methods show efficacy in motor symptom management, yet produce equivocal results in addressing non-motor dysfunction. The goal of this paper was to describe and investigate the efficacy and patient acceptance of a nonpharmacological intervention for treatment of executive dysfunction (ED) and anxiety in PD, in the context of a case study (the case of Mr. K). Brain and Mind Fitness Program (BMFP) is a short-term intervention, consisting of a combination of cognitive remediation and cognitive behavioral therapy (CBT). BMFP was demonstrated to be fully acceptable to Mr. K, based on ratings of 4 feasibility dimensions (fatigue, effort, progress, and enjoyment). The program also proved to be efficacious in alleviating Mr. K’s anxiety and depression symptoms, with benefits extending over the treatment period. BMFP, elsewhere shown to be an effective cognitive re-training of EF in PD patients, exhibited limited gains in the case of Mr. K., possibly due to his relatively intact cognitive abilities at baseline. Despite its limitations, the case of Mr. K presents a novel approach to treatment of PD non-motor symptoms and a learning opportunity for researchers and clinicians interested in expanding their knowledge across disciplines.Psy. D.Includes bibliographical referencesby Bianca R. Georgesc
BIANCA (Brain Intensity AbNormality Classification Algorithm): a new tool for automated segmentation of white matter hyperintensities
No full textReliable quantification of white matter hyperintensities of presumed vascular origin (WMHs) is increasingly needed, given the presence of these MRI findings in patients with several neurological and vascular disorders, as well as in elderly healthy subjects. We present BIANCA (Brain Intensity AbNormality Classification Algorithm), a fully automated, supervised method for WMH detection, based on the k-nearest neighbour (k-NN) algorithm. Relative to previous k-NN based segmentation methods, BIANCA offers different options for weighting the spatial information, local spatial intensity averaging, and different options for the choice of the number and location of the training points. BIANCA is multimodal and highly flexible so that the user can adapt the tool to their protocol and specific needs. We optimised and validated BIANCA on two datasets with different MRI protocols and patient populations (a “predominantly neurodegenerative” and a “predominantly vascular” cohort). BIANCA was first optimised on a subset of images for each dataset in terms of overlap and volumetric agreement with a manually segmented WMH mask. The correlation between the volumes extracted with BIANCA (using the optimised set of options), the volumes extracted from the manual masks and visual ratings showed that BIANCA is a valid alternative to manual segmentation. The optimised set of options was then applied to the whole cohorts and the resulting WMH volume estimates showed good correlations with visual ratings and with age. Finally, we performed a reproducibility test, to evaluate the robustness of BIANCA, and compared BIANCA performance against existing methods. Our findings suggest that BIANCA, which will be freely available as part of the FSL package, is a reliable method for automated WMH segmentation in large cross-sectional cohort studies. © 2016 The Author
Dataset: Culturally Responsive Supervision
No full textThesis title: A Study Exploring the Supervisory Relationship in the Context of Culturally Responsive Supervision: A Supervisee’s Perspective
Quantitative and qualitative survey data on supervisee perspectives of culturally responsive supervision and their supervisory relationship. The data was collected by the primary author and can be viewed in SPSS.
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