102,164 research outputs found
New materials from history of Crimean studies of 20th years of 20th century in correspondences by G. J. Krachkovsky and V. J. Filonenko
No full textУ статті репрезентовано складні процеси становлення орієнталістичних студій у Криму 20-х рр. ХХ ст. На підставі вивчення епістолярію з особового архівного фонду Г. Ю. Крачковського (зокрема, листування з В. Й. Филоненком) розкрито наукові зв’язки Провінція — Центр. Автором відновлені нові сторінки кримської історичної науки в галузі сходознавства, в тому числі — сторінки історії Східного відділення Кримського університету (педагогічного інституту). У науковий обіг уведено новий корпус інформативних джерел з історії кримознавства.Difficult processes of development of Soviet Oriental studies is opened in the article on basis of documents of Russian Academy of Sciences Archives branch’s (fund of academic Gnat Krachkovskiy) in Saint-Petersburg. Contacts of local orientalists (V. Y. Filonenko) with metropolitan academic science centres. It also showed in this article. Author shows the history of separating of orientalistic in Crimean University (Pedagogical institute) in 20-s years of XX century. Correspondence of academician G. Krachkovskiy with Crimean studies is the basis of researching
New materials from history of Crimean studies of 20th years of 20th century in correspondences by G. J. Krachkovsky and V. J. Filonenko
No full textУ статті репрезентовано складні процеси становлення орієнталістичних студій у Криму 20-х рр. ХХ ст. На підставі вивчення епістолярію з особового архівного фонду Г. Ю. Крачковського (зокрема, листування з В. Й. Филоненком) розкрито наукові зв’язки Провінція — Центр. Автором відновлені нові сторінки кримської історичної науки в галузі сходознавства, в тому числі — сторінки історії Східного відділення Кримського університету (педагогічного інституту). У науковий обіг уведено новий корпус інформативних джерел з історії кримознавства.Difficult processes of development of Soviet Oriental studies is opened in the article on basis of documents of Russian Academy of Sciences Archives branch’s (fund of academic Gnat Krachkovskiy) in Saint-Petersburg. Contacts of local orientalists (V. Y. Filonenko) with metropolitan academic science centres. It also showed in this article. Author shows the history of separating of orientalistic in Crimean University (Pedagogical institute) in 20-s years of XX century. Correspondence of academician G. Krachkovskiy with Crimean studies is the basis of researching
New materials from history of Crimean studies of 20th years of 20th century in correspondences by G. J. Krachkovsky and V. J. Filonenko
No full textУ статті репрезентовано складні процеси становлення орієнталістичних студій у Криму 20-х рр. ХХ ст. На підставі вивчення епістолярію з особового архівного фонду Г. Ю. Крачковського (зокрема, листування з В. Й. Филоненком) розкрито наукові зв’язки Провінція — Центр. Автором відновлені нові сторінки кримської історичної науки в галузі сходознавства, в тому числі — сторінки історії Східного відділення Кримського університету (педагогічного інституту). У науковий обіг уведено новий корпус інформативних джерел з історії кримознавства.Difficult processes of development of Soviet Oriental studies is opened in the article on basis of documents of Russian Academy of Sciences Archives branch’s (fund of academic Gnat Krachkovskiy) in Saint-Petersburg. Contacts of local orientalists (V. Y. Filonenko) with metropolitan academic science centres. It also showed in this article. Author shows the history of separating of orientalistic in Crimean University (Pedagogical institute) in 20-s years of XX century. Correspondence of academician G. Krachkovskiy with Crimean studies is the basis of researching
Regulation of ribosomal protein S6 kinases by ubiquitination
No full textRibosomal protein S6 kinase (S6K) is a key player in the regulation of cell growth and energy metabolism via the mTOR and PI3K signalling pathways. The activity and subcellular localization of S6K are regulated by multiple S/T phosphorylations in response to diverse extracellular stimuli. Downregulation of S6K signalling occurs through the action of S/T phosphatases (PP2A and PP1) and tumor suppressors (TSC1/2 and PTEN). We report here that, in addition to phosphorylation, S6Ks are ubiquitinated in cells. The pattern of ubiquitination and the effect of proteasomal inhibitors on the steady-state level of transiently overexpressed and endogenous S6Ks point to proteasome-mediated degradation of ubiquitinated S6Ks. Furthermore, we found that the site(s) of ubiquitination are located in the kinase domain and that the N- and C-terminal regulatory regions modulate the efficiency of S6K ubiquitination. This study suggests that S6K signalling also could be regulated through the proteasome-mediated turnover of S6Ks
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
The Right to Strike under the United States Constitution: Theory, Practice, and Possible Implications for Canada
No full textAnswering critics of the Canadian Supreme Court's judgment in B.C. Health, the author argues that the Court laid the foundation for a principled and durable doctrine protecting constitutional labour rights, one that goes directly to the heart of the matter — the inequality of workers’ power in the employment relation. In the author’s view, two paths could lead from B.C. Health to the recognition of Charter protec- tion for a right to strike: one that treats the right as an accessory to col- lective bargaining, and one that upholds the right directly on the basis of the Charter values of equality and participation. The author supports the latter approach, contending that constitutional rights should be defined in relation to fundamental values, in a way that is not contingent on time-bound or fact-sensitive assessments about the role of strikes within a particular collective bargaining regime. Although a Charter right to strike may involve the courts in difficult choices about when to defer to legislative policy decisions, and courts may lack the institutional capac- ity to deal effectively with labour law issues, the author points out that judges can look to ILO standards for expert guidance. Noting that the U.S. experience in this area might be of considerable use to Canadians, the author concludes by providing an overview of American case law concerning a constitutional right to strike.Peer reviewe
Übertragbarkeit der gesundheitsökonomischen Evaluationen : Methoden für die multinationalen Studien
No full textFilonenko A. Generalizability of health economic evaluations : methods for multinational patient-level studies. Bielefeld (Germany): Bielefeld University; 2010.Background: Cost-effectiveness outcomes collected in multinational health economic studies may vary across countries and geographic areas due to numerous clinical and socioeconomic factors. The between-country variability poses the question of generalizability of the cost-effectiveness estimates, i.e. applicability of the trial-wide results for the decision-making in particular jurisdiction.
Objectives: The purpose of this research is to illustrate how selected methods can improve generalizability of the results of patient-level health economic studies by a) exploring between-country variability in incremental costs, effectiveness and resource use, b) calculation of trial-wide and country-level incremental cost, effectiveness and resource use while accounting for patient- and country-level covariates, and c) assessing the potential of covariates to predict cost and effectiveness estimates for the settings outside the study.
Methods: Review of published health-economic evidence and international HTA guidelines was conducted to evaluate applied or recommended methods and analytical strategies to improve generalizability of the health economic outcomes. In the case study, qualitative and quantitative homogeneity test by Simon and Gail is used to explore between-country heterogeneity of the treatment effects measured by incremental costs, effectiveness, resource use (length of hospitalization) and incremental net monetary benefit. Hierarchical modelling is applied to calculate trial-wide and country-level estimates, while accounting for clustering and incorporating country- and patient-level covariates.
Results: Simon and Gail test indicated qualitative homogeneity for incremental effectiveness, costs, length of hospitalization and net monetary benefit between treatment and control arms. Trial-wide and country-level mean incremental costs and effectiveness were estimated using hierarchical models with and without covariates. Results of hierarchical modelling suggested, that new treatment was more efficacious, saved costs and resource use in majority of the countries.
Conclusions: Homogeneity test and hierarchical models are complementary methods to explore heterogeneity and to estimate trial-wide and country-level parameters for cost-effectiveness analysis. Hierarchical models allow for country-level estimates and adjustment for covariates. In the case study the patient-level covariates showed effect on incremental cost and effectiveness; country-level covariates had very small impact on estimates. The use of country-level covariates as predictors for incremental cost and resource use to improve generalizability of health economic studies beyond the study setting merits further investigation
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