31 research outputs found
Pensare con Schmitt contro Schmitt od oltre Schmitt?
No full textThe author tries to redirect Kervégan’s method of «thinking with Schmitt against Schmitt» into «thinking with Schmitt beyond Schmitt» as Apel would have done. This different approach could help in preserving and restoring the targets of Schmitt’s critics – i.e. liberal democratic regimes and their Constitutions – by using his own conceptual arsenal. Marzocchi offers, for instance, an original reinterpretation of Schmitt’s Verfassung-slehre employing the ideas presented there with constructive purposes instead of disruptive ones
Marxismo, individualismo metodologico, epistemologia delle scienze sociali
No full textNel discutere due recenti monografie di S. Bracaletti, il saggio mette a tema le proposte di alcuni teorici, i quali hanno avanzato critiche alle forme di olismo e strutturalismo, sottese alla teoria sociale marxista, e che avanzano una prospettiva incentrata sulla razionalità individuale e fondata sul principio dell’individualismo metodologico. Vengono quindi analizzate alcune inaggirabili difficoltà del paradigma riduzionista di tali autori, per comprendere cosa, a dispetto di tali limiti, si possa trarre da essi.By discussing S. Bracaletti’s recent works, this essay homes in on a series of scholars who criticize variants of holism and structuralism that are present in Marxist social theory, and propound a view that heeds individual rationality and is premised upon the principle of methodological individualism. The author then discusses some inescapable difficulties that the reductionist paradigm of these authors gets into and the lesson we can get from them despite these limits
Rationale and design of MILES-3 and MILES-4 studies: two randomized phase III trials comparing single-agent chemotherapy versus cisplatin-based doublets in elderly patients with advanced non-small cell lung cancer
No full textBACKGROUND:
Platinum-based chemotherapy is the cornerstone of treatment of advanced non-small-cell lung cancer (NSCLC) patients, but the efficacy of adding cisplatin to single-agent chemotherapy remains to be demonstrated in prospective phase III trials dedicated to elderly patients. Furthermore, the superiority of cisplatin/pemetrexed over cisplatin/gemcitabine in non-squamous NSCLC has not been confirmed prospectively. We present the rationale and design of two open-label, multicenter, randomized phase III trials for elderly patients with advanced NSCLC∶ Multicenter Italian Lung cancer in the Elderly Study (MILES)-3 and MILES-4. The aim is to evaluate the efficacy of adding cisplatin to single-agent chemotherapy (both trials) and the efficacy of pemetrexed versus gemcitabine in non-squamous tumors (MILES-4).
PATIENTS AND METHODS:
Both trials are dedicated to first-line therapy of patients older than 70 years with advanced NSCLC, ECOG performance status 0-1. In the MILES-3 trial, patients are randomized in a 1∶1 ratio to gemcitabine or cisplatin/gemcitabine. In the MILES-4 study patients with non-squamous histology are randomized, in a factorial design with 1∶1∶1∶1 ratio, to four arms: gemcitabine (A), cisplatin/gemcitabine (B), pemetrexed (C), cisplatin/pemetrexed (D). Two comparisons are planned∶ A+C vs B+D to test the role of cisplatin; A+B vs C+D to test the role of pemetrexed. Primary endpoint of both trials is overall survival. Secondary and exploratory endpoints include progression-free survival, response rate, toxicity, and quality of life.
CONCLUSIONS:
MILES-3 and MILES-4 results will add important evidence about the role of cisplatin-based doublets and pemetrexed in the first-line therapy of elderly patients with advanced NSCLC
Fra i “cigni del Tevere” accanto al Tasso: Antonio Decio da Orte, Fabio e Virginio II Orsini (con documenti inediti)
No full textIl saggio si propone di indagare in senso storico–letterario l’ambiente romano coevo di Luca Marenzio, partendo dal “nume tutelare” di tale ambiente, ovvero il Tasso, che nel corso dei suoi numerosi soggiorni a Roma intesse una serie di relazioni, in grado di lasciarvi un’impronta profonda e duratura.
Fra le personalità di spicco che costituiscono i maggiori contatti romani dell’ultimo Tasso, il primo in ordine di tempo è Fabio Orsini, dedicatario dell’unica tragedia di Antonio Decio da Orte, l’«Acripanda» (stampata per la prima volta nel 1592), ed autore egli stesso di una tragedia, annoverata da Angelo Ingegneri nell’àmbito del dramma pastorale. Formatosi nel pieno della «seconda Rinascita “ciceroniana”» (Marc Fumaroli), in cui occupa un ruolo fondamentale Marc-Antoine Muret, Fabio Orsini è dedicatario di «versi e prose» del Tasso (il «Rogo amoroso», due sonetti e la «Risposta di Roma a Plutarco»), e fa parte dell’accademia dei Pastori della Valle Tiberina, che riconosce «per Principe» un altro Orsini, Virginio II Duca di Bracciano — al quale è dedicato il «Quinto Libro de’ Madrigali a Sei Voci» del Marenzio (1591) —, insieme allo stesso Tasso e ad altri personaggi a vario titolo significativi nel panorama qui delineato, come il Decio, Giovan Battista Strozzi, Antonio Ongaro, Giovanni de’ Medici, Antonio Piccioli, per non menzionarne che alcuni. Quest’ultimo è autore delle «Prose Tiberine» (edite nel 1597), un “palinsesto” dell’«Arcadia» sannazariana, che ruota attorno ai poli dei due Orsini.
Anche là dove non ne rimangono che testimonianze indirette, l’esercizio poetico degli esponenti dell’accademia tiberina emerge come dato naturale, e consequenziale all’omaggio gerarchico, da alcune lettere, trascritte integralmente e commentate, che fanno parte della corrispondenza di Virginio II, un vasto patrimonio documentario raccolto nell’Archivio Orsini e custodito a Roma, presso l’Archivio Storico Capitolino.
Rime encomiastiche e rime spirituali costituiscono due dei cardini attorno ai quali ha ruotato l’attività poetica romana del Tasso, che da parte sua ha mostrato uno speciale interesse per Virginio II, dedicando a lui tre sonetti, ed alla moglie, Flavia Peretti, il «Tempio» (stampato nel 1591), una raccolta poetica di numerosi autori, originariamente concepita in occasione del loro matrimonio.
Il complesso di questa produzione letteraria appare del tutto in sintonia con le nuove poetiche degli anni fra i due secoli, vòlte ad una grandiosità “meravigliosa”, ed attraversate da un gusto musicale affine a quello espresso dai madrigalisti, fra i quali naturalmente il Marenzio occupa un ruolo fondamentale.The essay is a historical–literary investigation of the Roman literary milieu at the time of Luca Marenzio. It starts from its presiding spirit, Tasso, who formed a series of relations during his various stays in Rome that left a deep and lasting mark on it.
Of the prominent figures that made up Tasso’s main contacts in Rome towards the end, the first, chronologically, was Fabio Orsini, to whom Antonio Decio da Orte dedicated his only tragedy, «Acripanda» (first printed in 1592), and who was himself the author of a tragedy, which Angelo Ingegneri classified as a pastoral drama. As a young man he had absorbed the influence of the «second “Ciceronian” Renaissance» (Marc Fumaroli), in which Marc-Antoine Muret played a fundamental part, and was the dedicatee of «verse and prose» by Tasso (the «Rogo amoroso», two sonnets and the «Risposta di Roma a Plutarco»). Like Tasso, and other significant figures in the panorama described here, such as Decio, Giovan Battista Strozzi, Antonio Ongaro, Giovanni de’ Medici and Antonio Piccioli, he was also a member of the Academy of the «Pastori della Valle Tiberina», which recognized «as its Prince» another Orsini, Virginio II Duke of Bracciano — to whom Marenzio dedicated the «Quinto Libro de’ Madrigali a Sei Voci» (1591). Piccioli was the author of «Prose Tiberine» (published in 1597), a “palimpsest” of Sannazaro’s «Arcadia», which revolves around the poles of the two Orsini.
We have only indirect accounts, but the poetry of the exponents of the Tiber Academy grew naturally from this esteem, as emerges from some letters, transcribed complete with commentary, that are part of the correspondence of Virginio II: a vast legacy of documents held in the Orsini Archives in Rome, at the «Archivio Storico Capitolino».
Two of the main elements in Tasso’s Roman poetry were eulogies and spiritual verses. He showed particular interest in Virginio II, dedicating to him three sonnets, and to his wife, Flavia Peretti, the «Tempio» (printed in 1591), a collection of poems by various authors, originally conceived for their marriage.
Overall, this literary output seems wholly in keeping with the new poetics at the turn of the century, which aimed at a “marvellous” grandeur and was marked by a musical taste similar to that of the madrigalists, among whom, of course, Marenzio had a fundamental role
Tra le carte dell'Archivio Orsini : la "Calunnia d'Apelle" e la "Conversione di san Paolo" di Federico Zuccari e un tavolo di marmo commesso donato al cardinale Mazzarino
No full textAttraverso inediti documenti contabili l'autore ricostruisce la committenza di un tavolo in commesso marmoreo, oggi conservato nel Musée national d'Histoire naturale di Parigi e di ricondurlo con precisione a Cosimo Del Cartolaio, gioielliere e competitore di marmi attivo a Roma tra 1613 e 1615, e al committente Virginio Orsini, II duca di Bracciano. L'autore inoltre ricostruisce la storia del manufatto e il suo arrivo come dono al cardinale Giulio Raimondo Mazzarino, Primo Ministro di Francia. Inoltre per comprendere l'apporto del duca Orsini alle collezioni famigliari si analizzano le circostanze dell'acquisto della Calunnia di Apelle di Federico Zuccari.Through unpublished accounting documents, the author reconstructs the commissioning of a table in marble commesso, now preserved in the Musée national d'Histoire naturelle in Paris, and traces it back precisely to Cosimo Del Cartolaio, a jeweller and marble craftsman active in Rome between 1613 and 1615, and to the commissioner Virginio Orsini, II Duke of Bracciano. The author also reconstructs the history of the artefact and its arrival as a gift to Cardinal Giulio Raimondo Mazzarino, Prime Minister of France. Furthermore, to understand Duke Orsini's contribution to the family collections, the author analyses the circumstances of the purchase of Federico Zuccari's Calumny by Apelles
Brain-Metabolic Crossroads in Severe Mental Disorders – Focus on Metabolic Syndrome
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Orgy of exception: a literary project outline Reinaldo Moraes
No full textEm agosto de 1985, mesmo ano da publicação de Abacaxi, Reinaldo Moraes escreveu uma autocrítica capciosa sobre o seu segundo romance. Disfarçado com um pseudônimo, o autor matreiramente elevava sua obra como legítima representante do legado machadiano. Apesar do tom brincalhão e da ironia motora do texto que são traços estilísticos do escritor , a farsa do artigo pode ser lida no pormenor como um esboço de projeto literário. A questão central de tal esboço parece ser a procura de uma estratégia narrativa capaz de dar conta minimamente do contexto em que está inserida. O objetivo desta dissertação é descrever o caminho do dispositivo literário perseguido pelo autor desde o seu primeiro romance, Tanto faz (1981), e que se desdobra numa espécie de continuidade cindida em Abacaxi (1985), até encontrar o prumo e a régua na confecção de Pornopopeia (2009). No vértice histórico de vinte oito anos, que ata a produção das obras, está a gestação do horizonte de expectativas reduzidas, possível de ser apreendido na dinâmica interna dos romances. Os narradores de Reinaldo Moraes estão em fuga; e figuram sempre o encontro do impasse.In August 1985, the same year Abacaxi was published, Reinaldo Moraes wrote a very tricky review of his second novel. Disguised under a pseudonym, the author regarded his work as a legitimate representative of Machado de Assis\' legacy. Despite the playful tone and the text\'s purposed irony which are stylistic traits of the author , the falacious article may be read as an outline for a literary project. The central idea behind Moraes\' literary project seems to be the search for a narrative strategy that is able at least in part to give form to the context in which it operates. The aim of this work is to describe how the literary form pursued by the author evolves from his first novel, Tanto Faz (1981) unfolding into Abacaxi (1985), in a kind of icontinuous trajectory just to find its final form in the making of Pornopopeia (2009). As it may be seem in the internal dynamics of the novels, a horizon of reduced expectations is carefully laid out over the twenty eight years periode that lead to the production of Reinaldo Moraes\' works. His narrators are on the run; and always represent the meeting of the impasse
La limitazione del tempo di lavoro agile nella disciplina legale e collettiva
Full text linkThe essay addresses the issue of flexible working time in the context of agile work. It also deals with the instruments for limiting working hours to protect constitutional rights of individuals. Building upon the results of a research study conducted through interviews with companies and managerial and administrative personnel in a macro-sector of production in the Milan area, the author questions the adequacy of legal and collective contractual discipline in the field to address the trend of extending the number of hours worked remotely. The focus is particularly on the need to make the right to disconnect effective.El ensayo aborda la cuestión de la flexibilidad horaria en el trabajo ágil y los instrumentos de limitación del tiempo de trabajo para la protección de los derechos constitucionales de la persona. Partiendo de los resultados de una investigación llevada a cabo mediante entrevistas con empresas y personal directivo y administrativo de un macrocompartimento productivo del área de Milán, el autor cuestiona la adecuación de la disciplina legal y contractual-colectiva en la materia para hacer frente a la tendencia a ampliar el número de horas trabajadas a distancia, centrándose en particular en la necesidad de dar efectividad al derecho a la desconexión.Il saggio affronta il tema dell'orario di lavoro flessibile nel contesto del lavoro agile. Si occupa inoltre degli strumenti di limitazione dell'orario di lavoro a tutela dei diritti costituzionali delle persone. Sulla base dei risultati di una ricerca condotta attraverso interviste ad aziende e personale dirigenziale e amministrativo di un macro-settore produttivo dell'area milanese, l'autore si interroga sull'adeguatezza della disciplina legale e contrattuale collettiva in materia per affrontare la tendenza verso l'estensione del numero di ore lavorate da remoto. L'attenzione si concentra in particolare sulla necessità di rendere effettivo il diritto alla disconnessione
Cisplatin-Based First-Line Treatment of Elderly Patients With Advanced Non-Small-Cell Lung Cancer: Joint Analysis of MILES-3 and MILES-4 Phase III Trials
No full textPurpose To test the efficacy of adding cisplatin to first-line treatment for elderly patients with advanced non-small-cell lung cancer (NSCLC) within a combined analysis of two parallel phase III trials, MILES-3 and MILES-4. Patients and methods Patients with advanced NSCLC who were older than age 70 years with Eastern Cooperative Oncology Group performance status 0 to 1 were randomly assigned to gemcitabine or pemetrexed, without or with cisplatin. In each trial, 382 events were required to detect a hazard ratio (HR) of death of 0.75, with 80% power and two-tailed α of .05. Trials were closed prematurely because of slow accrual, but the joint database allowed us to analyze the efficacy of cisplatin on the basis of intention-to-treat and adjusted by trial, histotype, non-platinum companion drug, stage, performance status, sex, age, and size of the study center. Results From March 2011 to August 2016, 531 patients (MILES-3, 299; MILES-4, 232) were assigned to gemcitabine or pemetrexed without (n = 268) or with cisplatin (n = 263). Median age was 75 years, 79% were male, and 70% had nonsquamous histology. At a median 2-year follow-up, 384 deaths and 448 progression-free survival events were recorded. Overall survival was not significantly prolonged with cisplatin (HR, 0.86; 95% CI, 0.70 to 1.05; P = .14) and global health status score of quality of life was not improved, whereas progression-free survival (HR, 0.76; 95% CI, 0.63 to 0.92; P = .005) and objective response rate (15.5% v 8.5%; P = .02) were significantly better. Significantly more severe hematologic toxicity, fatigue, and anorexia were found with cisplatin. Conclusion The addition of cisplatin to single-agent chemotherapy does not significantly prolong overall survival, and it does not improve global health status score of quality of life in elderly patients with advanced NSCLC
Efficacy and Safety of Anti-PD-1 Immunotherapy in Patients Aged ≥ 75 Years With Non–small-cell Lung Cancer (NSCLC): An Italian, Multicenter, Retrospective Study
No full textThis study was conducted in the setting of advanced non–small-cell lung cancer in older patients. It is a multicenter retrospective analysis on very old persons that explores the efficacy and the safety of anti-programmed cell death protein 1 therapy. Older patients seem to tolerate immunotherapy as well as younger patients with comparable efficacy. This is a relevant message for everyday clinical practice
