17 research outputs found
Adaptation of the paleoseismological approach to local tectonic regime: comparative study of the intraplate Basel-Reinach fault, Switzerland and the interplate North Anatolian fault, Turkey.
No full textPrésident du jury: Jean-Pierre Burg.Rapporteurs: Mustapha Meghraoui, Adrian Pfiffner et Rolando Armijo.The assessment of seismic risk in a given region relies on the proper estimate of related seismic hazard, i.e. the probability that an earthquake of said magnitude occurs within a said time window. Calculating that probability requires a precise knowledge of local seismotectonic parameters such as the frequency of damaging earthquakes, their magnitude and the annual deformation rate. These parameters may only be properly determined when observed over a representative time window. As return periods for strong earthquakes vary between a few decades and several millennia, instrumental and historical seismological datasets often prove to be insufficient. To improve the completeness of available seismicity catalogues, we applied the paleoseismological approach to two different regions: the Basel region (southern Upper Rhine Graben) which was struck by a destructive earthquake in 1356 and the Izmit region (east of the Marmara Sea), partly destroyed in August 1999 by a magnitude 7.4 tremor.A full integrated study involving geomorphology, geophysics and trenching in the Basel region led to the identification of the seismogenic fault responsible for the last strong earthquake and to deciphering its seismic history for the Holocene. Thus, we demonstrate that the newly identified Basel-Reinach fault is the locus for a magnitude 6.4-6.7 earthquake every ~2600 years, on average. Furthermore, we give strong evidence for the probable extension of the fault through the city of Basel to the north and the folded Jura to the south. These results have a direct impact on the level of seismic risk to the region as it was consequently lowered by one degree on the basis of our original work.We applied a similar, though adapted, approach to the North Anatolian fault around the Marmara Sea. An extensive trenching effort combined with ground-penetrating radar profiles carried out on the Ganos fault to the west and the Izmit-Sapanca segment to the east evidence several recent events and yield measurements of pertaining co-seismic offsets. They clearly show characteristic behavior on both sides of the Marmara Sea, however with varying offsets: 4 to 5 m for the Ganos fault and 2 to 2.5 m for the Izmit-Sapanca segment. This brings new constrains to better characterize faulting behavior in the region and consequent seismic risk to the city of Istanbul.La prise en compte du risque sismique dans une région donnée passe par l'évaluation de l'aléas, c'est-à-dire la probabilité qu'un séisme de magnitude définie se produise dans un intervalle de temps défini. Le calcul de cette probabilité repose sur certains paramètres sismo-tectoniques locaux tels que la fréquence des tremblements de terre destructeurs, leur magnitude ainsi que le taux de déformation annuel. Ces paramètres ne seront convenablement déterminés qu'en disposant d'une fenêtre d'observation représentative des phénomènes en jeu. Face à des périodes de retour variant de quelques décennies à plusieurs millénaires, les données sismologiques instrumentales et historiques se révèlent souvent insuffisantes. Afin de compléter les catalogues de sismicité disponibles, nous avons appliqués les méthodes de la paléosismologie à deux régions très différentes : la région de Bâle (sud du Fossé Rhénan) frappée par un séisme destructeur en 1356 et la région d'Izmit (est de la Mer de Marmara) en grande partie détruite en Août 1999 par un séisme de magnitude 7.4.Une étude intégrée complète de la région de Bâle a permis d'identifier la faille responsable du dernier grand séisme puis de retracer son histoire sismique holocène. Nous avons ainsi démontré qu'elle est le lieu d'un évènement de magnitude 6.4-6.7 tous les 2600 ans, en moyenne. De plus, nous donnons des indications fortes sur son prolongement au travers de la ville de Bâle, au nord, et du Jura Plissé, au sud. Ces résultats ont une incidence directe sur le niveau de risque sismique régnant dans la région. En effet, celui-ci a diminué d'un degré depuis la prise en compte de ces éléments jusqu'ici inédits.Nous avons appliqué une approche similaire, quoique adaptée, à la faille Nord Anatolienne autour de la Mer de Marmara. Une campagne de tranchées menée sur la faille de Ganos à l'ouest et sur le segment Izmit-Sapanca à l'est ainsi que des profils de radar géologique ont mis en évidence plusieurs évènements récents et permis de déterminer l'amplitude des mouvements co-sismiques produits lors de ces séismes. Ceux-ci montrent clairement un comportement caractéristique des deux côtés de la Mer de Marmara, avec toutefois des déplacements co-sismiques différents : 4 à 5 m pour Ganos et 2 à 2.5 m pour Izmit-Sapanca
Estimating the disequilibrium in denudation rates due to divide migration at the scale of river basins
No full textInternational audienceBasin-averaged denudation rates may locally exhibit a wide dispersion, even in areas where the topographic steady state is supposedly achieved regionally. This dispersion is often attributed to the accuracy of the data or to some degree of natural variability of local erosion rates which can be related to stochastic processes such as landsliding. Another physical explanation of this dispersion is local and transient disequilibrium between tectonic forcing and erosion at the scale of catchments. Recent studies have shown that basin divide migration can potentially induce such perturbations, and they propose metrics to assess divide mobility based on cross-divide contrasts in headwater topographic features. Here, we use a set of landscape evolution models assuming spatially uniform uplift, rock strength and rainfall to assess the effect of divide mobility on basin-wide denudation rates. We propose using basin-averaged aggressivity metrics based on cross-divide contrasts (1) in channel chi, an integral function of position in the channel network; (2) in channel local gradient; and (3) in channel height, measured at a reference drainage area. From our simulations, we show that the metric based on differences in chi is the most reliable to diagnose local disequilibrium. The other metrics are more suitable for relatively active tectonic regions such as mountain belts, where contrasts in local gradient and elevation are more important. We find that the ratio of basin denudation associated with drainage migration to uplift can reach a factor of 2, regardless of the imposed uplift rate, erodibility, diffusivity coefficient or critical hillslope gradient. A comparison with field observations in the Great Smoky Mountains (southern Appalachians, USA) underlines the difficulty of using the metric based on chi, which depends on the - poorly constrained - elevation of the outlet of the investigated catchment. Regardless of the considered metrics, we show that observed dispersion is controlled by catchment size: a smaller basin may be more sensitive to divide migration and hence to disequilibrium. Our results thus highlight the relevance of divide stability analysis from digital elevation models as a fundamental preliminary step for basin-wide denudation rate studies based on cosmogenic radionuclide concentrations
Serial literature and its archives, 1840-1940
No full textCette thèse propose une approche de la littérature sérielle (produite et consommée en série, sous diverses formes de publication) à travers ses archives. Avec un corpus de plusieurs centaines de documents, mêlant archives auctoriales et éditoriales, elle va de 1840 (après la naissance du feuilleton) à 1940 (quand apparaît la logique du best-seller). On montre les évolutions dans la production de la littérature sérielle, qui vont dans le sens d’une rationalisation de la production, et d’une standardisation des contenus narratifs – sans considérer ces transformations comme nécessairement dévalorisantes. Une centaine d’auteurs se côtoient, incontournables célébrités de la littérature populaire (Ponson du Terrail, Adolphe d’Ennery, Jules Mary) ou écrivains dont le nom, comme leur production romanesque, est totalement effacé de la mémoire littéraire (Alexis Bouvier, Alexis Clerc, Marc Mario). La réflexion se déploie sur la question de la valeur littéraire et de la sélection qu’elle opère. Trace lacunaire d’une littérature considérée comme non littéraire, de pur divertissement, les archives du corpus sont en majorité inédites, ou pour le moins ignorées par les études littéraires. Après une partie introductive, destinée à poser les préambules méthodologiques et théoriques nécessaires, la partie II se concentre sur la production de la littérature sérielle vue de l’intérieur, en mettant l’accent sur le duo auteur-éditeur. La partie III envisage l’insertion de cette production sérielle dans le système médiatique, à travers la question des adaptations et de la circulation de discours symboliques. La partie IV propose une réflexion sur les acteurs de la production littéraire sérielle, et fait le choix de considérer l’expression de « littérature industrielle » au sens propre.This thesis proposes an approach to serial literature (written and read in series, in various forms of publication) through its archives. With a corpus of several hundred documents, combining authorial and editorial archives, it goes from 1840 (after the birth of the serial novel) to 1940 (when the logic of the bestseller appears). We show the evolutions in the production of serial literature, which often tend to a rationalization of production, and a standardization of narrative content – without considering these transformations as necessarily demeaning. About a hundred authors are gathered, from celebrities of popular literature (Ponson du Terrail, Adolphe d'Ennery, Jules Mary) to writers whose names, like their novels, have been completely erased from literary memory (Alexis Bouvier, Alexis Clerc, Marc Mario). The reflection unfolds on the question of literary value and the selection it operates. As the lacunary trace of a literature considered as non-literary, but pure entertainment, the archives of the corpus are mostly unpublished, or at least ignored by literary studies. After an introductory part, intended to lay down the necessary methodological and theoretical preambles, Part II focuses on the production of serial literature seen from the inside, emphasizing the author-editor duo. Part III considers the insertion of this serial production in the media system, through the question of adaptations and the circulation of symbolic discourses. Part IV offers a reflection on the actors of serial literary production, and makes the choice to consider the expression "industrial literature" in the proper sense
Lateral Variations of Interseismic Coupling along the Himalayan Arc in Bhutan : Clues from Time Series Analysis of Sentinel-1 InSAR Data ?
No full textA recent GPS study suggests interseismic coupling variations along the Main Himalayan Thrust in Bhutan, with implications on the regional seismic potential (Maréchal et al., 2016). We use the complete Sentinel-1 radar data acquired since 2014 along descending and ascending orbits to provide average velocity maps across the front range in Bhutan, based on radar interferometry (InSAR). We compare results from time series analysis from a Small Baseline Subset approach (NSBAS, Doin et al., 2011, Grandin, 2015) and Distributed Scatterers Interferometry techniques to better assess and mitigate the various sources of noise in our data set (Ansari et al., 2018, De Zan et al., 2015). We correct tropospheric delays using global atmospheric models (ERA5, ECMWF) and ionospheric delays with split-spectrum technique (Gomba et al., 2016), to improve the quality of the deformation signal especially at large scale.
We finally confront GPS and InSAR velocity profiles across range through simple 2D elastic modelling to better constrain the displacement rate across the range and discuss the existence of shallow creep in eastern Bhutan, as suggested by GPS data
Poly(Ethylene Oxide)-LiTFSI Solid Polymer Electrolyte Filaments for Fused Deposition Modeling Three-Dimensional Printing
No full textInternational audienceAdditive manufacturing technologies open the way to the direct-integration of electronics and solid-state battery within the final 3D object. Here, a 3D printable polyethylene oxide/lithium bis(trifluoromethanesulfonyl)imide (PEO/LiTFSI) filament (2.18 x 10(-3) S cm(-1) at 90 degrees C) optimized to be used as solid polymer electrolyte in a lithium-ion battery is produced to feed a fused deposition modeling (FDM) 3D-printer. Due to its relatively poor mechanical properties compared to classical polymer filament such as polylactic acid (PLA), deep modifications of the 3D-printer were implemented in order to facilitate its printability. The solid polymer electrolyte thermal, structural, morphological, mechanical and electrical characterization is reported. Interestingly, using three different electrochemical impedance spectroscopy sample holders (lateral, sandwich and interdigitated-comb), we demonstrate that conductivity values differs for a same sample, highlighting the PEO chains orientation effect on the conductivity measurements. (C) 2020 The Author(s). Published on behalf of The Electrochemical Society by IOP Publishing Limited
Author Correction: Prevalence and risk factors for lung involvement on low-dose chest CT (LDCT) in a paucisymptomatic population of 247 patients affected by COVID-19
No full textInternational audienc
Finite Volumes for Complex Applications VIII - Methods and Theoretical Aspects [electronic resource] : FVCA 8, Lille, France, June 2017 /
No full textThis first volume of the proceedings of the 8th conference on "Finite Volumes for Complex Applications" (Lille, June 2017) covers various topics including convergence and stability analysis, as well as investigations of these methods from the point of view of compatibility with physical principles. It collects together the focused invited papers comparing advanced numerical methods for Stokes and Navier–Stokes equations on a benchmark, as well as reviewed contributions from internationally leading researchers in the field of analysis of finite volume and related methods, offering a comprehensive overview of the state of the art in the field. The finite volume method in its various forms is a space discretization technique for partial differential equations based on the fundamental physical principle of conservation, and recent decades have brought significant advances in the theoretical understanding of the method. Many finite volume methods preserve further qualit ative or asymptotic properties, including maximum principles, dissipativity, monotone decay of free energy, and asymptotic stability. Due to these properties, finite volume methods belong to the wider class of compatible discretization methods, which preserve qualitative properties of continuous problems at the discrete level. This structural approach to the discretization of partial differential equations becomes particularly important for multiphysics and multiscale applications. The book is a valuable resource for researchers, PhD and master’s level students in numerical analysis, scientific computing and related fields such as partial differential equations, as well as engineers working in numerical modeling and simulations.PART 1. Invited Papers. Chi-Wang Shu, Bound-preserving high order finite volume schemes for conservation laws and convection-diffusion equations.-E.D. Fernandez-Nieto, Some geophysical applications with finite volume solvers of two-layer and two-phase systems.-Thierry Gallouet, Some discrete functional analysis tools.-Yuanzhen Cheng, Alina Chertock and Alexander Kurganov, A Simple Finite-Volume Method on a Cartesian Mesh for Pedestrian Flows with Obstacles -- PART 2. Franck Boyer and Pascal Omnes, Benchmark on discretization methods for viscous incompressible flows. Benchmark proposal for the FVCA8 conference : Finite Volume methods for the Stokes and Navier-Stokes equations.-Louis Vittoz, Guillaume Oger, Zhe Li, Matthieu De Leffe and David Le Touze, A high-order Finite Volume solver on locally refined Cartesian meshes.-Daniele A. Di Pietro and Stella Krell, Benchmark session : The 2D Hybrid High-Order method.-Jerome Droniou and Robert Eymard, Benchmark: two Hybrid M imetic Mixed schemes for the lid-driven cavity.-Eric Chenier, Robert Eymard and Raphaele Herbin, Results with a locally refined MAC scheme - benchmark session.-Sarah Delcourte and Pascal Omnes, Numerical results for a discrete duality finite volume discretization applied to the Navier-Stokes equations.-Franck Boyer and Stella Krell and Flore Nabet, Benchmark session : The 2D Discrete Duality Finite Volume Method.-P.-E. Angeli, M.-A. Puscas, G. Fauchet and A. Cartalade, FVCA8 benchmark for the Stokes and Navier-Stokes equations with the TrioCFD code – benchmark session.-PART 3. Theoretical Aspects of Finite Volumes. Franc¸oise Foucher, Moustafa Ibrahim and Mazen Saad, Analysis of a Positive CVFE Scheme For Simulating Breast Cancer Development, Local Treatment and Recurrence.-Christoph Erath and Dirk Praetorius, Céa-type quasi-optimality and convergence rates for (adaptive) vertexcentered FVM.-Helene Mathis and Nicolas Therme, Numerical convergence for a diffusive limit of the Goldstein-Taylor system on bounded domain.-Florian De Vuyst, Lagrange-Flux schemes and the entropy property.-Caterina Calgaro and Meriem Ezzoug, -stability of IMEX-BDF2 finite volume scheme for convection diffusion equation.-Raphaele Herbin, Jean-Claude Latche and Khaled Saleh, Low Mach number limit of a pressure correction MAC scheme for compressible barotropic flows.-T. Gallouet, R. Herbin, J.-C. Latche and K. Mallem, Convergence of the MAC scheme for variable density flows.-J. Droniou, J. Hennicker, R. Masson, Uniform-in-time convergence of numerical schemes for a two-phase discrete fracture model.-Claire Chainais-Hillairet, Benoıt Merlet and Antoine Zurek, Design and analysis of a finite volume scheme for a concrete carbonation model.-Rita Riedlbeck, Daniele A. Di Pietro, and Alexandre Ern, Equilibrated stress reconstructions for linear elasticity problems with application to a posteriori error analysis.-Patricio Farrell and Alexander Linke, Uniform Second Order Convergence of a Complete Flux Scheme on Nonuniform 1D Grids.-J. Droniou and R. Eymard, The asymmetric gradient discretisation method.-Robert Eymard and Cindy Guichard, DGM, an item of GDM.-Claire Chainais-Hillairet, Benoıt Merlet and Alexis F. Vasseur, Positive lower bound for the numerical solution of a convection-diffusion equation.-Franc¸ois Dubois, Isabelle Greff and Charles Pierre, Raviart Thomas Petrov Galerkin Finite Elements.-Naveed Ahmed, Alexander Linke, and Christian Merdon, Towards pressure-robust mixed methods for the incompressible Navier-Stokes equations.-Thierry Goudon, Stella Krell and Giulia Lissoni, Numerical analysis of the DDFV method for the Stokes problem with mixed Neumann/Dirichlet boundary conditions.-J. Droniou, R. Eymard, T. Gallouet, C. Guichard and R. Herbin, An error estimate for the approximation of linear parabolic equations by the Gradient Discretization Method.-M. Bessemoulin-Chatard, C. Chainais-Hillairet, and A. Jungel, Uniform estimates for approximate solutions of the bipolar driftdiffusion system.-Abdallah Bradji, Some convergence results of a multi-dimensional finite volume scheme for a time-fractional diffusion-wave equation.-Nina Aguillon and Franck Boyer, Optimal order of convergence for the upwind scheme for the linear advection on a bounded domain.-Matus Tibensky, Angela Handlovicova, Numerical scheme for regularised Riemannian mean curvature flow equation.-Ahmed Ait Hammou Oulhaj, A finite volume scheme for a seawater intrusion model.-Clement Cances and Flore Nabet, Finite volume approximation of a degenerate immiscible two-phase flow model of Cahn-Hilliard type.-Clement Cances, Claire Chainais-Hillairet and Stella Krell, A nonlinear Discrete Duality Finite Volume Scheme for convection-diffusion equations.-Wasilij Barsukow, Stationarity and vorticity preservation for the linearized Euler equations in multiple spatial dimensions.-Jan Giesselmann and Tristan Pryer, Goal-oriented error analysis of a DG scheme for a second gradient elastodynamics model.-Alain Prignet, Simplified model for the clarinet and numerical schemes -- Author Index.This first volume of the proceedings of the 8th conference on "Finite Volumes for Complex Applications" (Lille, June 2017) covers various topics including convergence and stability analysis, as well as investigations of these methods from the point of view of compatibility with physical principles. It collects together the focused invited papers comparing advanced numerical methods for Stokes and Navier–Stokes equations on a benchmark, as well as reviewed contributions from internationally leading researchers in the field of analysis of finite volume and related methods, offering a comprehensive overview of the state of the art in the field. The finite volume method in its various forms is a space discretization technique for partial differential equations based on the fundamental physical principle of conservation, and recent decades have brought significant advances in the theoretical understanding of the method. Many finite volume methods preserve further qualit ative or asymptotic properties, including maximum principles, dissipativity, monotone decay of free energy, and asymptotic stability. Due to these properties, finite volume methods belong to the wider class of compatible discretization methods, which preserve qualitative properties of continuous problems at the discrete level. This structural approach to the discretization of partial differential equations becomes particularly important for multiphysics and multiscale applications. The book is a valuable resource for researchers, PhD and master’s level students in numerical analysis, scientific computing and related fields such as partial differential equations, as well as engineers working in numerical modeling and simulations
Author Correction : Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
No full textAuthor Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
No full texta descriptive analysis of the Eurobact II study
No full textFunding Information: The Eurobact 2 study group, National coordinators, scientific committee and participating intensive care units: East Asia and Pacific: Australia —National Coordinator: A/Prof. Alexis Tabah; Scientific Committee: Prof. Jeffrey Lipman; Participating ICUs: The Prince Charles Hospital, Adult Intensive Care Services: Dr. Mahesh Ramanan. Fiona Stanley Hospital, Intensive Care Unit: Dr. Edward Litton, Ms Anna Maria Palermo, Mr Timothy Yap, Mr Ege Eroglu. Japan —National Coordinator: Dr. Yoshiro Hayashi; Participating ICUs: Hiroshima University Hospital, ICU: Dr. Koji Hosokawa. St. Marianna University School of Medicine Hospital, Mixed ICU: Dr. Hideki Yoshida, Prof. Shigeki Fujitani. Middle East and North Africa: Iran —National Coordinator: Prof. Farid Zand; Participating ICUs: Imam-Reza, General Icu: Prof Ata Mahmoodpoor. Zahedan University of Medical Sciences, Clinical Immunology Research Center: Dr. Seyed Mohammad Nasirodin (S.M.N.) Tabatabaei. Saudi Arabia —Participating ICUs: Prince Sultan Medical Military Center, Intensive Care Unit: Dr. Omar Elrabi, Dr. Ghaleb A Almekhlafi. Latin America and The Caribbean: Argentina —National Coordinator: Dr. Gabriela Vidal; Participating ICUs: Hospital Zatti, Ucia: Dra Marta Aparicio, Microbiologa Irene Alonzo. Mexico —National Coordinator: Dr. Silvio A. Namendys-Silva; Participating ICUs: Centenario Hospital Miguel Hidalgo: Dr. Mariana Hermosillo, Dr. Roberto Alejandro Castillo. Europe And Central Asia: Belgium —National Coordinator: Dr. Liesbet De Bus; Scientific Committee: Jan De Waele; Participating ICUs: A.S.Z., Iz: Dr. Isabelle Hollevoet. Clinique Saint-Pierre, Intensive Care Unit: Dr. Nicolas De Schryver, Dr. Nicolas Serck. Bosnia And Herzegovina —National Coordinator: Dr. Pedja Kovacevic; Participating ICUs: University Clinical Centre of The Republic Of Srpska, Medical Intensive Care Unit: Dr. Pedja Kovacevic, Dr. Biljana Zlojutro. France —National Coordinator: Prof. Marc Leone; Scientific Committee: Prof. Jean-François Timsit, Prof. Etienne Ruppe, Mr. Stephane Ruckly, Prof. Philippe Montravers; Participating ICUs: Centre Hospitalier De Bigorre, Service De Réanimation Polyvalente: Dr. Thierry Dulac, Dr. Jérémy Castanera. Centre Hospitalier De Pau, Réanimation Polyvalente: Dr. Alexandre Massri, Dr. Charlotte Guesdon. Ghef Site De Marne-La-Vallée, Réanimation Polyvalente: Dr. Pierre Garcon, Dr. Matthieu Duprey. Groupe Hospitalier Paris Saint Joseph, Médecine Intensive et Réanimation: Dr. François Philippart, Dr. Marc Tran, Dr. Cédric Bruel. Hôpital De La Source, Centre Hospitalier Régional D'orléans, Médecine Intensive & Réanimation (Medical Icu): Dr. François Barbier. Hôpital Louis Pasteur, Réanimation: Dr. Pierre Kalfon, Mr Gaëtan Badre. Sorbonne Universite Pitie Salpetriere, Médecine Intensive Et Réanimation Neurologique: Dr. Sophie Demeret, Dr. Loïc Le Guennec. Italy —National Coordinator: Prof. Matteo Bassetti and Dr. Daniele Giacobbe; Participating ICUs: Città Della Salute E Della Scienza - Molinette, Anestesia E Rianimazione Universitaria: Dr. Giorgia Montrucchio, Dr. Gabriele Sales. Irccs Sacro Cuore Don Calabria, Terapia Intensiva: Dr. Ivan Daroui, Dr. Giovanni Lodi. Policlino Paolo Giaccone, Università Degli Studi Di Palermo, Terapia Intensiva Polivalente: Dr. Andrea Cortegiani, Dr. Mariachiara Ippolito, Dr. Davide Bellina, Dr. Andrea Di Guardo. Sant'andrea Hospital Sapienza University of Rome, Department of Medical And Surgical Science And Translational Medicine Intensive Care Unit: Dr. Monica Rocco, Dr. Silvia Fiorelli. Poland —National Coordinator: Dr. Adam Mikstacki; Participating ICUs: Wss Im. Wl. Bieganskiego, Oddzial Anestezjologii I Intensywnej Terapii - Osrodek Pozaustrojowych Technik Wspomagania Czynnosci Nerek I Wątroby: Prof Assoc Mariusz Peichota, Dr. Iwona Pietraszek-Grzywaczewska. Portugal —National Coordinator: Prof. José-Artur Paiva; Scientific Committee: Prof. Pedro Póvoa; Participating ICUs: CHUA Faro, Smi-1: Dr. Andriy Krystopchuk, Dr. Ana Teresa. Hospital De Cascais Dr Jose De Almeida, Unidade de Cuidados Intensivos: Dr. António Manuel Pereira de Figueiredo, Dr. Isabel Botelho. Hospital Sao Francisco Xavier, CHLO, Unidade De Cuidados Intensivos Polivalente: Dr. Vasco Costa, Dr. Rui Pedro Cunha. Russian Federation —National Coordinator: Prof Alexey Gritsan; Participating ICUs: Privolzhskiy District Medical Center, Department Anesthesiology and Intensive Care: Dr. Vladislav Belskiy, Dr. Mikhail Furman. Spain —National Coordinator: Dr. Ricard Ferrer; Participating ICUs: Vall D'herbon, Intensive Care Medicine: Dr. Ricard Ferrer, Dr. Maria Martinez, Dr. Vanessa Casares. Hospital Del Mar, Critical Care Unit: Dr. Maria Pilar Gracia Arnillas, Dr. Rosana Munoz Bermudez. Hospital Punta De Europa, Intensive Care Unit: Dr. Alejandro Ubeda, Dra Maria Salgado. Hospital Universitario La Paz, Surgical Critical Care Unit: Dr. Emilio Maseda, Dr. Alejandro Suarez De La Rica. University Hospital Severo Ochoa, Intensive Care Unit: Dr. Miguel Angel Blasco-Navalpotro, Dr. Alberto Orejas Gallego. Switzerland —National Coordinator: Dr. Josef Prazak; Scientific Committee: Dr. Niccolò Buetti; Participating ICUs: Chuv, Service De Médecine Intensive Adulte: Dr. Jl Pagani, Mrs S Abed-Maillard. Turkey —National Coordinator: Prof. Akova Murat, Dr. Abdullah Tarık Aslan; Participating ICUs: Hacettepe University of Faculty of Medicine, Intensive Care Unit(ICU): Dr. Akova Murat, Dr. Abdullah Tarik Aslan, Dr. Arzu Topeli Iskit. Acibadem Kadikoy Hospital, ICU: Dr. Selcuk Mehtap, Dr. Solakoğlu Ceyhun. Ankara Yildirim Beyazit University, Ankara City Hospital, Infectious Diseases and Clinical Microbiology: Dr. Bircan Kayaaslan, Dr. Ayşe Kaya Kalem. Aydin Adnan Menderes University Research Hospital, Anesthesia and Reanimation ICU: Prof. Dr. Ibrahim Kurt, Dr. (Professor) Murat Telli, Dr. (Associate Professor) Barcin Ozturk. Hitit University Erol Olcok Education and Research Hospital, Infectious Diseases and Clinical Microbiology: Prof. Dr. Nurcan (N) Baykam, Assistant Prof. Dr. Özlem (O) Akdoğan. Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Sadi Sun ICU: Prof.Dr. Nese Saltoglu, Ass Prof.Dr. Ridvan Karaali. Karadeniz Technical University Faculty of Medicine, Infectious Disease and Clinical Microbiology: Prof Dr. Iftihar Koksal, Assist. Prof. Firdevs Aksoy. Kartal Dr. Lutfi Kirdar Training and Research Hospital, ICU: Dr. Kemal Tolga Saracoglu, Dr. Yeliz Bilir. Kayseri City Hospital, ICU: Dr. Seda Guzeldag. Mersin University Hospital, Department of Infectious Diseases and Clinical Microbiology: Dr. Gulden Ersoz, Dr. Guliz Evik. School Of Medicine, Medipol Mega University Hospitals Complex, Department of Anesthesiology and Reanimation: Dr. Cem Erdogan. Turgut Ozal Medical Center, Department of Infectious Diseases and Clinical Microbiology: Dr. Yasar Bayindir, Dr. Yasemin Ersoy. The United Kingdom —National Coordinator: Dr. Andrew Conway Morris; Participating ICUs: Addenbrookes Hospital, John V Farman Intensive Care Unit: Dr. Andrew Conway Morris, Dr. Matthew Routledge. Addenbrookes Hospital, Neurocritical Care Unit (NCCU): Dr. Andrew Conway Morris, Dr. Ari Ercole. Croydon University Hospital, Critical Care Unit: Dr. Ashok Raj, Dr. Artemis Zormpa, Dr. George Tinaslanidis, Mrs Reena Khade. Queen Elizabeth Hospital, Lewisham and Greenwich NHS Trust, Critical Care Unit: Dr. Ashraf Roshdy Sandwell And West Birmingham Hospitals NHS Trust, Intensive Care Unit: Dr. Santhana Kannan, Dr. Supriya Antrolikar, Dr. Nicholas Marsden. Warwick Hospital, Intensive Care Unit: Dr. Ben Attwood, Dr. Jamie Patel. South Asia: India —National Coordinator: Prof. Mohan Gurjar; Participating ICUs: St Johns Medical College Hospital, Department of Critical Care Medicine, Micu: Dr. Carol Dsilva, Dr. Jagadish Chandran. Sub-Saharan Africa: Sudan —National Coordinator: Dr. Bashir El Sanousi; Participating ICUs: East Nile Hospital, Intensive Care Unit: Dr. Elfayadh Saidahmed, Dr. Hytham K.S. Hamid. Funding Information: The authors have disclosed that they do not have conflict of interest. Dr. Buetti received a grant from the Swiss National Science Foundation (Grant Number: P4P4PM_194449). Prof. Timsit received fees for lectures to 3M, MSD, Pfizer, and BioMérieux; he received research grants from Astellas, 3M, MSD, and Pfizer; and he participated to advisory boards of 3M, MSD, Bayer Pharma, Nabriva, and Pfizer. Dr. Barbier received consulting and lecture fees from MSD and BioMérieux. Prof. Cortegiani received fees for lectures from Gilead, MSD, Pfizer; and he participated to advisory boards of MSD, Gilead, Pfizer. Dr. Montrucchio received fees for lectures from Gilead, Pfizer, Thermofisher; and she participated to advisory boards of Gilead. Dr. Conway Morris sits on the scientific advisory board of Cambridge Infection Diagnostics. Prof. Akova received grants from Pfizer and Gilead, had lecture fees paid to the institution by Pfizer and Sanofi. Dr. Ramanan acknowledges support from the Metro North Hospital and Health Services Clinician-Researcher Fellowship. Dr. Conway Morris sits on the scientific advisory board of Cambridge Infection Diagnostics. Dr. Conway Morris is supported by a Clinician Scientist Fellowship from the Medical Research Council (MR/V006118/1). Prof. José-Artur Paiva received fees for consulting, advisory boards or lectures from MSD, Pfizer, Astra-Zeneca, Gilead, Jansen, Cepheid, AOP Orphan Pharmaceuticals. Funding Information: Research grants were obtained from the European society of Intensive Care Medicine (ESICM) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) study Group for Infections in Critically Ill Patients (ESGCIP), the Norva Dahlia foundation and the Redcliffe Hospital Private Practice Trust Fund. Dr. Buetti received a grant from the Swiss National Science Foundation (Grant Number: P4P4PM_194449). The study was endorsed by the critically ill group of the ESCMID (ESGCIP) and by the infection group of the ESICM with scientific input of the OUTCOMEREA network. Publisher Copyright: © 2022, The Author(s).Background: The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods: We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients’ characteristics, source of infection and microorganism distribution. We studied the association between COVID-19 status and mortality using multivariable fragility Cox models. Results: A total of 53 centers from 19 countries over the 5 continents were eligible. Overall, 829 patients (median age 65 years [IQR 55; 74]; male, n = 538 [64.9%]) were treated for a HABSI. Included patients comprised 252 (30.4%) COVID-19 and 577 (69.6%) non-COVID-19 patients. The time interval between hospital admission and HABSI was similar between both groups. Respiratory sources (40.1 vs. 26.0%, p < 0.0001) and primary HABSI (25.4% vs. 17.2%, p = 0.006) were more frequent in COVID-19 patients. COVID-19 patients had more often enterococcal (20.5% vs. 9%) and Acinetobacter spp. (18.8% vs. 13.6%) HABSIs. Bacteremic COVID-19 patients had an increased mortality hazard ratio (HR) versus non-COVID-19 patients (HR 1.91, 95% CI 1.49–2.45). Conclusions: We showed that the epidemiology of HABSI differed between COVID-19 and non-COVID-19 patients. Enterococcal HABSI predominated in COVID-19 patients. COVID-19 patients with HABSI had elevated risk of mortality. Trial registration ClinicalTrials.org number NCT03937245. Registered 3 May 2019.publishersversionpublishe
