474 research outputs found
Pallidal Beta Activity Is Linked to Stimulation‐Induced Slowness in Dystonia
No full textBackground
Pallidal deep brain stimulation (DBS) effectively alleviates symptoms in dystonia patients, but may induce movement slowness as a side-effect. In Parkinson's disease, hypokinetic symptoms have been associated with increased beta oscillations (13–30 Hz). We hypothesize that this pattern is symptom-specific, thus accompanying DBS-induced slowness in dystonia.
Methods
In 6 dystonia patients, pallidal rest recordings with a sensing-enabled DBS device were performed and tapping speed was assessed using marker-less pose estimation over 5 time points following cessation of DBS.
Results
After cessation of pallidal stimulation, movement speed increased over time (P < 0.01). A linear mixed-effects model revealed that pallidal beta activity explained 77% of the variance in movement speed across patients (P = 0.01).
Conclusions
The association between beta oscillations and slowness across disease entities provides further evidence for symptom-specific oscillatory patterns in the motor circuit. Our findings might help DBS therapy improvements, as DBS-devices able to adapt to beta oscillations are already commercially available. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Deutsche ForschungsgesellschaftCharité‐Universitätsmedizin BerlinBerlin Institute of Health at Charité (BIH) http://dx.doi.org/10.13039/501100017268SPOKES Wellcome Trust Funded Translational Partnership Fellowshi
PRESSURE BROADENING OF WATER BETWEEN 80 K AND 600 K
No full textAuthor Institution: Department of Physics., The Ohio State University; Department of Physics, North Carolina Central University; Depatment of Physics, North Carolina Central UniversityThe results of recent experiments of water pressure broadened by , , He, and will be presented. The and transitions of water () were studied between 80 K and 600 K. Results for the temperature dependence of the pressure broadening parameters are compared with predictions from theory and with previous experimental results. Low temperature measurements were made in a collisionally cooled with a continuously variable temperature between 80 K and 300 K. Static measurements were made in a quartz cell enclosed in an oven with a continuously variable temperature between 80 K and 600 K. T.M. Goyette and F.C. De Lucia, J.Mol.Spectrose.143, 346(1990)."
The causes and the effects of the deficiency in the Pre-Legislative and Legislative scrutiny processes in St. Lucia
No full textThis dissertation argues that there is a significant deficiency in the pre-legislative and legislative scrutiny processes in St. Lucia, caused by the failure of Parliament to utilize the Standing Orders in the manner in which they were intended and develop and follow a more systematic scrutiny process. The author explains how this has hindered St. Lucia’s ability to gain more benefit from the legislative process and improve the quality of legislation produced with less likelihood of amendments
J-AND K-CHANGING ROTATIONAL COLLISIONAL PROCESSES IN
No full text H. O. Everitts and F. C. De Lucia, J. Chem. Phys. 92, 6480 (1990). H. O. Everitt and F. C. De Lucia, J. Chem. Phys. 90, 3520 (1989).Author Institution: Department of Physics, Duke University; Department of Physics, Ohio State University; Department of Physics, U.S. Army Research OfficeWe have used time-resolved infrared/mm-wave double resonance techniques to study rotational and vibrational collisional processes in methyl chloride. As was the case with , the dipole-dipole process in has the largest cross section, and the processes are well described by a two parameter Statistical Power Gap Law (SPG). In addition, we have measured a rapid thermalizing processes in of similar to that observed in of . However, the data exhibited a feature distinct from that of the . Whereas the process populates the final states with an ambient temperature Boltzmann distribution, it populates the states with an initially nonambient Boltzmann distribution. This initial temperature is related to the energy of the rotational state populated by the laser pump, and its relaxation rate is related to the rate that the process populates the A symmetry (the pumped symmetry) states. The and results will be reconciled
PRESSURE BROADENING OF HDO BETWEEN 90 K AND 600 K
No full text T.M Goyette and F.C. De Lucia, J. Mol. Spectrosc. 143, 346 (1990).Author Institution: Department of Physics, North Carolina Central University; Department of Physics, The Ohio State UniversityThe results of recent experiments of HDO pressure broadened by , , He, and will be presented. The 2-2, 3 and 7 -6 transitions of water (HDO) were studied between 90 K and 600 K. Results for the temperature dependence of the pressure broadening parameters and collisional cross sections are discussed. The transitions available for study in HDO allow a comparison of pressure broadened lines with widely different lower state energies. Trends in the 300K broadening parameter and temperature coefficient are noted. Low temperature measurements were made in a collisionally cooled with a continuously variable temperature between 80 K and 300 K. Static measurements were made in a quartz cell enclosed in an oven with a continuously variable temperature between 80 K and 600 K
PRESSURE BROADENING BETWEEN 80 K AND 600 K
No full text D. T. Tejwani, and E. S. Yeung,J. Chem, Phys. 63, 4562(1975). Ebenstein, and De Lucia. J. Mol. Spectrosc. (in press).Author Institution: Department of Physics, Duke University; Department of Physics, Duke University; Department of Physics, Duke University; Department of Physics, Duke University; Department of Physics, University of South Alabama; Department of Physics, Duke UniversityThe results of recent pressure broadening experiments on and pressure broadened by , and He will be presented. Nitrogen dioxide ) was studied over a wide range of quantum states at 300 K. The results are compared with previous Anderson theory calculations of Tejwani and . Water was studied between 80 K and 600 K. Nitric acid was studied between 80 K and 380 K. Results for the temperature dependence of the pressure broadening parameters are compared with predictions from Anderson theory. Low temperature measurements were made in a collisionally cooled with a continuously variable temperature between 80 K and 300 K. Static measurements were made in a quartz cell enclosed in an oven with a continuously variable temperature between 80 K and 600 K
Striato-pallidal oscillatory connectivity correlates with symptom severity in dystonia patients
No full textAbstract Dystonia is a hyperkinetic movement disorder that has been associated with an imbalance towards the direct pathway between striatum and internal pallidum, but the neuronal underpinnings of this abnormal basal ganglia pathway activity remain unknown. Here, we report invasive recordings from ten dystonia patients via deep brain stimulation electrodes that allow for parallel recordings of several basal ganglia nuclei, namely the striatum, external and internal pallidum, that all displayed activity in the low frequency band (3–12 Hz). In addition to a correlation with low-frequency activity in the internal pallidum (R = 0.88, P = 0.001), we demonstrate that dystonic symptoms correlate specifically with low-frequency coupling between striatum and internal pallidum (R = 0.75, P = 0.009). This points towards a pathophysiological role of the direct striato-pallidal pathway in dystonia that is conveyed via coupling in the enhanced low-frequency band. Our study provides a mechanistic insight into the pathophysiology of dystonia by revealing a link between symptom severity and frequency-specific coupling of distinct basal ganglia pathways
On the Cohomology of a Holomorphically Separable Complex Analytic Space
No full textThe author gives the following extension of a result of M. Raimondo and A. Silva. Let X be a holomorphically separable complex
space (reduced and with countable topology) of dimension n ≥ 1, F a coherent analytic sheaf
on X and q a fixed integer > −codh F. Then if Hk(X; F) = 0 for all k > q, the vector space
Hq(X; F) is either zero or infinite-dimensional
Actor as a co-author
No full textDiplomová práce se zabývá tématem herce jako spoluautora, možností autorského vkladu herce v inscenaci a hranicemi tohoto autorství. Celá problematika diplomové práce se vztahuje k autorskému magisterskému projektu Proměním se v zajíce se zármutkem a obrovskou opatrností. Obsahem první části diplomové práce je schopnost kolektivní spolupráce skupiny Gob Squad. V popisu jejich práce reflektuji své tvůrčí zkušenosti. Ve druhé části se zaměřuji na postup Anny Klimešové a kolektivu u zkoušení inscenace Proměním se v zajíce se zármutkem a obrovskou opatrností. Třetí část řeší téma herce jako spoluautora v souvislosti s výukou na katedře alternativního a loutkového divadla a jejího vlivu na mě, jako na herce a tvůrce.This master thesis focuses on the actor as a co-author, the possibilities of actor’s involvement as an author in the play and boundaries of the authorship. The research problem of the master thesis is tied to the master project I shall go into a hare with sorrow and such mickle care. The first part of the master thesis is focused on the collective ability of cooperation of the God Squad group. In their work I reflect my creative experiences. In the second part I focus on the progress of Anna Klimesova and the group while rehearsing the play I shall go into a hare with sorrow and such mickle care. The topic of the third part is the actor as a co-author in connection to learning on the department of alternative and puppet theatre and its influence on me as an actor and a creator
Statistická analýza některých hospodářských ukazatelů
Full text linkNazov prace: Statisticka analyza nekterych hospoddrskych ukazatelu Autor: Lucia Trlicovd Katedra: Pravdepodonosti a matematicke statistiky Vcduci prace: RNDr. Jitka Zichova, Di- e-mail veduceho: zichova(ci),karlin.mfj.cuni.cz Abstrakt: Tato prdca sa zaoberd analyzou vybranych hospoddrskych ukazovatel'ov pomocou roznych statistickych metod. Popisujem v nej pdf makroekonomickych ukazovatel'ov: index vnimania korupcie (CPI), rast redlneho HDP, redlny HDP na hlavu, mieru nczamestnanosti a infldciu. Pri analyzovani tychto velicin sow pouzila tri metody: koretacnu analyzu, regresnu analyzu a analyzu rozptylu. Vysledkom su vzt'ahy tnedzi velicinami, klore poukazuju na rdznu mieru zdvislosti medzi nimi. Zaverom je zhodnotenie tychto vzfahov. K praktickym vypoctom som vyuzlla statisticky software NCSS. Kfucove slova: hospoddrske veliciny, koreldcia, regresia, ANOVA Title: Statistical analysis of some economic indices Author: Lucia Trlicovd Department: Department of Probability and Mathematical Statistics Supervisor: RNDr. Jitka Zichovd, Dr. Supervisor's e-mail address: zichuvafykarlin.mffcuni.cz Abstract: This thesis concerns of analysis of selected economic indices using various statistical techniques. I describe therefive macroeconomic indices: corruption perception index (CPI), real (JDP growth, real CjDP per...Nazov prace: Statisticka analyza nekterych hospoddrskych ukazatelu Autor: Lucia Trlicovd Katedra: Pravdepodonosti a matematicke statistiky Vcduci prace: RNDr. Jitka Zichova, Di- e-mail veduceho: zichova(ci),karlin.mfj.cuni.cz Abstrakt: Tato prdca sa zaoberd analyzou vybranych hospoddrskych ukazovatel'ov pomocou roznych statistickych metod. Popisujem v nej pdf makroekonomickych ukazovatel'ov: index vnimania korupcie (CPI), rast redlneho HDP, redlny HDP na hlavu, mieru nczamestnanosti a infldciu. Pri analyzovani tychto velicin sow pouzila tri metody: koretacnu analyzu, regresnu analyzu a analyzu rozptylu. Vysledkom su vzt'ahy tnedzi velicinami, klore poukazuju na rdznu mieru zdvislosti medzi nimi. Zaverom je zhodnotenie tychto vzfahov. K praktickym vypoctom som vyuzlla statisticky software NCSS. Kfucove slova: hospoddrske veliciny, koreldcia, regresia, ANOVA Title: Statistical analysis of some economic indices Author: Lucia Trlicovd Department: Department of Probability and Mathematical Statistics Supervisor: RNDr. Jitka Zichovd, Dr. Supervisor's e-mail address: zichuvafykarlin.mffcuni.cz Abstract: This thesis concerns of analysis of selected economic indices using various statistical techniques. I describe therefive macroeconomic indices: corruption perception index (CPI), real (JDP growth, real CjDP per...Katedra pravděpodobnosti a matematické statistikyDepartment of Probability and Mathematical StatisticsMatematicko-fyzikální fakultaFaculty of Mathematics and Physic
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