3,567 research outputs found
Un grammatico in officina. Tommaso Ferrando e gli esordi della stampa a Brescia
No full textUn grammatico in officina. Tommaso Ferrando e gli esordi della stampa a Bresci
Il “mito” di Tommaso Ferrando nella storiografia dei sec. XVIII-XX
No full textIl “mito” di Tommaso Ferrando nella storiografia dei sec. XVIII-X
A imagem de Alessandro Baricco no Brasil
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis, 2013.Com a intenção de delinear o modo pelo qual o escritor italiano Alessandro Baricco se inseriu no sistema literário brasileiro e os caminhos percorridos pelos seus livros traduzidos, esta dissertação dá voz às experiências tradutórias de seus tradutores. A inserção de Bariccono Brasil tem seu início em 1997, através de uma proposição da Profa. Dra. Roberta Barni à editora Iluminuras da tradução de Oceano Mare. A partir daí, outras sete obras foram publicadas no Brasil, sendo três delas traduzidas por Roberta Barni e as outras quatro por quatro tradutores diferentes. De um lado, considera-se o tradutor como figura principal namediação entre culturas, e, de outro, se analisa a realidade desta figuradentro do sistema literário, sua invisibilidade, seus limites e o exercíciode sua profissão. A pesquisa conta, ainda, com críticas e resenhas referentes ao autor italiano publicadas em jornais consagrados no Brasil, considerando estas como parte constituinte da imagem de Baricco refletida em território nacional. Abstract : Intending to delineate the way the Italian writer Alessandro Baricco has been inserted in the Brazilian literary system and the paths his translated books have followed, this thesis gives voice to the translating experiences of his translators. Baricco's insertion in Brazil began in 1997, through a personal project of Dr. Roberta Barni, with her translation of Oceano Mare. Since then, seven other of his works have been published in Brazil, three of which were translated by Roberta Barni and the other four by four different translators. On the one hand,the translator is considered as the main figure in mediation betweencultures and, on the other, this figure's reality is analyzed within theliterary system: its invisibility, its limits and its professional practice. Criticisms and reviews of this Italian author published in well established Brazilian newspapers are also considered, with the understanding that they are part of Baricco's image reflected here
Recruitment of H3.3 histone chaperon activity to R-loops by the Splicing-Factor Proline and Arginine Rich (SFPQ) stabilizes repetitive elements in cancer cells
No full textR-loops are triple-stranded nucleic acid structures containing an RNA moiety paired with its antisense DNA template strand and the loop of the displaced, single-stranded DNA (ssDNA). RNA:DNA hybrids form under normal physiological conditions and exert multiple biological functions. However, persistent R-loops have been shown to mediate replication stress, DNA damage and drive genomic instability, with a particular relevance at vertebrate telomeres.
We recently found that the RNA-binding protein SFPQ has a critical role in limiting R-loops formation at telomeres of human cancer cell. In line with this, loss-of-function SFPQ cells show increased levels of RNA:DNA hybrids, replication stress and DNA damage markers and subsequent genomic instability at telomeres level.
Here we show that SFPQ function is not limited to telomeres, but expands to other non-coding repeat regions in the human genome, as depicted by ChIP-seq analysis, paralleled by increased R-loop levels and genomic instability.
Moreover, SFPQ action is mediated by the its novel interactor DAXX, that allows R-loop suppression by inserting H3.3 histone variant.
Finally, RNA-seq analysis pointed out a SFPQ - R-loop dependent signature of innate immune response activation, unveiling a novel connection between non coding genome regulation and immune response, suggesting SFPQ as putative target for sarcoma treatment.R-loops are triple-stranded nucleic acid structures containing an RNA moiety paired with its antisense DNA template strand and the loop of the displaced, single-stranded DNA (ssDNA). RNA:DNA hybrids form under normal physiological conditions and exert multiple biological functions. However, persistent R-loops have been shown to mediate replication stress, DNA damage and drive genomic instability, with a particular relevance at vertebrate telomeres.
We recently found that the RNA-binding protein SFPQ has a critical role in limiting R-loops formation at telomeres of human cancer cell. In line with this, loss-of-function SFPQ cells show increased levels of RNA:DNA hybrids, replication stress and DNA damage markers and subsequent genomic instability at telomeres level.
Here we show that SFPQ function is not limited to telomeres, but expands to other non-coding repeat regions in the human genome, as depicted by ChIP-seq analysis, paralleled by increased R-loop levels and genomic instability.
Moreover, SFPQ action is mediated by the its novel interactor DAXX, that allows R-loop suppression by inserting H3.3 histone variant.
Finally, RNA-seq analysis pointed out a SFPQ - R-loop dependent signature of innate immune response activation, unveiling a novel connection between non coding genome regulation and immune response, suggesting SFPQ as putative target for sarcoma treatment
La maturità di Alessandro Fei del Barbiere, in bilico tra Maniera e Riforma
No full textThis article studies the mature career of the Florentine painter Alessandro Fei del Barbiere (1537-1592), beginning with the rediscovery of the 'Ascension' altarpiece formerly in the Albizi Chapel in the destroyed church of San Pier Maggiore, Florence. Studying this painting and others recorded in 1584 by the biographer Raffaello Borghini, such as the two altarpieces for Santa Maria delle Grazie and the Madonna dell'Umiltà in Pistoia, the author reconstructs a body of works showing how in the 1580s Fei gradually went beyond the archaic style of his apprenticeship - he had been trained by Ridolfo del Ghirlandaio and Pierfrancesco Foschi, but was also marked by the Maniera of Vasari - evolving towards naturalism in both mimesis and pictorial handling. In Florence, his development partly parallels that of Santi di Tito and his circle, but Fei was also influenced by a probable sojourn during the early part of that decade in Rome, where he could have been inspired by Girolamo Muziano and the painters working for Pope Gregory XIII. Among other proposals, the author suggests that the artist was responsible for decorating the chancel of Fiesole Cathedral (c. 1584-1589), which consisted of an altarpiece, only rarely discussed by scholars, and a cycle of frescoes hitherto attributed to Nicodemo Ferrucci
Tra socialdemocrazie e Perestrojka. Le relazioni internazionali del Pci attraverso le carte di Alessandro Natta
No full textThis essay reconstructs the foreign policy of the Italian Communist Party during the four
years of Alessandro Natta’s secretariat (1984-1988) through largely original archival documentation,
from the Alessandro Natta Fonds of the Historical Archive of the Chamber of
Deputies. Natta’s papers are also cross-referenced with those kept in the PCI Archive at the
Gramsci Foundation. The author analyses the relationship that the PCI establishes with
Gorbachev’s Perestroika, Deng’s China, and European social democracies during the last
years of the Cold War
On prosperity and posterity: the need for fiscal discipline in a monetary union
No full textWe show how in a Blanchard-Yaari, overlapping generations framework, perfect substitutability of government bonds in Monetary Union tempts governments to exploit the enlarged common pool of savings. In Nash equilibrium all governments increase their bond financed transfers to current generations (prosperity effect) at the expense of future generations (posterity effect). The resulting deficit bias occurs even if one assumes that before Monetary Union countries had eliminated their deficit bias by designing appropriate domestic institutions. The paper provides a rationale for an increased focus on fiscal discipline in Monetary Union, without the need to assume imperfect credibility of existing Treaty provisions or to refer to extreme situations involving sovereign default. We draw on existing empirical evidence to argue that the degree of government bond substitutability within the European Monetary Union is an order of magnitude larger than in the global economy. JEL Classification: D62, E61, E63bond market integration, common pool, European Monetary Union, fiscal discipline, fiscal rules, fiscal spillover effects, overlapping generations
Micro-geometry characterisation of sloped surfaces: an improved methodology for roughness parameters estimation
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