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Pengaruh Fraksi Daun Sidagari (Sida rhombifolia L.) terhadap Kadar Asam Urat dan Uji Toksisitas Sub Akutnya pada Mencit Putih Jantan
No full textUJI AKTIVITAS EKSTRAK ETANOL BATANG DAN DAUN SIRIH CINA (Peperomia pellucida (L.) Kunth) TERHADAP Trichophyton rubrum: Antifungal Activity of Ethanolic Stem and Leaf Extracts of Peperomia pellucida (L.) Kunth against Trichophyton rubrum
Full text linkDermatofitosis adalah jenis infeksi kulit yang disebabkan oleh fungi dermatofita, salah satu penyebab yang paling umum adalah spesies Trichophyton rubrum. Tanaman sirih cina (Peperomia pellucida (L.) Kunth) merupakan bahan alam yang mengandung senyawa antijamur seperti alkaloid, flavonoid, saponin, tanin, dan terpenoid. Keefektifan penggunaan kombinasi batang dan daun sirih cina oleh masyarakat perlu dikaji secara saintifik. Oleh karena itu, penelitian ini ditujukan untuk mengetahui aktivitas antifungi dari ekstrak etanol batang dan daun Peperomia pellucida (L.) Kunth terhadap Trichophyton rubrum. Penelitian ini terdiri atas 14 kelompok perlakuan dengan 5 kali pengulangan. Aktivitas antifungi diuji menggunakan metode cup-plate dengan variasi konsentrasi 10%, 15%, 25%, 40%, 60%, 85% dari setiap ekstrak batang dan daun sirih cina. Uji ANOVA Dua Arah menunjukkan terdapat perbedaan diameter zona hambat yang nyata akibat pengaruh dari jenis ekstrak dan kelompok perlakuan. Uji lanjut Duncan menunjukkan bahwa ekstrak batang memberikan aktivitas antifungi yang lebih baik dari pada ekstrak daun dengan urutan daya hambat tertinggi hingga terendah yakni konsentrasi 85%, 60%, 40%, 25%, 15%, dan 10%. Dengan demikian dapat dinyatakan bahwa semakin tinggi konsentrasi maka semakin besar pula daya atau zona hambat yang terbentuk.Dermatofitosis adalah jenis infeksi kulit yang disebabkan oleh fungi dermatofita, salah satu penyebab yang paling umum adalah spesies Trichophyton rubrum. Tanaman sirih cina (Peperomia pellucida (L.) Kunth) merupakan bahan alam yang mengandung senyawa antijamur seperti alkaloid, flavonoid, saponin, tanin, dan terpenoid. Keefektifan penggunaan kombinasi batang dan daun sirih cina oleh masyarakat perlu dikaji secara saintifik. Oleh karena itu, penelitian ini ditujukan untuk mengetahui aktivitas antifungi dari ekstrak etanol batang dan daun Peperomia pellucida (L.) Kunth terhadap Trichophyton rubrum. Penelitian ini terdiri atas 14 kelompok perlakuan dengan 5 kali pengulangan. Aktivitas antifungi diuji menggunakan metode cup-plate dengan variasi konsentrasi 10%, 15%, 25%, 40%, 60%, 85% dari setiap ekstrak batang dan daun sirih cina. Uji ANOVA Dua Arah menunjukkan terdapat perbedaan diameter zona hambat yang nyata akibat pengaruh dari jenis ekstrak dan kelompok perlakuan. Uji lanjut Duncan menunjukkan bahwa ekstrak batang memberikan aktivitas antifungi yang lebih baik dari pada ekstrak daun dengan urutan daya hambat tertinggi hingga terendah yakni konsentrasi 85%, 60%, 40%, 25%, 15%, dan 10%. Dengan demikian dapat dinyatakan bahwa semakin tinggi konsentrasi maka semakin besar pula daya atau zona hambat yang terbentuk
Test of Teratogenic Effects of Transflutrin and D-Alletrin Compounds in Mosquito Drugs against Mice Fetus (Mus Musculus L.): Test of Teratogenic Effects of Transflutrin and D-Alletrin Compounds in Mosquito Drugs against Mice Fetus (Mus Musculus L.)
Full text linkTransflutrin and d-alletrin compounds in insect repellents that are widely used by people are classified as insecticides which can be teratogenic. This study aims to determine the teratogenic effects caused by a combination of transflutrin and d-alletrin compounds on fetus mice (Mus musculus L.) during the period of organogenesis. The design used was a randomized block design (RBD) with 4 treatments and 5 groups as replications. The treatment consisted of exposure to a combination of transflutrin and d-alletrin compounds with each dose of 4 mg and 45 mg for 0, 6, 8 and 10 hours at gestational age 6 to 15 days. On the 18th day the pregnancy was carried out laparotomy to take the fetus from the mother's uterus to the mice. The design used was a randomized block design (RBD) with 4 treatments and 5 groups as replications. The treatment consisted of exposure to a combination of transflutrin and d-alletrin compounds with each dose of 4 mg and 45 mg for 0, 6, 8 and 10 hours at gestational age 6 to 15 days. On the 18th day the pregnancy was carried out laparotomy to take the fetus from the mother's uterus to the mice. The results showed that the exposure of 6, 8 and 10 hours of the combination of transflutrin and d-alletrin compounds could cause 33.3%, 40.9% and 38.9% of fetal deaths, 19.1% of hemorrhages, respectively. 36.8% and 50%, body cancer as much as 2.38%, 2.6% and 5.6%, body humping (flexion) by 0%, 5.2% and 11.1%, bone deformities as much as 4.7%, 10, 5% and 16.7%, and abnormalities resulting from ossification of fetal mice were 7.1%, 13.2% and 19.4%. But the treatment of exposure did not affect body weight, body length and fetal morphology of mice. From the results of the study it can be concluded that the combination of transflutrin and d-alletrin compounds have mild teratogenic effects on fetus mice and the teratogenic effects increase with increasing exposure time to external abnormalities and fetal internal mice.
 
Pembudidayaan dan Pembuatan Teh Daun Binahong untuk Mengobati Penyakit Asam Urat: Cultivation and Production of Binahong Leaf Tea to Treat Gout
No full textThe community service program aims to introduce binahong plants, and its benefits to overcome gout and how to cultivate. The community will be given the skill of how to make binahong leaf tea so that utilization of binahong leaves to overcome gout become more practical, right doses so the goal of therapy for gout can be achieved. Gout is one form of arthritis that is often associated with reddish, swollen, hot and stiff joints. The prevalence of gout from the year is increasing. Men have a higher risk of gout than women. Community efforts in treating gout using chemical drugs have been shown to cause serious side effects. The use of herbal medicine can be used as an alternative therapy in dealing with this disease. The binahong plant is an empirically widely used plant to treat various illness. One of them is gout. The use of this plant in gout support therapy is essential because, from the research result, this plant has many properties with minimal toxicity. The method used in this service is by providing counselling and training. The results of evaluating the implementation of cultivation and making of binahong leaf tea for the treatment of gout, many as 29 residents of RT 02 Mendalo Indah Jambi, Luar Kota Village. The benefits of binahong as a treatment for gout as well as residents also know how to cultivate binahong for self-treatment and economic improvement container of the citizens
BREADFRUIT PEEL AS THE MOST POTENT RADICAL SCAVENGERS FOR SKIN PROTECTION
Full text linkThe sun's ultraviolet radiation causes erythema, premature aging, sunburn, hyperpigmentation, inflammation, and dry skin. For this purpose, sunscreen with an SPF value of over 15 is needed to protect the skin against UV rays. Breadfruit peel containing flavonoids may protect against free radicals and UV radiation. This study aims to increase SPF value from breadfruit fractionate by combining niacinamide and alpha-tocopherol. The ABTS and BSLT methods were used to screen potent free radical scavengers in n-hexane, dichloromethane, ethyl acetate, and methanol extracts. The dichloromethane extract had the highest potential as a free radical scavenger, with IC50 20,90 more or less 0,54, and the lowest toxicity, with LC50 234,42 more or less 1,06. Then, the scavenging activities and selective index of fractionates of dichloromethane were evaluated to show that the DM2 fraction had the strongest free radical scavenging activity and the lowest toxicity, with the highest selective index value of 46.08. The main active ingredient was DM2, combined with niacinamide and alpha-tocopherol into five compositions. The results of the lotion dosage forms revealed that the fifth formula, F5, met the requirement SNI standards and was stable during storage, with an SPF value of 20.61 more or less than 0.75, which was three times higher than the positive control with an SPF value of 6.67 more or less 1.28
Effect of Propolis Extract to Heal The Burns in New Zealand Rabbit
No full textPropolis contains arginine (amino acids), ferulic acid (a derivative compound cinnamic which promotes the formation of collagen), flavonoids (phenolic compounds), and other compounds that can prevent the growth of bacteria, virus, and fungi. The purpose of this study was to measure the most concentration of propolis extracts that effective to heal burns of New Zealand rabbit's. This was an experimental study with the post-test only control group design. As many as 15 male white rabbits were divided into 5 groups which treated by propolis extract with concentration of 50%, 75%, 100%, positive control by bioplacenton and negative control with propylene glycol. The macroscopic observation was done with detached necrosis tissue and the growth of collagen tissue as the parameter. Data were analyzed by using the one-way ANOVA and continued by the SNK test. The results of this study indicated that the propolis extracted have potency on healing burn wound with the significance of 0.00 (p≤0,05). In the concentration of 100%, extract of propolis has potency on healing burn wound that proportionates with bioplacenton with the significance value of 1.000 (p≥0,05). It is concluded that by increasing dose, the healing time of burn wound will be shortened.Keywords : Propolis, healing burns, rabbit</jats:p
Toxicity Test of Inggu (Ruta angustifolia (L)) Ethanol Leaves Extract to Male White Mice (Mus musculus)
Full text linkInggu leaf (Ruta angustifolia (L.) is one of the medicinal plants that is widely used by Indonesian people as traditional medicine for various diseases. One of the properties of the inggu plant can be used to treat fever, toothache, heartburn and ulcers. Toxicity testing ethanol extract of guinea leaf using a completely randomized design (CRD) with 7 treatments with stratified doses of 500, 1000, 2000, 4000, 8000, 16,000 mg/kg BW and control. Parameters observed after administration of the extract were diarrhea, changes in breathing, changes in aggressive behavior and decreased movement activity. Liver and kidney organs were taken to determine the organ weight ratio. The results showed that the ethanol extract of inggu leaves with graded doses up to a dose of 16,000 mg/kg BW in experimental animals did not cause death, which was included in the practically non-toxic category. Administration of ethanol extract of guinea leaves at a dose of 500 mg/kg BW to 16,000 mg/kg BW caused a decrease in locomotion activity in experimental animals during the 4-hour observation time. The ratio of organ weight of mice from the test results of the ratio of liver, right kidney and left kidney of mice was not different from that of control animals
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Laporan Hasil Riset Pembinaan Tenaga Kesehatan Evaluasi Pelaksanaan Praktik Laboratorium Pada Program Studi Dilingkungan Politeknik Kesehatan (Poltekkes) Kupang
No full textPoliteknik Kesehatan Kupang merupakan Instansi Perguruan Tinggi yang menyelenggakan program pendidikan vokasional dalam sejumlah bidang keahlian, khaususnya dalam lingkup ilmu-ilmu kesehatan. Dalam perkembangan kedepannya, Institusi Politeknik Kesehatan Kupang perlu ditata dan dikembangkan menjadi Institusi Unggulan dalam menghasilkan tenaga kesehatan yang berkualitas dan dapat memenuhi permintaan pasar. Untuk pencapaian hal diatas Politeknik Kesehatan Kupanng perlu melaksanakan upaya pengembangan Institusi secara komprehensiff dan berkelanjutan. Praktikum di laboratorium merupakan unsure yang sangat penting untuk menghasilkan tenaga kesehatan yang bermutu, sehingga pengembangan laboratorium sangat diperlukan. Tujuan dari penelitian ini untuk mengetahui pelaksanaan kegiatan PBM (Proses Belajar Mengajar) praktik khususnya praktikum di laboratorium pada semua program studi di lingkungan Poltekkes Kupang yang meliputi perencanaan, pelaksanaan dan evaluasi. Metode penelitian ini adalah survey dengan analisis deskripsi, responden program-program studi menggunakan lembar observasi.Hasil penelitian menunjukkan jumlah gedung laboratorium di setiap program studi masih kurang, belum sesuai dengan jumlah mata ajar yang memiliki praktikum di laboratorium sesuai kurikulum. Perencanaan pelaksanaan praktikum di program studi, sudah dilaksanakan ddengan baik, karena setiap praktikum disertakan dengan SAP dan Penuntun Praktikum, kecuali Program Studi Gizi, tingkat kehadiran dosen pengawas Instruktur) praktikum dan mahasiswa peserta praktikum baik (66,6 %-100 %). Kelulusan mahasiswa yang mengikuti praktikum di laboratorium sudah baik, berkisar antara 57 % sampai 100 %, kecuali pada program Studi Gigi dan Farmasi
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