117,348 research outputs found
Female stress incontinence and uterovaginal prolapse : collagen turnover and hormone sensitivity in urogenital tissue
No full textBackground: Prevalence of both stress urinary incontinence (SUI) and uterovaginal prolapse (UP) is high and rising with age. Risk factors include multiparity, obesity, chronic obstructive lung disease and previous gynecological surgery. The underlying pathology is still unknown but may include defective connective tissue.Aims: To study collagen turnover markers in urogenital tissue, in order to gain insight regarding a possible altered collagen synthesis or metabolism in SUI and UP, if circulating sex steroids have any influence on collagen turnover and if there are any differences in sex steroids between women with or without SUI.Methods: A total of 126 women were consecutively enrolled and classified according to urogenital status into three groups: SUI without UP, N=71; UP without incontinence, N=24; urologically healthy controls without UP, N=31. Urogenital tissue biopsies and serum was collected for analysis of the tissue and serum collagen turnover markers carboxy-terminal propeptide of type I procollagen (PICP), the carboxy-terminal telopeptide of type I collagen (ICTP) and the amino-terminal propeptide of procollagen III (PIIINP) and serum steroids, steroid binding proteins and IGF-I.Result: Compared to controls tissue (T-)PIIINP and T-ICTP were significantly lower in SUI and T-PICP and T-PIIINP significantly higher in UP. Tissue collagen turnover markers were positively correlated to serum estradiol-17beta, especially at physiological serum estrone levels, in the controls but not in SUI patients except to a certain degree in premenopausal subjects. Instead of being related to serum estradiol- 17beta, tissue collagen turnover markers in SUI patients were negatively correlated to serum total and free testosterone. There were no significant differences between comparable subgroups of SUI patients and controls in circulating sex steroids.Conclusions: Our findings indicate a reduced collagen breakdown in SUI and an increased collagen turnover in UP, both which may negatively tissue elasticity and strength. Urogenital tissue collagen turnover may be stimulated by estrogen in urologically healthy women but not in SUI patients in general but to a certain degree in premenopausal subjects. The latter finding may indicate menopause related changes as one underlying factor behind SUI. At supraphysiological concentrations estrone may act as a partial estradiol-17B antagonist also in vivo. Urogenital tissue collagen turnover in SUI patients may be inhibited by testosterone, perhaps by inhibition of matrix metalloprotease activity. Our findings emphasize the fact that SUI and UP have two distinctly different etiologies and shall be studied using »clean« patient materialsList of scientific papersI. Edwall L, Carlström K, Jonasson AF (2005). "Markers of collagen synthesis and degradation in urogenital tissue from women with and without stress urinary incontinence." Neurourol Urodyn 24(4): 319-24 https://pubmed.ncbi.nlm.nih.gov/15924353II. Edwall L, Carlström K, Jonasson AF (2007). "Endocrine status and markers of collagen synthesis and degradation in serum and urogenital tissue from women with and without stress urinary incontinence." Neurourol Urodyn 26(3): 410-5 https://pubmed.ncbi.nlm.nih.gov/17266139III. Edwall L, Carlström K, Fianu Jonasson A (2008). "Markers of collagen synthesis and degradation in urogenital tissue and serum from women with and without uterovaginal prolapse." Mol Hum Reprod 14(3): 193-7. Epub 2008 Jan 28 https://pubmed.ncbi.nlm.nih.gov/18230625IV. Edwall L, Carlström K, Fianu Jonasson A (2008). "Different estrogen sensitivity of urogenital tissue from women with and without stress urinary incontinence." Neurourology and Urodynamics (Submitted)</p
Rutinbesöket hos diabetessjuksköterskan - Vårdmötet och dess innebörd för personer med typ 2 diabetes
No full textBackground and aim: Diabetes care with diabetes nurse-led clinics in primary care has been
established in Sweden since the 1980s. Patients with Type 2 diabetes are involved in lifelong
treatment through annual diabetes check-up performed by the diabetes nurse specialists. The
meaning is to promote patient’s health, diabetes control as well as the recommended physical
examination. Knowledge about patients’ lived experience of these regular check-ups is
important for the further development of diabetes nursing in primary care (study I). However,
the communication depends on each party’s agenda or goals and the interaction structure
during these check-ups is rarely studied (study II). Another aim was to elucidate the essential
meaning of a consultation between diabetes nurse specialists and patients to gain a deeper
understanding of the patients’ experiences (study III). Finally the glycaemic control, patients’
perceived foot problems, reported self foot care and outcomes of foot examination performed by
DNSs over a four year period were investigated (study IV).
Methods: Narrative interviews were conducted with 20 patients and a phenomenologicalhermeneutic
method was used in the analysis and interpretation of the text (study I, III). In
study II an applied conversation analysis was used in 20 video observations. A descriptive
longitudinal study on foot examinations was completed at two diabetes nurse-led clinics in
primary care (study IV). Patients (n=243) were examined at the clinics in 1999 and 2004.
Results: Patients showed an overall positive influence on their way of living with the disease
by being confirmed, being guided within the disease process, becoming confident and
independent and being relieved(study I). Annual check-ups consisted of five phases: opening,
health history, physical examination, conclusion and closing. The informative value of checkups
varied depending on, the patients’ problems and the type of examination used, among
other things (study II). The patient’s experience of a consultation was interpreted as
manifestation of hold on the disease control. This means a safeguard to continue daily life
shown in the four themes being controlled, feeling exposed, feeling comfortable, and feeling
prepared (study III). Although the increased risk to patients’ foot complications over the period, a
lack of compliance to basic foot care was revealed. This raised question about the informative
value of foot care discussions at regular annual check-ups (study IV).
Relevance to clinical practice and implications: The development of diabetes-nurse-led
clinics from the perspective of the patient must consider the patient’s individual need for
support and continuity with the diabetes nurse specialist. Routines of instruction to patients
during physical examination procedures have an influence on patients’ understanding of
measurement outcomes. Diabetes nurse specialists need to monitor all patients’ foot care as
patients need to know the importance of self foot care
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Sarah L. Blum Author Visit - Warrior Nurse: PTSD and Healing
No full textHear Sarah L. Blum, author of Women Under Fire: Abuse in the Military, discuss her newest book, Warrior Nurse: PTSD and Healing followed by a Q&A and book signing.
Sarah L. Blum is a decorated Vietnam veteran who served as an operating room nurse during the intense fighting of 1967. In recognition of her service, she was awarded the Army Commendation Medal.
Sponsored by CWU Veterans Center and CWU Libraries.https://digitalcommons.cwu.edu/libraryevents/1252/thumbnail.jp
Lillian L. Lambert, Author, Speaker, and Entrepreneur
No full textLillian L. Lambert, Author, Speaker, and Entrepreneu
Letter to Alfred L. Shoemaker, February 10, 1948
No full textA handwritten letter from an unknown author addressed to Alfred L. Shoemaker, dated February 10, 1948. Within, the author discusses the Pennsylvania Dutch word for Ash Wednesday, along with traditions associated with this day.https://digitalcommons.ursinus.edu/shoemaker_documents/1118/thumbnail.jp
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