682 research outputs found
Uso do azul de toluidina seguido Da quimioluminiscência como método euxiliar de diagnóstico clínco de lesões bucais cancerizáveis
No full textTCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.O diagnóstico precoce do câncer de boca é fundamental para elevar as taxas de sobrevida dos pacientes, no entanto, a maioria destas lesões continua sendo diagnosticada nos estágios tardios da doença. Evidências demonstram que o desenvolvimento do câncer bucal está associado ao aparecimento de lesões bucais com potencial de transformação carcinomatosa, conhecidas como lesões cancerizáveis. Deste modo, o desenvolvimento de técnicas que facilitem o diagnóstico clínico adequado destas condições merece destaque. Enfatiza-se a técnica da aplicação do Azul de Toluidina (AT) seguido da Quimioluminiscência (QL), que destaca características de lesões bucais suspeitas de malignidade, facilitando o diagnóstico e monitoramento, além de ajuda na seleção do melhor sítio para biópsia. A amostra foi composta por 50 pacientes adultos portadores de lesões bucais brancas, nos quais se aplicou a técnica em estudo. A área mais corada pelo AT foi biopsiada e os resultados histopatológicos foram comparados aos diagnósticos clínicos. Os resultados mostraram que 95,8% dos resultados histopatológicos foram compatíveis com os clínicos. As áreas mais coradas pelo AT foram as que apresentaram maior grau de displasia epitelial, portanto, maior risco de transformação maligna, o que faz do AT um importante método auxiliar na detecção de lesões suspeitas de malignidade e na seleção de sítios para biópsia. Já o dispositivo de QL melhorou a visualização dos bordos de algumas lesões, mas não acrescentou dados clínicos significativos ao diagnóstico, segundo critérios observacionais
Uso do azul de toluidina seguido da quimioluminiscência como método auxiliar de diagnóstico clínico de lesões bucais cancerizáveis
No full textTCC (graduação) - Universidade Federal de Santa Catarina, Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Curso de Odontologia.O diagnóstico precoce do câncer de boca é fundamental para elevar as taxas de sobrevida dos pacientes, no entanto, a maioria destas lesões continua sendo diagnosticada nos estágios tardios da doença. Evidências demonstram que o desenvolvimento do câncer bucal está associado ao aparecimento de lesões bucais com potencial de transformação carcinomatosa, conhecidas como lesões cancerizáveis. Deste modo, o desenvolvimento de técnicas que facilitem o diagnóstico clínico adequado destas condições merece destaque. Enfatiza-se a técnica da aplicação do Azul de Toluidina (AT) seguido da Quimioluminiscência (QL), que destaca características de lesões bucais suspeitas de malignidade, facilitando o diagnóstico e monitoramento, além de ajuda na seleção do melhor sítio para biópsia. A amostra foi composta por 50 pacientes adultos portadores de lesões bucais brancas, nos quais se aplicou a técnica em estudo. A área mais corada pelo AT foi biopsiada e os resultados histopatológicos foram comparados aos diagnósticos clínicos. Os resultados mostraram que 95,8% dos resultados histopatológicos foram compatíveis com os clínicos. As áreas mais coradas pelo AT foram as que apresentaram maior grau de displasia epitelial, portanto, maior risco de transformação maligna, o que faz do AT um importante método auxiliar na detecção de lesões suspeitas de malignidade e na seleção de sítios para biópsia. Já o dispositivo de QL melhorou a visualização dos bordos de algumas lesões, mas não acrescentou dados clínicos significativos ao diagnóstico, segundo critérios observacionais
HERMENEUTICS OF THE WARIA: WARIA’S HERMENEUTICAL TAFSIR OF AL-FATIHAH
No full textQur’an, as it is believed by Muslims, is The Holy Book as well as the manifestation of The Words of God (Kalamullah). It has meanings which obviously was being ‘monopolized’ by The Ulama. In regarding of consequence, the authority of interpreting this Kalamullahseems ‘limited’ only for particular groups. Then, according the author it becomes the main factor leads the stagnancy of Quranic interpretation studies in this modern era. In this context, Schleiermacher’s teory about ‘psychological explication’ (1998), Paul Ricoeur’s theory about ‘distantiation and appropriation’ (1976), and ‘the marginalized reading of Scripture’ theory proposed by Simopoulos (2007), create a new path in interpreting Quran. From those theories, the author sheds the lights on hermeneutical interpretation of al-Fatihahby as one of the marginalized groups in Indonesia, the Waria. This paper concludes that the waria use their hermeneutical way of understanding the Scripture and produce not only anoriginal interpretation, but also contextual and full of theological reflections.Qur’an, as it is believed by Muslims, is The Holy Book as well as the manifestation of The Words of God (Kalamullah). It has meanings which obviously was being ‘monopolized’ by The Ulama. In regarding of consequence, the authority of interpreting this Kalamullahseems ‘limited’ only for particular groups. Then, according the author it becomes the main factor leads the stagnancy of Quranic interpretation studies in this modern era. In this context, Schleiermacher’s teory about ‘psychological explication’ (1998), Paul Ricoeur’s theory about ‘distantiation and appropriation’ (1976), and ‘the marginalized reading of Scripture’ theory proposed by Simopoulos (2007), create a new path in interpreting Quran. From those theories, the author sheds the lights on hermeneutical interpretation of al-Fatihahby as one of the marginalized groups in Indonesia, the Waria. This paper concludes that the waria use their hermeneutical way of understanding the Scripture and produce not only anoriginal interpretation, but also contextual and full of theological reflections
Melaena with Peutz-Jeghers syndrome: a case report
No full textIntroduction: Peutz-Jeghers syndrome (PJS) is a rare familial disorder characterised by mucocutaneous pigmentation, gastrointestinal and extragastrointestinal hamartomatous polyps and an increased risk of malignancy. Peutz-Jeghers polyps in the bowel may result in intussusception. This complication usually manifests with abdominal pain and signs of intestinal obstruction.
Case Presentation: We report the case of a 24-year-old Caucasian male who presented with melaena. Pigmentation of the buccal mucosa was noted but he was pain-free and examination of the abdomen was unremarkable. Upper gastrointestinal endoscopy revealed multiple polyps. An urgent abdominal computed tomography (CT) scan revealed multiple small bowel intussusceptions. Laparotomy was undertaken on our patient, reducing the intussusceptions and removing the polyps by enterotomies. Bowel resection was not needed.
Conclusion: Melaena in PJS needs to be urgently investigated through a CT scan even in the absence of abdominal pain and when clinical examination of the abdomen shows normal findings. Although rare, the underlying cause could be intussusception, which if missed could result in grave consequences
Alimentos de rua em Florianóplis: perfil do manipulador e características dos alimentos comercializados
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em NutriçãoO comércio informal de alimentos de rua desempenha papel importante em muitos países, destacando-se como fonte de emprego e de variedade de alimentos convenientes e acessíveis para as pessoas. Por outro lado, apresenta aspectos que podem comprometer a segurança dos alimentos comercializados. Apesar da importância dos alimentos de rua há poucos estudos na maioria dos municípios brasileiros, inclusive em Florianópolis, onde o estudo foi realizado. O objetivo deste estudo foi caracterizar o perfil do manipulador de alimentos de rua e os alimentos comercializados na região central da cidade de Florianópolis-SC. Realizou-se um estudo exploratório, descritivo, de natureza quali-quantitativa, com todos os vendedores de alimentos de rua cadastrados na lista da prefeitura local, que operavam em pontos de venda estacionários. Foram coletadas informações sobre as características sociodemográficas, gerais, do ponto de venda e as práticas de higiene do vendedor por meio de observação e de um roteiro de entrevista estruturado, pré-testado, entre novembro e dezembro de 2011. Dentre os 50 participantes do estudo, 60% eram do sexo masculino, a maior parte era casada e tinha idade entre 40 e 59 anos. Predominaram vendedores sem ensino formal ou fundamental incompleto e com estimativa de venda em reais de até dois salários mínimos. A partir dos dados sobre a atividade laboral, verificou-se que os pontos de vendas eram operados, em sua maioria, por um vendedor e que 90% não tinham outra fonte de renda. O interesse e a dificuldade em encontrar outro emprego foram os principais motivos que levaram os vendedores a trabalharem com a atividade. Dentre os vendedores, 46% nunca haviam realizado o curso para manipulação de alimentos e 28% não tinham o atestado de saúde. Com relação às práticas de higiene, foi observado que 86% dos vendedores usavam jaleco e o mantinham limpo. A maioria protegia parcialmente os cabelos com touca ou boné e quase ¾ usavam adornos. Dentre os 15 tabagistas deste estudo, 20% informaram fumar durante o preparo dos alimentos. Observou-se que quase todos manipulavam o dinheiro e o alimento, sem higienizar as mãos. Com base nas informações sobre o tipo de alimento comercializado, verificou-se que 30% dos participantes vendiam pipoca preparada no ponto de venda; 28%, doces e salgadinhos industrializados; 20%, cachorro-quente e churrasquinho; 22%, alimentos preparados com antecedência ou pré-preparados e finalizados no ponto de venda. O percentual de vendedores que tinha o curso para manipulação de alimentos foi maior para os de alimentos preparados antecipadamente ou pré-preparados e finalizados no ponto de venda, do que os de industrializados. A partir deste estudo, verificou-se que o comércio de alimentos de rua representa para muitos vendedores sua única fonte de renda e, que a maioria dos pontos de venda é operada por apenas um vendedor, que não movimenta a economia. Por meio dos vendedores, as pessoas que transitam pelo centro da cidade e os comerciantes têm disponíveis alimentos prontos e regionais, como o pinhão. Embora uma exigência legal, verificou-se que quase metade dos vendedores nunca havia feito o curso para manipulação de alimentos e 28% não tinham o atestado de saúde. Entre as práticas de higiene inadequadas observadas neste estudo destacam-se: manuseio de dinheiro e alimento sem higienizar as mãos; fumar durante o preparo dos alimentos; proteção parcial dos cabelos e uso de adornos. Constata-se a necessidade de repensar os treinamentos ofertados, a fim de que sejam efetivos para que os vendedores cumpram as normas básicas de higiene. Aos órgãos competentes cabe verificar a razão pela qual as exigências dispostas na lei não estão sendo cumpridas e o vendedor continua tendo seu alvará de licença renovado. Ainda, tornar mais eficientes as maneiras de verificar as razões pelas quais tais exigências e as boas práticas de higiene não estão sendo seguidas. Por fim, formular normas específicas para a venda de alimentos de rua e proporcionar infraestrutura básica e adequada ao vendedor.The informal trade of street food plays an important role in many countries, especially as a source of employment and of convenient and affordable food for people. On the other hand, it has aspects that may compromise food safety. Despite the importance of street food, there are few studies in most Brazilian cities, including Florianópolis, where this research was conducted. The aim of this study was to characterize the street food vendor profile and the food marketed in the central region of the city of Florianópolis-SC. An exploratory, descriptive, qualitative and quantitative study was held with all street food vendors registered with the local government, which operated in stationary points of sale. Information regarding general and sociodemographic characteristics, as well as good manipulation practices of the stationary vendors was collected through a pre-tested and well structured interview questionnaire, between November and December 2011. Among the 50 participants of the study, 60% were male; most were married and aged between 49 and 50 years. Their level of education was predominantly low and their average monthly income was between one and two minimum wages. The data collected about labour activity showed that the semi-permanent stationary vending stalls were mostly operated by a single seller and that 90% of them had no other source of income. The interest and the difficulty in finding another job were the main reasons that led vendors to work on this activity. Among the sellers, 46% had not received training in food handling and 72% had a health certificate. In relation to hygienic handling of street-vended foods, it was observed that 86% of the sellers wore a uniform or overall, changed daily and kept clean. More than half of the sellers partially covered their hair with a hair cap and approximately ¾ wore jewelry. Among the 15 sellers who were smokers, 20% informed smoking during food preparation. It was observed that almost all sellers handled money and food without cleaning their hands. Based on information about the type of food marketed, it was found that 30% of the participants sold prepared popcorn at the point of sale; 28% sold industrialized snacks and sweets and 20%, hot dog and barbecue; 22% sold food previously prepared or pre-prepared and finalized on the point of sale. The percentage of sellers that had taken the food handling course was higher for sellers of previously prepared or finalized food on the point of sale (cocada, pamonha, bonbon and churros), than those of industrialized snacks and sweets. From this study, it would appear that the street food trade represents, for many sellers, a source of employment and the only source of income. It was also observed that most of the points of sale were operated by only one seller that does not move the economy. Through the work of these street food vendors, people going through the city center, as well as traders, have available local and ready-to-eat foods, like the pine nut. Although a legal obligation, it was observed that almost half of the sellers had never had course of food handling and 28% had no health certificate. Among the inadequate hygienic practices observed in this study the following outstand: the handling of money and food without cleaning hands, smoking during food preparation, partial protection of the hair and use of jewelry. There is a need to rethink the trainings offered in order to be more effective and have the sellers following the basic rules of hygiene. With regards to regulatory organizations, it is their responsibility to verify why obligations existing in the law are not being followed and sellers continue to have permits renewed. Nevertheless, it is necessary to find more efficient ways to verify the reasons why these obligations and good handling practices are not being followed. Finally, it is necessary to formulate specific rules for the street food segment and provide some basic and adequate infrastructure to vendor
Relationship between distance run per week, omega-3 index, and arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio: An Observational Retrospective Study in Non-elite Runners
No full textBackground: Tissue availability of polyunsaturated fatty acids (PUFA) depends on several factors, including dietary intake, physical exercise, genetic variation, and metabolic turnover. However, there is limited evidence whether running training activity per se may influence indices associated with PUFA metabolism such as Omega-3 (ω-3) index and arachidonic acid (AA; 20:4ω-6)/eicosapentaenoic acid (EPA; 20:5ω-3) ratio. Objective: To examine the association between kilometers (Km) run per week and changes in ω-3 index and AA/EPA ratio. Methods: We conducted a retrospective, observational, cohort study of 257 non-elite runners (mean age: 40.85 ± 12.17 years) who consumed no fatty acid supplements and provided a blood sample for analysis. The whole blood samples were collected by finger sticks, stored on absorbent filter paper, and then PUFA were quantified by gas chromatography (GC) and ω-3 index and AA/EPA ratio measured. Results: In a multivariate linear regression model, a gradual decrease of the ω-3 index was observed with higher weekly running distance (β = −0.033; 95% CI −0.039 to −0.026; R2 = 0.447; p < 0.0001). We also found a progressive increase of the AA/EPA ratio in subjects who ran greater weekly distances (β = 0.092; 95% CI 0.038 to 0.146; R2 = 0.320; p = 0.001). No other significant associations were observed with other variables, including years of running training and weekly training frequency (hours/week). Finally, as expected, a significant inverse correlation between ω-3 index and AA/EPA ratio (β = −2.614; 95% CI −3.407 to −1.821; R2 = 0.336; p < 0.0001) was detected. Conclusions: These findings suggest that distance running training and its weekly volume may negatively contribute to changes of the ω-3 index and AA/EPA ratio. Further studies with greater sample size will be required to replicate and extend these data
Safety profile of sequential small caliber drug eluting bead chemoembolization (DEB-TACE): results in 237 patients
No full textPurpose: To record complications of DEB-TACE performed with DC Bead of diameters 100-300 and 300-500 μm loaded with doxorubicin.
Materials and Methods: Included are 237 patients treated with sequential DEB-TACE (3 sessions/6 month f-u). National Cancer Institute Common Terminology Criteria for Adverse Events (version 3.0) were used to categorize complications.
Results: Results are reported on intention to treat. There were no periprocedural deaths. Thirty day mortality was 1.26% with same overall grade 5 complications, notably one periprocedural sepsis and 2 liver abscesses. One liver abscess was treated conservatively (considered Grade 2 complication). Grade 4 complications resulted in 1.68% (4/237) (irreversible liver failure that led to the discontinuation of TACE). Grade 2 liver function deterioration developed in 10 pts (4.2%) that led to protocol abortion in 1.68%. Cholocystitis was documented with ultrasound in 2.95 to 5.06% across the three sessions (all grade 2 complications). Pleural effusion was observed in 2.1 to 2.95% across treatments (only one was a grade 3 complication requiring drainage; 0.42%). There was 1 patient who developed laboratory pancreatitis (0.42%) and 1 limited GI bleeding not related to varices (0.42%). Overall Post Embolization Syndrome (PES) classified as grade 1 or 2 complication was observed in 60.75 to 85.65% across treatments – the lower rates achieved after routine preventive administration of non-steroidal analgesics for 5 days post treatment.
Conclusion: This study shows that: 1) DEB TACE is safe with fewer complications compared to reported rates of conventional TACE, and 2) small calibres are safe and do not result in increased complication rates
Technical, organizational and oral history regarding the soil samples measurements for Cs-137 because of the Chernobyl accident fallout
No full textData are given, commentary is supplied and explanations are provided with
regard to the technical, the organizational and, of course, the human history
connected to the time of research, which resulted to the paper entitled "Soil
sampling and Cs-137 analysis of the Chernobyl fallout in Greece", written by
late Professor S.E. Simopoulos. This paper has been provided in Greek
translation within an issued honorary volume (ISBN 978-960-254-714-4).
Reasonably, the narration starts with the review of the political, the
financial and the social situation of Greece around 1986. Subsequently, an
analysis is given on the then available means, the persons involved, the
methods used, the lessons learned and any other connection with the oral
history of the NTUA's Nuclear Engineering Laboratory and other relevant Greek
Laboratories. For this history, written proof is now scarce and the persons
available to pass it on are growing less and less. N.P. Petropoulos, now
Laboratory member and then student of Professor S.E. Simopoulos was in charge
of preparation of this text.Comment: 28 pages, in Greek language, 20 figure
Molecular analysis of appendiceal mucinous cystadenoma and rectal adenocarcinoma in a patient with urothelial carcinoma: a case report
No full textIntroduction: In this report, we present the case of a patient affected by appendiceal cystadenoma, a colorectal adenocarcinoma, and a concomitant bladder carcinoma, as well as the results of the molecular study of the most relevant mutational pathways involved in these tumors.
Case presentation: A 68-year-old Italian man was admitted to our unit complaining of macrohematuria, rectorrhagia, and rectal tenesmus for about 2 months. A colonoscopy showed the presence of a rectal lesion at 11cm from the anal margin; multiple biopsies were performed and a diagnosis of moderately differentiated adenocarcinoma was made. Abdominal ultrasonography and total body computed tomography performed subsequently to stage the rectal cancer showed the presence of two round nodules, interpreted as swollen lymph nodes of neoplastic origin, at the anterior aspect of the iliopsoas muscle and a budding lesion affecting the bladder. The patient underwent transurethral biopsy of the lesion in the right retrotrigonal region; the diagnosis was grade II urothelial carcinoma. The patient underwent an open anterior rectal resection with loco-regional lymphadenectomy. An enlarged appendix and a voluminous whitish soft-tissue lesion requiring an appendicectomy were detected perioperatively. Transurethral resection of the bladder lesion was also performed. The histological examination revealed that the nodular lesions in the appendix were due to a cystadenoma. For mutation analysis, genomic deoxyribonucleic acid was isolated from tumor tissue samples; for PIK3CA mutations, screening revealed that all three samples analyzed carried mutations in exon 9.
Conclusions: Appendiceal mucoceles are rare but require adequate surgical treatment, given their malignant potential and the possibility of causing peritoneal pseudomyxoma. It is essential to make a correct preoperative evaluation based on a colonoscopy rather than ultrasound and computed tomography to exclude synchronous neoplasias often associated with mucoceles and to plan the optimum surgical strategy. The association between appendiceal mucoceles and other neoplasias is relatively frequent, especially with colorectal cancer. Oncogenic activation in the PIK3CA-depending pathway may contribute substantially to the pathogenesis of the different solid tumors in the same patient
Hermeneutics of the Waria: Waria's Hermeneutical Tafsir of Al-fatihah Fazlul Rahman Icrs Universitas Gadjah Mada, YOGYAKARTA
No full textQur‟an, as it is believed by Muslims, is The Holy Book as well as the manifestation of TheWords of God (Kalamullah). It has meanings which obviously was being „monopolized‟by The Ulama. In regarding of consequence, the authority of interpreting thisKalamullahseems „limited‟ only for particular groups. Then, according the author itbecomes the main factor leads the stagnancy of Quranic interpretation studies in thismodern era. In this context, Schleiermacher‟s teory about „psychological explication‟(1998), Paul Ricoeur‟s theory about „distantiation and appropriation‟ (1976), and „themarginalized reading of Scripture‟ theory proposed by Simopoulos (2007), create a newpath in interpreting Quran. From those theories, the author sheds the lights onhermeneutical interpretation of al-Fatihahby as one of the marginalized groups inIndonesia, the Waria. This paper concludes that the waria use their hermeneutical way ofunderstanding the Scripture and produce not only anoriginal interpretation, but alsocontextual and full of theological reflections
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