533 research outputs found
Complexation and enhancement of temozolomide solubility with cyclodextrins
No full textTemozolomide is a poorly soluble anti-cancer drug used in the treatment of some brain cancers. Following literature reports about the enhancement of solubility and stability for these kinds of drugs upon complexation with cyclodextrins, we aimed to form an inclusion complex between temozolomide and the different types of cyclodextrins (CDs) to enhance its solubility. In this study, three different cyclodextrins (beta-CD, hydroxyl-beta-CD and gamma-CD) were used, and changes in solubility was measured by UV-Vis Spectroscopy and HPLC. Morphological changes upon complexation were shown by the Scanning Electron Microscope (SEM), and weight loss profiles with respect to temperatures which were unique to the compounds were shown by Thermogravimetric Analysis. Changes in heat release profiles were shown by Differential Scanning Calorimeter (DSC). Drug solubility was measured to be increased to around 25% for 1:1 molar ratio for all used CD complexations. Changes of morphology, heat release and weight loss profiles are consistent with the formation of an inclusion complex between CDs and temozolomide. In this study, success was shown in the enhancement of temozolomide solubility upon complexation with different types of CDs. It has been demonstrated that cyclodextrins can be used as complexing agents for poorly soluble anti-cancer drugs, increasing their solubility and hence drug availability
Eskişehir Devlet Demir Yolları Yerleşkesi Lojman Konutları Plan Tipolojileri Üzerine bir Çalışma: Eskişehir Devlet Demir Yolları Yerleşkesi Lojman Konutları Plan Tipolojileri Üzerine bir Çalışma
No full textIndustrial facilities are not buildings containing only machines, but are the means of the presentation and dissemination of a new life style and its culture to the society. In this context, the founders of the industrial facilities created the Şirket Kentis in order to present the workers more efficient conditions. Industrialization as one of the founding factors of Modern Turkey, was used as a means of “organizing the society and intervening its inner dynamics” while transforming the society and making a difference. The Eskisehir State Railways (Tülomsafl) Campus, in this frame, is one of the pioneer cases of the industrial heritage of our time in terms of its functional and spatial features. The campus, is one of the first settlements satisfying the social, cultural, educational and residential needs of the workers as a multifunctional campus offering a micro scale city model. In the frame of the present article, the development of the Şirket Kentis that emerged in the West during 1800’s and became widespread in Turkey with the proclamation of the republic will be summarized and the residential plan typologies of the Eskisehir State Railways (Tülomsafl) Campus will be analyzed.Sanayi yapıları yalnızca makineleri barındıran binalar değil, yeni bir yaşam tarzının ve kültürünün topluma tanıtılmasının ve yayılmasının araçlarıdırlar. Bu kapsamda, İngiltere, Almanya ve ABD’de endüstri devrimi ile birlikte artan üretim mekânları ile yaygınlık kazanan, sanayi yapıları kurucuları, çalışanlardan daha etkin bir biçimde yararlanmak ve daha verimli şartlar sunma kaygısı ile Şirket Kenti’ları (Şirket Kentlerini) oluşturmuşlardır. Sanayileşme, Batıda olduğu gibi Modern Türkiye’nin kurucu öğelerinden olmuş, bir yandan toplumu dönüştürüp farklılaştırırken, diğer yandan toplumu örgütlemenin ve onun iç dinamiklerine müdahale etmenin bir aracı olarak kullanılmıştır. Eskişehir Devlet Demir Yolları (Tülomsaş) Yerleşkesi; günümüz endüstriyel mirasının fonksiyonel ve mekânsal bağlamda öncü örneklerindendir. Bir prototip olma özelliği taşıyan yerleşke; çalışanlarının çalışma dışında, barınma, sosyal, kültürel ve eğitime yönelik gereksinimlerini karşılayan mikro ölçekli bir kent modeli ortaya koyan ilk yapılanmalardan biri olma özelliği taşımaktadır. Makale kapsamında; Batıda 1800’lü yıllarda ortaya çıkan Türkiye’de ise Cumhuriyetin ilanı ile örneklerini veren Şirket Kentlerinin gelişimi özetlenerek Eskişehir’de bir şirket kenti örneği olan Devlet Demir Yolları (Tülomsaş) Yerleşkesinin konut plan tipolojileri incelenecektir
A novel semantic smoothing kernel for text classification with class-based weighting
No full textAltınel, Berna (Dogus Author), Diri, Banu (Dogus Author), Ganiz, Murat Can (Dogus Author) -- #articleinpress#Altınel, Berna (Dogus Author), Diri, Banu (Dogus Author), Ganiz, Murat Can (Dogus Author)In this study, we propose a novel methodology to build a semantic smoothing kernel to use with Support Vector Machines (SVM) for text classification. The suggested approach is based on two key concepts; class-based term weighting and changing the orthogonality of vector space. A class-based term weighting methodology is used for transformation of documents from the original space to the feature space. This class-based weighting basically groups terms based on their importance for each class and consequently smooths the representation of documents. This is accomplished by changing the orthogonality of the Vector Space Model (VSM) with introducing class-based dependencies between terms. As a result, on the extreme case, two documents can be seen as similar even if they do not share any terms but their terms are similarly weighted for a particular class. The resulting semantic kernel can directly make use of class information in extracting semantic information between terms, therefore it can be considered as a supervised kernel. For our experimental evaluation, we analyze the performance of the suggested kernel with a large number of experiments on benchmark textual datasets and present results with respect to varying experimental conditions. To the best of our knowledge, this is the first study to use class-based term weighting in order to build a supervised semantic kernel for SVM. We compare our results with kernels that are commonly used in SVM such as linear kernel, polynomial kernel, Radial Basis Function (RBF) kernel and with several corpus-based semantic kernels. According to our experimental results the proposed method favorably improves classification accuracy over linear kernel and several corpus-based semantic kernels in terms of both accuracy and speed
VIBRATIONAL SPECTRA OF THE MLCl COMPLEX FROM THEORETICAL CALCULATIONS
No full textAuthor Institution: Department of Physics, Mustafa Kemal University, Hatay, Turkey, 31034 (email to B.C.: [email protected])The geometric and vibrational parameters (harmonic and anharmonic frequencies) of the MLCl [M= Mn, Fe, Co, Ni, Cu, Zn, Cd, Hg; L= Ethylenediamine (en)] donor-acceptor complexes have been studied by using HF and MPW1PW91+iop(3/76=00572004280)/gen methods. Binding, reorganization, atomization, HOMO-LUMO and ionization potential energies have also been calculated with the same method. SQM calculations have been performed by using anharmonic frequencies and experimental data. The obtained results were found to be in good agreement with the corresponding experimental findings
Targeting of temozolomide using magnetic nanobeads: an in vitro study
No full textTemozolomide, a chemotherapeutic drug that is often administered for the treatment of brain cancer has severe side effects and a poor aqueous solubility. In order to decrease the detrimental effect of the drug over healthy cells, a novel drug delivery vehicle was developed where the therapeutic drug was encapsulated within the hydrophobic cavities of beta-CD modified magnetite nanoparticles, which are embedded in chitosan nanobeads prepared by salt addition. In-vitro studies have shown that the magnetic properties of the novel delivery vehicle are adequate for targeted drug delivery applications under an external magnetic field. Additionally, an increase in the amount of chitosan was shown to exhibit a strong shielding effect over the magnetic properties of the delivery vehicle, which lead to deterioration of the amount of captured drug at the targeted area, suggesting a delicate balance between the amounts of constituents composing the drug delivery vehicle
The effect of dietary iron intake on cognitive functions, depression levels and appetite status of elderly people living at home
No full textYüksek Lisans TeziBu çalışma, evde yaşayan yaşlı bireylerin diyet ile demir alım düzeylerinin bilişsel fonksiyonları, depresyon düzeyleri ve iştah durumları üzerine etkisini araştırmak amacıyla yapılmış kesitsel nitelikte bir çalışmadır. Çalışmaya, Eskişehir ilinde, evde yaşayan 65 yaş ve üzeri 84 gönüllü kadın ve erkek yaşlı birey katılmıştır. Çalışmada, sosyodemografik özellikler formu, antropometrik ölçümler, Geriatrik Depresyon Ölçeği Kısa Form (GDÖ-15), Basitleştirilmiş Beslenme İştahı Anketi (SNAQ), Mini Nütrisyonel Değerlendirme Formu Kısa Test (MNA-SF) ve Standardize Mini Mental Test (SMMT) ve 24 saatlik geriye dönük besin tüketim kaydı veri toplama aracı olarak kullanılmıştır. Veriler, araştırmacı tarafından yüz yüze görüşme yöntemiyle alınmıştır. Araştırmaya katılan bireylerin 51’i kadın, 33’ü erkek olup; katılımcıların yaş ortalaması 70,4±6,54 yıl olarak belirlenmiştir. Cinsiyete göre diyet demir alımları karşılaştırıldığında; kadın katılımcıların %52,9’unun ve erkek katılımcıların %33,3’ünün yetersiz demir aldığı saptanmıştır (p>0,05). Ayrıca diyet ile demir alım düzeylerinin, katılımcıların sosyodemografik özellikleri ve antropometrik ölçümleri üzerinde anlamlı bir etkisinin olmadığı belirlenmiştir (p>0,05). Günlük enerji ve besin ögesi alım miktarları değerlendirildiğinde; yeterli demir alan katılımcıların enerji, protein, karbonhidrat, yağ ve lif alımı ile mikrobesin ögelerinden E vitamini, B1 vitamini, B2 vitamini, B6 vitamini, B12 vitamini, potasyum, kalsiyum, magnezyum, fosfor ve çinko alımlarının daha yüksek olduğu saptanmıştır (p0,05). Beslenme durumları değerlendirildiğinde yetersiz demir alan katılımcıların MNA-SF puanı (13,0±1,25) yeterli demir alan katılımcıların puanından (13,6±1,12) düşük bulunmuş ancak nütrisyon riski açısından istatistiksel olarak anlamlı bir fark saptanmamıştır. İştah durumları değerlendirildiğinde; yetersiz demir alan katılımcıların SNAQ puan (15,0±1,84) yeterli demir alan katılımcılardan (16,0±2,01) düşük bulunmuştur (p>0,05). Ancak demir alım düzeylerinin son 6 ay içinde en az %5 vücut ağırlığı kaybı riskini arttırmadığı saptanmıştır. Ölçek puanları arasındaki ilişki değerlendirildiğinde; yetersiz demir alan katılımcılarda GDÖ-15 ile MNA-SF ve GDÖ-15 ile SMMT arasında orta düzeyde negatif yönlü anlamlı ilişki saptanmıştır. Yeterli demir alan katılımcılarda ise GDÖ-15 ile SMMT arasında zayıf düzeyde negatif yönlü anlamlı ilişki bulunmuştur. Her iki grupta da geriatrik depresyon puanı arttıkça bilişsel puanlarının anlamlı düzeyde azaldığı belirlenmiştir. Sonuç olarak, yaşlı bireylerde yetersiz demir alımı; bireylerin beslenme durumları ve iştahını etkileyebileceğini göstermektedir. Ayrıca depresyon düzeyleri bireylerin beslenme durumları ve bilişsel fonksiyonları ile ilişkili olabileceği gösterilmiştir. Bu doğrultuda; yaşlı bireylerin düzenli beslenme taramaları yapılmalı, özellikle yetersiz demir alımı olan bireylerin iştah ve malnütrisyon düzeyleri değerlendirilmelidir. Aynı zamanda multidisipliner bir sağlık yaklaşımı ile yaşlıların sağlığı bütüncül değerlendirilmelidir.This cross-sectional study was conducted to investigate the effects of dietary iron intake levels on cognitive functions, depression levels, and appetite status in elderly individuals living at home. A total of 84 voluntary elderly individuals (51 women and 33 men), aged 65 years and older, residing in Eskişehir province, participated in the study. Data collection tools included a sociodemographic characteristics form, anthropometric measurements, the Geriatric Depression Scale–Short Form (GDS-15), the Simplified Nutritional Appetite Questionnaire (SNAQ), the Mini Nutritional Assessment–Short Form (MNA-SF), the Standardized Mini-Mental Test (SMMT), and a 24-hour dietary recall. Data were collected by the researcher through face-to-face interviews. The mean age of the participants was 70,4±6,54 years. When dietary iron intake was compared by gender, it was found that 52,9% of female and 33,3% of male participants had inadequate iron intake (p>0,05). Furthermore, dietary iron intake levels did not significantly affect participants sociodemographic characteristics or anthropometric measurements (p>0,05). Evaluation of daily energy and nutrient intake revealed that participants with adequate iron intake had significantly higher intakes of energy, protein, carbohydrates, fat, fiber, and micronutrients such as vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, potassium, calcium, magnesium, phosphorus, and zinc (p0,05). Although the MNA-SF score of participants with inadequate iron intake (13,0±1,25) was lower than that of those with adequate intake (13,6±1,12), this difference was not statistically significant in terms of nutritional risk. Regarding appetite, SNAQ scores of participants with inadequate iron intake (15,0±1,84) were significantly lower than those of participants with adequate intake (16,0±2,01) (p<0,05); however, iron intake levels were not associated with a ≥5% weight loss risk in the past 6 months. When the relationships among scale scores were evaluated, a moderate negative correlation was found between GDS-15 and both MNA-SF and SMMT in participants with inadequate iron intake, while a weak negative correlation was observed between GDS-15 and SMMT in participants with adequate iron intake. In both groups, higher geriatric depression scores were significantly associated with lower cognitive function scores. In conclusion, inadequate dietary iron intake in older adults may negatively impact their nutritional status and appetite. Additionally, depression levels may be associated with both nutritional status and cognitive function. Accordingly, regular nutritional screenings should be conducted for older individuals, and those with inadequate iron intake should be evaluated in terms of appetite and malnutrition risk. Furthermore, the health of the elderly should be assessed holistically using a multidisciplinary approach
Experimental evaluation of meta-heuristics for multi-objective capacitated multiple allocation hub location problem
No full textQuasi-greedy bases for sequences with gaps
No full textIn this paper, we establish new results in the theory started by T. Oikhberg in Oikhberg (2018) where the author joins greedy approximation theory with the use of sequences with gaps. Concretely, we study and provide some answers to three open questions related to quasi-greedy bases for sequences with gaps posed in Oikhberg (2018)[Section 6].Fil: Berasategui, Miguel Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigaciones Matemáticas "Luis A. Santaló". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Matemáticas "Luis A. Santaló"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; ArgentinaFil: Berna Larrosa, Pablo Manuel. Universidad San Pablo; Españ
The Effects Of Women’s Insight Levels On Breast Cancer Prevention Behaviors: A Cross-Sectional Study
No full textWomen & HealthThe aim of this study is to determine the effect of women’s insight levels on their breast cancer prevention behaviors in primary health care services. A systematic sampling method was used to select a sample of 393 women in a province in Turkey. Socio-demographic Characteristics Form, Insight Scale and Scale for Determining Factors Affecting Women’s Breast Cancer Prevention Behaviour were used as data collection tools. Data were collected face-to-face and then analyzed statistically using Student’s t-test, one-way analysis of variance, Tukey HSD, Spearman correlation test and multiple regression analysis. The results showed that those who felt “healthy” had significantly higher mean breast cancer prevention behavior (p < .05). It was determined that there was a weak positive correlation between the level of insight and breast cancer prevention behaviors, and the increase in the level of insight had a significant positive effect of 0.37 ± 0.051 points on breast cancer prevention behaviors. It was found that there was a significant negative effect on prevention behaviors with 1.66 ± 0.796 points in those with a high education level and 1.58 ± 0.505 points in those with suspected disease. In conclusion, in this study, it was determined that insight level, education level, and awareness of early diagnosis affected the prevention behaviors of breast cancer
A New Model for the Multi-Objective Multiple Allocation Hub Network Design and Routing Problem
No full textIn this paper, we propose a new model for the multi-objective multiple allocation hub network design and routing problem which contains determining the location of hubs, the design of hub network, and the routing of commodities between source-destination pairs in the given network. The selected hubs are not assumed to be fully connected, and each node and arc in the network has capacity constraints. The multiple objectives of the problem are the minimization of total fixed and transportation costs and the minimization of the maximum travel time required for routing. We propose a mathematical formulation for the multi-objective problem and present a meta-heuristic solution based on a well-known multi-objective evolutionary algorithm. Using the proposed formulation, we are able to find the optimal solution for small networks of five nodes and seven nodes. To evaluate the performance of our heuristic approach on real data, the computational experiments are conducted on Turkish postal system data set. The results demonstrate that our heuristic approach can find feasible solutions to the problem in reasonable execution time, which is less than 10 min
- …
